Thalidomide

Catalog No.S1193

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.

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In DMSO USD 190 In stock
USD 147 In stock
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Thalidomide Chemical Structure

Thalidomide Chemical Structure
Molecular Weight: 258.23

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Thalidomide is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Thalidomide was introduced as a sedative drug in the late 1950s. However, it was withdrawn due to a teratogenic effect on fetal development. Thalidomide binds to inactivate the protein cereblon, which is important to limb formation. [1]
There is now a growing clinical interest in thalidomide since it is introduced as an immunomodulatory agent used primarily, combined with dexamethasone, to treat multiple myeloma. The combination of thalidomide and dexamethasone, often in combination with melphalan, is now one of the most common regimens for patients with newly diagnosed multiple myeloma, with an improved response rate of up to 60-70%. [1]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02076009 Not yet recruiting Multiple Myeloma Janssen Research & Development, LLC 2014-04 Phase 3
NCT02086604 Not yet recruiting Lymphoma, Large B-Cell, Diffuse Washington University School of Medicine 2014-05 Phase 1
NCT02087943 Not yet recruiting Dermatitis, Atopic Dermatitis Celgene Corporation 2014-06 Phase 2
NCT01995669 Not yet recruiting Lymphoma M.D. Anderson Cancer Center|Celgene Corporation|Genentech 2014-06 Phase 1|Phase 2
NCT01861340 Not yet recruiting Myeloma Sidney Kimmel Comprehensive Cancer Center|MedImmune LLC 2014-08 Phase 0

Chemical Information

Download Thalidomide SDF
Molecular Weight (MW) 258.23
Formula

C13H10N2O4

CAS No. 50-35-1
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 52 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (7 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

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