Catalog No.S8133 Synonyms: R-848

Resiquimod Chemical Structure

Molecular Weight(MW): 314.38

Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.

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Biological Activity

Description Resiquimod is an immune response modifier that acts as a potent TLR 7/8 agonist. Phase 2.
TLR7 [1] TLR8 [1]
In vitro

Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. [1] Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. [2] Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 cells NFL2R5dHfW6ldHnvckBie3OjeR?= NHLlellC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRNWjdiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyClb3X4dJJme3OrbnegdG5qTnS7Mj3TSWFRKHKncH;yeIVzKGK7IILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6yOlAyKM7:TR?= NUTHc2Z7OjB{M{K4NlQ>
HEK293 cells MmDBSpVv[3Srb36gZZN{[Xl? M16xO|I1KGh? MlrTRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUUHIuPyCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFI1KGi{czDifUBUTUGSIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MT61JO69VQ>? NX3hcGJROjR|OEO0O|U>
human PBMC NFvwfIdHfW6ldHnvckBie3OjeR?= M3PjUFI1KGh? NEPNcI5KdmO{ZXHz[UBqdiCLRl7hcJBp[SCuZY\lcEBqdiCqdX3hckBRSk2FIHHmeIVzKDJ2IHjyd{Bz\WyjdHn2[UB1dyClb370do9t Ml;ONVc2PDh2OUe=
Huh7 replicon cells MWXGeY5kfGmxbjDhd5NigQ>? M4X5ZmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhEXiCrbn\lZ5Rm\CCqdX3hckBJfWh5IILldIxq[2:wIHPlcIx{KHS{ZXH0[YQhf2m2aDDkdpVoNWmwZIXj[YQhcHWvYX6gVGJOSyC|dYDldo5ifGGwdIOgZZN{\XO|ZXSgZZMhfmm{YXygcIV3\Wy|IHL5JIx2[2moZYLhd4Uh[XO|YYm= MnTZNVc2PDh2OUe=

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In vivo In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines. [1] In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling. [4]


Animal Research:


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  • Animal Models: Wild-type mice, TLR7-deficient mice, and MyD88-deficient mice
  • Formulation: saline
  • Dosages: 50 nmol
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 63 mg/mL (200.39 mM)
Ethanol 21 mg/mL warmed (66.79 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.38


CAS No. 144875-48-9
Storage powder
Synonyms R-848

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02126579 Recruiting Melanoma|Metastatic Melanoma|Mucosal Melanoma Craig L Slingluff, Jr|University of Virginia April 2014 Phase 1|Phase 2
NCT01737580 Completed Influenza Vaccination in Seniors University of British Columbia April 2013 Phase 1
NCT01808950 Terminated Nodular Basal Cell Carcinoma Spirig Pharma Ltd. February 2013 Phase 1|Phase 2
NCT01748747 Active, not recruiting Recurrent Melanoma|Stage IIA Melanoma|Stage IIB Melanoma|Stage IIC Melanoma|Stage IIIA Melanoma|Stage IIIB Melanoma|Stage IIIC Melanoma|Stage IV Melanoma Mayo Clinic|National Cancer Institute (NCI) October 2012 --
NCT01583816 Completed Actinic Keratosis Spirig Pharma Ltd. May 2012 Phase 2
NCT01676831 Active, not recruiting Cutaneous T Cell Lymphoma Abramson Cancer Center of the University of Pennsylvania February 2012 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID