Catalog No.S7577

AGK2 Chemical Structure

Molecular Weight(MW): 434.27

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

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1 Customer Review

  • The effect of AGK-2 on AKT activation in HeLa cells in response to insulin.

    J Biol Chem, 2014, 289(9): 6054-66 . AGK2 purchased from Selleck.

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Biological Activity

Description AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
SIRT2 [1]
(Cell-free assay)
3.5 μM
In vitro

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Escherichia coli BL21 (DE3) cells MnL2SpVv[3Srb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKG[3bHygcIVv\3SqIHj1cYFvKFOLUmSyJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMhfXOrbneg[ox2d3KxZ3XubYMhPy2jbXnuc{01NW2ndHj5cINwfW2jcnnuJEhCVUNrLXzhZoVt\WRicHXweIll\SCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;MT61OkDPxE1? NEnuS5YzPTJ5NUiyOC=>
human 30PT cells NXLHNWd2S3m2b4TvfIlkyqCjc4PhfS=> NHvFSFQ4OiCq M1vTN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFMxWFRiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JGNmdGxvdHn0[ZIhT0yxIHHzd4F6NCCFQ{WwQVkvPiEQvF2= MlO2NlI6OzF3Mk[=
human 30P cells MmfCR5l1d3SxeHnjxsBie3OjeR?= M4L0SFczKGh? MlnMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gN|BRKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCFQ{WwQVEzNjVizszN NYrt[GhiOjNzOEm5Olc>
H4 cells MWPGeY5kfGmxbjDhd5NigQ>? MXeyOEBp NF3NT5FKdmirYnn0bY9vKG:oIGPJVnQzKGmwIFi0JINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHigZYxxcGGVeX6gZY5lKHO7boDobYxqdjFiYYPz[ZN{\WRiYYOg[Y5t[XKpZXSgZYxxcGGVeX6gbY5kdHW|aX;ud{Bi\nSncjCyOEBpenN? MkHvNVc2QDh7MEC=
human HCT116 cells MUTGeY5kfGmxbjDhd5NigQ>? NV:xUVRIOTBizszN NUT1XGVxQCCq NInROI9KdmirYnn0bY9vKG:oIGPJVnQzKGmwIHj1cYFvKEiFVEGxOkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3X0fYxifGWmIHHsdIhiNXS3YoXsbY4h[XRiMUCgeW0h[W[2ZYKgPEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M{fTWVIzPjR{M{Cw
HeLa cells MVXGeY5kfGmxbjDhd5NigQ>? NFf0RmlKdmirYnn0bY9vKG:oIH;2[ZIu\XiycnXzd4VlKFOLUmSyJIludXWwb4Dy[YNqeGm2YYTl[EBnem:vIFjlUIEh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDTTXJVOi2veXOg[ZhxemW|c3nvckBkd26|dIL1Z5Q> MXqxO|U5QDlyMB?=

... Click to View More Cell Line Experimental Data

In vivo In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]


Animal Research:


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  • Animal Models: Drosophila model of parkinson
  • Formulation: DMSO
  • Dosages: 1mM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL warmed (23.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
8% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.27


CAS No. 304896-28-4
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID