Thiotepa

Synonyms: Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide

Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.

Thiotepa Chemical Structure

Thiotepa Chemical Structure

CAS No. 52-24-4

Purity & Quality Control

Thiotepa Related Products

Biological Activity

Description Thiotepa (Thioplex, Tiofosyl, Tiofosfamid, Triethylenethiophosphoramide) is an alkylating agent used to treat cancer.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05021770 Not yet recruiting
Refractory and Relapsed Primary CNS Lymphoma|PCNSL|Non Hodgkin Lymphoma
Huiqiang Huang|Guangdong 999 Brain Hospital|Sun Yat-sen University
December 2021 Phase 1|Phase 2
NCT03609840 Completed
Hematologic Malignancies|Nonmalignant Diseases|Immune Deficiency|Hemoglobinopathies|Genetic Inborn Errors of Metabolism|Fanconi Anemia|Thalassemia|Sickle Cell Disease
University of California San Francisco
May 24 2017 --
NCT05167370 Terminated
Solid Tumors|Brain Tumors
Children''s Hospital Medical Center Cincinnati
December 13 2010 Phase 2
NCT01068301 Completed
Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin''s Lymphoma
St. Jude Children''s Research Hospital|Genzyme a Sanofi Company
May 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 189.22 Formula

C6H12N3PS

CAS No. 52-24-4 SDF Download Thiotepa SDF
Smiles C1CN1P(=S)(N2CC2)N3CC3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (200.82 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : 3 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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