Salermide
Catalog No.S8460

Molecular Weight(MW): 394.47
Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
Purity & Quality Control
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Biological Activity
Description | Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targets |
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In vitro |
Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1]. |
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Cell Data |
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In vivo | Salermide is well tolerated by mice at concentrations up to 100 μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1]. |
Protocol
Cell Research:[1] |
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Animal Research:[1] |
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Solubility (25°C)
In vitro | DMSO | 78 mg/mL (197.73 mM) |
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Ethanol | 7 mg/mL warmed (17.74 mM) | |
Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 394.47 |
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Formula | C26H22N2O2 |
CAS No. | 1105698-15-4 |
Storage | powder |
Synonyms | N/A |
Bio Calculators
Molarity Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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