MG132

Synonyms: (S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al

MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM).

MG132 Chemical Structure

MG132 Chemical Structure

CAS: 1211877-36-9

Selleck's MG-132 had a noticeably greater effect when compared with similar products from Sigma: This is directly due to using the (S, R, S) - (-) - 2 configuration.

P21 protein can be degraded through ubiquitylation pathway. Inhibition of proteasome activities results in the accumulation of P21 protein, therefore, the more powerful the inhibiting effect, the more P21 protein is accumulated. (testing protein: P21; Cell line: Hela; treatment condition: final concentration of MG-132 is 5μM, with a 6 hour treatment time)

Selleck's MG132 has been cited by 1933 publications

Purity & Quality Control

Batch: Purity: 99.69%
99.69

Products often used together with MG132

Cycloheximide


Cycloheximide is a protein synthesis inhibitor. It is used in combination with MG132 to investigate whether the protein changes are due to the synthesis pathway or the proteasome degradation pathway.


Qin M, et al. Cancer Med. 2023 Apr;12(7):8415-8432.

Chloroquine


Chloroquine is an inhibitor of lysosomes. The combined use of Chloroquine and MG132 is to investigate the reasons for changes in protein levels, whether it is due to lysosomal or proteasomal degradation.


Kortenoeven MLA,et al. J Biol Chem. 2021 Aug;297(2):100915.

Bafilomycin A1 (Baf-A1)


Bafilomycin A1 can inhibit autophagy. Simultaneous use of MG-132 and bafilomycin A1 can lead to the activation of inflammasomes in iPSC-RPE cells.


Hytti M,et al. Int J Mol Sci. 2021 Jun 24;22(13):6800.

Epoxomicin (BU-4061T)


Epoxomicin is a highly selective and irreversible proteasome inhibitor, which is used in conjunction with MG132 to compare the efficacy differences of different proteasome inhibitors.


Kisselev AF. Site-Specific Proteasome Inhibitors. Biomolecules. 2021 Dec 31;12(1):54.

Bortezomib


Bortezomib is also a proteasome inhibitor, primarily targeting the β5 subunit of the proteasome. MG13 and Bortezomib exert different inhibitory effects on NSCLS cell lines.


Li Y,et al. Oncol Res. 2020 Dec 10;28(5):497-507.

MG132 Related Products

Choose Selective Proteasome Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LP-1 Apoptosis Assay 300 nM 24 h DMSO Induces apoptosis by increasing cleaved PARP level and reducing Mcl-1 protein level 15958589
PC3 Growth Inhibition Assay 20 μM 48 h DMSO IC50=0.6 μM 16686537
PC12 Function Assay 100 μM  24 h DMSO Inhibits 6-OHDA- and H2O2-induced cytotoxicity 17158454
LPS-stimulated RAW264.7 cells Function Assay DMSO Inhibits NF-kappaB DNA binding 17407277
OCI-Ly3 Function Assay 10 μM  4 h DMSO Induces human IkappaBalpha stabilization with EC50 of 1 μM 18024113
A2780 cDDP Apoptosis Assay 24 h DMSO Induces apoptosis by inhibiting PTEN degradation 17684018
COS-7 Cytotoxic Assay 10 μM DMSO IC50<10 μM 18088097
HuH-7 Cytotoxic Assay 10 μM DMSO IC50<10 μM 18088097
Hepa-1c1c7 Function Assay 25 μM 6 h DMSO Increases Nrf2 protein level 20392544
IPC227F Cytotoxic Assay 1 μM 48 h DMSO IC50=0.077 μM 21924528
Calu6 Function Assay 10 μM 18 h DMSO Significantly accumulates frataxin precursor 23506486
IFN-gamma-induced RAW264.7 Function Assay DMSO Inhibits nitric oxide production with IC50 of 0.077 μM 22277277
HEK-293 Kinase Assay 2 and 20 μM 2 h DMSO Inhibits ChT-L activity with IC50 of 9 nM 23540790
MCF10A Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.29 μM 24153206
MCF-7 Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.13 μM 24153206
HeLa Kinase Assay 10 μM 1 h DMSO Induces PARP cleavage by inhibiting proseasome activity 24321833
MDA-MB-231 Growth Inhibition Assay 1 μM 72 h DMSO IC50=0.18 μM 24153206
293T Cytotoxic Assay 10 μM 72 h DMSO IC50<2 μM 24625088
293T Function Assay 10 μM 24 h DMSO Moderately induces heat-shock 24625088
NCI-H929 Cytotoxic Assay 1 μM 72 h DMSO IC50=0.17 μM 24625088
A-549 Cytotoxic Assay 40 μM 48 h DMSO IC50<10 μM 24697496
MCF-7 Cytotoxic Assay 40 μM 48 h DMSO IC50=7.3 μM 24697496
SW-480 Cytotoxic Assay 40 μM 48 h DMSO IC50=4 μM 24697496
HL-60 Cytotoxic Assay 40 μM 48 h DMSO IC50<10 μM 24697496
SMMC-7721 Cytotoxic Assay 40 μM 48 h DMSO IC50=7.1 μM 24697496
LPS-stimulated RAW264.7 cells Function Assay 25 μM DMSO Inhibits nitric oxide production with IC50 of 0.1 μM 24697496
lymphoblastoid Function assay IC50 = 0.002 μM 17996987
LCL Function assay 12 h IC50 = 0.002 μM 20687609
HL-60 Function assay IC50 = 0.068 μM 15780623
IPC227F Function assay 1 h IC50 = 0.077 μM 16220988
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.08 μM 22620677
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.1 μM 23819871
RAW264.7 Function assay IC50 = 0.1 μM 24597894
RAW264.7 Function assay 18 h IC50 = 0.1 μM 24219809
RAW264.7 Function assay 18 h IC50 = 0.15 μM 23327668
RAW264.7 Function assay 18 h IC50 = 0.15 μM 26757019
RAW264.7 Antiinflammatory activity assay 18 h IC50 = 0.18 μM 27203291
RAW264.7 Antiinflammatory activity assay 1 h IC50 = 0.2 μM 29338260
MDA-MB-231 Cytotoxicity assay IC50 = 0.25 μM 18598018
MCF7 Cytotoxicity assay IC50 = 0.3 μM 18598018
RAW264.7 Function assay 18 h IC50 = 0.35 μM 21044847
RAW264.7 Antiinflammatory activity assay IC50 = 0.439 μM 21561060
HEK293 Function assay 2 h IC50 = 0.6 μM 23540790
RAW264.7 Toxicity assay IC50 = 0.63 μM 22858297
lymphoblastoid Function assay IC50 = 1.077 μM 17996987
LCL Function assay 12 h IC50 = 1.077 μM 20687609
HL-60 Function assay IC50 = 1.4 μM 15780623
HL-60 Function assay IC50 = 4.5 μM 15780623
C8166 Growth Inhibition Assay IC50=345.338 μM SANGER
P30-OHK Growth Inhibition Assay IC50=283.847 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=271.456 μM SANGER
THP-1 Growth Inhibition Assay IC50=264.738 μM SANGER
MS-1 Growth Inhibition Assay IC50=239.121 μM SANGER
REH Growth Inhibition Assay IC50=236.626 μM SANGER
TE-441-T Growth Inhibition Assay IC50=199.739 μM SANGER
TALL-1 Growth Inhibition Assay IC50=198.304 μM SANGER
SF539 Growth Inhibition Assay IC50=192.728 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=190.064 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=188.866 μM SANGER
IMR-5 Growth Inhibition Assay IC50=181.571 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=180.331 μM SANGER
TUR Growth Inhibition Assay IC50=167.87 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=156.279 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=148.268 μM SANGER
NB14 Growth Inhibition Assay IC50=147.082 μM SANGER
EW-12 Growth Inhibition Assay IC50=144.699 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=143.708 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=139.736 μM SANGER
BE-13 Growth Inhibition Assay IC50=134.044 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=127.32 μM SANGER
DMS-153 Growth Inhibition Assay IC50=121.745 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=118.009 μM SANGER
DMS-79 Growth Inhibition Assay IC50=117.382 μM SANGER
DG-75 Growth Inhibition Assay IC50=113.352 μM SANGER
MN-60 Growth Inhibition Assay IC50=109.69 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=109.671 μM SANGER
BV-173 Growth Inhibition Assay IC50=108.728 μM SANGER
EW-22 Growth Inhibition Assay IC50=106.19 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=104.242 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=99.7588 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=98.4061 μM SANGER
NB7 Growth Inhibition Assay IC50=95.7786 μM SANGER
EW-3 Growth Inhibition Assay IC50=94.9081 μM SANGER
ECC4 Growth Inhibition Assay IC50=93.8269 μM SANGER
KY821 Growth Inhibition Assay IC50=91.6551 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=84.2107 μM SANGER
LU-134-A Growth Inhibition Assay IC50=83.1351 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=82.9075 μM SANGER
RS4-11 Growth Inhibition Assay IC50=82.2505 μM SANGER
COLO-668 Growth Inhibition Assay IC50=81.5884 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=79.4136 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=78.5877 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=78.3709 μM SANGER
HCC1187 Growth Inhibition Assay IC50=77.6122 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=75.0754 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=74.9514 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=74.9367 μM SANGER
HCC1599 Growth Inhibition Assay IC50=74.8732 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=74.7509 μM SANGER
ATN-1 Growth Inhibition Assay IC50=74.505 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=72.7456 μM SANGER
SCC-15 Growth Inhibition Assay IC50=72.34 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=71.9507 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=71.032 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=70.4447 μM SANGER
NB5 Growth Inhibition Assay IC50=70.3468 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=70.06 μM SANGER
UACC-812 Growth Inhibition Assay IC50=69.5209 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=69.0047 μM SANGER
U-698-M Growth Inhibition Assay IC50=68.5687 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=63.9892 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=62.1491 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=61.8266 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=61.231 μM SANGER
SCH Growth Inhibition Assay IC50=60.9638 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=58.9526 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=58.8172 μM SANGER
KP-N-RT-BM-1 Growth Inhibition Assay IC50=56.6638 μM SANGER
SW962 Growth Inhibition Assay IC50=54.8357 μM SANGER
TC-YIK Growth Inhibition Assay IC50=50.0363 μM SANGER
A3-KAW Growth Inhibition Assay IC50=49.8061 μM SANGER
HT Growth Inhibition Assay IC50=45.7007 μM SANGER
SW954 Growth Inhibition Assay IC50=47.4128 μM SANGER
CW-2 Growth Inhibition Assay IC50=44.8342 μM SANGER
EoL-1- Growth Inhibition Assay IC50=44.1568 μM SANGER
MPP-89 Growth Inhibition Assay IC50=42.5875 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=42.9067 μM SANGER
SBC-1 Growth Inhibition Assay IC50=42.1806 μM SANGER
MLMA Growth Inhibition Assay IC50=41.7595 μM SANGER
DEL Growth Inhibition Assay IC50=41.4405 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=40.8716 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=40.0948 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=39.7388 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=38.5653 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=39.4337 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=38.2083 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=38.1603 μM SANGER
K-562 Growth Inhibition Assay IC50=37.0864 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=36.9048 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=34.9057 μM SANGER
TE-11 Growth Inhibition Assay IC50=34.4822 μM SANGER
L-428 Growth Inhibition Assay IC50=34.7536 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=34.2993 μM SANGER
EW-13 Growth Inhibition Assay IC50=33.8969 μM SANGER
NB69 Growth Inhibition Assay IC50=33.6454 μM SANGER
EW-24 Growth Inhibition Assay IC50=32.3474 μM SANGER
L-363 Growth Inhibition Assay IC50=32.2144 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=31.3126 μM SANGER
JAR Growth Inhibition Assay IC50=31.3799 μM SANGER
NCI-H2107 Growth Inhibition Assay IC50=31.2338 μM SANGER
NB6 Growth Inhibition Assay IC50=30.9503 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=30.7952 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=29.9281 μM SANGER
COLO-800 Growth Inhibition Assay IC50=28.2956 μM SANGER
ETK-1 Growth Inhibition Assay IC50=28.3446 μM SANGER
LU-165 Growth Inhibition Assay IC50=28.0861 μM SANGER
COR-L279 Growth Inhibition Assay IC50=26.7922 μM SANGER
U-87-MG Growth Inhibition Assay IC50=26.7644 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=26.0623 μM SANGER
ST486 Growth Inhibition Assay IC50=25.1113 μM SANGER
LS-123 Growth Inhibition Assay IC50=24.9012 μM SANGER
NB1 Growth Inhibition Assay IC50=24.6939 μM SANGER
CPC-N Growth Inhibition Assay IC50=24.0201 μM SANGER
EHEB Growth Inhibition Assay IC50=21.6731 μM SANGER
CHP-126 Growth Inhibition Assay IC50=21.6181 μM SANGER
GR-ST Growth Inhibition Assay IC50=21.417 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=21.0643 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=21.3602 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=20.8821 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=21.0311 μM SANGER
IM-9 Growth Inhibition Assay IC50=20.6224 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=20.4753 μM SANGER
HL-60 Growth Inhibition Assay IC50=20.1965 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=19.6482 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=19.4066 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=18.8208 μM SANGER
Daudi Growth Inhibition Assay IC50=18.9231 μM SANGER
CAL-148 Growth Inhibition Assay IC50=17.9796 μM SANGER
HCC2157 Growth Inhibition Assay IC50=17.4755 μM SANGER
LS-1034 Growth Inhibition Assay IC50=17.6818 μM SANGER
BOKU Growth Inhibition Assay IC50=15.9608 μM SANGER
GOTO Growth Inhibition Assay IC50=16.9617 μM SANGER
COLO-824 Growth Inhibition Assay IC50=14.7994 μM SANGER
BC-3 Growth Inhibition Assay IC50=15.398 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=14.7448 μM SANGER
JVM-2 Growth Inhibition Assay IC50=14.7735 μM SANGER
DB Growth Inhibition Assay IC50=13.9885 μM SANGER
697 Growth Inhibition Assay IC50=14.4511 μM SANGER
TE-12 Growth Inhibition Assay IC50=13.6994 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=13.736 μM SANGER
EB2 Growth Inhibition Assay IC50=13.8505 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=13.2902 μM SANGER
KU812 Growth Inhibition Assay IC50=13.6124 μM SANGER
NB13 Growth Inhibition Assay IC50=12.9783 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=13.195 μM SANGER
COR-L88 Growth Inhibition Assay IC50=12.9382 μM SANGER
K5 Growth Inhibition Assay IC50=12.9462 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=12.7496 μM SANGER
LU-139 Growth Inhibition Assay IC50=12.9026 μM SANGER
NOS-1 Growth Inhibition Assay IC50=12.0345 μM SANGER
AM-38 Growth Inhibition Assay IC50=12.5633 μM SANGER
A498 Growth Inhibition Assay IC50=12.7069 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=11.8061 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=11.9822 μM SANGER
EW-11 Growth Inhibition Assay IC50=11.5186 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=11.4102 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=11.0965 μM SANGER
SR Growth Inhibition Assay IC50=11.0185 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=10.7031 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=10.6596 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=10.4969 μM SANGER
CA46 Growth Inhibition Assay IC50=10.361 μM SANGER
NH-12 Growth Inhibition Assay IC50=10.2433 μM SANGER
CTV-1 Growth Inhibition Assay IC50=10.0979 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=9.74198 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=9.29317 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=9.09091 μM SANGER
MC116 Growth Inhibition Assay IC50=8.9794 μM SANGER
D-283MED Growth Inhibition Assay IC50=8.91719 μM SANGER
OMC-1 Growth Inhibition Assay IC50=8.52191 μM SANGER
RL95-2 Growth Inhibition Assay IC50=8.10842 μM SANGER
NB10 Growth Inhibition Assay IC50=7.99556 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=7.86558 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=7.72231 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=7.71089 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=7.24254 μM SANGER
SHP-77 Growth Inhibition Assay IC50=7.2243 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=7.00326 μM SANGER
NALM-6 Growth Inhibition Assay IC50=6.86754 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=6.84787 μM SANGER
EM-2 Growth Inhibition Assay IC50=6.67099 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=6.71895 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=6.45854 μM SANGER
U-266 Growth Inhibition Assay IC50=6.51926 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=6.36897 μM SANGER
TGW Growth Inhibition Assay IC50=6.45593 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=6.08118 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=6.23849 μM SANGER
ARH-77 Growth Inhibition Assay IC50=5.67087 μM SANGER
ALL-PO Growth Inhibition Assay IC50=5.63795 μM SANGER
GCIY Growth Inhibition Assay IC50=5.47236 μM SANGER
Calu-6 Growth Inhibition Assay IC50=5.622 μM SANGER
SIMA Growth Inhibition Assay IC50=5.30765 μM SANGER
RL Growth Inhibition Assay IC50=5.37541 μM SANGER
RKO Growth Inhibition Assay IC50=5.23422 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=5.19352 μM SANGER
BT-474 Growth Inhibition Assay IC50=5.23102 μM SANGER
EB-3 Growth Inhibition Assay IC50=5.03041 μM SANGER
GT3TKB Growth Inhibition Assay IC50=5.17662 μM SANGER
HAL-01 Growth Inhibition Assay IC50=4.57034 μM SANGER
LP-1 Growth Inhibition Assay IC50=4.72371 μM SANGER
BC-1 Growth Inhibition Assay IC50=5.00447 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=4.56308 μM SANGER
ES5 Growth Inhibition Assay IC50=4.40255 μM SANGER
ES3 Growth Inhibition Assay IC50=4.32824 μM SANGER
YT Growth Inhibition Assay IC50=4.35424 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=4.15797 μM SANGER
D-336MG Growth Inhibition Assay IC50=4.01166 μM SANGER
TE-6 Growth Inhibition Assay IC50=3.94561 μM SANGER
NKM-1 Growth Inhibition Assay IC50=3.77378 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=3.75634 μM SANGER
SKM-1 Growth Inhibition Assay IC50=3.71376 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=3.67723 μM SANGER
SNB75 Growth Inhibition Assay IC50=3.60103 μM SANGER
NB12 Growth Inhibition Assay IC50=3.59888 μM SANGER
MEG-01 Growth Inhibition Assay IC50=3.5968 μM SANGER
HCC2218 Growth Inhibition Assay IC50=3.46937 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=3.44266 μM SANGER
RH-1 Growth Inhibition Assay IC50=3.38748 μM SANGER
SCC-3 Growth Inhibition Assay IC50=3.10848 μM SANGER
ES4 Growth Inhibition Assay IC50=3.06111 μM SANGER
KG-1 Growth Inhibition Assay IC50=2.88791 μM SANGER
SW982 Growth Inhibition Assay IC50=2.5148 μM SANGER
MFM-223 Growth Inhibition Assay IC50=2.50871 μM SANGER
HCE-T Growth Inhibition Assay IC50=2.44883 μM SANGER
ECC12 Growth Inhibition Assay IC50=2.3794 μM SANGER
KM-H2 Growth Inhibition Assay IC50=2.29043 μM SANGER
MC-CAR Growth Inhibition Assay IC50=2.2295 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=2.16762 μM SANGER
no-11 Growth Inhibition Assay IC50=2.03104 μM SANGER
DJM-1 Growth Inhibition Assay IC50=2.02552 μM SANGER
EW-18 Growth Inhibition Assay IC50=2.02337 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=2.01252 μM SANGER
JVM-3 Growth Inhibition Assay IC50=1.93904 μM SANGER
TE-15 Growth Inhibition Assay IC50=1.92373 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=1.72685 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=1.71281 μM SANGER
LS-411N Growth Inhibition Assay IC50=1.69807 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=1.67317 μM SANGER
D-502MG Growth Inhibition Assay IC50=1.67211 μM SANGER
NCI-H2227 Growth Inhibition Assay IC50=1.61561 μM SANGER
LC-1F Growth Inhibition Assay IC50=1.55198 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=1.55196 μM SANGER
GI-1 Growth Inhibition Assay IC50=1.47131 μM SANGER
DMS-114 Growth Inhibition Assay IC50=1.44539 μM SANGER
Raji Growth Inhibition Assay IC50=1.4185 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=1.40208 μM SANGER
HC-1 Growth Inhibition Assay IC50=1.3817 μM SANGER
NCI-H128 Growth Inhibition Assay IC50=1.35814 μM SANGER
EW-16 Growth Inhibition Assay IC50=1.31347 μM SANGER
HCE-4 Growth Inhibition Assay IC50=1.30221 μM SANGER
SW684 Growth Inhibition Assay IC50=1.28659 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=1.27411 μM SANGER
PSN1 Growth Inhibition Assay IC50=1.27016 μM SANGER
IA-LM Growth Inhibition Assay IC50=1.24116 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=1.2041 μM SANGER
MFH-ino Growth Inhibition Assay IC50=1.17501 μM SANGER
LU-65 Growth Inhibition Assay IC50=1.12753 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=1.12374 μM SANGER
L-540 Growth Inhibition Assay IC50=1.11839 μM SANGER
ES1 Growth Inhibition Assay IC50=1.07921 μM SANGER
KGN Growth Inhibition Assay IC50=1.05045 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=1.04016 μM SANGER
EKVX Growth Inhibition Assay IC50=1.03442 μM SANGER
SF126 Growth Inhibition Assay IC50=0.98971 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.9643 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.93854 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.90658 μM SANGER
ES7 Growth Inhibition Assay IC50=0.8965 μM SANGER
KM12 Growth Inhibition Assay IC50=0.85466 μM SANGER
Becker Growth Inhibition Assay IC50=0.79621 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.77955 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.72124 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.70739 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.69545 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.69388 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.68619 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.66751 μM SANGER
SW872 Growth Inhibition Assay IC50=0.65729 μM SANGER
SF268 Growth Inhibition Assay IC50=0.65641 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.62669 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.61033 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=0.59036 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.56811 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.53611 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.51762 μM SANGER
EVSA-T Growth Inhibition Assay IC50=0.49911 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.49096 μM SANGER
A704 Growth Inhibition Assay IC50=0.48692 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.47972 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.47674 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.46584 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.45119 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.43607 μM SANGER
NB17 Growth Inhibition Assay IC50=0.4297 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.39837 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.38844 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.37103 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.35104 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.34279 μM SANGER
HH Growth Inhibition Assay IC50=0.32897 μM SANGER
NCCIT Growth Inhibition Assay IC50=0.31783 μM SANGER
KLE Growth Inhibition Assay IC50=0.31306 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.313 μM SANGER
CMK Growth Inhibition Assay IC50=0.3112 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.30323 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.29524 μM SANGER
K052 Growth Inhibition Assay IC50=0.2899 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.27907 μM SANGER
CP67-MEL Growth Inhibition Assay IC50=0.2673 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.26374 μM SANGER
LOUCY Growth Inhibition Assay IC50=0.25456 μM SANGER
TK10 Growth Inhibition Assay IC50=0.25435 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.25015 μM SANGER
ES8 Growth Inhibition Assay IC50=0.24763 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.24257 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.24198 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.23303 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.2319 μM SANGER
ACN Growth Inhibition Assay IC50=0.22638 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.22257 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.22049 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.21851 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.21047 μM SANGER
GAK Growth Inhibition Assay IC50=0.20534 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.20094 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.19658 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.1934 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.19306 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=0.19303 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.19115 μM SANGER
HEL Growth Inhibition Assay IC50=0.18517 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.17559 μM SANGER
CESS Growth Inhibition Assay IC50=0.1706 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.16706 μM SANGER
A253 Growth Inhibition Assay IC50=0.16128 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.16006 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.15482 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.15141 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.1479 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.14278 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.14247 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.13895 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.13278 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.12935 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.11995 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.11927 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.11806 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.10949 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.10938 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.10474 μM SANGER
A388 Growth Inhibition Assay IC50=0.09065 μM SANGER
no-10 Growth Inhibition Assay IC50=0.08909 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.08036 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.075 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.07268 μM SANGER
D-247MG Growth Inhibition Assay IC50=0.07209 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.07066 μM SANGER
BL-41 Growth Inhibition Assay IC50=0.06947 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.06458 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.05957 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.05772 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.05289 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.04441 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.0431 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.0376 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.03737 μM SANGER
A101D Growth Inhibition Assay IC50=0.03279 μM SANGER
ES6 Growth Inhibition Assay IC50=0.01306 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.1111 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.27009 μM SANGER
A101D Growth Inhibition Assay IC50=0.30094 μM SANGER
ES6 Growth Inhibition Assay IC50=0.33014 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.33422 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.4231 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.42592 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.47349 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.47626 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.56207 μM SANGER
HH Growth Inhibition Assay IC50=0.57053 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.58379 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.60509 μM SANGER
no-10 Growth Inhibition Assay IC50=0.60813 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.62764 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.63942 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.68642 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.71274 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.7182 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.74747 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.75792 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.75837 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.83646 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.87076 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.87844 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.89904 μM SANGER
RKO Growth Inhibition Assay IC50=0.93176 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.95567 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.97175 μM SANGER
HEL Growth Inhibition Assay IC50=1.07025 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=1.07291 μM SANGER
KGN Growth Inhibition Assay IC50=1.17566 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=1.18954 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=1.20033 μM SANGER
HCC1599 Growth Inhibition Assay IC50=1.25589 μM SANGER
TK10 Growth Inhibition Assay IC50=1.28397 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=1.30754 μM SANGER
Raji Growth Inhibition Assay IC50=1.46531 μM SANGER
KALS-1 Growth Inhibition Assay IC50=1.46658 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.49911 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=1.55279 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=1.58368 μM SANGER
DEL Growth Inhibition Assay IC50=1.5921 μM SANGER
HT Growth Inhibition Assay IC50=1.70043 μM SANGER
TE-5 Growth Inhibition Assay IC50=1.83901 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=1.85897 μM SANGER
JVM-2 Growth Inhibition Assay IC50=1.95209 μM SANGER
Daudi Growth Inhibition Assay IC50=2.05459 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=2.07059 μM SANGER
BL-41 Growth Inhibition Assay IC50=2.11804 μM SANGER
OMC-1 Growth Inhibition Assay IC50=2.15065 μM SANGER
HCC2157 Growth Inhibition Assay IC50=2.15677 μM SANGER
MLMA Growth Inhibition Assay IC50=2.18576 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=2.23667 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=2.25183 μM SANGER
697 Growth Inhibition Assay IC50=2.26226 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=2.30393 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=2.31255 μM SANGER
A3-KAW Growth Inhibition Assay IC50=2.38186 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=2.38967 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=2.45622 μM SANGER
SCC-3 Growth Inhibition Assay IC50=2.47955 μM SANGER
SW872 Growth Inhibition Assay IC50=2.60022 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=2.67382 μM SANGER
NCCIT Growth Inhibition Assay IC50=2.67795 μM SANGER
ACN Growth Inhibition Assay IC50=2.84394 μM SANGER
CAS-1 Growth Inhibition Assay IC50=2.86126 μM SANGER
GB-1 Growth Inhibition Assay IC50=2.88421 μM SANGER
EW-16 Growth Inhibition Assay IC50=2.98023 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=3.0086 μM SANGER
KM-H2 Growth Inhibition Assay IC50=3.14413 μM SANGER
Becker Growth Inhibition Assay IC50=3.20254 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=3.21082 μM SANGER
BC-1 Growth Inhibition Assay IC50=3.24287 μM SANGER
GR-ST Growth Inhibition Assay IC50=3.59266 μM SANGER
SCC-15 Growth Inhibition Assay IC50=3.59326 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=3.62126 μM SANGER
A253 Growth Inhibition Assay IC50=3.76302 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=3.82083 μM SANGER
LAN-6 Growth Inhibition Assay IC50=3.85926 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=3.96369 μM SANGER
MPP-89 Growth Inhibition Assay IC50=3.98406 μM SANGER
K-562 Growth Inhibition Assay IC50=3.9918 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=3.99677 μM SANGER
THP-1 Growth Inhibition Assay IC50=4.04835 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=4.06592 μM SANGER
EW-1 Growth Inhibition Assay IC50=4.19255 μM SANGER
K5 Growth Inhibition Assay IC50=4.26164 μM SANGER
SR Growth Inhibition Assay IC50=4.3002 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=4.36265 μM SANGER
A388 Growth Inhibition Assay IC50=4.39507 μM SANGER
HCC2218 Growth Inhibition Assay IC50=4.44812 μM SANGER
EB2 Growth Inhibition Assay IC50=4.5114 μM SANGER
UACC-257 Growth Inhibition Assay IC50=4.51454 μM SANGER
LC-1F Growth Inhibition Assay IC50=4.63784 μM SANGER
NB1 Growth Inhibition Assay IC50=4.8413 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=4.90737 μM SANGER
NALM-6 Growth Inhibition Assay IC50=4.92582 μM SANGER
NB7 Growth Inhibition Assay IC50=5.04589 μM SANGER
ECC4 Growth Inhibition Assay IC50=5.05273 μM SANGER
no-11 Growth Inhibition Assay IC50=5.16913 μM SANGER
COLO-824 Growth Inhibition Assay IC50=5.40415 μM SANGER
LXF-289 Growth Inhibition Assay IC50=5.40704 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=5.48599 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=5.63865 μM SANGER
ATN-1 Growth Inhibition Assay IC50=5.76359 μM SANGER
NOS-1 Growth Inhibition Assay IC50=5.85194 μM SANGER
PSN1 Growth Inhibition Assay IC50=5.90945 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=5.99228 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=6.10875 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=6.3288 μM SANGER
ES8 Growth Inhibition Assay IC50=6.36816 μM SANGER
LS-1034 Growth Inhibition Assay IC50=6.55658 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=6.64033 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=6.674 μM SANGER
ES4 Growth Inhibition Assay IC50=6.92652 μM SANGER
SNB75 Growth Inhibition Assay IC50=7.20588 μM SANGER
P30-OHK Growth Inhibition Assay IC50=7.21282 μM SANGER
Calu-6 Growth Inhibition Assay IC50=7.27563 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=7.32929 μM SANGER
DU-4475 Growth Inhibition Assay IC50=7.57964 μM SANGER
U-698-M Growth Inhibition Assay IC50=7.85992 μM SANGER
IM-9 Growth Inhibition Assay IC50=8.12437 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=8.13337 μM SANGER
NB5 Growth Inhibition Assay IC50=8.23226 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=8.27928 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=8.46677 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=8.5574 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=8.79201 μM SANGER
CMK Growth Inhibition Assay IC50=8.84538 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=8.86801 μM SANGER
MEG-01 Growth Inhibition Assay IC50=8.88154 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=9.15716 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=9.27307 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=9.52951 μM SANGER
SKM-1 Growth Inhibition Assay IC50=9.61824 μM SANGER
YT Growth Inhibition Assay IC50=9.83673 μM SANGER
LS-123 Growth Inhibition Assay IC50=10.1011 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=10.2198 μM SANGER
NH-12 Growth Inhibition Assay IC50=10.2432 μM SANGER
NKM-1 Growth Inhibition Assay IC50=10.5981 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=10.616 μM SANGER
TUR Growth Inhibition Assay IC50=10.8222 μM SANGER
NB14 Growth Inhibition Assay IC50=11.7876 μM SANGER
CESS Growth Inhibition Assay IC50=12.0629 μM SANGER
ES5 Growth Inhibition Assay IC50=12.1105 μM SANGER
EB-3 Growth Inhibition Assay IC50=12.4485 μM SANGER
SNU-C1 Growth Inhibition Assay IC50=12.6517 μM SANGER
CA46 Growth Inhibition Assay IC50=12.9298 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=13.0111 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=13.2394 μM SANGER
ST486 Growth Inhibition Assay IC50=13.3147 μM SANGER
D-263MG Growth Inhibition Assay IC50=13.565 μM SANGER
L-540 Growth Inhibition Assay IC50=13.6084 μM SANGER
LOUCY Growth Inhibition Assay IC50=13.7564 μM SANGER
EW-3 Growth Inhibition Assay IC50=13.8253 μM SANGER
HCC1187 Growth Inhibition Assay IC50=13.8349 μM SANGER
KU812 Growth Inhibition Assay IC50=14.0902 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=14.1004 μM SANGER
SCH Growth Inhibition Assay IC50=14.1615 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=14.3226 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=14.5781 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=14.6373 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=15.0867 μM SANGER
TE-12 Growth Inhibition Assay IC50=15.1938 μM SANGER
OCUB-M Growth Inhibition Assay IC50=15.3376 μM SANGER
ES3 Growth Inhibition Assay IC50=15.6556 μM SANGER
GOTO Growth Inhibition Assay IC50=15.8269 μM SANGER
SW962 Growth Inhibition Assay IC50=15.8866 μM SANGER
BC-3 Growth Inhibition Assay IC50=16.566 μM SANGER
GT3TKB Growth Inhibition Assay IC50=17.0105 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=17.1644 μM SANGER
LU-65 Growth Inhibition Assay IC50=17.6506 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=18.0735 μM SANGER
ARH-77 Growth Inhibition Assay IC50=18.3741 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=18.5752 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=18.6376 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=18.7023 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=18.944 μM SANGER
TE-15 Growth Inhibition Assay IC50=18.9815 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=19.3517 μM SANGER
ES7 Growth Inhibition Assay IC50=19.46 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=19.5619 μM SANGER
U-87-MG Growth Inhibition Assay IC50=19.6307 μM SANGER
GAK Growth Inhibition Assay IC50=19.7956 μM SANGER
TE-9 Growth Inhibition Assay IC50=20.0459 μM SANGER
TE-1 Growth Inhibition Assay IC50=20.8915 μM SANGER
DMS-79 Growth Inhibition Assay IC50=20.9557 μM SANGER
GDM-1 Growth Inhibition Assay IC50=21.0468 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=21.2129 μM SANGER
D-283MED Growth Inhibition Assay IC50=21.4585 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=22.3294 μM SANGER
EW-13 Growth Inhibition Assay IC50=22.4135 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=22.956 μM SANGER
A498 Growth Inhibition Assay IC50=23.2708 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=23.8942 μM SANGER
D-247MG Growth Inhibition Assay IC50=23.9489 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=24.239 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=24.9878 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=25.1851 μM SANGER
LS-513 Growth Inhibition Assay IC50=25.5136 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=25.9507 μM SANGER
TALL-1 Growth Inhibition Assay IC50=26.5085 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=26.5486 μM SANGER
L-363 Growth Inhibition Assay IC50=26.6166 μM SANGER
MC-CAR Growth Inhibition Assay IC50=26.6901 μM SANGER
KNS-42 Growth Inhibition Assay IC50=26.8177 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=27.479 μM SANGER
SF126 Growth Inhibition Assay IC50=27.6883 μM SANGER
BV-173 Growth Inhibition Assay IC50=27.8955 μM SANGER
C8166 Growth Inhibition Assay IC50=27.9353 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=28.9415 μM SANGER
LP-1 Growth Inhibition Assay IC50=29.1543 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=29.2129 μM SANGER
RL95-2 Growth Inhibition Assay IC50=29.5637 μM SANGER
GCIY Growth Inhibition Assay IC50=29.7428 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=29.9399 μM SANGER
KY821 Growth Inhibition Assay IC50=30.5434 μM SANGER
