Home Apoptosis TNF-alpha inhibitor - Interleukins inhibitor JTE-607 Dihydrochloride For research use only.

JTE-607 Dihydrochloride

JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.

JTE-607 Dihydrochloride Chemical Structure

JTE-607 Dihydrochloride Chemical Structure

CAS: 188791-09-5

Purity & Quality Control

Batch: Purity: 99.17%
99.17

JTE-607 Dihydrochloride Related Products

Signaling Pathway

TNF-alpha Signaling Pathways

TNF-alpha Signaling Pathway

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Biological Activity

Description

JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.
Targets
CPSF3 [2] IL-1beta [1]
(in LPS-stimulated human PBMC)		 IL-8 [1]
(in LPS-stimulated human PBMC)		 IL-6 [1]
(in LPS-stimulated human PBMC)		 IL-10 [1]
(in LPS-stimulated human PBMC)		 Click to View More Targets
5.9 nM 7.3 nM 8.8 nM 9.1 nM

Chemical Information & Solubility

Molecular Weight 597.36 Formula

C25H31Cl2N3O5.2ClH
CAS No. 188791-09-5 SDF --
Smiles Cl.Cl.CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(OCCN3CCN(C)CC3)C(=C2O)Cl)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (167.4 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 5 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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