Thiomyristoyl

Catalog No.S8245 Synonyms: TM

Thiomyristoyl Chemical Structure

Molecular Weight(MW): 581.85

Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.

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Biological Activity

Description Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Targets
SIRT2 [1]
(Cell-free assay)
28 nM
In vitro

Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. In vitro, it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM[1].

In vivo The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: breast cancer cell lines MCF-7
  • Concentrations: 1, 5, 10, 25, 50 μM
  • Incubation Time: 6 h
  • Method: Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft model
  • Formulation: DMSO
  • Dosages: 1.5 mg/50 μL (IP); 0.75 mg/50 μL (IT)
  • Administration: intraperitoneal (IP) or intra-tumor (IT) injections
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (171.86 mM)
Ethanol 100 mg/mL warmed (171.86 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 581.85
Formula

C34H51N3O3S

CAS No. 1429749-41-6
Storage powder
Synonyms TM

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID