Rapamycin(Sirolimus)

M.Wt: 914.18
Formula: C₅₁H₇₉NO₁₃
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 53123-88-9

Price and Availability of Rapamycin(Sirolimus):

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Applications & Customer's Feedback of Rapamycin(Sirolimus):

Biological Activity of Rapamycin(Sirolimus):

RAPA administration in two types of fully allogeneic BM transplantation (BMT) systems in which host T cells mediate the rejection of TCD BM grafts (DBAf1 transplanted into C57BLf6 and BALBfc transplanted into C57BLf6). In both instances, RAPA administration prevented the rejection of the donor graft, accelerated post-BMT hematopoietic recovery, and did not compromise recipient survival. ^[2]
In vitro, rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL. ^[3]

References on Rapamycin(Sirolimus):

[1] Janice P. Dutcher. Current Oncology Reports. 2004 April;6(2):111-115

[2] Bruce R. Blazar et al. Blood. 1994 January 15;83(2):600-609

[3] VF Quesniaux et al. Blood. 1994 September 1; 84(5) :1543-1552

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