• Compare CFTR Products
  • Research Area

CFTR Inhibitors | Activators | Modulators (7)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S6003 Ataluren (PTC124) Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.
  • J Clin Invest, 2013, 124(1):111-6
  • Hum Mol Genet, 2015, 24(4):972-86
  • Hum Mol Genet, 2014, 24(1):185-96
S1144 Ivacaftor (VX-770) Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.
  • Sci Transl Med, 2014, 6(246):246ra96
  • Nat Protoc, 2015, 10(3):363-81
  • Am J Respir Crit Care Med, 2012, 186(7):694-6
S1565 VX-809 (Lumacaftor) VX-809 (Lumacaftor) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.
  • Nat Med, 2013, 19(7):939-45
  • Sci Transl Med, 2014, 6(246):246ra96
  • Nat Protoc, 2015, 10(3):363-81
S7059 VX-661 VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
  • Sci Transl Med, 2014, 6(246):246ra96
S1675 Lubiprostone Lubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.
S7139 CFTRinh-172 CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
S7329 IOWH032 IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.

Hover Mouse over '+' to display IC50

Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S6003 Ataluren (PTC124) <1 mg/mL 57 mg/mL <1 mg/mL
S1144 Ivacaftor (VX-770) <1 mg/mL 78 mg/mL <1 mg/mL
S1565 VX-809 (Lumacaftor) <1 mg/mL 90 mg/mL 6 mg/mL
S7059 VX-661 <1 mg/mL 100 mg/mL <1 mg/mL
S1675 Lubiprostone <1 mg/mL 78 mg/mL 78 mg/mL
S7139 CFTRinh-172 <1 mg/mL 82 mg/mL <1 mg/mL
S7329 IOWH032 <1 mg/mL 100 mg/mL <1 mg/mL
Contact Us