Salermide

Catalog No.S8460

Salermide Chemical Structure

Molecular Weight(MW): 394.47

Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.

Size Price Stock Quantity  
USD 97 In stock
USD 397 In stock
USD 997 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Sirtuin Inhibitors

Biological Activity

Description Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
Targets
SIRT1 [1] SIRT2 [1]
In vitro

Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CRO cells NUPGfJd{S3m2b4TvfIlkcXS7IHHzd4F6 NHjXdmg4OiCq M2rDemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNTVyClZXzsd{Bi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdyCudX3pcoV{[2WwdDDhd5NigSxiQ1O1NF03NjdizszN MXSyN|E5QTl4Nx?=
CRC 1.1 cells MkLxR5l1d3SxeHnjbZR6KGG|c3H5 NY\iTHZjPzJiaB?= NF[4WmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEWkNiMT6xJINmdGy|IHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvJIx2dWmwZYPj[Y51KGG|c3H5MEBESzVyPUmuO{DPxE1? M{fldVI{OTh7OU[3
30PT cells NVXnOVZ3S3m2b4TvfIlkcXS7IHHzd4F6 M4KxO|czKGh? NXK5UmJ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOzCSVDDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubzDseY1qdmW|Y3XueEBie3OjeTygR2M2OD1|Nj61JO69VQ>? MnzxNlMyQDl7Nke=
30P cells MnTpR5l1d3SxeHnjbZR6KGG|c3H5 M3X3VFczKGh? NWjESVBiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOzCSIHPlcIx{KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDDR|UxRTRzIN88US=> MXyyN|E5QTl4Nx?=
MCF7 cells NFLRNYRRem:uaX\ldoF1cW:wIHHzd4F6 MVOzNEDPxE1? NVyxUnFNOjRvN{KgbC=> NED0TZRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZQhOzBidV2gZYZ1\XJiMkSgeI8hPzJiaILz MWeyOFM1ODF4OR?=
U937 cells NWfSfpR6TnWwY4Tpc44h[XO|YYm= M3Szb|UxKM7:TR?= NYHSeGdRPDViaB?= MWfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKFV7M{egZ4VtdHNiYYSgOVAhfU1iYX\0[ZIhPDViaILzJIJ6KG[ub4egZ5l1d22ndIL5 M{K4O|I{OTh7OU[3
MOLT4 cells MoXiVJJwdGmoZYLheIlwdiCjc4PhfS=> NIDWSogzPSEQvF2= MoPRNlQuPzJiaB?= NV7MfWlXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xVPCClZXzsd{BifCB{NTD1UUBi\nSncjCyOEB1dyB5MjDodpMh[nliTWTUJIF{e2G7 MUOyN|E5QTl4Nx?=
MDA-MB-231 cells NWL0b3dEWHKxbHnm[ZJifGmxbjDhd5NigQ>? MXyyOUDPxE1? NX;TWYx1OjRvN{KgbC=> M{ns[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTJ|MTDj[YxteyCjdDCyOUB2VSCjZoTldkAzPCC2bzC3NkBpenNiYomgUXRVKGG|c3H5 MYqyN|E5QTl4Nx?=
RKO cells NEi3U45Rem:uaX\ldoF1cW:wIHHzd4F6 NGTmZpkzPSEQvF2= NV3jZ|htOjRvN{KgbC=> NXrlVIRpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDST28h[2WubIOgZZQhOjVidV2gZYZ1\XJiMkSgeI8hPzJiaILzJIJ6KE2WVDDhd5NigQ>? NILTc3MzOzF6OUm2Oy=>

... Click to View More Cell Line Experimental Data

In vivo Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: MOLT4, MDA-MB-231 and SW480 cancer cell lines
  • Concentrations: 0, 25, 50, 75 or 100 μM
  • Incubation Time: 24 h
  • Method: Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μm) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Athymic (BALB/c, nu/nu) female nude mice
  • Formulation: --
  • Dosages: 100 μl of 100 μM
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 78 mg/mL (197.73 mM)
Ethanol 7 mg/mL warmed (17.74 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 394.47
Formula

C26H22N2O2

CAS No. 1105698-15-4
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Sirtuin Signaling Pathway Map

Related Sirtuin Products

Tags: buy Salermide | Salermide supplier | purchase Salermide | Salermide cost | Salermide manufacturer | order Salermide | Salermide distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID