Catalog No.S7314 Synonyms: Caspase-8 Inhibitor
Molecular Weight(MW): 654.68
Z-IETD-FMK is a specific Caspase-8 inhibitor.
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|Description||Z-IETD-FMK is a specific Caspase-8 inhibitor.|
Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli.  Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3.  Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. 
|In vivo||In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection.  Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. |
|In vitro||DMSO||91 mg/mL (138.99 mM)|
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