Potassium Channel

Sigaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1658 Dofetilide <1 mg/mL 88 mg/mL <1 mg/mL
S2456 Chlorpromazine HCl 71 mg/mL 71 mg/mL 71 mg/mL
S1979 Amiodarone HCl <1 mg/mL 23 mg/mL 11 mg/mL
S1344 Glimepiride <1 mg/mL 11 mg/mL <1 mg/mL
S1160 TRAM-34 <1 mg/mL 0.4 mg/mL <1 mg/mL
S4733 Retigabine <1 mg/mL 60 mg/mL 35 mg/mL
S4734 Retigabine 2HCl 75 mg/mL 75 mg/mL 25 mg/mL
S4632 Hexachlorophene <1 mg/mL 81 mg/mL 81 mg/mL
S4630 Diazoxide <1 mg/mL 46 mg/mL <1 mg/mL
S1426 Repaglinide <1 mg/mL 91 mg/mL 91 mg/mL
S1971 Nicorandil 17 mg/mL 42 mg/mL 42 mg/mL
S2502 Quinine HCl Dihydrate 43 mg/mL 79 mg/mL 79 mg/mL
S1716 Glyburide (Glibenclamide) <1 mg/mL 99 mg/mL <1 mg/mL
S2443 Tolbutamide <1 mg/mL 54 mg/mL 54 mg/mL
S3151 Gliquidone <1 mg/mL 105 mg/mL 6 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S2489 Nateglinide <1 mg/mL 63 mg/mL 63 mg/mL
S8016 Vonoprazan Fumarate (TAK-438) <1 mg/mL 62 mg/mL <1 mg/mL
S2825 ML133 HCl <1 mg/mL 63 mg/mL 6 mg/mL
S2562 Hydralazine HCl 1 mg/mL <1 mg/mL <1 mg/mL
S2601 Gliclazide <1 mg/mL 65 mg/mL <1 mg/mL
S4037 Doxapram HCl 25 mg/mL 87 mg/mL 2 mg/mL
S2073 Mitiglinide Calcium <1 mg/mL <1 mg/mL 2 mg/mL
Catalog No. Information Product Use Citations Product Validations
S1658

Dofetilide

Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

S1979

Amiodarone HCl

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

S1344

Glimepiride

Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.

S1160

TRAM-34

TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.

S4734New

Retigabine 2HCl

Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.

S1426

Repaglinide

Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.

S2502

Quinine HCl Dihydrate

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

S1716

Glyburide (Glibenclamide)

Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.

S2443

Tolbutamide

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.

S2114

Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S2489

Nateglinide

Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.

S8016

Vonoprazan Fumarate (TAK-438)

Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.

S2825

ML133 HCl

ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

S2601

Gliclazide

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

S4037

Doxapram HCl

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

S2073

Mitiglinide Calcium

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

S4733New

Retigabine

Retigabine(free base) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.

S4632New

Hexachlorophene

Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.

S4630New

Diazoxide

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

S1971

Nicorandil

Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).

S2562

Hydralazine HCl

Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

S3151

Gliquidone

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

Catalog No. Information Product Use Citations Product Validations
S1658

Dofetilide

Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.

S2456

Chlorpromazine HCl

Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

S1979

Amiodarone HCl

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

S1344

Glimepiride

Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.

S1160

TRAM-34

TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.

S4734New

Retigabine 2HCl

Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.

S1426

Repaglinide

Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II diabetes.

S2502

Quinine HCl Dihydrate

Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.

S1716

Glyburide (Glibenclamide)

Glyburide (Glibenclamide) is a known blocker of vascular ATP-sensitive K+ channels (KATP), used in the treatment of type 2 diabetes.

S2443

Tolbutamide

Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.

S2114

Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

S2489

Nateglinide

Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.

S8016

Vonoprazan Fumarate (TAK-438)

Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.

S2825

ML133 HCl

ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

S2601

Gliclazide

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.

S4037

Doxapram HCl

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

S2073

Mitiglinide Calcium

Mitiglinide Calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

Catalog No. Information Product Use Citations Product Validations
S4733New

Retigabine

Retigabine(free base) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.

S4632New

Hexachlorophene

Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.

S4630New

Diazoxide

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

S1971

Nicorandil

Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).

2016, 10.1177/1074248416636477

S2562

Hydralazine HCl

Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

2014, 44(9):827-41

Catalog No. Information Product Use Citations Product Validations
S3151

Gliquidone

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.