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Sirtuin Inhibitors | Activators (11)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1129 SRT1720 SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.
  • Nat Med, 2015, 10.1038/nm.3821
  • EMBO J, 2013, 32(6):791-804
  • Cancer Res, 2013, 74(1):298-308
S1541 EX 527 (Selisistat) EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3.
  • Blood, 2014, 124(1):121-33
  • Cancer Res, 2014, 74(1):298-308
  • J Pineal Res, 2014, 57(2):228-38
S1396 Resveratrol Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
  • Cell Physiol Biochem, 2015, 35(6):2255-2271
  • Adv Mater Sci Eng, 2015, 10.1155/2015/838513
S2804 Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
  • Nat Biotechnol, 2015, 10.1038/nbt.3130
  • Biochem Biophys Res Commun, 2014, 452(3):649-54
  • Biomed Res Int, 2014, 2014:783459
S1899 Nicotinamide (Vitamin B3) Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
  • Cancer Cell, 2014, 26(4):534-48
  • PLoS Biol, 2013, 12(1):e1001758
S7792 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
S7593 Splitomicin Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.
S7577 AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.
S2391 Quercetin Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
  • Nat Biotechnol, 2015, 10.1038/nbt.3130
S2298 Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1129 SRT1720 <1 mg/mL 38 mg/mL <1 mg/mL
S1541 EX 527 (Selisistat) <1 mg/mL 50 mg/mL 18 mg/mL
S1396 Resveratrol <1 mg/mL 45 mg/mL <1 mg/mL
S2804 Sirtinol <1 mg/mL 23 mg/mL <1 mg/mL
S1899 Nicotinamide (Vitamin B3) 24 mg/mL 24 mg/mL 24 mg/mL
S7792 SRT2104 (GSK2245840) <1 mg/mL 16 mg/mL <1 mg/mL
S7593 Splitomicin <1 mg/mL 39 mg/mL 39 mg/mL
S7577 AGK2 <1 mg/mL 10 mg/mL <1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S2298 Fisetin <1 mg/mL 57 mg/mL 3 mg/mL
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