Emricasan

Catalog No.S7775 Synonyms: IDN-6556, PF 03491390, PF-03491390

Emricasan Chemical Structure

Molecular Weight(MW): 569.50

Emricasan is a potent irreversible pan-caspase inhibitor.

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Biological Activity

Description Emricasan is a potent irreversible pan-caspase inhibitor.
Targets
caspase [1]
In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
JFas cells M1;JXGZ2dmO2aX;uJIF{e2G7 MkHxTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiSl\hd{Bk\WyuczygTWM2OD1yLkCyOUDPxE1? MoP3NVYzPTB4M{W=
THP-1 cells NIX0eGVHfW6ldHnvckBie3OjeR?= M33NR2lvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IGTIVE0yKGOnbHzzMEBKSzVyPUCuNlch|ryP Mn3YNVYzPTB4M{W=

... Click to View More Cell Line Experimental Data

In vivo Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan[1]. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection[2].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: Astrocytes
  • Concentrations: 9 μM
  • Incubation Time: 1 h
  • Method: Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: C57BL/6J mice
  • Formulation: 2% (v/v) DMSO in 0.5% (w/v) methylcellulose
  • Dosages: 0.3mg/kg/day
  • Administration: i.g.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (175.59 mM)
Ethanol 100 mg/mL (175.59 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 569.50
Formula

C26H27F4N3O7

CAS No. 254750-02-2
Storage powder
Synonyms IDN-6556, PF 03491390, PF-03491390

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID