TRP Channel Activators

Cat.No.	Product Name	Information	Product Use Citations
S6657	2-APB (2-Aminoethyl Diphenylborinate)	2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulates IP3-induced calcium release. It also inhibits the SOC channel activity and, at higher concentrations, inhibits TRP channel.	Cell Prolif, 2025, e70120. PLoS Pathog, 2025, 21(1):e1012872 Liver Int, 2025, 45(10):e70341
S8107	GSK1016790A	GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.	Brain Stimul, 2025, 18(5):1455-1469 Am J Physiol Lung Cell Mol Physiol, 2024, 326(3):L252-L265 iScience, 2023, 26(5):106749
S8073	Optovin	Optovin is a reversible photoactivated TRPA1 activator.	Cancer Drug Resist, 2025, 8:45
S9926	ML-SA1	ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. This compound also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of this chemical against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. It induces autophagy. It can be used for the research of broad-spectrum antiviral.	Sci Rep, 2024, 14(1):24836
S3851	Camphor	Camphor (2-Bornanone, Bornan-2-one, 2-Camphanone, Formosa) is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora and used topically as a skin antipruritic and as an anti-infective agent.	iScience, 2023, 26(5):106749
S4714	(-)-Menthol	(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.	Curr Biol, 2019, 29(11):1787-1799.e5
S6947	MK6-83	MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
S7848	QX-314 chloride	QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.
S5419	1,4-Cineole	1,4-Cineole (Isocineole) is a widely distributed, natural, oxygenated monoterpene. This compound, present in eucalyptus oil, activates both human TRPM8 and human TRPA1.
S4516	(+)-Camphor	Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.
S8639	DPI (Diphenyleneiodonium chloride)	Diphenyleneiodonium chloride (DPI) is an inhibitor of NADPH oxidase and also a potent, irreversible, and time-, temperature-dependent iNOS/eNOS inhibitor. It also functions as a TRPA1 activator and selectively inhibits intracellular reactive oxygen species (ROS).	Redox Biol, 2025, 80:103485 Sci Adv, 2025, 11(34):eadv6937 Exp Mol Med, 2024, 56(12):2602-2616