MG-132

Catalog No.S2619

MG-132 Chemical Structure

Molecular Weight(MW): 475.62

MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.

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Cited by 47 Publications

10 Customer Reviews

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Nek2A impedes SuFu ubiquitination. HEK293T cells transfected with Nek2A-Myc and Flag-SuFu for 48 h were treated with MG-132 to enrich ubiquitinated proteins, and subsequently subjected to co-immunoprecipitation assay. Precipitated proteins were probed using anti-Ub antibody.

    Int J Oncol, 2017, 50(2):373-380. MG-132 purchased from Selleck.

    Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

Purity & Quality Control

Choose Selective Proteasome Inhibitors

Biological Activity

Description MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively.
Targets
20S proteasome [9]
()
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells NWDEb5VsTnWwY4Tpc44hSXO|YYm= NXXSXlczOjVizszN M2jiVGROW09? MnHPTY5pcWKrdIOgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvOSEQvF2= NXjMXWxEOjR4OUe0PVY>
HL-60 MUfDfZRwfG:6aXOgRZN{[Xl? NFrzS4Y1OCEQvF2= MoG5OFghcA>? NEGx[JpFVVOR MnfWTWM2ODxzMDFOwG0> MlW4NlQ3QTd2OU[=
SMMC-7721 M2DpS2N6fG:2b4jpZ{BCe3OjeR?= MkLkOFAh|ryP NH;XblY1QCCq MVzEUXNQ M{X4XGlEPTB;Nz6xJO69VQ>? NHzpT4MzPDZ7N{S5Oi=>
A-549 MWXDfZRwfG:6aXOgRZN{[Xl? M4HQXFQxKM7:TR?= MnjuOFghcA>? MlPFSG1UVw>? NUPLV29wUUN3MEyxNEDPxE1? MYeyOFY6PzR7Nh?=
MCF-7 MY\DfZRwfG:6aXOgRZN{[Xl? MV20NEDPxE1? MmOxOFghcA>? NGLSPYxFVVOR NFzFe21KSzVyPUeuN{DPxE1? MlmwNlQ3QTd2OU[=
SW-480 MV;DfZRwfG:6aXOgRZN{[Xl? NW\tbGtLPDBizszN NIHIVYI1QCCq NVXvZlBKTE2VTx?= NW\nUHUxUUN3ME20JO69VQ>? M2m0dlI1Pjl5NEm2
NCI-H929 NWrSVpE2S3m2b4TvfIlkKEG|c3H5 NFjUUG0yKM7:TR?= MoH6O|IhcA>? NEToXWVFVVOR NFvQ[XVKSzVyPUCuNVch|ryP M2\4[FI1PjJ3MEi4
293T MYnDfZRwfG:6aXOgRZN{[Xl? MX:xNEDPxE1? NU\2enQxPzJiaB?= NFzlWXZFVVOR NXL5fGJ5UUN3MEyyJO69VQ>? NULzOmtuOjR4MkWwPFg>
293T M3zzRmZ2dmO2aX;uJGF{e2G7 M3HCe|ExKM7:TR?= NFLt[nozPCCq MUDEUXNQ MWnNc4RmemG2ZXz5JIlv\HWlZYOgbIVifC2|aH;jb{Ah MY[yOFYzPTB6OB?=
HeLa Mo\TT4lv[XOnIFHzd4F6 NUDDbnJtOTBizszN MYSxJIg> MoS4SG1UVw>? M{fTbWlv\HWlZYOgVGFTWCClbHXheoFo\SCkeTDpcohq[mm2aX7nJJBzd3OnYYPvcYUh[WO2aY\peJk> NVjGfpZvOjR|MkG4N|M>
MDA-MB-231 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PxelEh|ryP NVT2RWQ1PzJiaB?= NGXle|RFVVOR MXLJR|UxRTBwMUig{txO Mnv0NlQyPTN{ME[=
MCF-7 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH2XlQ3OSEQvF2= MVu3NkBp MWrEUXNQ MlvvTWM2OD1yLkGzJO69VQ>? NYC5[3BHOjRzNUOyNFY>
MCF10A M3TGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWmxJO69VQ>? NFi3eYU4OiCq MVLEUXNQ NUPONmpGUUN3ME2wMlI6KM7:TR?= Ml33NlQyPTN{ME[=
HEK-293 MmfmT4lv[XOnIFHzd4F6 NIK5NY4zKGGwZDCyNEDPxE1? NFX6UXUzKGh? MoHxSG1UVw>? NV\ObXh2UW6qaXLpeJMhS2iWLVygZYN1cX[rdImge4l1cCCLQ{WwJI9nKDlibl2g NGnZPGczOzV2MEe5NC=>
Calu6 MYHGeY5kfGmxbjDBd5NigQ>? Mor3NVAh|ryP M{fpSlE5KGh? NUHlW2JjTE2VTx?= Moe0V4lodmmoaXPhcpRtgSCjY3P1cZVt[XSnczDmdoF1[XirbjDwdoVkfXK|b4K= MmSyNlM2ODZ2OE[=
IFN-gamma-induced RAW264.7 NI\qNpJHfW6ldHnvckBCe3OjeR?= MkXBSG1UVw>? MV3Jcohq[mm2czDubZRzcWNib4jp[IUheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE4xPzdizszN NHvocm0zOjJ5N{K3Oy=>
IPC227F Ml;3R5l1d3SxeHnjJGF{e2G7 NHjzOpYyKM7:TR?= MmHjOFghcA>? NHjFTVFFVVOR NFXCUGxKSzVyPUCuNFc4KM7:TR?= NWDE[VVZOjF7MkS1Nlg>
Hepa-1c1c7 NUjTdY9nTnWwY4Tpc44hSXO|YYm= NX;HZXJXOjVizszN MV62JIg> MmPISG1UVw>? MnXXTY5kemWjc3XzJG5z\jJicILveIVqdiCuZY\lcC=> NVf0XnRtOjB|OUK1OFQ>
COS-7 NIPkdVhEgXSxdH;4bYMhSXO|YYm= MYixNEDPxE1? MYjEUXNQ MUPJR|UxRDFyIN88US=> MWSxPFA5QDB7Nx?=
HuH-7 NUC2THVlS3m2b4TvfIlkKEG|c3H5 MkXUNVAh|ryP MUHEUXNQ M2TB[WlEPTB:MUCg{txO NVnQU2tEOThyOEiwPVc>
OCI-Ly3 NH72S3FHfW6ldHnvckBCe3OjeR?= Ml6zNVAh|ryPwrC= M2jXV|QhcA>? NYezPINVTE2VTx?= MV;JcoR2[2W|IHj1cYFvKEmtYYDwZWJidHCqYTDzeIFjcWyrenH0bY9vKHerdHigSWM2OCCxZjCxJO69VQ>? M2fBcVE5ODJ2MUGz
A2780 cDDP MmjYRZBweHSxc3nzJGF{e2G7 MXqyOEBp NVf3VIlPTE2VTx?= NH7KWnJKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? MnnpNVc3QDRyMUi=
LPS-stimulated RAW264.7 cells M4[3[mZ2dmO2aX;uJGF{e2G7 NUfHTFQxTE2VTx?= NFLrfZJKdmirYnn0d{BPTi2tYYDwZWIhTE6DIHLpcoRqdmd? MU[xO|QxPzJ5Nx?=
PC12 M3z6TWZ2dmO2aX;uJGF{e2G7 MUSxNFAh|ryPwrC= NGfsbYEzPCCq MXnEUXNQ M2f6c2lvcGmkaYTzJFYuV0iGQT2gZY5lKEh{T{KtbY5lfWOnZDDjfZRwfG:6aXPpeJk> MU[xO|E2QDR3NB?=
PC3 NFHVXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXwNmRMOjBizszN MW[0PEBp M1ezc2ROW09? MXnJR|UxRTBwNjFOwG0> NGjReGUyPjZ6NkWzOy=>
LP-1 NEDZSnJCeG:ydH;zbZMhSXO|YYm= MV[zNFAhdk1? NUXnOXVxOjRiaB?= M37SZWROW09? M2f2bmlv\HWlZYOgZZBweHSxc3nzJIJ6KGmwY4LlZZNqdmdiY3zlZZZm\CCSQWLQJIxmfmWuIHHu[EBz\WS3Y3nu[{BO[2xvMTDwdo91\WmwIHzleoVt MljsNVU6PTh3OEm=
ES6 Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEGzNFYh|ryP NUXEN292W0GQR1XS
A101D MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXyZYFYUUN3ME2wMlA{Ojd7IN88US=> NX;Bb41JW0GQR1XS
OCUB-M MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDyTWM2OD1yLkCzO|M4KM7:TR?= M1P3UXNCVkeHUh?=
LB2518-MEL MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjZZolKSzVyPUCuNFM4PiEQvF2= NXvISY1GW0GQR1XS
SH-4 NIT2fJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDZTWM2OD1yLkC0N|Eh|ryP MWLTRW5ITVJ?
KNS-42 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjje|lLUUN3ME2wMlA1PDRzIN88US=> NWTRfod6W0GQR1XS
DSH1 NITkTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfFTWM2OD1yLkC1Nlg6KM7:TR?= NEPKOm5USU6JRWK=
NTERA-S-cl-D1 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWwTJpGUUN3ME2wMlA2Pzd{IN88US=> Mnj6V2FPT0WU
D-542MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHpbW4yUUN3ME2wMlA2QTV5IN88US=> MWXTRW5ITVJ?
KS-1 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULtd3hbUUN3ME2wMlA3PDV6IN88US=> MnrMV2FPT0WU
BL-41 M4rySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzxbol{UUN3ME2wMlA3QTR5IN88US=> NFS3VW1USU6JRWK=
LXF-289 NHTXRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPKWVg1UUN3ME2wMlA4ODZ4IN88US=> NE\EZnVUSU6JRWK=
D-247MG NU\jPWg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[wTWM2OD1yLkC3NlA6KM7:TR?= MnrNV2FPT0WU
MMAC-SF M4Xp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEeyOlgh|ryP NWHDW21rW0GQR1XS
CP66-MEL Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3sTWM2OD1yLkC3OUDPxE1? NXvYbXVTW0GQR1XS
LB771-HNC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\q[JBKSzVyPUCuNFgxOzZizszN M{f2e3NCVkeHUh?=
no-10 NXvtSYZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[2fIhKSzVyPUCuNFg6ODlizszN MnnPV2FPT0WU
A388 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHxTWM2OD1yLkC5NFY2KM7:TR?= NIXtbm9USU6JRWK=
OPM-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\sOoNKSzVyPUCuNVA1PzRizszN MoTNV2FPT0WU
OVCAR-4 NHjmVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMUC5N|gh|ryP NFf3PJFUSU6JRWK=
HOP-62 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LCUWlEPTB;MD6xNFk1QSEQvF2= MXPTRW5ITVJ?
ML-2 MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\1TWM2OD1yLkGxPFA3KM7:TR?= M2faO3NCVkeHUh?=
UACC-257 NEjlOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMUG5Nlch|ryP NFjlNm5USU6JRWK=
NEC8 M2XYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzxfHdKSzVyPUCuNVE6QTVizszN MYTTRW5ITVJ?
ONS-76 NFO4d2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli0TWM2OD1yLkGyPVM2KM7:TR?= M2joe3NCVkeHUh?=
KE-37 NF7iVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrOd|VzUUN3ME2wMlE{Ojd6IN88US=> M1fRfXNCVkeHUh?=
HT-144 NGO2fnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf6T5B6UUN3ME2wMlE{QDl3IN88US=> M2fZ[3NCVkeHUh?=
LB2241-RCC Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M134RmlEPTB;MD6xOFI1PyEQvF2= MX\TRW5ITVJ?
TE-5 MoLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17mXGlEPTB;MD6xOFI4QCEQvF2= MWDTRW5ITVJ?
KINGS-1 M3zjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUS3PUDPxE1? Mle2V2FPT0WU
NCI-H69 M1nybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP5TWM2OD1yLkG1NVQyKM7:TR?= MlvHV2FPT0WU
CAS-1 NVT5dYZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH6TWM2OD1yLkG1OFgzKM7:TR?= NYnjNG42W0GQR1XS
D-263MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITQ[mhKSzVyPUCuNVYxODZizszN Mlu0V2FPT0WU
A253 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6xTpRKSzVyPUCuNVYyOjhizszN M4roSnNCVkeHUh?=
PF-382 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[2XGlEPTB;MD6xOlcxPiEQvF2= NV3OU2hrW0GQR1XS
CESS MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTLU|U{UUN3ME2wMlE4ODZizszN NYS1Z|NSW0GQR1XS
MZ2-MEL MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMUe1OVkh|ryP NXrlW5JZW0GQR1XS
HEL NETJd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorLTWM2OD1yLkG4OVE4KM7:TR?= NYr3cplWW0GQR1XS
D-392MG NGDsdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SwW2lEPTB;MD6xPVEyPSEQvF2= NVOwU2drW0GQR1XS
SK-LMS-1 NFLKOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXaTWM2OD1yLkG5N|A{KM7:TR?= MnTHV2FPT0WU
GI-ME-N M{iyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMUmzNFYh|ryP NFG4U5VUSU6JRWK=
LB831-BLC Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTmTWM2OD1yLkG5N|Qh|ryP Mkj2V2FPT0WU
DU-4475 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjvR29HUUN3ME2wMlE6PjV6IN88US=> NHr4d5hUSU6JRWK=
IST-SL1 M{[1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXexS5NnUUN3ME2wMlIxODl2IN88US=> MlniV2FPT0WU
GAK NXfCToFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMkC1N|Qh|ryP MU\TRW5ITVJ?
EW-1 NIXrbZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW3fpFmUUN3ME2wMlIyODR5IN88US=> M2\oVnNCVkeHUh?=
LAMA-84 NVnhTppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEntNlFKSzVyPUCuNlE5PTFizszN MWLTRW5ITVJ?
SK-UT-1 M4X0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe0OFNKSzVyPUCuNlIxPDlizszN MWfTRW5ITVJ?
VA-ES-BJ NGDkUZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUL2NIs{UUN3ME2wMlIzOjV5IN88US=> MU\TRW5ITVJ?
ACN M4\aZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkK2N|gh|ryP Ml;CV2FPT0WU
SK-PN-DW M2XpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX6TWM2OD1yLkKzNVkh|ryP NX7PTIM3W0GQR1XS
HD-MY-Z M2fIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnuTWM2OD1yLkKzN|A{KM7:TR?= NWXwO4xbW0GQR1XS
LB373-MEL-D MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHhTWM2OD1yLkK0NVk5KM7:TR?= M3XzNHNCVkeHUh?=
COLO-829 M3zaZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMkSyOVch|ryP NHLjZnVUSU6JRWK=
ES8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH3[4NKSzVyPUCuNlQ4PjNizszN NFK0WpVUSU6JRWK=
RXF393 M3HlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HVcWlEPTB;MD6yOVAyPSEQvF2= MUjTRW5ITVJ?
TK10 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL5bYpFUUN3ME2wMlI2PDN3IN88US=> MX3TRW5ITVJ?
LOUCY NH\FemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPMSIUyUUN3ME2wMlI2PDV4IN88US=> NIjzcXhUSU6JRWK=
MZ7-mel M1XEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXziWXo6UUN3ME2wMlI3Ozd2IN88US=> NGHTV4NUSU6JRWK=
CP67-MEL Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPJTWM2OD1yLkK2O|Mh|ryP NY\LdJJtW0GQR1XS
C2BBe1 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMke5NFch|ryP Mn7nV2FPT0WU
K052 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMki5PUDPxE1? NH\S[Y9USU6JRWK=
MOLT-16 M{n3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DIT2lEPTB;MD6yPVUzPCEQvF2= M3ywb3NCVkeHUh?=
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KLE M3PtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LydWlEPTB;MD6zNVMxPiEQvF2= M4XBNnNCVkeHUh?=
NCCIT NVriXlM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnEdoluUUN3ME2wMlMyPzh|IN88US=> NEnaeolUSU6JRWK=
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TE-8 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXCTWM2OD1yLkO0Nlc6KM7:TR?= Mn;EV2FPT0WU
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NCI-H1092 M3PjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwM{i4OFQh|ryP M3XPdnNCVkeHUh?=
8-MG-BA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHMcGJKSzVyPUCuN|k5OzdizszN MVnTRW5ITVJ?
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CCRF-CEM MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PCd2lEPTB;MD60O|Y4PCEQvF2= MV;TRW5ITVJ?
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MONO-MAC-6 M3TjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPiNWNCUUN3ME2wMlU{PjFzIN88US=> NEHLOXBUSU6JRWK=
BB65-RCC M3XGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzDTWM2OD1yLkW2PFEyKM7:TR?= MmP5V2FPT0WU
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NCI-H2126 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGwTWM2OD1yLk[yOlY6KM7:TR?= MXzTRW5ITVJ?
SF268 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnOTWM2OD1yLk[1OlQyKM7:TR?= MlexV2FPT0WU
SW872 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K0ZWlEPTB;MD62OVczQSEQvF2= NYm4VFAxW0GQR1XS
LS-513 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTDSm1JUUN3ME2wMlY3PzVzIN88US=> Mln2V2FPT0WU
NCI-H1355 NYC5UWJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPHTWM2OD1yLk[4OlE6KM7:TR?= MV3TRW5ITVJ?
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NCI-SNU-5 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwNkm1OFUh|ryP NGTPd2lUSU6JRWK=
SNU-C2B MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrYdpNVUUN3ME2wMlcxPzN7IN88US=> MmHLV2FPT0WU
GB-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu3PWlKSzVyPUCuO|IyOjRizszN M1LJd3NCVkeHUh?=
CTB-1 M{mwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjtfGVLUUN3ME2wMlc4QTV3IN88US=> NWLm[HpjW0GQR1XS
Becker Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDwZYVKSzVyPUCuO|k3OjFizszN MkTvV2FPT0WU
KM12 M1;KcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XKXGlEPTB;MD64OVQ3PiEQvF2= M3fOUHNCVkeHUh?=
ES7 NVHOTFg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELlVHNKSzVyPUCuPFk3PSEQvF2= NUjDbmROW0GQR1XS
COLO-684 NE\BbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DOWWlEPTB;MD65NFY2QCEQvF2= MmToV2FPT0WU
HCC2998 NHXZPWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrBSlR[UUN3ME2wMlk{QDV2IN88US=> NIX2clVUSU6JRWK=
TE-10 NXLhfJFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwOU[0N{DPxE1? NIfTW49USU6JRWK=
SF126 MnHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHWZZdyUUN3ME2wMlk5QTdzIN88US=> NI\BT|VUSU6JRWK=
EKVX NGPTeGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLGUYNQUUN3ME2xMlA{PDR{IN88US=> NHfHVVZUSU6JRWK=
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KURAMOCHI MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwMUKzO|Qh|ryP NU\rfHpyW0GQR1XS
LU-65 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwMUK3OVMh|ryP M4foXXNCVkeHUh?=
MFH-ino NHvUZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLXT4UzUUN3ME2xMlE4PTBzIN88US=> M1PkZ3NCVkeHUh?=
NCI-H23 NULOPFd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjSTWM2OD1zLkKwOFEh|ryP Mlf2V2FPT0WU
IA-LM Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnKemtKSzVyPUGuNlQyOTZizszN NWXOU5lJW0GQR1XS
PSN1 NV;6R2xvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwMkewNVYh|ryP M{HZUHNCVkeHUh?=
NCI-H719 MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFwMke0NVEh|ryP MlrwV2FPT0WU
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EW-16 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLzTWM2OD1zLkOxN|Q4KM7:TR?= NIHlO2FUSU6JRWK=
NCI-H128 M1XW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[0U4FTUUN3ME2xMlM2QDF2IN88US=> M4HoOHNCVkeHUh?=
HC-1 NHHHeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TUcmlEPTB;MT6zPFE4KM7:TR?= MoCzV2FPT0WU
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DMS-114 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFwNES1N|kh|ryP NWTOU3JqW0GQR1XS
GI-1 NX2zXm9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTFwNEexN|Eh|ryP MVPTRW5ITVJ?
NCI-H2081 NFnTcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[2SGlEPTB;MT61OVE6PiEQvF2= MYrTRW5ITVJ?
LC-1F Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTFwNUWxPVgh|ryP MlLPV2FPT0WU
NCI-H2227 M1vWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jsOGlEPTB;MT62NVU3OSEQvF2= NEnMZWxUSU6JRWK=
D-502MG NXnjdlNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTkWVFjUUN3ME2xMlY4OjFzIN88US=> NFjzNpJUSU6JRWK=
NCI-H2141 M3fCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHDXndWUUN3ME2xMlY4OzF5IN88US=> M3fQbXNCVkeHUh?=
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JVM-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\j[IpVUUN3ME2xMlk{QTB2IN88US=> NGfVU|RUSU6JRWK=
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QIMR-WIL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37UcGlEPTB;Mj6xOlc3OiEQvF2= MmXHV2FPT0WU
MC-CAR MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPBN4tKSzVyPUKuNlI6PSEQvF2= MVPTRW5ITVJ?
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ECC12 M{nwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTSTWM2OD1{LkO3PVQh|ryP MnjmV2FPT0WU
HCE-T M1zSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwNES4PFMh|ryP Mn3WV2FPT0WU
MFM-223 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G0dGlEPTB;Mj61NFg4OSEQvF2= MnfOV2FPT0WU
SW982 NEn0N|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwNUG0PEDPxE1? NW\XO204W0GQR1XS
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RH-1 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwM{i3OFgh|ryP NH7zToZUSU6JRWK=
NCI-H748 M17mPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTlSW1UUUN3ME2zMlQ1OjZ4IN88US=> NHH2OYxUSU6JRWK=
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MEG-01 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoizTWM2OD1|LkW5Olgh|ryP M1vW[XNCVkeHUh?=
NB12 M4nEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwNUm4PFgh|ryP M3npXnNCVkeHUh?=
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HAL-01 NX60O2tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRwNUewN|Qh|ryP NYDQdVdGW0GQR1XS
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BC-1 NHGy[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2e2FYUUN3ME21MlAxPDR5IN88US=> M1i2VXNCVkeHUh?=
EB-3 NWPPNnNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\TW41uUUN3ME21MlA{ODRzIN88US=> NU\OUGhEW0GQR1XS
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NCI-H209 M3zVXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTVwMUmzOVIh|ryP M2nsRnNCVkeHUh?=
BT-474 M4PYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTVwMkOxNFIh|ryP MlziV2FPT0WU
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SIMA M1jhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjaTWM2OD13LkOwO|Y2KM7:TR?= M2nPSXNCVkeHUh?=
RL MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\weFg6UUN3ME21MlM4PTRzIN88US=> NXXVN5p1W0GQR1XS
GCIY M{D4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLqTWM2OD13LkS3NlM3KM7:TR?= MWrTRW5ITVJ?
Calu-6 NH7hb|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;FTWM2OD13Lk[yNkDPxE1? MUnTRW5ITVJ?
ALL-PO NYK0TYs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H3bWlEPTB;NT62N|c6PSEQvF2= M3LM[HNCVkeHUh?=
ARH-77 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHFTpBKSzVyPUWuOlcxQDdizszN MXXTRW5ITVJ?
A4-Fuk NVXrRVRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7PTWM2OD14LkC4NVE5KM7:TR?= M3vxWHNCVkeHUh?=
NCI-H1581 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:wXmx4UUN3ME22MlI{QDR7IN88US=> NFzVdXZUSU6JRWK=
HUTU-80 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHLRmlKSzVyPU[uN|Y5QTdizszN MWfTRW5ITVJ?
TGW MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfybpRKSzVyPU[uOFU2QTNizszN M4\4U3NCVkeHUh?=
SK-N-FI NGTzbVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jye2lEPTB;Nj60OVg2PCEQvF2= Mn3sV2FPT0WU
U-266 NHTEbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD14LkWxPVI3KM7:TR?= Mn;OV2FPT0WU
EM-2 NXz0eJhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjYZo9KSzVyPU[uOlcxQTlizszN NEj6RYJUSU6JRWK=
NMC-G1 M4Dl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\Zd21KSzVyPU[uO|E5QTVizszN NUDlZW13W0GQR1XS
KASUMI-1 M1zpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nJc2lEPTB;Nj64OFc5PyEQvF2= M4rpOHNCVkeHUh?=
NALM-6 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j0WGlEPTB;Nj64Olc2PCEQvF2= NXfXeZM{W0GQR1XS
OCI-AML2 NH7uNXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLGXIJbUUN3ME23MlAxOzJ4IN88US=> NIr5VYpUSU6JRWK=
SHP-77 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor6TWM2OD15LkKyOFMh|ryP MkXWV2FPT0WU
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SK-N-DZ NVrBXFRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;BTWM2OD15LkexNFg6KM7:TR?= NXm5S5dOW0GQR1XS
LB1047-RCC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[0WZB7UUN3ME23MlczOjNzIN88US=> MmfBV2FPT0WU
MZ1-PC NEPGRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe3TWM2OD15Lki2OVU5KM7:TR?= MmTZV2FPT0WU
NB10 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3PPWJKSzVyPUeuPVk2PTZizszN MX3TRW5ITVJ?
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OMC-1 M3LSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRThwNUKxPVEh|ryP NE\uRpNUSU6JRWK=
D-283MED NFnXe5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\LTWM2OD16LkmxO|E6KM7:TR?= M3jSZXNCVkeHUh?=
MC116 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRThwOUe5OEDPxE1? MU\TRW5ITVJ?
SJSA-1 NGDlTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTlwMEmwPVEh|ryP MkTsV2FPT0WU
JiyoyeP-2003 M3S2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\6TmlEPTB;OT6yPVMyPyEQvF2= NEi5PHlUSU6JRWK=
IST-MEL1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L0UmlEPTB;OT63OFE6QCEQvF2= M1TNXnNCVkeHUh?=
CTV-1 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXSTWM2OD1zMD6wPVc6KM7:TR?= NIKzcFlUSU6JRWK=
NH-12 NYTTfIlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnnNpFNUUN3ME2xNE4zPDN|IN88US=> MVXTRW5ITVJ?
CA46 M3j1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFyLkO2NUDPxE1? NWP6c3MzW0GQR1XS
NCI-SNU-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFyLkS5Olkh|ryP MULTRW5ITVJ?
SCLC-21H NXfBXHV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e4ZmlEPTB;MUCuOlU6PiEQvF2= MV3TRW5ITVJ?
EC-GI-10 M4Lp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm3TWM2OD1zMD63NFMyKM7:TR?= NXO5[XhNW0GQR1XS
SR NXfkUIxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH4UYR2UUN3ME2xNU4xOTh3IN88US=> M3HuVHNCVkeHUh?=
NCI-H1648 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFzLkC5OlUh|ryP Ml3tV2FPT0WU
TGBC1TKB MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjVenpKSzVyPUGxMlQyODJizszN MUDTRW5ITVJ?
EW-11 M3\NZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3veW1sUUN3ME2xNU42OTh4IN88US=> Mo\tV2FPT0WU
SK-MM-2 NFu0[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;XSGlEPTB;MUGuPFA3OSEQvF2= MkLrV2FPT0WU
NCI-H524 NWrrSm17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13aUGlEPTB;MUGuPVgzOiEQvF2= NVfLWFJFW0GQR1XS
NOS-1 NXHUN|JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnlOok2UUN3ME2xNk4xOzR3IN88US=> MXvTRW5ITVJ?
AM-38 M1PZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF{LkW2N|Mh|ryP NHPzbVBUSU6JRWK=
A498 NEflOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF{LkewOlkh|ryP MWXTRW5ITVJ?
KARPAS-422 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;6TWhiUUN3ME2xNk44PDl4IN88US=> MWrTRW5ITVJ?
LU-139 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTMTWM2OD1zMj65NFI3KM7:TR?= M{XYSHNCVkeHUh?=
COR-L88 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\GTWM2OD1zMj65N|gzKM7:TR?= MYjTRW5ITVJ?
K5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF{Lkm0OlIh|ryP Mnn3V2FPT0WU
NB13 M1zYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{Lkm3PFMh|ryP NY\ieHpuW0GQR1XS
MRK-nu-1 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n3WmlEPTB;MUOuNVk2KM7:TR?= M1jSeHNCVkeHUh?=
MHH-NB-11 M4nWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[4fVVYUUN3ME2xN{4zQTB{IN88US=> MYTTRW5ITVJ?
KU812 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF|Lk[xNlQh|ryP M3nxeHNCVkeHUh?=
TE-12 MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DmcGlEPTB;MUOuOlk6PCEQvF2= MnnrV2FPT0WU
NCI-N87 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjnRWtIUUN3ME2xN{44OzZizszN NWjvUIJxW0GQR1XS
EB2 NELEZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrUYRKSzVyPUGzMlg2ODVizszN M2C3R3NCVkeHUh?=
DB NYO1NZg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF|Lkm4PFUh|ryP M4fPVHNCVkeHUh?=
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MSTO-211H MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr4dZNKSzVyPUG0Mlc1PDhizszN MnnMV2FPT0WU
JVM-2 NH\TbWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\JbWlEPTB;MUSuO|c{PSEQvF2= NEHOOoJUSU6JRWK=
COLO-824 NXq5RZZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vGUGlEPTB;MUSuO|k6PCEQvF2= M2fQV3NCVkeHUh?=
BC-3 MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PTfWlEPTB;MUWuN|k5KM7:TR?= NIjH[VBUSU6JRWK=
BOKU NX7XcIF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF3Lkm2NFgh|ryP MV;TRW5ITVJ?
GOTO M2nZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DP[GlEPTB;MU[uPVYyPyEQvF2= NFvibW9USU6JRWK=
HCC2157 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnnfWtVUUN3ME2xO{41PzV3IN88US=> NYrqUpZzW0GQR1XS
LS-1034 M3fJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW0TWM2OD1zNz62PFE5KM7:TR?= M{XzUnNCVkeHUh?=
CAL-148 M{LvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOwd2VOUUN3ME2xO{46Pzl4IN88US=> NF3LWnNUSU6JRWK=
MOLT-4 NV3jcJlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TsRWlEPTB;MUiuPFIxQCEQvF2= MnzkV2FPT0WU
Daudi NXLEV3JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHZU5RKSzVyPUG4MlkzOzFizszN NIrFTohUSU6JRWK=
J-RT3-T3-5 NH7pS|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTF7LkSwOlYh|ryP NFzXSXpUSU6JRWK=
KMOE-2 MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTF7Lk[0PFIh|ryP M2HJN3NCVkeHUh?=
HL-60 NHXOb|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn35TWM2OD1{MD6xPVY2KM7:TR?= MY\TRW5ITVJ?
P31-FUJ MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTLTWM2OD1{MD60O|U{KM7:TR?= NYnsRWI3W0GQR1XS
IM-9 NEfrTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJyLk[yNlQh|ryP M{O4WnNCVkeHUh?=
HDLM-2 MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:2TWM2OD1{MD64PFIyKM7:TR?= MX7TRW5ITVJ?
NCI-H1304 NILKZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TmcGlEPTB;MkGuNFMyOSEQvF2= MXjTRW5ITVJ?
NCI-H345 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX4TWM2OD1{MT6wOlQ{KM7:TR?= Mo\yV2FPT0WU
RPMI-6666 NGLXV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DufGlEPTB;MkGuN|YxOiEQvF2= NXizV4U3W0GQR1XS
GR-ST M13RT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3ZTWM2OD1{MT60NVch|ryP NVjqUpM{W0GQR1XS
CHP-126 M3vVWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnqTWM2OD1{MT62NVgyKM7:TR?= MlizV2FPT0WU
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NB1 MkDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ2Lk[5N|kh|ryP MnzqV2FPT0WU
LS-123 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fJVWlEPTB;MkSuPVAyOiEQvF2= M3vPcHNCVkeHUh?=
ST486 MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS5TWM2OD1{NT6xNVE{KM7:TR?= MWHTRW5ITVJ?
NCI-H1963 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjVUlBVUUN3ME2yOk4xPjJ|IN88US=> M2rUbXNCVkeHUh?=
U-87-MG Ml3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3GPGdKSzVyPUK2Mlc3PDRizszN NVz1VmliW0GQR1XS
COR-L279 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJ4Lke5NlIh|ryP M{TwO3NCVkeHUh?=
LU-165 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTRSGtqUUN3ME2yPE4xQDZzIN88US=> M4rzOHNCVkeHUh?=
COLO-800 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f1PWlEPTB;MkiuNlk2PiEQvF2= MWPTRW5ITVJ?
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LNCaP-Clone-FGC M3y4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;WTWM2OD1{OT65NlgyKM7:TR?= NYHlNmt2W0GQR1XS
SIG-M5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELaNZRKSzVyPUOwMlc6PTJizszN MlHUV2FPT0WU
NB6 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjHO3VKSzVyPUOwMlk2ODNizszN NVLBcm1DW0GQR1XS
NCI-H2107 NI\GRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjpOW84UUN3ME2zNU4zOzN6IN88US=> MonFV2FPT0WU
SNU-C1 NUfL[lVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT0TWM2OD1|MT6zNVI3KM7:TR?= MXrTRW5ITVJ?
JAR M2nZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGOwNZJKSzVyPUOxMlM4QTlizszN NXvWcpk{W0GQR1XS
L-363 MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli2TWM2OD1|Mj6yNVQ1KM7:TR?= MXvTRW5ITVJ?
EW-24 NEjhVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnNWG5KSzVyPUOyMlM1PzRizszN MYHTRW5ITVJ?
NB69 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfxfnlCUUN3ME2zN{43PDV2IN88US=> NXiyPYU{W0GQR1XS
EW-13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fPPWlEPTB;M{OuPFk3QSEQvF2= MXLTRW5ITVJ?
Ramos-2G6-4C10 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[2TWM2OD1|ND6yPVk{KM7:TR?= NILLb4tUSU6JRWK=
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L-428 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN2Lke1N|Yh|ryP NYDET3ROW0GQR1XS
KP-N-YN NH;VbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHQWVJKSzVyPUO0MlkxPTdizszN NFrTTmNUSU6JRWK=
CGTH-W-1 NWHtbIh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN4LkmwOFgh|ryP M4rjVXNCVkeHUh?=
K-562 NVzzfJB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jyemlEPTB;M{euNFg3PCEQvF2= MkHvV2FPT0WU
