MG-132

Catalog No.S2619

MG-132 Chemical Structure

Molecular Weight(MW): 475.62

MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.

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USD 170 In stock
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Cited by 47 Publications

10 Customer Reviews

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Nek2A impedes SuFu ubiquitination. HEK293T cells transfected with Nek2A-Myc and Flag-SuFu for 48 h were treated with MG-132 to enrich ubiquitinated proteins, and subsequently subjected to co-immunoprecipitation assay. Precipitated proteins were probed using anti-Ub antibody.

    Int J Oncol, 2017, 50(2):373-380. MG-132 purchased from Selleck.

    Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

Purity & Quality Control

Choose Selective Proteasome Inhibitors

Biological Activity

Description MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.
Targets
Proteasome [1]
(Cell-free assay)
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells MoKzSpVv[3Srb36gRZN{[Xl? M1;KRVI2KM7:TR?= MWjEUXNQ MVHJcohq[mm2czDubZRzcWNib4jp[IUheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE4yKM7:TR?= MVmyOFY6PzR7Nh?=
HL-60 MYrDfZRwfG:6aXOgRZN{[Xl? NW\oRXFOPDBizszN NV\zUXdYPDhiaB?= NVPlb2hRTE2VTx?= NV[3cY5KUUN3MEyxNEDPxE1? NXf3TFM1OjR4OUe0PVY>
SMMC-7721 NV\xW5dqS3m2b4TvfIlkKEG|c3H5 MWq0NEDPxE1? MUO0PEBp NYrXXldsTE2VTx?= M3XMZWlEPTB;Nz6xJO69VQ>? MkTiNlQ3QTd2OU[=
A-549 NVHEdJNSS3m2b4TvfIlkKEG|c3H5 M1LPNlQxKM7:TR?= MX60PEBp NUjkNY5wTE2VTx?= MmHuTWM2ODxzMDFOwG0> M4PNXlI1Pjl5NEm2
MCF-7 MV3DfZRwfG:6aXOgRZN{[Xl? MlftOFAh|ryP M1XpS|Q5KGh? MXzEUXNQ MVLJR|UxRTdwMzFOwG0> NIHyWHYzPDZ7N{S5Oi=>
SW-480 NGS3V3dEgXSxdH;4bYMhSXO|YYm= MVu0NEDPxE1? Mnv6OFghcA>? MlrlSG1UVw>? M4rLVmlEPTB;NDFOwG0> NWD1N4p5OjR4OUe0PVY>
NCI-H929 NHWzR4xEgXSxdH;4bYMhSXO|YYm= NWP5bIZ5OSEQvF2= NXXQXI91PzJiaB?= NIjz[JZFVVOR NHPOOI5KSzVyPUCuNVch|ryP NHn4eY8zPDZ{NUC4PC=>
293T NXO3bGhYS3m2b4TvfIlkKEG|c3H5 MlHuNVAh|ryP MXy3NkBp NWGwOnB7TE2VTx?= NXO5N3hDUUN3MEyyJO69VQ>? MVuyOFYzPTB6OB?=
293T M1m1NmZ2dmO2aX;uJGF{e2G7 MmXKNVAh|ryP M1jTR|I1KGh? MVTEUXNQ M3zTZW1w\GW{YYTlcJkhcW6mdXPld{Bp\WG2LYPoc4NsKCB? MYGyOFYzPTB6OB?=
HeLa M3HNeWtqdmG|ZTDBd5NigQ>? M4rZSVExKM7:TR?= NXLjZllNOSCq M1GxPGROW09? MYfJcoR2[2W|IGDBVnAh[2ynYY\h[4Uh[nliaX7obYJqfGmwZzDwdo9{\WG|b33lJIFkfGm4aYT5 NF2y[5gzPDN{MUizNy=>
MDA-MB-231 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfZVFZLOSEQvF2= NHq4VWc4OiCq MVLEUXNQ NYK3TJhmUUN3ME2wMlE5KM7:TR?= M3jQWlI1OTV|MkC2
MCF-7 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrBNUDPxE1? Ml75O|IhcA>? MlHoSG1UVw>? M4\OcGlEPTB;MD6xN{DPxE1? NXfVfW1zOjRzNUOyNFY>
MCF10A MlTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:0dlEh|ryP MYq3NkBp NWrtZlFsTE2VTx?= NUmwfY5EUUN3ME2wMlI6KM7:TR?= Mm\XNlQyPTN{ME[=
HEK-293 MVjLbY5ie2ViQYPzZZk> NHzaSVQzKGGwZDCyNEDPxE1? NF;KUVAzKGh? MXTEUXNQ MXXJcohq[mm2czDDbHQuVCCjY4Tpeol1gSC5aYToJGlEPTBib3[gPUBvVSB? NH2x[YUzOzV2MEe5NC=>
Calu6 MVzGeY5kfGmxbjDBd5NigQ>? MlHMNVAh|ryP MYKxPEBp NGfSd3ZFVVOR NHnCUmlUcWewaX\pZ4FvfGy7IHHjZ5VufWyjdHXzJIZz[XSjeHnuJJBz\WO3coPvdi=> M2HzUlI{PTB4NEi2
IFN-gamma-induced RAW264.7 NH\ZdHpHfW6ldHnvckBCe3OjeR?= MYXEUXNQ M374V2lvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjB5NzFOwG0> NGXHd2wzOjJ5N{K3Oy=>
IPC227F M{HrcWN6fG:2b4jpZ{BCe3OjeR?= M2fUbVEh|ryP M1;oNlQ5KGh? NGHwcnlFVVOR NXvVV45LUUN3ME2wMlA4PyEQvF2= M3;4WVIyQTJ2NUK4
Hepa-1c1c7 MYnGeY5kfGmxbjDBd5NigQ>? MVuyOUDPxE1? NWHnTWtZPiCq NXrX[Vd4TE2VTx?= NX;zVWRKUW6lcnXhd4V{KE6{ZkKgdJJwfGWrbjDs[ZZmdA>? NG\yVVEzODN7MkW0OC=>
COS-7 Ml7YR5l1d3SxeHnjJGF{e2G7 M2PVeFExKM7:TR?= NFPBXHNFVVOR Ml3jTWM2ODxzMDFOwG0> NH;1OJYyQDB6OEC5Oy=>
HuH-7 NUjJbWRwS3m2b4TvfIlkKEG|c3H5 MXyxNEDPxE1? MmDlSG1UVw>? NUnMZWxCUUN3MEyxNEDPxE1? NXewU4JxOThyOEiwPVc>
OCI-Ly3 MWHGeY5kfGmxbjDBd5NigQ>? M3;mcFExKM7:TdMg NW\CTWQ1PCCq MYnEUXNQ NF7O[nRKdmS3Y3XzJIh2dWGwIFnrZZBx[UKjbIDoZUB{fGGkaXzpfoF1cW:wIIfpeIghTUN3MDDv[kAyKM7:TR?= NVLKTWhCOThyMkSxNVM>
A2780 cDDP NHL3To5CeG:ydH;zbZMhSXO|YYm= NWO5UoE3OjRiaB?= NGfGNHVFVVOR NF;tPVFKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? MorGNVc3QDRyMUi=
LPS-stimulated RAW264.7 cells MnfJSpVv[3Srb36gRZN{[Xl? NXLZS3RVTE2VTx?= M{HaT2lvcGmkaYTzJG5HNWujcIDhRkBFVkFiYnnu[Ilv\w>? NIHBPZYyPzRyN{K3Oy=>
PC12 MXLGeY5kfGmxbjDBd5NigQ>? NWrTRlM3OTByIN88UeKh MUSyOEBp M3vCc2ROW09? M4\w[mlvcGmkaYTzJFYuV0iGQT2gZY5lKEh{T{KtbY5lfWOnZDDjfZRwfG:6aXPpeJk> MXixO|E2QDR3NB?=
PC3 M3\IXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXVNlAh|ryP NVrOSI5iPDhiaB?= M4fG[mROW09? NV7EZXVrUUN3ME2wMlYh|ryP M3u5e|E3Pjh4NUO3
LP-1 M1m5UGFxd3C2b4Ppd{BCe3OjeR?= MmPlN|AxKG6P MlLsNlQhcA>? NYTOZodUTE2VTx?= MmXSTY5lfWOnczDhdI9xfG:|aYOgZpkhcW6lcnXhd4lv\yClbHXheoVlKFCDUmCgcIV3\WxiYX7kJJJm\HWlaX7nJG1kdC1zIIDyc5RmcW5ibHX2[Yw> NH;YZVcyPTl3OEW4PS=>
ES6 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\sT2lEPTB;MD6wNVMxPiEQvF2= MX7TRW5ITVJ?
A101D NF\2N3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfBRWZVUUN3ME2wMlA{Ojd7IN88US=> NXWzNpJkW0GQR1XS
OCUB-M MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHZPYpKSzVyPUCuNFM4OzdizszN MnnYV2FPT0WU
LB2518-MEL NVTpZ3hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO5cHhKSzVyPUCuNFM4PiEQvF2= MVPTRW5ITVJ?
SH-4 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;5TWM2OD1yLkC0N|Eh|ryP MWXTRW5ITVJ?
KNS-42 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMES0OFEh|ryP NV21TGZEW0GQR1XS
DSH1 M1\1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4WJBKSzVyPUCuNFUzQDlizszN NFLvclFUSU6JRWK=
NTERA-S-cl-D1 NYHoWWVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPlTWM2OD1yLkC1O|czKM7:TR?= M3rBeHNCVkeHUh?=
D-542MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;HNoh3UUN3ME2wMlA2QTV5IN88US=> NVPl[IZQW0GQR1XS
KS-1 NWS4[2RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;jTmlKSzVyPUCuNFY1PThizszN M4e0N3NCVkeHUh?=
BL-41 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;1TWM2OD1yLkC2PVQ4KM7:TR?= NXPjR|NHW0GQR1XS
LXF-289 M{mzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrSPW9KSzVyPUCuNFcxPjZizszN NXnXcHhGW0GQR1XS
D-247MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTGbnBiUUN3ME2wMlA4OjB7IN88US=> NE\K[FVUSU6JRWK=
MMAC-SF MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTjTWM2OD1yLkC3NlY5KM7:TR?= NG\2PFFUSU6JRWK=
CP66-MEL NEDTT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPTeI45UUN3ME2wMlA4PSEQvF2= M1HVfXNCVkeHUh?=
LB771-HNC M1jmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELRdYFKSzVyPUCuNFgxOzZizszN MXPTRW5ITVJ?
no-10 NVPFNWw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK5OHJKSzVyPUCuNFg6ODlizszN M1niTXNCVkeHUh?=
A388 M2\t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13LfmlEPTB;MD6wPVA3PSEQvF2= M4LLTnNCVkeHUh?=
OPM-2 NUn3[3BPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVKzZ21tUUN3ME2wMlExPDd2IN88US=> MnfkV2FPT0WU
OVCAR-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnmfIY{UUN3ME2wMlExQTN6IN88US=> NUm2TI5LW0GQR1XS
HOP-62 NHSweY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL4TWM2OD1yLkGwPVQ6KM7:TR?= NU\rbHd2W0GQR1XS
ML-2 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUG4NFYh|ryP Mm\NV2FPT0WU
UACC-257 M2DF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\vTWM2OD1yLkGxPVI4KM7:TR?= M1PU[XNCVkeHUh?=
NEC8 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMUG5PVUh|ryP MYTTRW5ITVJ?
ONS-76 MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzyVFJKSzVyPUCuNVI6OzVizszN NV;KbGJoW0GQR1XS
KE-37 NX3hUnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTrTWM2OD1yLkGzNlc5KM7:TR?= NH\4SpBUSU6JRWK=
HT-144 NEDPbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XOdmlEPTB;MD6xN|g6PSEQvF2= MnTTV2FPT0WU
LB2241-RCC MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK0TWM2OD1yLkG0NlQ4KM7:TR?= MlfMV2FPT0WU
TE-5 NU\YUWxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMUSyO|gh|ryP MnPuV2FPT0WU
KINGS-1 NYPuPZVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4SyWGlEPTB;MD6xOFc6KM7:TR?= MWPTRW5ITVJ?
NCI-H69 NXqzR4dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3qTWM2OD1yLkG1NVQyKM7:TR?= MXvTRW5ITVJ?
CAS-1 M1r4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzPN5NKSzVyPUCuNVU1QDJizszN MoHpV2FPT0WU
D-263MG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPGTWM2OD1yLkG2NFA3KM7:TR?= NEXlPZFUSU6JRWK=
A253 NX\IWXRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMU[xNlgh|ryP NXnaTI9{W0GQR1XS
PF-382 NHT3dWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMU[3NFYh|ryP NULVTGJoW0GQR1XS
CESS M3G2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXTTWM2OD1yLkG3NFYh|ryP M2KyZ3NCVkeHUh?=
MZ2-MEL Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrRTWM2OD1yLkG3OVU6KM7:TR?= MVPTRW5ITVJ?
HEL M4PxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK2TWM2OD1yLkG4OVE4KM7:TR?= MX\TRW5ITVJ?
D-392MG NUPMfHBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq4[I1PUUN3ME2wMlE6OTF3IN88US=> MVnTRW5ITVJ?
SK-LMS-1 M1PHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMUmzNFMh|ryP NGX3S|lUSU6JRWK=
GI-ME-N NUKySFdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjCXpBKSzVyPUCuNVk{ODZizszN NUO1b5pUW0GQR1XS
LB831-BLC M1zJZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUmzOEDPxE1? MmTXV2FPT0WU
DU-4475 NVXCcmdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n2XWlEPTB;MD6xPVY2QCEQvF2= MlrpV2FPT0WU
IST-SL1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rjUGlEPTB;MD6yNFA6PCEQvF2= NGf0[2hUSU6JRWK=
GAK MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDMblc{UUN3ME2wMlIxPTN2IN88US=> NYjmTm5NW0GQR1XS
EW-1 M{XNTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTFSZlpUUN3ME2wMlIyODR5IN88US=> M{HDbnNCVkeHUh?=
LAMA-84 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDyTWM2OD1yLkKxPFUyKM7:TR?= M{HOSXNCVkeHUh?=
SK-UT-1 M1zpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\yTWM2OD1yLkKyNFQ6KM7:TR?= MXnTRW5ITVJ?
VA-ES-BJ M2exemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT3TWM2OD1yLkKyNlU4KM7:TR?= NWX5OYg2W0GQR1XS
ACN MlPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr3enlKSzVyPUCuNlI3OzhizszN NGHyZ4RUSU6JRWK=
SK-PN-DW NWWxe2hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPkTWM2OD1yLkKzNVkh|ryP NHe5VpJUSU6JRWK=
HD-MY-Z NVrxWVZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvVTWM2OD1yLkKzN|A{KM7:TR?= MUjTRW5ITVJ?
LB373-MEL-D M1H0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PFU2lEPTB;MD6yOFE6QCEQvF2= NGTWVIpUSU6JRWK=
COLO-829 NWK0c3JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XmeGlEPTB;MD6yOFI2PyEQvF2= NGLTe5RUSU6JRWK=
ES8 NIG2TINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjlNopPUUN3ME2wMlI1PzZ|IN88US=> MYfTRW5ITVJ?
RXF393 NFjve|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWKzOJczUUN3ME2wMlI2ODF3IN88US=> NIrKcHFUSU6JRWK=
TK10 NFnZeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkW0N|Uh|ryP Ml;ZV2FPT0WU
LOUCY M{D3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXYRmpFUUN3ME2wMlI2PDV4IN88US=> NUW4U45vW0GQR1XS
MZ7-mel M1jDR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nQe2lEPTB;MD6yOlM4PCEQvF2= MkK1V2FPT0WU
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D-502MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\FW5hKSzVyPUGuOlczOTFizszN NIHVXopUSU6JRWK=
NCI-H2141 NYjMVol2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HyVmlEPTB;MT62O|MyPyEQvF2= NIjnU4JUSU6JRWK=
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MFM-223 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXftenJmUUN3ME2yMlUxQDdzIN88US=> NGrDeHhUSU6JRWK=
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SCC-3 NHfkcpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3IOI9nUUN3ME2zMlExQDR6IN88US=> MYrTRW5ITVJ?
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ES5 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTRwNECyOVUh|ryP M3y0V3NCVkeHUh?=
LB647-SCLC M4PCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpc45KSzVyPUSuOVY{ODhizszN NHTaSnpUSU6JRWK=
HAL-01 NX\aPHI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3UU2ZkUUN3ME20MlU4ODN2IN88US=> NVfNU2dGW0GQR1XS
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NCI-H209 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vJbGlEPTB;NT6xPVM2OiEQvF2= MmTPV2FPT0WU
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Calu-6 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPMTWM2OD13Lk[yNkDPxE1? MX7TRW5ITVJ?
ALL-PO M1z4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTVwNkO3PVUh|ryP MWrTRW5ITVJ?
ARH-77 NVLwcoo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O3U2lEPTB;NT62O|A5PyEQvF2= NIK2PVVUSU6JRWK=
A4-Fuk NEOyOXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn2UYZCUUN3ME22MlA5OTF6IN88US=> M373SnNCVkeHUh?=
NCI-H1581 NXH5WZRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4CxUWlEPTB;Nj6yN|g1QSEQvF2= NGTGfW1USU6JRWK=
HUTU-80 M3HGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PnT2lEPTB;Nj6zOlg6PyEQvF2= M1zzRnNCVkeHUh?=
TGW M3[zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\XTWM2OD14LkS1OVk{KM7:TR?= Mn3VV2FPT0WU
SK-N-FI MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ZRYgyUUN3ME22MlQ2QDV2IN88US=> MXfTRW5ITVJ?
U-266 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTuTHlKSzVyPU[uOVE6OjZizszN MWfTRW5ITVJ?
EM-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi2TWM2OD14Lk[3NFk6KM7:TR?= NH;IfVlUSU6JRWK=
NMC-G1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy3O3pHUUN3ME22MlcyQDl3IN88US=> M4fOUHNCVkeHUh?=
KASUMI-1 NWf2NFBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTZwOES3PFch|ryP M1rTVXNCVkeHUh?=
NALM-6 MkPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\tU|NUUUN3ME22Mlg3PzV2IN88US=> M3;HZ3NCVkeHUh?=
OCI-AML2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r2dGlEPTB;Nz6wNFMzPiEQvF2= NIDOfppUSU6JRWK=
SHP-77 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoOxTWM2OD15LkKyOFMh|ryP NEfq[VZUSU6JRWK=
NOMO-1 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkexTWM2OD15LkK0NlU1KM7:TR?= Mk\XV2FPT0WU
SK-N-DZ NVPoVpViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmyOoVKSzVyPUeuO|ExQDlizszN Mmj0V2FPT0WU
LB1047-RCC M4Lzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W5bWlEPTB;Nz63NlI{OSEQvF2= NVXHSm9iW0GQR1XS
MZ1-PC M2HOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTdwOE[1OVgh|ryP NHviNXVUSU6JRWK=
NB10 NYXlXIpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlGwTWM2OD15Lkm5OVU3KM7:TR?= MXnTRW5ITVJ?
RL95-2 NWDFOW06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnSTHF4UUN3ME24MlExQDR{IN88US=> M1j3NXNCVkeHUh?=
OMC-1 Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDxTWM2OD16LkWyNVkyKM7:TR?= M3vTUXNCVkeHUh?=
D-283MED MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPpd|lKSzVyPUiuPVE4OTlizszN NIW4TlVUSU6JRWK=
MC116 M3jXVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjkWotKSzVyPUiuPVc6PCEQvF2= NU\YUFl[W0GQR1XS
SJSA-1 NUjoRmJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknMTWM2OD17LkC5NFkyKM7:TR?= NXnsNII2W0GQR1XS
JiyoyeP-2003 NIOyfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTlwMkmzNVch|ryP M3nTWXNCVkeHUh?=
IST-MEL1 Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrKU5FEUUN3ME25Mlc1OTl6IN88US=> Mk\jV2FPT0WU
CTV-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPhS2hKSzVyPUGwMlA6PzlizszN Mn3BV2FPT0WU
NH-12 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTFyLkK0N|Mh|ryP NFnLSlJUSU6JRWK=
CA46 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnzTWM2OD1zMD6zOlEh|ryP MWDTRW5ITVJ?
NCI-SNU-1 NVTxS5NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFyLkS5Olkh|ryP NWjucYY3W0GQR1XS
SCLC-21H MoLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf1TWM2OD1zMD62OVk3KM7:TR?= MWTTRW5ITVJ?
EC-GI-10 M3ra[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFyLkewN|Eh|ryP MofMV2FPT0WU
SR MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHETWM2OD1zMT6wNVg2KM7:TR?= MoT4V2FPT0WU
NCI-H1648 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFzLkC5OlUh|ryP MWrTRW5ITVJ?
TGBC1TKB NYT4bWFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFzLkSxNFIh|ryP MmSwV2FPT0WU
EW-11 NGrIOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTFzLkWxPFYh|ryP MVnTRW5ITVJ?
SK-MM-2 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfTNFNGUUN3ME2xNU45ODZzIN88US=> NXrVSGVFW0GQR1XS
NCI-H524 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFzLkm4NlIh|ryP Mnv0V2FPT0WU
NOS-1 M1\ScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPMXXplUUN3ME2xNk4xOzR3IN88US=> NHm4NW1USU6JRWK=
AM-38 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF{LkW2N|Mh|ryP MnrVV2FPT0WU
A498 NGLYUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF{LkewOlkh|ryP Mo[zV2FPT0WU
KARPAS-422 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTF{Lke0PVYh|ryP MV;TRW5ITVJ?
LU-139 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n6[mlEPTB;MUKuPVAzPiEQvF2= M3v5fXNCVkeHUh?=
COR-L88 M1vIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULzNYVLUUN3ME2xNk46Ozh{IN88US=> NX3NUHZlW0GQR1XS
K5 M{TDXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfwW3lKSzVyPUGyMlk1PjJizszN MVPTRW5ITVJ?
NB13 NV\sdXhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDleG5QUUN3ME2xNk46Pzh|IN88US=> MljrV2FPT0WU
MRK-nu-1 NHi4VJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm3bGFKSzVyPUGzMlE6PSEQvF2= M2fzbXNCVkeHUh?=
MHH-NB-11 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7UTWM2OD1zMz6yPVAzKM7:TR?= M{D0UHNCVkeHUh?=
KU812 NIPxN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF|Lk[xNlQh|ryP NEPxZ5pUSU6JRWK=
TE-12 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i5UGlEPTB;MUOuOlk6PCEQvF2= MXXTRW5ITVJ?
NCI-N87 MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF|LkezOkDPxE1? MWHTRW5ITVJ?
EB2 M{ToSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nKUmlEPTB;MUOuPFUxPSEQvF2= M1:5NXNCVkeHUh?=
DB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PTTGlEPTB;MUOuPVg5PSEQvF2= MlrqV2FPT0WU
697 M4nRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG3TWM2OD1zND60OVEyKM7:TR?= MlrOV2FPT0WU
MSTO-211H NUHTdWx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LveGlEPTB;MUSuO|Q1QCEQvF2= MYjTRW5ITVJ?
JVM-2 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH2VWVKSzVyPUG0Mlc4OzVizszN NGjO[YtUSU6JRWK=
COLO-824 M2DxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF2Lke5PVQh|ryP MX\TRW5ITVJ?
BC-3 MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jIcmlEPTB;MUWuN|k5KM7:TR?= NX\kZo42W0GQR1XS
BOKU NHj0TWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP6TWM2OD1zNT65OlA5KM7:TR?= M{XCbnNCVkeHUh?=
GOTO M4DKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nlOGlEPTB;MU[uPVYyPyEQvF2= M4ewSHNCVkeHUh?=
HCC2157 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTHTWM2OD1zNz60O|U2KM7:TR?= NV;wVIxoW0GQR1XS
LS-1034 NYTQUYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfqNWpxUUN3ME2xO{43QDF6IN88US=> MmO3V2FPT0WU
CAL-148 NF36U5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEP3[4lKSzVyPUG3Mlk4QTZizszN Ml:wV2FPT0WU
MOLT-4 M1XvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjjTWM2OD1zOD64NlA5KM7:TR?= M1;MbHNCVkeHUh?=
Daudi NHLSXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTQTWM2OD1zOD65NlMyKM7:TR?= NYXQOYNQW0GQR1XS
J-RT3-T3-5 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGH6N3ZKSzVyPUG5MlQxPjZizszN NXG4XWs2W0GQR1XS
KMOE-2 M4nyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ne2lEPTB;MUmuOlQ5OiEQvF2= MoDBV2FPT0WU
HL-60 NUfPV2V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HsZ2lEPTB;MkCuNVk3PSEQvF2= MkHxV2FPT0WU
P31-FUJ M1\2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJyLkS3OVMh|ryP MlTxV2FPT0WU
IM-9 NEP6ZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJyLk[yNlQh|ryP MXrTRW5ITVJ?
HDLM-2 NGXWUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnToTWM2OD1{MD64PFIyKM7:TR?= NXvRc|h6W0GQR1XS
NCI-H1304 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4iyWmlEPTB;MkGuNFMyOSEQvF2= NHPvN3RUSU6JRWK=
NCI-H345 NIHuVZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJzLkC2OFMh|ryP NWHoW|JzW0GQR1XS
RPMI-6666 NH6xeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\MTWM2OD1{MT6zOlAzKM7:TR?= Mn\iV2FPT0WU
GR-ST NI\se5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJzLkSxO{DPxE1? NUnBd2dVW0GQR1XS
CHP-126 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXuTWM2OD1{MT62NVgyKM7:TR?= MoDnV2FPT0WU
EHEB MkfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvjN5dKSzVyPUKxMlY4OzFizszN M3\pfnNCVkeHUh?=
CPC-N NHTIdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ2LkCyNFEh|ryP MnrhV2FPT0WU
NB1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjnSWtHUUN3ME2yOE43QTN7IN88US=> M{LafHNCVkeHUh?=
LS-123 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXoTWM2OD1{ND65NFEzKM7:TR?= M2HqSnNCVkeHUh?=
ST486 M{noXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn6cpFwUUN3ME2yOU4yOTF|IN88US=> NVziOnRxW0GQR1XS
NCI-H1963 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJ4LkC2NlMh|ryP M3jwcHNCVkeHUh?=
U-87-MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn36TWM2OD1{Nj63OlQ1KM7:TR?= NIH1WoZUSU6JRWK=
COR-L279 NYXmeXoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2SxbWlEPTB;Mk[uO|kzOiEQvF2= M1rsWHNCVkeHUh?=
LU-165 NYLQRmh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf5NWpKSzVyPUK4MlA5PjFizszN MnzFV2FPT0WU
COLO-800 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[wOGlEPTB;MkiuNlk2PiEQvF2= NILKcXlUSU6JRWK=
ETK-1 NVHQTnVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXUUFJKSzVyPUK4MlM1PDZizszN Mlv6V2FPT0WU
LNCaP-Clone-FGC NEe4NVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfnSnhKSzVyPUK5MlkzQDFizszN NWKzcFZtW0GQR1XS
SIG-M5 NF:ySFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r1UWlEPTB;M{CuO|k2OiEQvF2= M3vr[nNCVkeHUh?=
NB6 MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\mSmlEPTB;M{CuPVUxOyEQvF2= NWDMPI46W0GQR1XS
NCI-H2107 NUD2U45ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XtU2lEPTB;M{GuNlM{QCEQvF2= M4j3bHNCVkeHUh?=
SNU-C1 NVG3ZVdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnSXW1uUUN3ME2zNU4{OTJ4IN88US=> MYnTRW5ITVJ?
JAR MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\oSWVrUUN3ME2zNU4{Pzl7IN88US=> M1z4R3NCVkeHUh?=
L-363 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu4TWM2OD1|Mj6yNVQ1KM7:TR?= MnPkV2FPT0WU
EW-24 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XkdWlEPTB;M{KuN|Q4PCEQvF2= M3jHOHNCVkeHUh?=
NB69 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTN|Lk[0OVQh|ryP NUjj[VA3W0GQR1XS
EW-13 NFSwem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHscJlZUUN3ME2zN{45QTZ7IN88US=> MYHTRW5ITVJ?
Ramos-2G6-4C10 M2nX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTN2LkK5PVMh|ryP NGWyRo5USU6JRWK=
TE-11 M4jDdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTJcW1KSzVyPUO0MlQ5OjJizszN Mm\OV2FPT0WU
L-428 NXPUWZRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTN2Lke1N|Yh|ryP MYjTRW5ITVJ?
KP-N-YN MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPxTWM2OD1|ND65NFU4KM7:TR?= NGLYWIVUSU6JRWK=
CGTH-W-1 M1jPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHDeoY2UUN3ME2zOk46ODR6IN88US=> MWrTRW5ITVJ?
K-562 NWfZO29VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDHTWM2OD1|Nz6wPFY1KM7:TR?= MWnTRW5ITVJ?
NCI-H1299 NGXkcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[wXGNjUUN3ME2zPE4yPjB|IN88US=> MXTTRW5ITVJ?
RCC10RGB Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN6LkKwPFMh|ryP MXzTRW5ITVJ?
NCI-SNU-16 NHzvdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP3dWU6UUN3ME2zPE42PjV|IN88US=> NHHtTFNUSU6JRWK=
LC-2-ad M{TE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN7LkSzN|ch|ryP M4C4fHNCVkeHUh?=
MHH-PREB-1 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLpNJNKSzVyPUO5Mlc{QDhizszN MWnTRW5ITVJ?
NCI-H64 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH3Z3pvUUN3ME20NE4xQTR6IN88US=> NXr0O2pGW0GQR1XS
LB996-RCC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXTTWM2OD12MD64O|E3KM7:TR?= Mli4V2FPT0WU
DEL NX73TnlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\oTWM2OD12MT60OFA2KM7:TR?= MVPTRW5ITVJ?
MLMA NH7Ue2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLV[FlHUUN3ME20NU44PTl3IN88US=> MkHhV2FPT0WU
SBC-1 NH;rT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzZTWM2OD12Mj6xPFA3KM7:TR?= M4TmS3NCVkeHUh?=
MPP-89 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q3VWlEPTB;NEKuOVg4PSEQvF2= MWDTRW5ITVJ?
MV-4-11 Mon0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;sRmlEPTB;NEKuPVA3PyEQvF2= M1jmRnNCVkeHUh?=
EoL-1- M2DsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjZTWM2OD12ND6xOVY5KM7:TR?= NH;pdohUSU6JRWK=
CW-2 NXziW4w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTR2LkizOFIh|ryP Mn;yV2FPT0WU
HT M4PE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL1TWM2OD12NT63NFA4KM7:TR?= MWXTRW5ITVJ?
SW954 NFPTToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XnbWlEPTB;NEeuOFEzQCEQvF2= NEWycJFUSU6JRWK=
A3-KAW MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LwXWlEPTB;NEmuPFA3OSEQvF2= Mn74V2FPT0WU
TC-YIK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDKNYdKSzVyPUWwMlA{PjNizszN NIfTXldUSU6JRWK=
SW962 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H1O2lEPTB;NUSuPFM2PyEQvF2= MlTvV2FPT0WU
KP-N-RT-BM-1 NHq3W5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrEW5MzUUN3ME21Ok43PjN6IN88US=> MXvTRW5ITVJ?
NCI-H1395 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPJTWM2OD13OD64NVczKM7:TR?= M3TBWnNCVkeHUh?=
RPMI-8402 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v2U2lEPTB;NUiuPVUzPiEQvF2= NHP3SIJUSU6JRWK=
SCH Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnXT296UUN3ME22NE46PjN6IN88US=> NUXxc4xGW0GQR1XS
NCI-H2196 NYHGPHdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTjOGNSUUN3ME22NU4zOzFizszN NVP1OItnW0GQR1XS
LOXIMVI NFP5bppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDRcFJnUUN3ME22NU45OjZ4IN88US=> MVfTRW5ITVJ?
TGBC24TKB M2nHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTZ{LkG0PVEh|ryP NXrLW4xvW0GQR1XS
SK-MEL-2 Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LnZWlEPTB;NkOuPVg6OiEQvF2= M1rpOXNCVkeHUh?=
U-698-M NVfKeohUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ZZmlEPTB;NkiuOVY5PyEQvF2= NIH6e21USU6JRWK=
NCI-H1522 NVniR|V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7GTWM2OD14OT6wNFQ4KM7:TR?= NUfNTmpuW0GQR1XS
UACC-812 NXnj[GpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTZ7LkWyNFkh|ryP Ml\6V2FPT0WU
MHH-CALL-2 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rqWWlEPTB;N{CuNFYh|ryP MkfvV2FPT0WU
NB5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nSZWlEPTB;N{CuN|Q3QCEQvF2= NYr0U3lyW0GQR1XS
KARPAS-299 M{Pte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PY[mlEPTB;N{CuOFQ1PyEQvF2= NGTrXoxUSU6JRWK=
NCI-H1694 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTdzLkCzNkDPxE1? NXO0V3R1W0GQR1XS
NCI-H82 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTdzLkm1NFch|ryP MnLvV2FPT0WU
SCC-15 M3nENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHlSZpKSzVyPUeyMlM1KM7:TR?= NFPBT2FUSU6JRWK=
NCI-H1436 M3HZO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;0eHpKUUN3ME23Nk44PDV4IN88US=> MXrTRW5ITVJ?
ATN-1 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonjTWM2OD15ND61NFUh|ryP NFrVS3FUSU6JRWK=
RPMI-8866 M4niNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTrV4l1UUN3ME23OE44PTB7IN88US=> M3e2OXNCVkeHUh?=
HCC1599 NGWxNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vSeGlEPTB;N{SuPFc{OiEQvF2= MXLTRW5ITVJ?
NCI-H1155 NV3OZY9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vldGlEPTB;N{SuPVM3PyEQvF2= MV3TRW5ITVJ?
DOHH-2 NInSPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHBTWM2OD15ND65OVE1KM7:TR?= NIH5W|ZUSU6JRWK=
SK-NEP-1 NVTEenhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvDTJNpUUN3ME23OU4xPzV2IN88US=> NFHYPGpUSU6JRWK=
HCC1187 NYe5OGJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TMRmlEPTB;N{euOlEzOiEQvF2= MXXTRW5ITVJ?
NCI-H322M MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLvN3RKSzVyPUe4MlM4ODlizszN NYHWdo1[W0GQR1XS
NCI-H526 M4rEdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfsTWM2OD15OD61PFc4KM7:TR?= M{TN[3NCVkeHUh?=
NCI-H2171 MlWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzC[FdKSzVyPUe5MlQyOzZizszN MV7TRW5ITVJ?
COLO-668 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRThzLkW4PFQh|ryP MVLTRW5ITVJ?
RS4-11 M3vBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm2VZVLUUN3ME24Nk4zPTB3IN88US=> M2rLenNCVkeHUh?=
NCI-H716 M{HBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr2UVkzUUN3ME24Nk46ODd3IN88US=> MVvTRW5ITVJ?
LU-134-A M{O5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LXPGlEPTB;OEOuNVM2OSEQvF2= NVn5OlBIW0GQR1XS
RPMI-8226 NGf3WGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe0eHd2UUN3ME24OE4zOTB5IN88US=> M4Pz[3NCVkeHUh?=
KY821 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jlN2lEPTB;OUGuOlU2OSEQvF2= MUTTRW5ITVJ?
ECC4 MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vPZWlEPTB;OUOuPFI3QSEQvF2= M3LGR3NCVkeHUh?=
EW-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTl2LkmwPFEh|ryP MYPTRW5ITVJ?
NB7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3WTWM2OD17NT63O|g3KM7:TR?= NHLT[IFUSU6JRWK=
NCI-H720 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i2OWlEPTB;OUiuOFA3OSEQvF2= MX\TRW5ITVJ?
NCI-H446 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnX2TWM2OD17OT63OVg5KM7:TR?= M{LnUXNCVkeHUh?=
NCI-H889 NWH1WpU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFyND6yOFIh|ryP M3HZWHNCVkeHUh?=
EW-22 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjxZ|dKUUN3ME2xNFYvOTlizszN NHTGNGNUSU6JRWK=
BV-173 M3O0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTqTWM2OD1zMEiuO|I5KM7:TR?= M4rJW3NCVkeHUh?=
WSU-NHL NV;tRlNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7IeFFKSzVyPUGwPU43PzFizszN MnLsV2FPT0WU
MN-60 M1TiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi4c3pMUUN3ME2xNFkvPjlizszN MlnEV2FPT0WU
DG-75 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\XTWM2OD1zMUOuN|UzKM7:TR?= MmTDV2FPT0WU
DMS-79 M4TTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX6yeYhpUUN3ME2xNVcvOzh{IN88US=> NXzHR45yW0GQR1XS
SK-MEL-1 M3WyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7oNINKSzVyPUGxPE4xODlizszN Mn7JV2FPT0WU
DMS-153 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjlRpA5UUN3ME2xNlEvPzR3IN88US=> NFXOOYdUSU6JRWK=
NCI-H510A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP0b25OUUN3ME2xNlcvOzJizszN MojVV2FPT0WU
BE-13 M{nWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu5OYpkUUN3ME2xN|QvODR2IN88US=> NVXtNI5mW0GQR1XS
KP-N-YS M3LVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\x[FdKSzVyPUGzPU44OzZizszN MoCxV2FPT0WU
SUP-T1 NH;sZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3UTWM2OD1zNEOuO|A5KM7:TR?= M4m3bnNCVkeHUh?=
EW-12 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LJeWlEPTB;MUS0MlY6QSEQvF2= NEOw[GNUSU6JRWK=
NB14 M3jCNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O2SGlEPTB;MUS3MlA5OiEQvF2= M3nzPHNCVkeHUh?=
MDA-MB-134-VI MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmxO|FKSzVyPUG0PE4zPjhizszN M{\IXnNCVkeHUh?=
NCI-H1770 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKwcmlKSzVyPUG1Ok4zPzlizszN MWTTRW5ITVJ?
TUR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\zTWM2OD1zNkeuPFch|ryP M32yXnNCVkeHUh?=
NCI-H1417 NHH0boxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITYZYtKSzVyPUG4NE4{OzFizszN M3:5U3NCVkeHUh?=
IMR-5 NGH4O4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vZWGlEPTB;MUixMlU4OSEQvF2= NUfOXmZkW0GQR1XS
NCI-H226 M3nRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF6OD64OlYh|ryP M4TodnNCVkeHUh?=
NCI-H187 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\UVWlEPTB;MUmwMlA3PCEQvF2= MnjEV2FPT0WU
SF539 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17VdWlEPTB;MUmyMlczQCEQvF2= NWDiPGVoW0GQR1XS
TALL-1 NHPkbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXpTWM2OD1zOUiuN|A1KM7:TR?= NVHGN|RvW0GQR1XS
TE-441-T NVrScHpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jYVGlEPTB;MUm5Mlc{QSEQvF2= M3zxSXNCVkeHUh?=
REH NHPsNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33JS2lEPTB;MkO2MlYzPiEQvF2= MnrrV2FPT0WU
MS-1 NH\DWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ|OT6xNlEh|ryP NG\2PFBUSU6JRWK=
THP-1 M1;OOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fmTGlEPTB;Mk[0Mlc{QCEQvF2= NYTJfGd3W0GQR1XS
NCI-H1838 NHnDRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjrU4syUUN3ME2yO|EvPDV4IN88US=> NVrwepR6W0GQR1XS
P30-OHK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUGyXFJ1UUN3ME2yPFMvQDR5IN88US=> MUHTRW5ITVJ?
C8166 NES2O|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rE[GlEPTB;M{S1MlM{QCEQvF2= NYLhWZE3W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Protocol

Kinase Assay:

[1]

+ Expand

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research:

[3]

+ Expand
  • Cell lines: KIM-2, HC11, and ES
  • Concentrations: Dissolved in DMSO, final concentrations ~25 μM
  • Incubation Time: 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Male mdx (C57BL/10ScSn DMD mdx) mice
  • Formulation: Dissolved in DMSO, and diluted in PBS
  • Dosages: ~10 μg/kg/day
  • Administration: Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+20% propylene glycol+ddH2O 2mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 475.62
Formula

C26H41N3O5

CAS No. 133407-82-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID