SGLT

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1548 Dapagliflozin <1 mg/mL 82 mg/mL 17 mg/mL
S2760 Canagliflozin <1 mg/mL 88 mg/mL <1 mg/mL
S8022 Empagliflozin (BI 10773) <1 mg/mL 90 mg/mL <1 mg/mL
S8103 Sotagliflozin (LX4211) <1 mg/mL 84 mg/mL 17 mg/mL
S8558 Tofogliflozin(CSG 452) 4 mg/mL 84 mg/mL 84 mg/mL
S8637 Ipragliflozin (ASP1941) <1 mg/mL 80 mg/mL 80 mg/mL
S2342 Phloretin <1 mg/mL 54 mg/mL 54 mg/mL
S2343 Phlorizin <1 mg/mL 87 mg/mL 9 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1548

Dapagliflozin

Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.

S2760

Canagliflozin

Canagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.

S8022

Empagliflozin (BI 10773)

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

S8103

Sotagliflozin (LX4211)

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.

S8558New

Tofogliflozin(CSG 452)

Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and Hsglt1, respectively.

S8637New

Ipragliflozin (ASP1941)

Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.

S2342

Phloretin

Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

S2343

Phlorizin

Phlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees.