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Rapamycin (Sirolimus)
(SynonymsRapamune
)Add to Favor
M.Wt: 914.18
Formula: C51H79NO13
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 53123-88-9
Price and Availability of Rapamycin (Sirolimus):
Applications & Customer's Feedback of Rapamycin (Sirolimus):
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Rapamycin-Sirolimus was purchased from Selleck.Data from Biochem Pharmacol 2011.April;82:216-226.
Inhibition of mTOR activity may be responsible for sorafenib-induced down-regulation of survivin. H1299 cells were treated with the indicated concentration of RAD001 or Rapamycin for 48 h. Then H1299 cells were incubated with or without 5 mM sorafenib, with or without 5 mM RAD001, and with or without 2 mM rapamycin for 48 h. The indicated protein levels were determined by Western blot analysis. b-Actin protein levels were measured as loading controls.
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Rapamycin was purchased from Selleck.Data were provided by Dr.Ulrich Bommer of University of Wollongong.
Rapamycin inhibits growth‐dependent TCTP induction. Cells were serum‐starved for 24h and restimulated with 20% FBS for the indicated times in the presence or absence of rapamycin. The graph shows the relative TCTP signal, corrected for the loading control.
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Rapamycin was purchased from Selleck.Data from Cancer Cell 2011.June;19:1–13.
Cooperative Effects of AR and mTOR Inhibition In Vitro and In Vivo (A) In vitro response of Pten null;Ar+ murine (CaP8) and human (LNCaP) prostate cancer cells to AR knockdown (sh-AR) or pharmacological inhibition of AR (MDV3100, 10 mM) with and without rapamycin (R: 1 nM) treatment (Sc, control sh oligo). (B and D) In vivo response to treatments with castration, MDV3100, rapamycin, or their combinations as measured by cell proliferation (Ki67+cells) and (C and D) tumor burden in Pb-Cre+;-PtenL/L and Pb-Cre+;PtenL/L:ArL/Y mutants. Scale bars represent 2 mm (C), 200 mm (D), and 75 mm (D, inset). Error bars represent mean ± SD.
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Rapamycin was purchased from Selleck.Data from Journal of Lipid Research 2011.September;52:1617-25.
Rapamycin (RPM) inhibits OA-induced lipogenesis. Male SD rats were divided into three groups, and then treated as follows for seven days: group I (control; Ctrl), normal diet + vehicle; group II (OA), 1% OA diet + vehicle; group III (OA + RPM), 1% OA diet + RPM. (A) Hepatic TG concentrations were determined using the serum triglyceride determination kit. (B) Fixed liver sections were subjected to HE and Oil Red O staining as well as immunohistochemistry assays with SREBP-1 antibody. Representative microphotographs of liver specimens from all groups of rats are shown. (C) The levels of mRNA of the indicated genes involved in lipogenesis were determined by real-time PCR. Each bar represents the mean ± SE of the results obtained from six rats. * P < 0.05, ** P < 0.01, *** P < 0.001.
Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. ------Kwang-Yu Chang,Shan-Yin Tsai,et al.Clin Cancer Res. 2011 Nov.17:7116-26.
Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. ------Eun-Jeong Jung,Sung-Won Kwon,et al.J Lipid Res.2011 Sep;52:1617-25.
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. ------ David J.Mulholland,Linh M.Tran,et al.Cancer Cell. 2011 Jun.19:792-804.
Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of rapamycin (mTOR)-dependent survivin expression. ------Young-Sun Kim,Hyeon-Ok Jin,et al.Biochem Pharmacol. 2011 Aug.82:216-26.
Biological Activity of Rapamycin (Sirolimus):
RAPA administration in two types of fully allogeneic BM transplantation (BMT) systems in which host T cells mediate the rejection of TCD BM grafts (DBAf1 transplanted into C57BLf6 and BALBfc transplanted into C57BLf6). In both instances, RAPA administration prevented the rejection of the donor graft, accelerated post-BMT hematopoietic recovery, and did not compromise recipient survival. [2]
In vitro, rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL. [3]
References on Rapamycin (Sirolimus):
[1] Janice P. Dutcher. Current Oncology Reports. 2004 April;6(2):111-115
[2] Bruce R. Blazar et al. Blood. 1994 January 15;83(2):600-609
[3] VF Quesniaux et al. Blood. 1994 September 1; 84(5) :1543-1552
MSDS
Batch S103903: H-NMR HPLC COA
Batch S103904: H-NMR HPLC COA
Batch S103905: H-NMR HPLC COA
mTORWe give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) See Details
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