Home PI3K/Akt/mTOR GSK-3 inhibitor - Apoptosis related activator Elraglusib For research use only.

Elraglusib

Synonyms: 9-ing-41

Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

Elraglusib Chemical Structure

Elraglusib Chemical Structure

CAS: 1034895-42-5

Purity & Quality Control

Batch: S960201 DMSO] 81 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.63%
99.63

Elraglusib Related Products

Signaling Pathway

GSK-3 Signaling Pathways

GSK-3 Signaling Pathway

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Biological Activity

Description Elraglusib(9-ING-41) is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.
Targets
GSK-3 [1]
In vitro
In vitro

9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells.[1] 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.[2]
Cell Research Cell lines Neuroblastoma cell lines SK-N-DZ, SK-N-BE
Concentrations 0.1 μM–1 μM
Incubation Time 48 h
Method

Measurement of cell viability. Relative number of viable cancer cells is determined by measuring the optical density using CellTiter 96 Aqueous One Solution Cell Proliferation Assay kit according to the manufacturer’s instructions. A GI50 value for each compound is calculated with a non-linear regression model of standard slope using GraphPad Prism 6.0 software.
In Vivo
In vivo

9-ING-41 has single-agent antitumor activity in a mouse model of MCL.[2] Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.[1]
Animal Research Animal Models 6–8 week-old female athymic nude mice
Dosages 70 mg/kg
Administration IP

Chemical Information & Solubility

Molecular Weight 404.35 Formula

C22H13FN2O5
CAS No. 1034895-42-5 SDF --
Smiles CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 81 mg/mL ( (200.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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