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Reverse Transcriptase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S1401 Tenofovir Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
J Biomed Sci, 2024, 31(1):34
Hepatol Commun, 2024, 8(1)e0351
Verified customer review of Tenofovir
S1400 Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.
Clin Immunol, 2024, 260:109915
Antiviral Res, 2024, 231:106010
Front Cell Infect Microbiol, 2024, 14:1334126
Verified customer review of Tenofovir Disoproxil Fumarate
S1706 Lamivudine (3TC, BCH-189) Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
FASEB J, 2025, 39(12):e70720
HIV Med, 2025, 26(2):285-294
Verified customer review of Lamivudine (3TC, BCH-189)
S2579 Zidovudine Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. This compound could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency.
Nat Commun, 2024, 15(1):2716
Nat Commun, 2024, 15(1):9321
J Immunother Cancer, 2024, 12(11)e009805
S1704 Emtricitabine (FTC) Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor, and its intracellular half-life is 39 h.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
HIV Med, 2025, 26(2):285-294
Immunity, 2024, 57(12):2928-2944.e6
S4685 Efavirenz Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
Cell Research, 2024, 58-75
Front Cell Infect Microbiol, 2024, 14:1334126
Frontiers in Cellular and Infection Microbiology, 2024, 1334126
S5246 Entecavir Entecavir(BMS200475,SQ34676), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
J Virol, 2025, e0010025.
J Biomed Sci, 2024, 31(1):34
NPJ Vaccines, 2024, 9(1):22
S7303 Rilpivirine Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.
Nat Chem Biol, 2023, 19(4):431-439
Antimicrob Agents Chemother, 2023, 67(7):e0046223
J Virol, 2022, JVI0173021
S1252 Entecavir Hydrate Entecavir Hydrate (ETV, Baraclude,BMS200475 Hydrate,SQ34676 Hydrate), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cancer Discov, 2022, candisc.1117.2021
Hepatology, 2022, 10.1002/hep.32614
S1742 Nevirapine (NSC 641530) Nevirapine (NSC 641530, NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
Nat Commun, 2024, 15(1):9321
Biomolecules, 2024, 14(7)819
Antimicrob Agents Chemother, 2023, 67(7):e0046223
Verified customer review of Nevirapine (NSC 641530)
S2914 Dapivirine (TMC120) Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. It inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
J Control Release, 2024, 376:1209-1224
Sci Rep, 2024, 14(1):30103
Pharmaceutics, 2022, 14(9)1938
S5215 Abacavir Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
Antimicrob Agents Chemother, 2023, 67(7):e0046223
Antimicrobial Agents and Chemotherapy, 2023, e00462-23
Cancer Discov, 2022, candisc.1117.2021
S7856 Tenofovir Alafenamide Tenofovir Alafenamide is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
Viruses, 2026, 187
Antiviral Res, 2024, 231:106010
Hepatol Commun, 2024, 8(1)e0351
S3080 Etravirine Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
mSystems, 2025, 10(9):e0043825
Antimicrob Agents Chemother, 2023, 67(7):e0046223
Antimicrobial Agents and Chemotherapy, 2023, e00462-23
Verified customer review of Etravirine
S1719 Zalcitabine Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
Sci Rep, 2024, 14(1):9167
Cancer Discov, 2022, candisc.1117.2021
Cell Death & Disease, 2022, 1020
S1398 d4T (Stavudine) Stavudine (d4T, BMY-27857, Sanilvudine, NSC 163661) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
Nat Commun, 2024, 15(1):2716
Nat Commun, 2024, 15(1):9321
S1702 Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
Nat Commun, 2024, 15(1):9321
Antimicrob Agents Chemother, 2023, 67(7):e0046223
Cancer Res Commun, 2023, 3(10):2030-2043
S3165 Abacavir sulfate Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
Cell, 2023, 186(2):287-304.e26
Cell Rep, 2023, 42(6):112593
Cancer Discov, 2022, candisc.1117.2021
S1718 Adefovir Dipivoxil (GS 0840) Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor used in the treatment of chronic hepatitis B virus (HBV).
Biomedicines, 2021, 9(8)996
Front Immunol, 2020, 11:616570
Oncol Lett, 2018, 15(5):6107-6114
S1651 Telbivudine Telbivudine(NV 02B) is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.
Biomedicines, 2021, 996
Biomedicines, 2021, 9(8)996
Oncotarget, 2017, 8(15):24694-24705
S3076 Foscarnet Sodium Foscarnet Sodium (Phosphonoformate) inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.
BMC Medicine, 2026, Article number: 4680
Frontiers in Cellular and Infection Microbiology, 2021, 536150
Sci Adv, 2021, 7(52):eabl3858
S4428 Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Cells, 2021, 2321
Cells, 2021, 10(9)2321
Proceedings of the National Academy of Sciences, 2020, 12368-12374
S5959 Tenofovir Disoproxil Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
J Virol, 2022, JVI0173021
Journal of Virology, 2022, e01730-21
Front Microbiol, 2018, 9:278
S3606 Fangchinoline Fangchinoline, a bisbenzylisoquinoline alkaloid, is a novel HIV-1 inhibitor with pain-relieving, blood pressure-depressing, and antibiotic activities.
iScience, 2024, 27(10):110862
Pathogens, 2023, 845
Pathogens, 2023, 12(6)845
S6492 Doravirine Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.
Nat Chem Biol, 2023, 19(4):431-439
International Journal of Molecular Sciences, 2023, 11664
Nature Chemical Biology, 2022, 431–439
S4879 Tenofovir hydrate Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections.
Cancer Discov, 2022, candisc.1117.2021
Cells, 2020, 9(4)E1003
S6452 Delavirdine mesylate Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.
J Cheminform, 2021, 13(1):90
Journal of Cheminformatics, 2021, 90
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. It is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
Toxicol Lett, 2025, 406:31-37
S4187 Salicylanilide Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
Hum Mol Genet, 2020, ddaa244
S4427 Tenofovir alafenamide hemifumarate Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Front Microbiol, 2018, 9:278
S5068 Adefovir Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
Hepatol Commun, 2024, 8(1)e0351
S4890 Bifendate Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.
E0815 Rilpivirine Hydrochloride Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.
E1745 Ulonivirine Ulonivirine(MK-8507) is a selective and potent inhibitor of HIV-1 nonnucleoside reverse transcriptase (NNRTI) that binds to the classic NNRTI hydrophobic binding pocket near the polymerase active site. It demonstrates a potential to treat HIV-1 infections and induce the expression of CYP3A4, an enzyme often involved in drug metabolism.
S8055 Lersivirine (UK-453061) Lersivirine (UK-453061) is a potent and selective inhibitor of nonnucleoside reverse transcriptase (NNRTI) with IC50 of 0.119 μM.
S5423 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor.
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. This compound has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071