TWS119 Chemical Structure
SB 216763 inhibited human GSK-3α with IC50s of 34 nM.
GSK-3 inhibitor, IC50= 7 nM
SB 415286 is a potent and selective cell-permeable, ATP-competitive GSK3α inhibitor with an IC50 and a Ki of 78 and 31 nM, respectively.
CHIR 98014 is a potent and selective human GSK-3 inhibitor for human GSK-3ɑ and human GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively.
BEZ235 (NVP-BEZ235)is a dual ATP-competitive phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM,respectively.
Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR.
Perifosine is an Akt inhibitor. the antiproliferative properties of perifosine with an IC50 of 0.6–8.9 µM.
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family member inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.
Rapamycin also known as Sirolimus & Rapamune is an mTOR inhibitor. Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated pathways.
Temsirolimus (Torisel) is a mTOR inhibitor.
TWS119 is a glycogen synthase kinase-3β inhibitor with an IC50 of 30 nM. At 400 nM, it induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). [1]
| Molecular Weight (WM): | 318.33 |
|---|---|
| Formula: | C18H14N4O2 |
| CAS No.: | 601514-19-6 |
| Synonyms: |
N/A
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| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
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A unique collection of 63 GPCR small molecules
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