SGLT
Sigaling Pathway Map
Research Area
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1548 | Dapagliflozin | <1 mg/mL | 82 mg/mL | 17 mg/mL |
| S2760 | Canagliflozin | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| S8022 | Empagliflozin (BI 10773) | <1 mg/mL | 90 mg/mL | <1 mg/mL |
| S8103 | Sotagliflozin (LX4211) | <1 mg/mL | 84 mg/mL | 17 mg/mL |
| S2342 | Phloretin | <1 mg/mL | 54 mg/mL | 54 mg/mL |
| S2343 | Phlorizin | <1 mg/mL | 87 mg/mL | 9 mg/mL |
Isoform-specific Inhibitors
- SGLT Inhibitors (6)
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3. |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
||
| S2342 |
PhloretinPhloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. |
||
| S2343 |
PhlorizinPhlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. |
|
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1548 |
DapagliflozinDapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4. |
(B) Clonogenic survival of prostate cancer cells treated with Canagliflozin, Dapagliflozin or Salicylate and expressed relative to the vehicle controls.
|
|
| S2760 |
CanagliflozinCanagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. |
Canagliflozin dose-dependently increases pAMPK and pACC in PC3 cells after 30 min
|
|
| S8022 |
Empagliflozin (BI 10773)Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3. |
||
| S8103 |
Sotagliflozin (LX4211)Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3. |
||
| S2342 |
PhloretinPhloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. |
||
| S2343 |
PhlorizinPhlorizin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. |
|
