SirReal2

Catalog No.S7845

SirReal2 Chemical Structure

Molecular Weight(MW): 420.55

SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.

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Biological Activity

Description SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Targets
SIRT2 [1]
(Cell-free assay)
140 nM
In vitro

SirReal2 selectively inhibits Sirt2 via a Sirt2-specific amino acid network, and induces a tubulin hyperacetylation and a significant depletion of BubR1 in HeLa cells. [1]

In vivo In vivo, SirReal2 inhibits Sirt2 activity without affecting the activity of the other Class-I sirtuins Sirt1 and Sirt3. [1]

Protocol

Solubility (25°C)

In vitro DMSO 84 mg/mL warmed (199.73 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 420.55
Formula

C22H20N4OS2

CAS No. 709002-46-0
Storage powder
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Sirtuin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID