Catalog No.S8460

Salermide Chemical Structure

Molecular Weight(MW): 394.47

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

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Biological Activity

Description Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
SIRT1 [1] SIRT2 [1]
In vitro

Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CRO cells MYrDfZRwfG:6aXPpeJkh[XO|YYm= NVW0VFRtPzJiaB?= MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDVm8h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8hdHWvaX7ld4NmdnRiYYPzZZktKEOFNUC9Ok44KM7:TR?= M1LTSlI{OTh7OU[3
CRC 1.1 cells NF;uU3pEgXSxdH;4bYNqfHliYYPzZZk> NVK0bY9LPzJiaB?= NWHMV3ppS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS1KFIEGuNUBk\WyuczDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{BtfW2rbnXzZ4VvfCCjc4PhfUwhS0N3ME25Mlch|ryP Mn75NlMyQDl7Nke=
30PT cells MkmzR5l1d3SxeHnjbZR6KGG|c3H5 NFHvRpA4OiCq NHfs[m1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA{OFCWIHPlcIx{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDDR|UxRTN4LkWg{txO MViyN|E5QTl4Nx?=
30P cells MmTNR5l1d3SxeHnjbZR6KGG|c3H5 MWm3NkBp NUjofZFtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOzCSIHPlcIx{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDDR|UxRTRzIN88US=> MkLUNlMyQDl7Nke=
MCF7 cells NWHkSld2WHKxbHnm[ZJifGmxbjDhd5NigQ>? NHrMVZY{OCEQvF2= NVnWVYhHOjRvN{KgbC=> MlyyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHH0JFMxKHWPIHHmeIVzKDJ2IITvJFczKGi{cx?= MlfTNlQ{PDBzNkm=
U937 cells M4WxRWZ2dmO2aX;uJIF{e2G7 MVi1NEDPxE1? NHywO3g1PSCq NV3tS2ZuUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDVPVM4KGOnbHzzJIF1KDVyIIXNJIFnfGW{IES1JIhzeyCkeTDmcI94KGO7dH;t[ZRzgQ>? MVyyN|E5QTl4Nx?=
MOLT4 cells NWezWIZpWHKxbHnm[ZJifGmxbjDhd5NigQ>? M1i2OVI2KM7:TR?= M135[FI1NTd{IHi= M2PyeGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MWFQh[2WubIOgZZQhOjVidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KE2WVDDhd5NigQ>? MYKyN|E5QTl4Nx?=
MDA-MB-231 cells MY\Qdo9tcW[ncnH0bY9vKGG|c3H5 NXTTN4ZYOjVizszN M3;OfVI1NTd{IHi= NXywRpYxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHH0JFI2KHWPIHHmeIVzKDJ2IITvJFczKGi{czDifUBOXFRiYYPzZZk> M2HqdFI{OTh7OU[3
RKO cells M2TBNHBzd2yrZnXyZZRqd25iYYPzZZk> MUOyOUDPxE1? M2TENFI1NTd{IHi= NYPoR4J1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDST28h[2WubIOgZZQhOjVidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KE2WVDDhd5NigQ>? NXrXPHNwOjNzOEm5Olc>

... Click to View More Cell Line Experimental Data

In vivo Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1].


Cell Research:[1]
+ Expand
  • Cell lines: MOLT4, MDA-MB-231 and SW480 cancer cell lines
  • Concentrations: 0, 25, 50, 75 or 100 μM
  • Incubation Time: 24 h
  • Method: Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μm) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Athymic (BALB/c, nu/nu) female nude mice
  • Formulation: --
  • Dosages: 100 μl of 100 μM
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 78 mg/mL (197.73 mM)
Ethanol 7 mg/mL warmed (17.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 394.47


CAS No. 1105698-15-4
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID