MG-132

Catalog No.S2619

MG-132 Chemical Structure

Molecular Weight(MW): 475.62

MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.

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Cited by 47 Publications

10 Customer Reviews

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Nek2A impedes SuFu ubiquitination. HEK293T cells transfected with Nek2A-Myc and Flag-SuFu for 48 h were treated with MG-132 to enrich ubiquitinated proteins, and subsequently subjected to co-immunoprecipitation assay. Precipitated proteins were probed using anti-Ub antibody.

    Int J Oncol, 2017, 50(2):373-380. MG-132 purchased from Selleck.

    Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

Purity & Quality Control

Choose Selective Proteasome Inhibitors

Biological Activity

Description MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.
Targets
Proteasome [1]
(Cell-free assay)
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells NEXRbI1HfW6ldHnvckBCe3OjeR?= MUmyOUDPxE1? NVu3NVhzTE2VTx?= M{ixbmlvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjFizszN MnKxNlQ3QTd2OU[=
HL-60 M4HHOmN6fG:2b4jpZ{BCe3OjeR?= NITP[ZU1OCEQvF2= NXnNR45HPDhiaB?= M{fMfmROW09? MUPJR|UxRDFyIN88US=> MmHoNlQ3QTd2OU[=
SMMC-7721 MmHWR5l1d3SxeHnjJGF{e2G7 NWrOT|NLPDBizszN MnLMOFghcA>? NEDCVo1FVVOR NGO5R3hKSzVyPUeuNUDPxE1? M{X1[|I1Pjl5NEm2
A-549 M13uU2N6fG:2b4jpZ{BCe3OjeR?= NYi1WGN6PDBizszN MkfrOFghcA>? M3;KeGROW09? M3vBWmlEPTB:MUCg{txO MXmyOFY6PzR7Nh?=
MCF-7 M2DJXmN6fG:2b4jpZ{BCe3OjeR?= NUP2V3ROPDBizszN M2LqflQ5KGh? MnPISG1UVw>? MXTJR|UxRTdwMzFOwG0> MUGyOFY6PzR7Nh?=
SW-480 Ml7HR5l1d3SxeHnjJGF{e2G7 NWrnVoVLPDBizszN MoHCOFghcA>? NGH3dpZFVVOR NUDhfpZ[UUN3ME20JO69VQ>? M{DCOFI1Pjl5NEm2
NCI-H929 MVLDfZRwfG:6aXOgRZN{[Xl? MnPaNUDPxE1? NGPDcFE4OiCq M3G3[GROW09? Mnu3TWM2OD1yLkG3JO69VQ>? Mo\kNlQ3OjVyOEi=
293T M{iwV2N6fG:2b4jpZ{BCe3OjeR?= NXvSe|ZiOTBizszN NHHLcVQ4OiCq NEfiU|RFVVOR MkDDTWM2ODx{IN88US=> NWX2S2JnOjR4MkWwPFg>
293T MnnKSpVv[3Srb36gRZN{[Xl? MXexNEDPxE1? NELXW5YzPCCq M2LzbWROW09? NWWzbXlKVW:mZYLheIVtgSCrbnT1Z4V{KGinYYStd4hw[2tiIB?= NInHPVQzPDZ{NUC4PC=>
HeLa MY\LbY5ie2ViQYPzZZk> M{Dib|ExKM7:TR?= NYHXTWRlOSCq MnfvSG1UVw>? M2eyXWlv\HWlZYOgVGFTWCClbHXheoFo\SCkeTDpcohq[mm2aX7nJJBzd3OnYYPvcYUh[WO2aY\peJk> MmnCNlQ{OjF6M{O=
MDA-MB-231 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;3NUDPxE1? NGXuV484OiCq NX\iNnJITE2VTx?= MlvPTWM2OD1yLkG4JO69VQ>? Mk\FNlQyPTN{ME[=
MCF-7 MnjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r0VlEh|ryP NXLVT4dmPzJiaB?= MnnxSG1UVw>? MV;JR|UxRTBwMUOg{txO NES1VoMzPDF3M{KwOi=>
MCF10A NX\MbZBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:3e2oyKM7:TR?= MYC3NkBp NEDyWGhFVVOR NYfFWW5wUUN3ME2wMlI6KM7:TR?= MXiyOFE2OzJyNh?=
HEK-293 NV7YU5pkU2mwYYPlJGF{e2G7 MWiyJIFv\CB{MDFOwG0> NIHOZ2EzKGh? NGDSeW9FVVOR MmPmTY5pcWKrdIOgR4hVNUxiYXP0bZZqfHlid3n0bEBKSzVyIH;mJFkhdk1i NILzWowzOzV2MEe5NC=>
Calu6 Mm\KSpVv[3Srb36gRZN{[Xl? Mn7pNVAh|ryP M37NUVE5KGh? MlTGSG1UVw>? MmXOV4lodmmoaXPhcpRtgSCjY3P1cZVt[XSnczDmdoF1[XirbjDwdoVkfXK|b4K= MUSyN|UxPjR6Nh?=
IFN-gamma-induced RAW264.7 MmjnSpVv[3Srb36gRZN{[Xl? MYjEUXNQ M2DSV2lvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> NITEZYkzOjJ5N{K3Oy=>
IPC227F MVTDfZRwfG:6aXOgRZN{[Xl? MVixJO69VQ>? M1:5[VQ5KGh? NF7EUWNFVVOR MoTLTWM2OD1yLkC3O{DPxE1? MYGyNVkzPDV{OB?=
Hepa-1c1c7 NE\3WmZHfW6ldHnvckBCe3OjeR?= M{LEfFI2KM7:TR?= Mnf2OkBp NGLnc4FFVVOR M3KyXWlv[3KnYYPld{BPemZ{IIDyc5RmcW5ibHX2[Yw> Mm\INlA{QTJ3NES=
COS-7 NXraNGN5S3m2b4TvfIlkKEG|c3H5 MlzLNVAh|ryP NXrsdJZHTE2VTx?= NXXXTGNbUUN3MEyxNEDPxE1? MWexPFA5QDB7Nx?=
HuH-7 NULrWFVQS3m2b4TvfIlkKEG|c3H5 Mm\yNVAh|ryP MlzGSG1UVw>? MUjJR|UxRDFyIN88US=> MXuxPFA5QDB7Nx?=
OCI-Ly3 NHPJ[ZZHfW6ldHnvckBCe3OjeR?= MnvQNVAh|ryPwrC= M2i2W|QhcA>? NGHtUZdFVVOR M1G4UWlv\HWlZYOgbJVu[W5iSXvhdJBiSmGucHjhJJN1[WKrbHn6ZZRqd25id3n0bEBGSzVyIH;mJFEh|ryP M4XRb|E5ODJ2MUGz
A2780 cDDP M3jjN2Fxd3C2b4Ppd{BCe3OjeR?= MWmyOEBp M4e4emROW09? MnLFTY5lfWOnczDhdI9xfG:|aYOgZpkhcW6qaXLpeIlv\yCSVFXOJIRm\3KjZHH0bY9v M4L5[FE4Pjh2MEG4
LPS-stimulated RAW264.7 cells NGrYfJZHfW6ldHnvckBCe3OjeR?= M4LDbWROW09? M2HOeGlvcGmkaYTzJG5HNWujcIDhRkBFVkFiYnnu[Ilv\w>? MmrJNVc1ODd{N{e=
PC12 M2DlUGZ2dmO2aX;uJGF{e2G7 M1WzV|ExOCEQvF5CpC=> MmrTNlQhcA>? NEnCXHpFVVOR NXToU2I1UW6qaXLpeJMhPi2RSFTBMUBidmRiSELPNk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gQ>? MWqxO|E2QDR3NB?=
PC3 M{K2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX6NGMzOCEQvF2= MU[0PEBp MWrEUXNQ M2PBVmlEPTB;MD62JO69VQ>? M3TkdlE3Pjh4NUO3
LP-1 NVXiSWhoSXCxcITvd4l{KEG|c3H5 MUCzNFAhdk1? NGi1[GozPCCq NEnEPYlFVVOR M4D5R2lv\HWlZYOgZZBweHSxc3nzJIJ6KGmwY4LlZZNqdmdiY3zlZZZm\CCSQWLQJIxmfmWuIHHu[EBz\WS3Y3nu[{BO[2xvMTDwdo91\WmwIHzleoVt MU[xOVk2QDV6OR?=
ES6 NXv3R4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG3TWM2OD1yLkCxN|A3KM7:TR?= NHq4XnlUSU6JRWK=
A101D MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLDTWM2OD1yLkCzNlc6KM7:TR?= NF7TRopUSU6JRWK=
OCUB-M NHT3fHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36xUWlEPTB;MD6wN|c{PyEQvF2= NGW1dWFUSU6JRWK=
LB2518-MEL Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEO3OkDPxE1? M3HEfnNCVkeHUh?=
SH-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILjPYpKSzVyPUCuNFQ{OSEQvF2= NF2yVIpUSU6JRWK=
KNS-42 MkjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMES0OFEh|ryP M4PON3NCVkeHUh?=
DSH1 NFX4VYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u3[mlEPTB;MD6wOVI5QSEQvF2= MkDtV2FPT0WU
NTERA-S-cl-D1 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXmfplKSzVyPUCuNFU4PzJizszN Mn21V2FPT0WU
D-542MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrabYRKSzVyPUCuNFU6PTdizszN MV\TRW5ITVJ?
KS-1 NX;XWFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DwO2lEPTB;MD6wOlQ2QCEQvF2= MV3TRW5ITVJ?
BL-41 NIH0cFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml64TWM2OD1yLkC2PVQ4KM7:TR?= NF\UT|lUSU6JRWK=
LXF-289 NVfF[2ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnBTWM2OD1yLkC3NFY3KM7:TR?= NEKyS3JUSU6JRWK=
D-247MG Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLuTWM2OD1yLkC3NlA6KM7:TR?= NVPEO4hPW0GQR1XS
MMAC-SF MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rLfmlEPTB;MD6wO|I3QCEQvF2= NUnTU|RQW0GQR1XS
CP66-MEL Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PHW2lEPTB;MD6wO|Uh|ryP NVj2[3NIW0GQR1XS
LB771-HNC NX\ZRWVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vrXGlEPTB;MD6wPFA{PiEQvF2= MULTRW5ITVJ?
no-10 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPrS|lKSzVyPUCuNFg6ODlizszN M{nGN3NCVkeHUh?=
A388 M3LlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXyUYJKSzVyPUCuNFkxPjVizszN NVfWcWNiW0GQR1XS
OPM-2 NHrkfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMUC0O|Qh|ryP M{PDUHNCVkeHUh?=
OVCAR-4 M2XDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n3cmlEPTB;MD6xNFk{QCEQvF2= Mke2V2FPT0WU
HOP-62 NX3YXGVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUC5OFkh|ryP NFjGcGhUSU6JRWK=
ML-2 NWPLe3NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TSUGlEPTB;MD6xNVgxPiEQvF2= NELiS5lUSU6JRWK=
UACC-257 M2DCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7qcpJKSzVyPUCuNVE6OjdizszN NFr3UlhUSU6JRWK=
NEC8 M13tOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMUG5PVUh|ryP NFjOVFdUSU6JRWK=
ONS-76 M3ToeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17D[2lEPTB;MD6xNlk{PSEQvF2= NFv1[mpUSU6JRWK=
KE-37 NVjs[lZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;xfWlEPTB;MD6xN|I4QCEQvF2= MULTRW5ITVJ?
HT-144 M13u[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMUO4PVUh|ryP NGHBWnpUSU6JRWK=
LB2241-RCC NXWz[WpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUSyOFch|ryP MVPTRW5ITVJ?
TE-5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHteGVTUUN3ME2wMlE1Ojd6IN88US=> MVPTRW5ITVJ?
KINGS-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG1TWM2OD1yLkG0O|kh|ryP M{LNVnNCVkeHUh?=
NCI-H69 NVzlNIFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W4UmlEPTB;MD6xOVE1OSEQvF2= Mn\iV2FPT0WU
CAS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS3TWM2OD1yLkG1OFgzKM7:TR?= M1O3[HNCVkeHUh?=
D-263MG NFnLV49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn4TWM2OD1yLkG2NFA3KM7:TR?= MmniV2FPT0WU
A253 NYD6b3NCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jzb2lEPTB;MD6xOlEzQCEQvF2= NIS5WGxUSU6JRWK=
PF-382 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnIR|IyUUN3ME2wMlE3PzB4IN88US=> MlHLV2FPT0WU
CESS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG3TWM2OD1yLkG3NFYh|ryP NWXxeG1qW0GQR1XS
MZ2-MEL M4TaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMUe1OVkh|ryP NFS3fWhUSU6JRWK=
HEL M4XyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHwPJBKSzVyPUCuNVg2OTdizszN NEPk[VJUSU6JRWK=
D-392MG MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHL[49KSzVyPUCuNVkyOTVizszN MVXTRW5ITVJ?
SK-LMS-1 NWf6ephqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLzTWM2OD1yLkG5N|A{KM7:TR?= MYnTRW5ITVJ?
GI-ME-N M3u0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;rTWM2OD1yLkG5N|A3KM7:TR?= MXjTRW5ITVJ?
LB831-BLC Mne0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP2RlR[UUN3ME2wMlE6OzRizszN M3:3cXNCVkeHUh?=
DU-4475 M3SxUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTNTWM2OD1yLkG5OlU5KM7:TR?= MkDIV2FPT0WU
IST-SL1 NUfw[4c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMkCwPVQh|ryP NV3nOlNuW0GQR1XS
GAK NH34NFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXuZ49KSzVyPUCuNlA2OzRizszN NWLDWoRKW0GQR1XS
EW-1 NXnQNXFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMkGwOFch|ryP MnLqV2FPT0WU
LAMA-84 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\4ZXZKSzVyPUCuNlE5PTFizszN M{DxXHNCVkeHUh?=
SK-UT-1 M{PrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjhUpRKSzVyPUCuNlIxPDlizszN MYjTRW5ITVJ?
VA-ES-BJ M4C4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rpbmlEPTB;MD6yNlI2PyEQvF2= M2TydnNCVkeHUh?=
ACN M4LldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHEPGdXUUN3ME2wMlIzPjN6IN88US=> MoLiV2FPT0WU
SK-PN-DW MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTtTWM2OD1yLkKzNVkh|ryP NX;FU5lMW0GQR1XS
HD-MY-Z NYHZcVVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMkOzNFMh|ryP M{LtPHNCVkeHUh?=
LB373-MEL-D M1zkWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXNTWM2OD1yLkK0NVk5KM7:TR?= M1LXbHNCVkeHUh?=
COLO-829 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XLVGlEPTB;MD6yOFI2PyEQvF2= M4\kR3NCVkeHUh?=
ES8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qyWWlEPTB;MD6yOFc3OyEQvF2= NYTEOmtuW0GQR1XS
RXF393 NET3U4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2W0TWlEPTB;MD6yOVAyPSEQvF2= MVrTRW5ITVJ?
TK10 NF;MRmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMkW0N|Uh|ryP Mk\VV2FPT0WU
LOUCY NVPDV4hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG0PWJnUUN3ME2wMlI2PDV4IN88US=> MmGxV2FPT0WU
MZ7-mel MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTuV5NKSzVyPUCuNlY{PzRizszN NFHsdnVUSU6JRWK=
CP67-MEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDXTWM2OD1yLkK2O|Mh|ryP MUjTRW5ITVJ?
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NCI-H1882 M3zNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrtcW9KSzVyPUCuOVkxOzZizszN MWfTRW5ITVJ?
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GB-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LPdmlEPTB;MD63NlEzPCEQvF2= NH\SO3BUSU6JRWK=
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LU-65 NFTENnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\JZoxOUUN3ME2xMlEzPzV|IN88US=> M3LJPXNCVkeHUh?=
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NCI-H719 Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j3XGlEPTB;MT6yO|QyOSEQvF2= NFi1OGNUSU6JRWK=
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EW-16 NU[1SnAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnBS2hzUUN3ME2xMlMyOzR5IN88US=> MVLTRW5ITVJ?
NCI-H128 NXu2WppST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;OXIRvUUN3ME2xMlM2QDF2IN88US=> M{noPXNCVkeHUh?=
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NCI-H1650 NYTsTlNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTRwMUW3PVch|ryP Mn7lV2FPT0WU
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EB-3 M2\hVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHaTWM2OD13LkCzNFQyKM7:TR?= M2jVUHNCVkeHUh?=
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NCI-H209 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\DSmdKSzVyPUWuNVk{PTJizszN Mnf5V2FPT0WU
BT-474 M1\nZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrIUY55UUN3ME21MlI{OTB{IN88US=> MmHOV2FPT0WU
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ARH-77 NIrD[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LiSWlEPTB;NT62O|A5PyEQvF2= MmLFV2FPT0WU
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NCI-H1581 NGK2Z2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:4TWM2OD14LkKzPFQ6KM7:TR?= MYTTRW5ITVJ?
HUTU-80 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTZwM{[4PVch|ryP MV7TRW5ITVJ?
TGW MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXKNFZKSzVyPU[uOFU2QTNizszN NIDmR|NUSU6JRWK=
SK-N-FI NULzWWxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLkTWM2OD14LkS1PFU1KM7:TR?= M3fHenNCVkeHUh?=
U-266 M2DaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP5U49KSzVyPU[uOVE6OjZizszN M33RcHNCVkeHUh?=
EM-2 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljZTWM2OD14Lk[3NFk6KM7:TR?= Ml\UV2FPT0WU
NMC-G1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHZR3ZTUUN3ME22MlcyQDl3IN88US=> Mo\kV2FPT0WU
KASUMI-1 NEDQO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjDcXhKSzVyPU[uPFQ4QDdizszN NFLOUHZUSU6JRWK=
NALM-6 MkntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TleGlEPTB;Nj64Olc2PCEQvF2= M2DDZnNCVkeHUh?=
OCI-AML2 MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPXTWM2OD15LkCwN|I3KM7:TR?= MWLTRW5ITVJ?
SHP-77 M4LGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;6RnRKSzVyPUeuNlI1OyEQvF2= NX;OVY4zW0GQR1XS
NOMO-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG3PYNKSzVyPUeuNlQzPTRizszN M{fUNnNCVkeHUh?=
SK-N-DZ MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vFeWlEPTB;Nz63NVA5QSEQvF2= NYrUUXdMW0GQR1XS
LB1047-RCC NUS5OJJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTdwN{KyN|Eh|ryP MXjTRW5ITVJ?
MZ1-PC Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTdwOE[1OVgh|ryP NXjheWpWW0GQR1XS
NB10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P4[2lEPTB;Nz65PVU2PiEQvF2= M2rTbnNCVkeHUh?=
RL95-2 MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRThwMUC4OFIh|ryP Mo\sV2FPT0WU
OMC-1 NYXE[3RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjlNWNKSzVyPUiuOVIyQTFizszN MUDTRW5ITVJ?
D-283MED MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRThwOUG3NVkh|ryP NV;rXIVKW0GQR1XS
MC116 MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fwbGlEPTB;OD65O|k1KM7:TR?= M2q0cHNCVkeHUh?=
SJSA-1 NWf1NIdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HkdmlEPTB;OT6wPVA6OSEQvF2= NF\kR3dUSU6JRWK=
JiyoyeP-2003 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TROGlEPTB;OT6yPVMyPyEQvF2= M4O1PXNCVkeHUh?=
IST-MEL1 M37XOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnNVlJKSzVyPUmuO|QyQThizszN NXr1fXBLW0GQR1XS
CTV-1 NIrNcnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K5OWlEPTB;MUCuNFk4QSEQvF2= NIL2cmJUSU6JRWK=
NH-12 NXWzOohyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLQTWM2OD1zMD6yOFM{KM7:TR?= NVP5SGxSW0GQR1XS
CA46 NWqyflZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK3WnlKSzVyPUGwMlM3OSEQvF2= MonDV2FPT0WU
NCI-SNU-1 NYPi[os4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHQcZdKSzVyPUGwMlQ6PjlizszN MXLTRW5ITVJ?
SCLC-21H MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLYTWM2OD1zMD62OVk3KM7:TR?= M1P4Z3NCVkeHUh?=
EC-GI-10 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFyLkewN|Eh|ryP NI\U[GRUSU6JRWK=
SR Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T4OGlEPTB;MUGuNFE5PSEQvF2= NGjz[2NUSU6JRWK=
NCI-H1648 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPhRnc4UUN3ME2xNU4xQTZ3IN88US=> MmnjV2FPT0WU
TGBC1TKB M131RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES0eYtKSzVyPUGxMlQyODJizszN Mlr1V2FPT0WU
EW-11 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy4PY1lUUN3ME2xNU42OTh4IN88US=> NHXROFJUSU6JRWK=
SK-MM-2 NXHCe21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fUdWlEPTB;MUGuPFA3OSEQvF2= M3Xo[HNCVkeHUh?=
NCI-H524 M4i3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFzLkm4NlIh|ryP M{fVNHNCVkeHUh?=
NOS-1 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX5VVBKSzVyPUGyMlA{PDVizszN NILJPVRUSU6JRWK=
AM-38 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFriO|hKSzVyPUGyMlU3OzNizszN M3LoZ3NCVkeHUh?=
A498 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvpTWM2OD1zMj63NFY6KM7:TR?= Mke2V2FPT0WU
KARPAS-422 NFPUR4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\JdWlEPTB;MUKuO|Q6PiEQvF2= MWfTRW5ITVJ?
LU-139 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HsUWlEPTB;MUKuPVAzPiEQvF2= MWnTRW5ITVJ?
COR-L88 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInyR|FKSzVyPUGyMlk{QDJizszN NX;meXFHW0GQR1XS
K5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF{Lkm0OlIh|ryP M2DzO3NCVkeHUh?=