NB13 Growth Inhibition Assay IC50=30.9584 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=31.0823 μM SANGER
EW-24 Growth Inhibition Assay IC50=32.3473 μM SANGER
GI-1 Growth Inhibition Assay IC50=33.7814 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=34.065 μM SANGER
HC-1 Growth Inhibition Assay IC50=34.4958 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=34.7578 μM SANGER
COLO-829 Growth Inhibition Assay IC50=35.1091 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=35.8459 μM SANGER
HOP-62 Growth Inhibition Assay IC50=36.8021 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=36.9848 μM SANGER
LS-411N Growth Inhibition Assay IC50=36.9919 μM SANGER
ETK-1 Growth Inhibition Assay IC50=37.05 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=37.2234 μM SANGER
EKVX Growth Inhibition Assay IC50=37.3946 μM SANGER
SF539 Growth Inhibition Assay IC50=38.6705 μM SANGER
RL Growth Inhibition Assay IC50=38.6818 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=38.9944 μM SANGER
NCI-H128 Growth Inhibition Assay IC50=39.5567 μM SANGER
SHP-77 Growth Inhibition Assay IC50=39.7722 μM SANGER
EVSA-T Growth Inhibition Assay IC50=40.0164 μM SANGER
DB Growth Inhibition Assay IC50=40.4441 μM SANGER
TE-441-T Growth Inhibition Assay IC50=40.7601 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=40.7771 μM SANGER
ALL-PO Growth Inhibition Assay IC50=40.8264 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=41.0485 μM SANGER
EW-24 Growth Inhibition Assay IC50=41.4224 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=41.7115 μM SANGER
AM-38 Growth Inhibition Assay IC50=43.4398 μM SANGER
COLO-684 Growth Inhibition Assay IC50=43.4687 μM SANGER
L-428 Growth Inhibition Assay IC50=44.6708 μM SANGER
RXF393 Growth Inhibition Assay IC50=44.7331 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=45.9253 μM SANGER
TE-10 Growth Inhibition Assay IC50=46.4915 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=46.5661 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=46.8105 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=47.7106 μM SANGER
REH Growth Inhibition Assay IC50=47.8793 μM SANGER
CAL-148 Growth Inhibition Assay IC50=49.101 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=51.0359 μM SANGER
NEC8 Growth Inhibition Assay IC50=51.178 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=54.3092 μM SANGER
SF268 Growth Inhibition Assay IC50=56.4043 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=57.0315 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=58.6442 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=58.6841 μM SANGER
BL-70 Growth Inhibition Assay IC50=58.8002 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=59.7717 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=60.4282 μM SANGER
RH-1 Growth Inhibition Assay IC50=61.2697 μM SANGER
D-336MG Growth Inhibition Assay IC50=61.2933 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=62.2931 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=65.0102 μM SANGER
DG-75 Growth Inhibition Assay IC50=65.873 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=66.8299 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=67.97 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=69.6286 μM SANGER
KM12 Growth Inhibition Assay IC50=70.1607 μM SANGER
TE-6 Growth Inhibition Assay IC50=71.6266 μM SANGER
HCE-T Growth Inhibition Assay IC50=72.7372 μM SANGER
ES1 Growth Inhibition Assay IC50=75.1944 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=75.8461 μM SANGER
SW954 Growth Inhibition Assay IC50=78.0688 μM SANGER
LU-139 Growth Inhibition Assay IC50=78.4739 μM SANGER
SBC-1 Growth Inhibition Assay IC50=79.7008 μM SANGER
K052 Growth Inhibition Assay IC50=81.9603 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=82.9596 μM SANGER
TGW Growth Inhibition Assay IC50=84.6867 μM SANGER
LU-134-A Growth Inhibition Assay IC50=85.9404 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=86.8607 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=88.1676 μM SANGER
MC116 Growth Inhibition Assay IC50=88.8718 μM SANGER
JAR Growth Inhibition Assay IC50=89.0582 μM SANGER
BT-474 Growth Inhibition Assay IC50=97.7609 μM SANGER
IMR-5 Growth Inhibition Assay IC50=99.7585 μM SANGER
HL-60 Growth Inhibition Assay IC50=102.901 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=103.457 μM SANGER
NB17 Growth Inhibition Assay IC50=106.528 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=107.635 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=108.33 μM SANGER
NB69 Growth Inhibition Assay IC50=112.333 μM SANGER
JVM-3 Growth Inhibition Assay IC50=113.512 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=114.376 μM SANGER
CTV-1 Growth Inhibition Assay IC50=115.234 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=115.583 μM SANGER
DMS-153 Growth Inhibition Assay IC50=117.411 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=118.868 μM SANGER
DJM-1 Growth Inhibition Assay IC50=119.978 μM SANGER
CTB-1 Growth Inhibition Assay IC50=123.948 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=134.232 μM SANGER
NB6 Growth Inhibition Assay IC50=135.081 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=135.852 μM SANGER
HAL-01 Growth Inhibition Assay IC50=136.429 μM SANGER
COLO-668 Growth Inhibition Assay IC50=136.607 μM SANGER
NB10 Growth Inhibition Assay IC50=139.732 μM SANGER
U-266 Growth Inhibition Assay IC50=146.561 μM SANGER
D-502MG Growth Inhibition Assay IC50=148.717 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=165.958 μM SANGER
MN-60 Growth Inhibition Assay IC50=167.261 μM SANGER
SW684 Growth Inhibition Assay IC50=182.57 μM SANGER
COR-L279 Growth Inhibition Assay IC50=186.961 μM SANGER
CPC-N Growth Inhibition Assay IC50=188.945 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=201.087 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=209.004 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=209.602 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=230.298 μM SANGER
COR-L88 Growth Inhibition Assay IC50=231.162 μM SANGER
CHP-126 Growth Inhibition Assay IC50=237.146 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=240.731 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=243.062 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=246.503 μM SANGER
LU-165 Growth Inhibition Assay IC50=247.336 μM SANGER
DMS-114 Growth Inhibition Assay IC50=253.811 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=259.637 μM SANGER
SIMA Growth Inhibition Assay IC50=312.028 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=312.685 μM SANGER
NH-12 Growth Inhibition Assay IC50=316.901 μM SANGER
MS-1 Growth Inhibition Assay IC50=327.666 μM SANGER
MFM-223 Growth Inhibition Assay IC50=340.486 μM SANGER
EW-11 Growth Inhibition Assay IC50=348.123 μM SANGER
KG-1 Growth Inhibition Assay IC50=387.778 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=414.626 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=428.541 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=434.624 μM SANGER
NCI-H322M Growth Inhibition Assay IC50=452.677 μM SANGER
CW-2 Growth Inhibition Assay IC50=483.609 μM SANGER
COLO-800 Growth Inhibition Assay IC50=525.413 μM SANGER
EW-12 Growth Inhibition Assay IC50=557.847 μM SANGER
EW-18 Growth Inhibition Assay IC50=672.665 μM SANGER
Click to View More Cell Line Experimental Data

