PAC-1 Chemical Structure
VX-765 is a novel and irreversible IL-converting enzyme/caspase-1 inhibitor with an IC50 of 0.8 nM.
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
Lenalidomide also known as CC-5013 & Revlimid is TNF-alpha inhibitor. Revlimid with purity >99% & solubility DMSO is available.
Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM.
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
ABT-263 (Navitoclax) is a potent, small-molecule Bcl-2 family protein inhibitor for Bcl-xL, Bcl-2 and Bcl-w with IC50 of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.
HA14-1 is an inhibitor of Bcl-2 (IC50 of ≈9 µM).
TW-37 is a Bcl-2 protein family inhibitor with a Ki of 0.29 μM.
YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor of survivin with IC50 of 0.54 nM.
JNJ-26854165 is an orally bioavailable, first-in-class small-molecule HDM2 antagonist with potential antineoplastic activity.
| Molecular Weight (WM): | 392.49 |
|---|---|
| Formula: | C23H28N4O2 |
| CAS No.: | 315183-21-2 |
| Synonyms: |
Procaspase activating compound 1
|
| Dissolve in (25°C): | DMSO ≥78mg/mL |
| Water <1mg/mL | |
| Ethanol ≥16mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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