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United States ( Change Country )
DMXAA (ASA404) Chemical Structure
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Biological Activity
DMXAA is a tumor-vascular disrupting agent with an IC50 of 9.46 ± 1.7 nM. It attacks the blood supply of a cancerous tumor to cause tumor regression. [1][2] It has a striking antivascular and in some cases curative effect in experimental tumors. Its action on vascular endothelial cells seems to involve a cascade of events leading to induction of tumour haemorrhagic necrosis. These events include both direct and indirect effects, the latter involving the release of further vasoactive agents, such as serotonin, tumour necrosis factor, other cytokines, and nitric oxide from host cells. [3][4]
References on DMXAA (ASA404)
- [1] http://en.wikipedia.org/wiki/Vadimezan ;
- [2] Biochem Pharmacol. 1999 Jul 15;;58(2):303-10.
- [3] 2007 Jul 9;;204(7):1559-69.
- [4] Lancet Oncol. 2003 Mar;;4(3):141-8.
Chemical Information
| Molecular Weight (WM): | 282.29 |
|---|---|
| Formula: | C17H14O4 |
| CAS No.: | 117570-53-3 |
| Synonyms: |
AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan
|
| Dissolve in (25°C): | DMSO ≥7mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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