TRP Channel Modulators

Cat.No.	Product Name	Information	Product Use Citations
S6409	Zucapsaicin	Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.	Arch Biochem Biophys, 2024, 754:109958
S2556	Rosiglitazone (BRL 49653)	Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.	Signal Transduct Target Ther, 2025, 10(1):394 Nat Commun, 2025, 16(1):6241 Lab Invest, 2025, 105(4):104103
S2505	Rosiglitazone maleate	Rosiglitazone maleate, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. This compound also modulates TRP channels and induces autophagy. It prevents ferroptosis.	Stem Cell Reports, 2022, 17(11):2531-2547 Cell Death Dis, 2021, 12(11):972 Antioxidants (Basel), 2021, 10(2)155

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6409

Zucapsaicin

Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator.

Arch Biochem Biophys, 2024, 754:109958

S2556

Rosiglitazone (BRL 49653)

Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.

Signal Transduct Target Ther, 2025, 10(1):394

Nat Commun, 2025, 16(1):6241

Lab Invest, 2025, 105(4):104103

Verified customer review of Rosiglitazone (BRL 49653)

S2505

Rosiglitazone maleate

Rosiglitazone maleate, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. This compound also modulates TRP channels and induces autophagy. It prevents ferroptosis.

Stem Cell Reports, 2022, 17(11):2531-2547

Cell Death Dis, 2021, 12(11):972

Antioxidants (Basel), 2021, 10(2)155

Verified customer review of Rosiglitazone maleate