Research Area
Product Type
United States ( Change Country )
EX 527 Chemical Structure
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Biological Activity
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). It was thought to block the release of deacetylated peptide and O-acetyl-ADP-ribose from the enzyme following the deacetylation process. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation. Blocking of SIRT1 by EX 527 also demonstrated that deacetylation of the important tumor suppressor protein p53 is mediated by SIRT1 as well. [1][2]
References on EX 527
- [1] MOLECULAR AND CELLULAR BIOLOGY Jan. 2006;26：28–38
- [2] J. Med. Chem 2008;51：4377–4380
Chemical Information
| Molecular Weight (WM): | 248.71 |
|---|---|
| Formula: | C13H13ClN2O |
| CAS No.: | 49843-98-3 |
| Synonyms: |
SEN0014196
|
| Dissolve in (25°C): | DMSO ≥50mg/mL |
| Water <1mg/mL | |
| Ethanol ≥28mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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