Biological Activity

Description MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM).
Targets
ChTL [9]
(Cell-free assay)
0.22 μM
In vitro
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Kinase Assay Measurement of inhibitory activities of MG-132 against 20S proteasome
The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research Cell lines KIM-2, HC11, and ES
Concentrations Dissolved in DMSO, final concentrations ~25 μM
Incubation Time 24 and 48 hours
Method

Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.

Experimental Result Images Methods Biomarkers Images PMID
Western Blot Bcr-Abl Ac-histone H3 Cleaved-caspase3 Cleaved-PARP ASCL1 CgA Nrf2 HO-1 26722260
Immunofluorescence C2GnT-M / NMIIA AGS3 / Vimentin Bak 22525330
Growth inhibition assay Apoptosis assay Cell viability cell proliferation 20557369
ELISA IL-8 IL-1beta 11160671
In Vivo
In vivo

Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Animal Research Animal Models Male mdx (C57BL/10ScSn DMD mdx) mice
Dosages ~10 μg/kg/day
Administration Injection

Chemical Information & Solubility

Molecular Weight 475.62 Formula

C26H41N3O5

CAS No. 1211877-36-9 SDF Download MG132 SDF
Smiles CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 95 mg/mL ( (199.73 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 95 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I want to know whether it contains EDTA or other chelating agent in this product(S2619)?

Answer:
Our S2619 MG-132 doesn't contain EDTA or other chelating agent.

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