CFTR Cystic Fibrosis Transmembrane Conductance Regulator

Cat.No.	Product Name	Information	Product Citations
S6003	PTC124 (Ataluren)	PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM.	Hum Mutat, 2012, 33(6):973-80 J Inherit Metab Dis, 2011, 34(2), 443-447 J Inherit Metab Dis, 2013, 36(2):363-71
S1565	VX-809	VX-809 is a CFTR modulator with EC50 of 0.1 μM.	Biochem Pharmacol, 2012, 83(3), 345-354 J Biol Chem, 2012, 287(52):43630-8
S1144	Ivacaftor (VX-770)	Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
S7059	VX-661	VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.

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