NB13 NU\mOnV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF{Lkm3PFMh|ryP MV;TRW5ITVJ?
MRK-nu-1 NWjGbIw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vK[2lEPTB;MUOuNVk2KM7:TR?= NHnqOZhUSU6JRWK=
MHH-NB-11 MmTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2radGlEPTB;MUOuNlkxOiEQvF2= MoDCV2FPT0WU
KU812 NEXXTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV34XoxHUUN3ME2xN{43OTJ2IN88US=> NIPsUWdUSU6JRWK=
TE-12 NFzLSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvuOHpGUUN3ME2xN{43QTl2IN88US=> M1XxSXNCVkeHUh?=
NCI-N87 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV6yeHBCUUN3ME2xN{44OzZizszN NYewdnNOW0GQR1XS
EB2 M1jxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;F[GVTUUN3ME2xN{45PTB3IN88US=> NUPpZYhbW0GQR1XS
DB NV7MdnA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:ze2Z4UUN3ME2xN{46QDh3IN88US=> NE\vbGVUSU6JRWK=
697 NVrh[pJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TkTmlEPTB;MUSuOFUyOSEQvF2= MlLzV2FPT0WU
MSTO-211H MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PIbGlEPTB;MUSuO|Q1QCEQvF2= M2PPSXNCVkeHUh?=
JVM-2 NF3QNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rYRmlEPTB;MUSuO|c{PSEQvF2= MXrTRW5ITVJ?
COLO-824 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;pPFBZUUN3ME2xOE44QTl2IN88US=> MnXjV2FPT0WU
BC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF3LkO5PEDPxE1? M4PUNHNCVkeHUh?=
BOKU MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInjT5dKSzVyPUG1Mlk3ODhizszN M1XtcHNCVkeHUh?=
GOTO M1vsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TQWWlEPTB;MU[uPVYyPyEQvF2= MnThV2FPT0WU
HCC2157 M1fueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfZNHdsUUN3ME2xO{41PzV3IN88US=> M3XnWnNCVkeHUh?=
LS-1034 NYTteZc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF5Lk[4NVgh|ryP NXnveW5nW0GQR1XS
CAL-148 M1vyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTF5Lkm3PVYh|ryP NHzGUHpUSU6JRWK=
MOLT-4 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH5TWM2OD1zOD64NlA5KM7:TR?= Mn;KV2FPT0WU
Daudi M4XVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVizVIhCUUN3ME2xPE46OjNzIN88US=> NYO3R2h4W0GQR1XS
J-RT3-T3-5 NEfY[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW3TWM2OD1zOT60NFY3KM7:TR?= NEPmb2hUSU6JRWK=
KMOE-2 M2jOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF7Lk[0PFIh|ryP Ml2yV2FPT0WU
HL-60 NHjTbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJyLkG5OlUh|ryP MYLTRW5ITVJ?
P31-FUJ NEe2RYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJyLkS3OVMh|ryP MVjTRW5ITVJ?
IM-9 M13UZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXmSXNKSzVyPUKwMlYzOjRizszN MV\TRW5ITVJ?
HDLM-2 NXjQUFZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHuTHF5UUN3ME2yNE45QDJzIN88US=> NGLYdm5USU6JRWK=
NCI-H1304 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfwTWM2OD1{MT6wN|EyKM7:TR?= NH\yVFhUSU6JRWK=
NCI-H345 NXe2XnVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJzLkC2OFMh|ryP MX;TRW5ITVJ?
RPMI-6666 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTUOYpQUUN3ME2yNU4{PjB{IN88US=> MXHTRW5ITVJ?
GR-ST NH7EfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf0TWM2OD1{MT60NVch|ryP M1TEeHNCVkeHUh?=
CHP-126 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPRcndKSzVyPUKxMlYyQDFizszN NEXvUm9USU6JRWK=
EHEB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLF[o5pUUN3ME2yNU43PzNzIN88US=> Mkn0V2FPT0WU
CPC-N NXrQbJpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\CbmlEPTB;MkSuNFIxOSEQvF2= NUTQO2RjW0GQR1XS
NB1 NWT4RWFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;rXGlEPTB;MkSuOlk{QSEQvF2= MoO3V2FPT0WU
LS-123 NVrJc2VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvLfYlKSzVyPUK0MlkxOTJizszN NWrKbnVFW0GQR1XS
ST486 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\WTWM2OD1{NT6xNVE{KM7:TR?= MmTrV2FPT0WU
NCI-H1963 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X3VWlEPTB;Mk[uNFYzOyEQvF2= NXq5PVZbW0GQR1XS
U-87-MG NFm3TYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3Odo1KSzVyPUK2Mlc3PDRizszN MlTTV2FPT0WU
COR-L279 NHu3O|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\tTWM2OD1{Nj63PVIzKM7:TR?= MoG5V2FPT0WU
LU-165 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4e3bmlEPTB;MkiuNFg3OSEQvF2= MkL0V2FPT0WU
COLO-800 NHfSfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L3RmlEPTB;MkiuNlk2PiEQvF2= MnT0V2FPT0WU
ETK-1 NGDDSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDhbXNKSzVyPUK4MlM1PDZizszN M4S0dXNCVkeHUh?=
LNCaP-Clone-FGC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJ7LkmyPFEh|ryP NYq3UnhyW0GQR1XS
SIG-M5 M{L6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\HR|RKSzVyPUOwMlc6PTJizszN M4H5U3NCVkeHUh?=
NB6 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{eyV2lEPTB;M{CuPVUxOyEQvF2= MX\TRW5ITVJ?
NCI-H2107 NUPHeWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XvbGlEPTB;M{GuNlM{QCEQvF2= NILSdZdUSU6JRWK=
SNU-C1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNzLkOxNlYh|ryP NX;FRXdvW0GQR1XS
JAR NHvy[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj1TWM2OD1|MT6zO|k6KM7:TR?= MUDTRW5ITVJ?
L-363 NXfzPZV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljZTWM2OD1|Mj6yNVQ1KM7:TR?= MmDkV2FPT0WU
EW-24 M1:0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rCSWlEPTB;M{KuN|Q4PCEQvF2= MYDTRW5ITVJ?
NB69 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN|Lk[0OVQh|ryP MVHTRW5ITVJ?
EW-13 M3\vT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[0cWlEPTB;M{OuPFk3QSEQvF2= MmLtV2FPT0WU
Ramos-2G6-4C10 NHntcmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Xne2lEPTB;M{SuNlk6OyEQvF2= M4T6bHNCVkeHUh?=
TE-11 NGq0ZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN2LkS4NlIh|ryP MkTMV2FPT0WU
L-428 NHP1Z3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXezd|RyUUN3ME2zOE44PTN4IN88US=> NUHnVJE{W0GQR1XS
KP-N-YN NX;xUW1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1GyRmlEPTB;M{SuPVA2PyEQvF2= M4GyenNCVkeHUh?=
CGTH-W-1 NHnTbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTN4LkmwOFgh|ryP NFKyOXlUSU6JRWK=
K-562 NUfpS4lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr1TWM2OD1|Nz6wPFY1KM7:TR?= NWjKRoE1W0GQR1XS
NCI-H1299 M37WOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DFU2lEPTB;M{iuNVYxOyEQvF2= M1vOfXNCVkeHUh?=
RCC10RGB M{LoU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTN6LkKwPFMh|ryP NVPGfZhpW0GQR1XS
NCI-SNU-16 M{jjZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHkTWM2OD1|OD61OlU{KM7:TR?= NVSzVZFPW0GQR1XS
LC-2-ad MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\SUlFKSzVyPUO5MlQ{OzdizszN M3fkNHNCVkeHUh?=
MHH-PREB-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPLTWM2OD1|OT63N|g5KM7:TR?= M2\LbXNCVkeHUh?=
NCI-H64 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRyLkC5OFgh|ryP NYXIbXFIW0GQR1XS
LB996-RCC NWrB[o5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rNeGlEPTB;NECuPFcyPiEQvF2= M2XDVnNCVkeHUh?=
DEL MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;QNWlEPTB;NEGuOFQxPSEQvF2= M2\yOnNCVkeHUh?=
MLMA NVH4Z3h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTRzLke1PVUh|ryP MmD5V2FPT0WU
SBC-1 NEP6dHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTR{LkG4NFYh|ryP NVzPXIpxW0GQR1XS
MPP-89 M1PaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR{LkW4O|Uh|ryP MWPTRW5ITVJ?
MV-4-11 NGLrXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTR{LkmwOlch|ryP NUGy[I1{W0GQR1XS
EoL-1- NWP4RnAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\wTWM2OD12ND6xOVY5KM7:TR?= MkL0V2FPT0WU
CW-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfHcHBKSzVyPUS0Mlg{PDJizszN MYXTRW5ITVJ?
HT MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYO2VWJ{UUN3ME20OU44ODB5IN88US=> MmC5V2FPT0WU
SW954 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTR5LkSxNlgh|ryP NXn5N5Q4W0GQR1XS
A3-KAW NFPMWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DubGlEPTB;NEmuPFA3OSEQvF2= Mn20V2FPT0WU
TC-YIK NHPXNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvWTWM2OD13MD6wN|Y{KM7:TR?= NUnZfm1YW0GQR1XS
SW962 NIDQfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHOTWM2OD13ND64N|U4KM7:TR?= M3naeHNCVkeHUh?=
KP-N-RT-BM-1 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7GTHMxUUN3ME21Ok43PjN6IN88US=> NXXmVlBJW0GQR1XS
NCI-H1395 NXrCdmFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn3Ro42UUN3ME21PE45OTd{IN88US=> MlTiV2FPT0WU
RPMI-8402 NYnHVG05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf0TWM2OD13OD65OVI3KM7:TR?= NEPxW4RUSU6JRWK=
SCH NFHaeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXvSJpKSzVyPU[wMlk3OzhizszN NU[weVN2W0GQR1XS
NCI-H2196 NV7BRW9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\YcXJXUUN3ME22NU4zOzFizszN NHv5PY9USU6JRWK=
LOXIMVI NVT3flBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTZzLkiyOlYh|ryP NX;EeYl[W0GQR1XS
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COLO-668 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DUeWlEPTB;OEGuOVg5PCEQvF2= M{TkSXNCVkeHUh?=
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P30-OHK NU\jO4g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvoTWM2OD1{OEOuPFQ4KM7:TR?= MXTTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Protocol

Kinase Assay:

[1]

+ Expand

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research:

[3]

+ Expand
  • Cell lines: KIM-2, HC11, and ES
  • Concentrations: Dissolved in DMSO, final concentrations ~25 μM
  • Incubation Time: 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Male mdx (C57BL/10ScSn DMD mdx) mice
  • Formulation: Dissolved in DMSO, and diluted in PBS
  • Dosages: ~10 μg/kg/day
  • Administration: Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 90 mg/mL (189.22 mM)
Ethanol 25 mg/mL (52.56 mM)
Water Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+20% propylene glycol+ddH2O
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 475.62
Formula

C26H41N3O5

CAS No. 133407-82-6
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I want to know whether it contains EDTA or other chelating agent in this product(S2619)?

  • Answer:

    Our S2619 MG-132 doesn't contain EDTA or other chelating agent.

Proteasome Signaling Pathway Map

Proteasome Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID