Catalog No.S8133 Synonyms: R-848
Molecular Weight(MW): 314.38
Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
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|Description||Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.|
Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway.  Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.  Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. 
|In vivo||In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines.  In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. |
|In vitro||DMSO||63 mg/mL (200.39 mM)|
|Ethanol||21 mg/mL warmed (66.79 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02126579||Recruiting||Melanoma|Metastatic Melanoma|Mucosal Melanoma||Craig L Slingluff, Jr|University of Virginia||April 2014||Phase 1|Phase 2|
|NCT01737580||Completed||Influenza Vaccination in Seniors||University of British Columbia||April 2013||Phase 1|
|NCT01808950||Terminated||Nodular Basal Cell Carcinoma||Spirig Pharma Ltd.||February 2013||Phase 1|Phase 2|
|NCT01748747||Active, not recruiting||Recurrent Melanoma|Stage IIA Melanoma|Stage IIB Melanoma|Stage IIC Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma||Mayo Clinic|National Cancer Institute (NCI)||October 2012||--|
|NCT01583816||Completed||Actinic Keratosis||Spirig Pharma Ltd.||May 2012||Phase 2|
|NCT01676831||Active, not recruiting||Cutaneous T Cell Lymphoma||Abramson Cancer Center of the University of Pennsylvania||February 2012||Phase 1|Phase 2|
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