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SGLT Inhibitors (4)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1548 Dapagliflozin Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.
  • Mol Cell Endocrinol, 2016, 420:37-45
  • Drug Metab Dispos, 2015, 43(10):1468-76
  • Mol Cell Biochem, 2015, 400(1-2):57-68
S2760 Canagliflozin Canagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.
  • Drug Metab Dispos, 2015, 43(10):1468-76
S8022 Empagliflozin (BI 10773) Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.
S8103 Sotagliflozin (LX4211) Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.
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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1548 Dapagliflozin <1 mg/mL 82 mg/mL 17 mg/mL
S2760 Canagliflozin <1 mg/mL 88 mg/mL <1 mg/mL
S8022 Empagliflozin (BI 10773) <1 mg/mL 90 mg/mL <1 mg/mL
S8103 Sotagliflozin (LX4211) <1 mg/mL 84 mg/mL 17 mg/mL
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