SGLT
Signaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1548 | Dapagliflozin | <1 mg/mL | 82 mg/mL | 17 mg/mL |
| S2760 | Canagliflozin | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| S8022 | Empagliflozin (BI 10773) | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S8103 | Sotagliflozin (LX4211) | <1 mg/mL | 84 mg/mL | 17 mg/mL |
| S8558 | Tofogliflozin(CSG 452) | 4 mg/mL | 84 mg/mL | 84 mg/mL |
| S5413 | Ertugliflozin | 87 mg/mL | 87 mg/mL | 87 mg/mL |
| S5566 | Dapagliflozin propanediol monohydrate | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S8637 | Ipragliflozin (ASP1941) | <1 mg/mL | 80 mg/mL | 80 mg/mL |
| S2342 | Phloretin | <1 mg/mL | 54 mg/mL | 54 mg/mL |
| S2343 | Phlorizin | <1 mg/mL | 87 mg/mL | 9 mg/mL |
Isoform-specific Inhibitors
- SGLT Inhibitors (10)
- New SGLT Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
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| S2760 |
CanagliflozinCanagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
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| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3. |
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| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
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| S8558New |
Tofogliflozin(CSG 452)Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively. |
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| S5413New |
ErtugliflozinErtugliflozin is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0.877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1. |
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| S5566New |
Dapagliflozin propanediol monohydrateDapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors. |
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| S8637New |
Ipragliflozin (ASP1941)Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1. |
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| S2342 |
PhloretinPhloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. |
Specificity of FDG uptake in BJAB, OCI-LY3 and SU-DHL-6 cells. Cells were incubated without inhibitors or with 2 mM 2-DG, 5 μM cytochalasin B or 10 μM phloretin for 24 h or with 50 μM CoCl2 for 30 min and 100 kBq of FDG for 30 min. Cell-bound radioactivity was normalized to protein concentration determined from a parallel sample and expressed as % of untreated control, mean ± standard deviation from fourfold determinations; Asterisks indicates significant decrease or increase (p < 0.05, Student’s t test)
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| S2343 |
PhlorizinPhlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. |
The survival of cells treated with PQ in the presence or absence of STF-31 (d), phlorizin (e), or AA (f) was determined as explained
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