• Compare GSK-3 Products
  • Research Area

GSK-3 Inhibitors (18)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2924 CHIR-99021 (CT99021) HCl CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.
  • Nature, 2015, 10.1038/nature14413
  • Nature, 2013, 500(7461):222-6
  • Cell Stem Cell, 2015, 10.1016/j.stem.2015.04.020
S1075 SB216763 SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
  • Mol Cancer Ther, 2013, 13(1):37-48
  • Mol Cancer Ther, 2013, 13(2):454-67
  • Breast Cancer Res, 2014, 16(4):408
S2745 CHIR-98014 CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
  • Stem Cells Dev, 2013, 22(13):1893-906
S1590 TWS119 TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.
  • Mol Neurobiol, 2015, 10.1007/s12035-015-9607-2
  • Int J Biochem Cell Biol, 2013, 45(9):2066-75
  • Cancer Immunol Res, 2014, 2(9):839-45
S2823 Tideglusib Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
  • Mol Cancer Ther, 2014, 13(2):454-67
  • PLoS One, 2015, 9(7):e100947
S2729 SB415286 SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.
  • Cancer Lett, 2016, 370(2):332-44
S7198 BIO BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
  • PLoS One, 2014, 9(7):e100947
S7915 BIO-acetoxime BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
S7722 Bikinin Bikinin is an ATP-competitive Arabidopsis GSK-3 inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.
S7566 IM-12 IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
  • Exp Cell Res, 2016, 10.1016/j.yexcr.2016.06.007
S7193 1-Azakenpaullone 1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
  • Dev Neurobiol, 2015, 10.1002/dneu.22370
  • Dev Genes Evol, 2015, 225(1):47-53
S7063 LY2090314 LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. Phase 2.
S7145 AZD1080 AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
S7253 AZD2858 AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
S7435 AR-A014418 AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
S1263 CHIR-99021 (CT99021) CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.
  • nature, 2016, 10.1038/nature17408
  • nature, 2016, 10.1038/nature17408
  • Circulation, 2016, 10.1161/CIRCULATIONAHA.115.017443
S2926 TDZD-8 TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
S2386 Indirubin Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.

Hover Mouse over '+' to display IC50

Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S2924 CHIR-99021 (CT99021) HCl <1 mg/mL 93 mg/mL 2 mg/mL
S1075 SB216763 <1 mg/mL 23 mg/mL <1 mg/mL
S2745 CHIR-98014 <1 mg/mL 8 mg/mL <1 mg/mL
S1590 TWS119 <1 mg/mL 64 mg/mL <1 mg/mL
S2823 Tideglusib <1 mg/mL 66 mg/mL <1 mg/mL
S2729 SB415286 <1 mg/mL 72 mg/mL 72 mg/mL
S7198 BIO <1 mg/mL 71 mg/mL 21 mg/mL
S7915 BIO-acetoxime <1 mg/mL 19 mg/mL <1 mg/mL
S7722 Bikinin <1 mg/mL 54 mg/mL <1 mg/mL
S7566 IM-12 <1 mg/mL 75 mg/mL 10 mg/mL
S7193 1-Azakenpaullone <1 mg/mL 66 mg/mL <1 mg/mL
S7063 LY2090314 <1 mg/mL 100 mg/mL 2 mg/mL
S7145 AZD1080 <1 mg/mL 52 mg/mL <1 mg/mL
S7253 AZD2858 <1 mg/mL 7 mg/mL <1 mg/mL
S7435 AR-A014418 <1 mg/mL 62 mg/mL <1 mg/mL
S1263 CHIR-99021 (CT99021) <1 mg/mL 78 mg/mL <1 mg/mL
S2926 TDZD-8 <1 mg/mL 44.5 mg/mL 44.5 mg/mL
S2386 Indirubin <1 mg/mL 53 mg/mL <1 mg/mL
Contact Us