Catalog No.S4099 Synonyms: T 168390，TAK 390
Molecular Weight(MW): 369.36
Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.
Purity & Quality Control
Choose Selective Proton Pump Inhibitors
|Description||Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.|
|Features||A modified release formulation of an enantiomer of lansoprazole.|
Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship.  Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production. 
|In vitro||DMSO||74 mg/mL (200.34 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||T 168390，TAK 390|
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03011125||Not yet recruiting||Safety Issues||First Affiliated Hospital of Zhejiang University|Jiangsu Aosaikang Oharmaceutical Co. Ltd||January 2017||Phase 1|
|NCT02873689||Recruiting||Heartburn|Gastroesophageal Reflux Disease||Takeda||December 2016||Phase 3|
|NCT02873702||Recruiting||Erosive Esophagitis||Takeda||December 2016||Phase 3|
|NCT02442752||Suspended||Pediatric Gastroesophageal Reflux Disease||Takeda||February 2016||Phase 1|
|NCT02616302||Suspended||Gastroesophageal Reflux||Takeda||November 2015||Phase 2|
|NCT02615184||Suspended||Erosive Esophagitis||Takeda||November 2015||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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