NCI-H1299 NUXHPFIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN6LkG2NFMh|ryP MljOV2FPT0WU
RCC10RGB NGL0W5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK3bZFKSzVyPUO4MlIxQDNizszN M4Lrd3NCVkeHUh?=
NCI-SNU-16 M4DlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXnb3hKSzVyPUO4MlU3PTNizszN Mnm2V2FPT0WU
LC-2-ad M3zPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7SOXNKSzVyPUO5MlQ{OzdizszN M{Wx[XNCVkeHUh?=
MHH-PREB-1 NVHGTmdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vRVWlEPTB;M{muO|M5QCEQvF2= M1Xm[nNCVkeHUh?=
NCI-H64 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTRyLkC5OFgh|ryP NXHoSZpqW0GQR1XS
LB996-RCC Mn3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTRyLki3NVYh|ryP M{PXfXNCVkeHUh?=
DEL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkezTWM2OD12MT60OFA2KM7:TR?= MkCyV2FPT0WU
MLMA MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W5VmlEPTB;NEGuO|U6PSEQvF2= MXfTRW5ITVJ?
SBC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[wTWM2OD12Mj6xPFA3KM7:TR?= NEDOOIpUSU6JRWK=
MPP-89 NFHqeFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LCPWlEPTB;NEKuOVg4PSEQvF2= NIDET2hUSU6JRWK=
MV-4-11 NFXyWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR{LkmwOlch|ryP NUL0SHJYW0GQR1XS
EoL-1- M4noRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nlUWlEPTB;NESuNVU3QCEQvF2= NFjtXldUSU6JRWK=
CW-2 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5cYpKSzVyPUS0Mlg{PDJizszN MlHCV2FPT0WU
HT M1fDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTR3LkewNFch|ryP NXnJZ5RSW0GQR1XS
SW954 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zRUmlEPTB;NEeuOFEzQCEQvF2= NHe3XFhUSU6JRWK=
A3-KAW NEnNdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzRflZSUUN3ME20PU45ODZzIN88US=> Mn\RV2FPT0WU
TC-YIK NIqzOIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTVyLkCzOlMh|ryP NF7wUnVUSU6JRWK=
SW962 NX2wRYU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXPTWM2OD13ND64N|U4KM7:TR?= MkHSV2FPT0WU
KP-N-RT-BM-1 NEDrTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HTUmlEPTB;NU[uOlY{QCEQvF2= NFq5dlZUSU6JRWK=
NCI-H1395 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv6VZhwUUN3ME21PE45OTd{IN88US=> NHvuV2ZUSU6JRWK=
RPMI-8402 M1nFXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fUeWlEPTB;NUiuPVUzPiEQvF2= NHr3SXhUSU6JRWK=
SCH MlXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfKRoRKSzVyPU[wMlk3OzhizszN NG\p[GhUSU6JRWK=
NCI-H2196 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTZzLkKzNUDPxE1? M{XxSnNCVkeHUh?=
LOXIMVI MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrRTWM2OD14MT64NlY3KM7:TR?= M2nwd3NCVkeHUh?=
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NCI-H446 M2LTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;CfIZZUUN3ME25PU44PTh6IN88US=> NYqze3NLW0GQR1XS
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NCI-H1838 M{D2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[0[WlEPTB;MkexMlQ2PiEQvF2= MYHTRW5ITVJ?
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C8166 NX3SVGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LqRWlEPTB;M{S1MlM{QCEQvF2= MYnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Protocol

Kinase Assay:

[1]

+ Expand

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research:

[3]

+ Expand
  • Cell lines: KIM-2, HC11, and ES
  • Concentrations: Dissolved in DMSO, final concentrations ~25 μM
  • Incubation Time: 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Male mdx (C57BL/10ScSn DMD mdx) mice
  • Formulation: Dissolved in DMSO, and diluted in PBS
  • Dosages: ~10 μg/kg/day
  • Administration: Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 90 mg/mL (189.22 mM)
Ethanol 25 mg/mL (52.56 mM)
Water Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+20% propylene glycol+ddH2O
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 475.62
Formula

C26H41N3O5

CAS No. 133407-82-6
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to know whether it contains EDTA or other chelating agent in this product(S2619)?

  • Answer:

    Our S2619 MG-132 doesn't contain EDTA or other chelating agent.

Proteasome Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID