AGK2

Catalog No.S7577

AGK2 Chemical Structure

Molecular Weight(MW): 434.27

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

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1 Customer Review

  • The effect of AGK-2 on AKT activation in HeLa cells in response to insulin.

    J Biol Chem, 2014, 289(9): 6054-66 . AGK2 purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
Targets
SIRT2 [1]
(Cell-free assay)
3.5 μM
In vitro

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Escherichia coli BL21 (DE3) cells M3;Dd2Z2dmO2aX;uJIF{e2G7 MYXJcohq[mm2aX;uJI9nKG[3bHygcIVv\3SqIHj1cYFvKFOLUmSyJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMhfXOrbneg[ox2d3KxZ3XubYMhPy2jbXnuc{01NW2ndHj5cINwfW2jcnnuJEhCVUNrLXzhZoVt\WRicHXweIll\SCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;MT61OkDPxE1? NIjtPJkzPTJ5NUiyOC=>
human 30PT cells MYXDfZRwfG:6aXRCpIF{e2G7 NWe1PJZ[PzJiaB?= MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjCzNHBVKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtNXSrdHXyJGdNdyCjc4PhfUwhS0N3ME25MlYh|ryP MYKyNlk{OTV{Nh?=
human 30P cells M{\ifGN6fG:2b4jpZ:Kh[XO|YYm= NGryT5U4OiCq MoDCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gN|BRKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCFQ{WwQVEzNjVizszN M3GwUFI{OTh7OU[3
H4 cells MWrGeY5kfGmxbjDhd5NigQ>? MYKyOEBp NWfyfoRWUW6qaXLpeIlwdiCxZjDTTXJVOiCrbjDIOEBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJIFteGijU4nuJIFv\CC|eX7wbIltcW5zIHHzd4V{e2WmIHHzJIVvdGG{Z3XkJIFteGijU4nuJIlv[2y3c3nvcpMh[W[2ZYKgNlQhcHK| NIn4ZZAyPzV6OEmwNC=>
human HCT116 cells NIrCSG5HfW6ldHnvckBie3OjeR?= MVyxNEDPxE1? M2DoflghcA>? M3HtVWlvcGmkaYTpc44hd2ZiU1nSWFIhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGGlZYT5cIF1\WRiYXzwbIEufHWkdXzpckBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MYiyNlY1OjNyMB?=
HeLa cells Mk\JSpVv[3Srb36gZZN{[Xl? NF\icnlKdmirYnn0bY9vKG:oIH;2[ZIu\XiycnXzd4VlKFOLUmSyJIludXWwb4Dy[YNqeGm2YYTl[EBnem:vIFjlUIEh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDTTXJVOi2veXOg[ZhxemW|c3nvckBkd26|dIL1Z5Q> MWSxO|U5QDlyMB?=

... Click to View More Cell Line Experimental Data

In vivo In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: Drosophila model of parkinson
  • Formulation: DMSO
  • Dosages: 1mM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL warmed (23.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
8% DMSO+30% PEG 300+ddH2O
1.4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.27
Formula

C23H13Cl2N3O2

CAS No. 304896-28-4
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID