3-TYP

Catalog No.S8628 Synonyms: 3-(1H-1,2,3-triazol-4-yl) pyridine

3-TYP Chemical Structure

Molecular Weight(MW): 146.15

3-TYP is a selective inhibitor of SIRT3 which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.

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Description 3-TYP is a selective inhibitor of SIRT3 which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
Targets
SIRT3 [1]
(cell-free)
SIRT1 [1]
(cell-free)
SIRT2 [1]
(cell-free)
16 nM 88 nM 92 nM
In vitro

Melatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium)[2].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: HepG2 cells
  • Concentrations: 50 μM
  • Incubation Time: 12 h
  • Method:

    Cells are randomly divided into the following treatment groups: 10 μM Cd; melatonin (1 μM)+10 μM Cd; 3-TYP (50 μM)+10 μM Cd; and 3-TYP (50 μM)+melatonin (1 μM)+10 μM Cd. cells are treated for 12 h. The role of the SIRT3-SOD2 pathway in hepatic cell protection after melatonin pretreatment is investigated.


    (Only for Reference)
Animal Research:

[3]

+ Expand
  • Animal Models: Sprague-Dawley rats
  • Formulation: ethanol (70%), propylene glycol (20%), NaHCO3 (10%)
  • Dosages: 5 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 29 mg/mL (198.42 mM)
Ethanol 29 mg/mL (198.42 mM)
Water 5 mg/mL (34.21 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.15
Formula

C7H6N4

CAS No. 120241-79-4
Storage powder
in solvent
Synonyms 3-(1H-1,2,3-triazol-4-yl) pyridine

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Sirtuin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID