Dexlansoprazole

Catalog No.S4099 Synonyms: T 168390,TAK 390

Dexlansoprazole Chemical Structure

Molecular Weight(MW): 369.36

Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.

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Biological Activity

Description Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties.
Features A modified release formulation of an enantiomer of lansoprazole.
Targets
Proton pump [1]
In vitro

Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship. [1] Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production. [2]

Protocol

Solubility (25°C)

In vitro DMSO 74 mg/mL (200.34 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.36
Formula

C16H14F3N3O2S

CAS No. 138530-94-6
Storage powder
Synonyms T 168390,TAK 390

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03011125 Not yet recruiting Safety Issues First Affiliated Hospital of Zhejiang University|Jiangsu Aosaikang Oharmaceutical Co. Ltd January 2017 Phase 1
NCT02873689 Recruiting Heartburn|Gastroesophageal Reflux Disease Takeda December 2016 Phase 3
NCT02873702 Recruiting Erosive Esophagitis Takeda December 2016 Phase 3
NCT02442752 Suspended Pediatric Gastroesophageal Reflux Disease Takeda February 2016 Phase 1
NCT02616302 Suspended Gastroesophageal Reflux Takeda November 2015 Phase 2
NCT02615184 Suspended Erosive Esophagitis Takeda November 2015 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Proton Pump Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID