MG-132

Catalog No.S2619

MG-132 Chemical Structure

Molecular Weight(MW): 475.62

MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.

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In DMSO USD 100 In stock
USD 50 In stock
USD 170 In stock
USD 470 In stock

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Cited by 46 Publications

9 Customer Reviews

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.
Targets
Proteasome [1]
(Cell-free assay)
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells NVzPdHF4TnWwY4Tpc44hSXO|YYm= M4LzXlI2KM7:TR?= MknBSG1UVw>? M3OyN2lvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjFizszN NYj0dmFsOjR4OUe0PVY>
HL-60 MmTKR5l1d3SxeHnjJGF{e2G7 MnLxOFAh|ryP MUW0PEBp NF\CRXJFVVOR M3\oOmlEPTB:MUCg{txO MU[yOFY6PzR7Nh?=
SMMC-7721 MluyR5l1d3SxeHnjJGF{e2G7 MkfFOFAh|ryP MYW0PEBp MYHEUXNQ NH7MSZVKSzVyPUeuNUDPxE1? M2CzXFI1Pjl5NEm2
A-549 M2e4W2N6fG:2b4jpZ{BCe3OjeR?= MYW0NEDPxE1? NHL4UXI1QCCq MlH5SG1UVw>? M2rIXGlEPTB:MUCg{txO NWDTWYQ{OjR4OUe0PVY>
MCF-7 M2D2TGN6fG:2b4jpZ{BCe3OjeR?= M{PzcVQxKM7:TR?= Ml:5OFghcA>? MnX2SG1UVw>? M2HkfWlEPTB;Nz6zJO69VQ>? NITTbpgzPDZ7N{S5Oi=>
SW-480 MXzDfZRwfG:6aXOgRZN{[Xl? NGPSSIM1OCEQvF2= M3P6O|Q5KGh? M1PyfWROW09? MlzlTWM2OD12IN88US=> M4XIcFI1Pjl5NEm2
NCI-H929 MYnDfZRwfG:6aXOgRZN{[Xl? M{e5OFEh|ryP NVfOXnQzPzJiaB?= M33WdGROW09? Ml;vTWM2OD1yLkG3JO69VQ>? NYmzeJZmOjR4MkWwPFg>
293T M4XNeGN6fG:2b4jpZ{BCe3OjeR?= NVzRb3VMOTBizszN NISyZ4s4OiCq NH3KNFFFVVOR NF\yS2lKSzVyPEKg{txO MUCyOFYzPTB6OB?=
293T Mni1SpVv[3Srb36gRZN{[Xl? MVyxNEDPxE1? MkLxNlQhcA>? MWXEUXNQ NULVS4NFVW:mZYLheIVtgSCrbnT1Z4V{KGinYYStd4hw[2tiIB?= NWn3SXRZOjR4MkWwPFg>
HeLa M2G5RmtqdmG|ZTDBd5NigQ>? MojhNVAh|ryP M2n4XlEhcA>? NWf6SFdbTE2VTx?= MXTJcoR2[2W|IGDBVnAh[2ynYY\h[4Uh[nliaX7obYJqfGmwZzDwdo9{\WG|b33lJIFkfGm4aYT5 NVLDdlJLOjR|MkG4N|M>
MDA-MB-231 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixJO69VQ>? MnvXO|IhcA>? NHjLW2dFVVOR NYXJeG1mUUN3ME2wMlE5KM7:TR?= MV[yOFE2OzJyNh?=
MCF-7 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELLcpIyKM7:TR?= NUHBcZpPPzJiaB?= NEHjNXNFVVOR NIXxR5ZKSzVyPUCuNVMh|ryP NEXxfVQzPDF3M{KwOi=>
MCF10A NV\vSnpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDpNUDPxE1? M1vyVlczKGh? NGTidXZFVVOR NWrqWYJOUUN3ME2wMlI6KM7:TR?= NEXwfWozPDF3M{KwOi=>
HEK-293 MWXLbY5ie2ViQYPzZZk> NIHMdIIzKGGwZDCyNEDPxE1? Mn\VNkBp NFjnbGpFVVOR NF\LO5RKdmirYnn0d{BEcFRvTDDhZ5Rqfmm2eTD3bZRpKEmFNUCgc4YhQSCwTTC= M1HpN|I{PTRyN{mw
Calu6 M2\ycmZ2dmO2aX;uJGF{e2G7 MVuxNEDPxE1? MlPUNVghcA>? NHnXfo9FVVOR M1jHT3Nq\26rZnnjZY51dHliYXPjeY12dGG2ZYOg[pJifGG6aX6gdJJm[3W{c3;y NEjMV3czOzVyNkS4Oi=>
IFN-gamma-induced RAW264.7 MmewSpVv[3Srb36gRZN{[Xl? NV20[ZhoTE2VTx?= NWD4cGNWUW6qaXLpeJMhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDBwMEe3JO69VQ>? MVSyNlI4PzJ5Nx?=
IPC227F NXTYXpdKS3m2b4TvfIlkKEG|c3H5 NGLucVUyKM7:TR?= MlmzOFghcA>? MVTEUXNQ MXzJR|UxRTBwMEe3JO69VQ>? MXWyNVkzPDV{OB?=
Hepa-1c1c7 NFLTSJlHfW6ldHnvckBCe3OjeR?= NWLseGpzOjVizszN M3Tkc|YhcA>? M{PZc2ROW09? NGDiTolKdmO{ZXHz[ZMhVnKoMjDwdo91\WmwIHzleoVt NWjYUXpvOjB|OUK1OFQ>
COS-7 M2njNWN6fG:2b4jpZ{BCe3OjeR?= NWPidnRDOTBizszN NGDuW3dFVVOR NF\hSJFKSzVyPEGwJO69VQ>? MmHVNVgxQDhyOUe=
HuH-7 NUnxT|lMS3m2b4TvfIlkKEG|c3H5 MlPmNVAh|ryP NGr2UZlFVVOR NEHmbodKSzVyPEGwJO69VQ>? NITjZYwyQDB6OEC5Oy=>
OCI-Ly3 M{jvSGZ2dmO2aX;uJGF{e2G7 MXixNEDPxE4EoB?= MXe0JIg> M4i2cGROW09? MnTPTY5lfWOnczDoeY1idiCLa3HwdIFD[WyyaHGgd5Ri[mmuaYrheIlwdiC5aYToJGVEPTBib3[gNUDPxE1? NVniUmtCOThyMkSxNVM>
A2780 cDDP MUPBdI9xfG:|aYOgRZN{[Xl? NH21NoozPCCq M4\aNmROW09? NFH3[4FKdmS3Y3XzJIFxd3C2b4Ppd{BjgSCrbnjpZol1cW6pIGDUSW4h\GWpcnHkZZRqd25? M1W1XlE4Pjh2MEG4
LPS-stimulated RAW264.7 cells M{HNT2Z2dmO2aX;uJGF{e2G7 M2HueWROW09? NWXQXmljUW6qaXLpeJMhVkZva3HwdIFDKESQQTDibY5lcW6p NU\UNoM2OTd2MEeyO|c>
PC12 NVj6PIVwTnWwY4Tpc44hSXO|YYm= M4jwO|ExOCEQvF5CpC=> NVXVSpFROjRiaB?= NWPDeZdxTE2VTx?= MUjJcohq[mm2czC2MW9JTEFvIHHu[EBJOk9{LXnu[JVk\WRiY4n0c5RwgGmlaYT5 NXPKWXZWOTdzNUi0OVQ>
PC3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[yNEDPxE1? NU\OdYpDPDhiaB?= Ml\vSG1UVw>? MmT5TWM2OD1yLk[g{txO M3P0OFE3Pjh4NUO3
LP-1 NWGzcldbSXCxcITvd4l{KEG|c3H5 M33wWVMxOCCwTR?= MknzNlQhcA>? MWTEUXNQ M{D1Z2lv\HWlZYOgZZBweHSxc3nzJIJ6KGmwY4LlZZNqdmdiY3zlZZZm\CCSQWLQJIxmfmWuIHHu[EBz\WS3Y3nu[{BO[2xvMTDwdo91\WmwIHzleoVt M3XIO|E2QTV6NUi5
ES6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrGeIxKSzVyPUCuNFE{ODZizszN MXfTRW5ITVJ?
A101D NFnye2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\iTWM2OD1yLkCzNlc6KM7:TR?= NGHGTIhUSU6JRWK=
OCUB-M MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;CeGlEPTB;MD6wN|c{PyEQvF2= Mn;YV2FPT0WU
LB2518-MEL NVvpWogzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrhVY0yUUN3ME2wMlA{PzZizszN NHnxVZVUSU6JRWK=
SH-4 NYPrZoFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonwTWM2OD1yLkC0N|Eh|ryP MWHTRW5ITVJ?
KNS-42 M4n5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nudGlEPTB;MD6wOFQ1OSEQvF2= MkP0V2FPT0WU
DSH1 M2nLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq5[5hKSzVyPUCuNFUzQDlizszN M12zcXNCVkeHUh?=
NTERA-S-cl-D1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[wTWM2OD1yLkC1O|czKM7:TR?= M3;wUXNCVkeHUh?=
D-542MG MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrsTWM2OD1yLkC1PVU4KM7:TR?= MYnTRW5ITVJ?
KS-1 Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37GSmlEPTB;MD6wOlQ2QCEQvF2= NHHrco1USU6JRWK=
BL-41 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwME[5OFch|ryP M1;KXHNCVkeHUh?=
LXF-289 M4\tO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvtNJY2UUN3ME2wMlA4ODZ4IN88US=> MVTTRW5ITVJ?
D-247MG NWqzdIJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITiZXZKSzVyPUCuNFczODlizszN M1f1enNCVkeHUh?=
MMAC-SF NEHNXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEeyOlgh|ryP MYjTRW5ITVJ?
CP66-MEL NV;uenhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULJeooyUUN3ME2wMlA4PSEQvF2= MWnTRW5ITVJ?
LB771-HNC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEiwN|Yh|ryP MWPTRW5ITVJ?
no-10 NHL1NGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD2TWM2OD1yLkC4PVA6KM7:TR?= MmmwV2FPT0WU
A388 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEmwOlUh|ryP Mne4V2FPT0WU
OPM-2 NHftU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMUC0O|Qh|ryP MVjTRW5ITVJ?
OVCAR-4 M2PCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUC5N|gh|ryP NX7HdZY{W0GQR1XS
HOP-62 NVvyNo9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TGN2lEPTB;MD6xNFk1QSEQvF2= NW\hcI1UW0GQR1XS
ML-2 NHvC[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMUG4NFYh|ryP MlvSV2FPT0WU
UACC-257 MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlexTWM2OD1yLkGxPVI4KM7:TR?= NXXa[21[W0GQR1XS
NEC8 M3zadGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGT2lEPTB;MD6xNVk6PSEQvF2= M{L5UXNCVkeHUh?=
ONS-76 NEfM[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxcoZKSzVyPUCuNVI6OzVizszN MWnTRW5ITVJ?
KE-37 NGrqfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMUOyO|gh|ryP M3PTcXNCVkeHUh?=
HT-144 NGO3UpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rFXGlEPTB;MD6xN|g6PSEQvF2= M{HVWXNCVkeHUh?=
LB2241-RCC M3vvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTOTWM2OD1yLkG0NlQ4KM7:TR?= MkjGV2FPT0WU
TE-5 NEfTd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGyU3lKSzVyPUCuNVQzPzhizszN MknQV2FPT0WU
KINGS-1 NUf4TZZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\hTWM2OD1yLkG0O|kh|ryP NIPpOopUSU6JRWK=
NCI-H69 NFr6XpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj1dGlvUUN3ME2wMlE2OTRzIN88US=> MUnTRW5ITVJ?
CAS-1 NVnWNXd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULRNlN{UUN3ME2wMlE2PDh{IN88US=> MY\TRW5ITVJ?
D-263MG MkPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yy[GlEPTB;MD6xOlAxPiEQvF2= NHHFW|NUSU6JRWK=
A253 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PHRmlEPTB;MD6xOlEzQCEQvF2= M1nHXXNCVkeHUh?=
PF-382 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\GRlFKSzVyPUCuNVY4ODZizszN MlTqV2FPT0WU
CESS NIHPTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK5fI1KSzVyPUCuNVcxPiEQvF2= NYrt[GVqW0GQR1XS
MZ2-MEL M3[5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMUe1OVkh|ryP MXXTRW5ITVJ?
HEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTkZZo1UUN3ME2wMlE5PTF5IN88US=> MnfxV2FPT0WU
D-392MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH5TWM2OD1yLkG5NVE2KM7:TR?= NUnZdYl6W0GQR1XS
SK-LMS-1 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjESJlKSzVyPUCuNVk{ODNizszN M1nqbHNCVkeHUh?=
GI-ME-N NWjVeXJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrMe3RWUUN3ME2wMlE6OzB4IN88US=> NFfPZ|NUSU6JRWK=
LB831-BLC Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnpWYlKSzVyPUCuNVk{PCEQvF2= MV\TRW5ITVJ?
DU-4475 NXK0e|B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnlT4dUUUN3ME2wMlE6PjV6IN88US=> NFPpdm5USU6JRWK=
IST-SL1 NVz6NYYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMkCwPVQh|ryP MYnTRW5ITVJ?
GAK M3LFRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMkC1N|Qh|ryP MoK1V2FPT0WU
EW-1 M3\uSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMkGwOFch|ryP NGqx[Y1USU6JRWK=
LAMA-84 M1vGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYiwSY9FUUN3ME2wMlIyQDVzIN88US=> MYXTRW5ITVJ?
SK-UT-1 NFL2NZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfFdVdKSzVyPUCuNlIxPDlizszN NIPhTHhUSU6JRWK=
VA-ES-BJ MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnLV2tKSzVyPUCuNlIzPTdizszN NXPBOIpXW0GQR1XS
ACN NVXlXVQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\hTWM2OD1yLkKyOlM5KM7:TR?= NWT3XHVNW0GQR1XS
SK-PN-DW Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMkOxPUDPxE1? M{fzOnNCVkeHUh?=
HD-MY-Z MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nafWlEPTB;MD6yN|MxOyEQvF2= NF\XbIVUSU6JRWK=
LB373-MEL-D MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMkSxPVgh|ryP M4rKXHNCVkeHUh?=
COLO-829 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X3W2lEPTB;MD6yOFI2PyEQvF2= M1TvU3NCVkeHUh?=
ES8 NV[zd5ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknvTWM2OD1yLkK0O|Y{KM7:TR?= MkTZV2FPT0WU
RXF393 NUi4WYM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDKVIpKSzVyPUCuNlUxOTVizszN NGLnWINUSU6JRWK=
TK10 NETLfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnrXWd4UUN3ME2wMlI2PDN3IN88US=> MnHTV2FPT0WU
LOUCY M4POS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DiSGlEPTB;MD6yOVQ2PiEQvF2= NIn5SoNUSU6JRWK=
MZ7-mel M37Fc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfYcnRKSzVyPUCuNlY{PzRizszN MlrIV2FPT0WU
CP67-MEL NX7pe45tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW3N2dIUUN3ME2wMlI3PzNizszN M1fZcXNCVkeHUh?=
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NCI-H2126 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDSW4VKSzVyPUCuOlI3PjlizszN MkSyV2FPT0WU
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LS-513 NE\3OIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTkUnF3UUN3ME2wMlY3PzVzIN88US=> MXfTRW5ITVJ?
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L-540 MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTVN|dlUUN3ME2xMlEyQDN7IN88US=> MW\TRW5ITVJ?
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LU-65 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwMUK3OVMh|ryP MUjTRW5ITVJ?
MFH-ino MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe2[XliUUN3ME2xMlE4PTBzIN88US=> M13senNCVkeHUh?=
NCI-H23 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwMkC0NUDPxE1? M1LzWnNCVkeHUh?=
IA-LM NYC5[Wl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwMkSxNVYh|ryP MlzkV2FPT0WU
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NCI-H719 NEDjeZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFwMke0NVEh|ryP M2X6SHNCVkeHUh?=
SW684 NFzvXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GxSGlEPTB;MT6yPFY2QSEQvF2= NFjr[VBUSU6JRWK=
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EW-16 NHHD[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\nUplmUUN3ME2xMlMyOzR5IN88US=> NFzSTplUSU6JRWK=
NCI-H128 NVvK[Xk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTRTWM2OD1zLkO1PFE1KM7:TR?= NWS1flhNW0GQR1XS
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DMS-114 M2T3d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLXTWM2OD1zLkS0OVM6KM7:TR?= MV7TRW5ITVJ?
GI-1 NEfFWGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfDTWM2OD1zLkS3NVMyKM7:TR?= NUXNTYhqW0GQR1XS
NCI-H2081 NH3qblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPNTWM2OD1zLkW1NVk3KM7:TR?= MWHTRW5ITVJ?
LC-1F NVPIWWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX5TWM2OD1zLkW1NVk5KM7:TR?= Mn\TV2FPT0WU
NCI-H2227 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG5TWM2OD1zLk[xOVYyKM7:TR?= NUDNbXpvW0GQR1XS
D-502MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnBXWdKSzVyPUGuOlczOTFizszN M2SyU3NCVkeHUh?=
NCI-H2141 NXOz[mFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFwNkezNVch|ryP NEjHeIVUSU6JRWK=
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TE-15 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwOUKzO|Mh|ryP NGniUodUSU6JRWK=
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EW-18 NYHjRWg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrKOnI1UUN3ME2yMlAzOzN5IN88US=> Mle3V2FPT0WU
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QIMR-WIL MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPtOYhKSzVyPUKuNVY4PjJizszN MnvNV2FPT0WU
MC-CAR MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13WcWlEPTB;Mj6yNlk2KM7:TR?= M3z4UXNCVkeHUh?=
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ECC12 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHNfHdKSzVyPUKuN|c6PCEQvF2= M1u0S3NCVkeHUh?=
HCE-T NFH4RmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwNES4PFMh|ryP MlXFV2FPT0WU
MFM-223 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{SxO2lEPTB;Mj61NFg4OSEQvF2= MmezV2FPT0WU
SW982 M1vrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS1TWM2OD1{LkWxOFgh|ryP MUDTRW5ITVJ?
KG-1 NVjITI9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3THS2lEPTB;Mj64PFc6OSEQvF2= MVXTRW5ITVJ?
ES4 Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\STWM2OD1|LkC2NVEyKM7:TR?= M4e2dnNCVkeHUh?=
SCC-3 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTNwMUC4OFgh|ryP NF\CSI9USU6JRWK=
RH-1 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGG5SlNKSzVyPUOuN|g4PDhizszN MnX5V2FPT0WU
NCI-H748 NIP0RmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPmUWZKSzVyPUOuOFQzPjZizszN MoLuV2FPT0WU
HCC2218 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTNwNE[5N|ch|ryP MXzTRW5ITVJ?
MEG-01 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvwb29KSzVyPUOuOVk3QCEQvF2= MmPUV2FPT0WU
NB12 NH;CcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPyTWM2OD1|LkW5PFg5KM7:TR?= MXvTRW5ITVJ?
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HAL-01 NXfLcmpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTRwNUewN|Qh|ryP MXTTRW5ITVJ?
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EB-3 NXfVTGNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwMEOwOFEh|ryP NFPnOJhUSU6JRWK=
GT3TKB MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L3fmlEPTB;NT6xO|Y3OiEQvF2= Ml;jV2FPT0WU
NCI-H209 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX5TWM2OD13LkG5N|UzKM7:TR?= M2XZc3NCVkeHUh?=
BT-474 MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILCOoFKSzVyPUWuNlMyODJizszN NXHFTY45W0GQR1XS
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RL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j1bGlEPTB;NT6zO|U1OSEQvF2= NVjHd2FsW0GQR1XS
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A4-Fuk MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTqb4hKSzVyPU[uNFgyOThizszN NF3WZWlUSU6JRWK=
NCI-H1581 M3L4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTZwMkO4OFkh|ryP M4DnVXNCVkeHUh?=
HUTU-80 M4L2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTZwM{[4PVch|ryP MmS1V2FPT0WU
TGW Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLmbXJFUUN3ME22MlQ2PTl|IN88US=> M{DmdHNCVkeHUh?=
SK-N-FI NYnTS4lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrZTWM2OD14LkS1PFU1KM7:TR?= M4POVHNCVkeHUh?=
U-266 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HCRmlEPTB;Nj61NVkzPiEQvF2= NF:1eFRUSU6JRWK=
EM-2 MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTZwNkewPVkh|ryP MVHTRW5ITVJ?
NMC-G1 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TCb2lEPTB;Nj63NVg6PSEQvF2= M37xV3NCVkeHUh?=
KASUMI-1 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;wTWM2OD14Lki0O|g4KM7:TR?= NH\ueZJUSU6JRWK=
NALM-6 NImxTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWzXZhKSzVyPU[uPFY4PTRizszN MoGxV2FPT0WU
OCI-AML2 NIm1c4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD4VZppUUN3ME23MlAxOzJ4IN88US=> MWXTRW5ITVJ?
SHP-77 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDwXGVUUUN3ME23MlIzPDNizszN M4rDXXNCVkeHUh?=
NOMO-1 NHTPVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvPNY4{UUN3ME23MlI1OjV2IN88US=> NWn3U3A6W0GQR1XS
SK-N-DZ NGTzWXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfjTWM2OD15LkexNFg6KM7:TR?= NXHIfYhuW0GQR1XS
LB1047-RCC MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUTWM2OD15LkeyNlMyKM7:TR?= NW[ydJVRW0GQR1XS
MZ1-PC MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rQR2lEPTB;Nz64OlU2QCEQvF2= Mmn0V2FPT0WU
NB10 NX\POW55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGftcm9KSzVyPUeuPVk2PTZizszN M1XvS3NCVkeHUh?=
RL95-2 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRThwMUC4OFIh|ryP Mn\pV2FPT0WU
OMC-1 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRThwNUKxPVEh|ryP M1XXbnNCVkeHUh?=
D-283MED NUHJPZhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRThwOUG3NVkh|ryP MormV2FPT0WU
MC116 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELQPHNKSzVyPUiuPVc6PCEQvF2= Mlq1V2FPT0WU
SJSA-1 MonQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTlwMEmwPVEh|ryP MYnTRW5ITVJ?
JiyoyeP-2003 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTlwMkmzNVch|ryP NX7HSIx4W0GQR1XS
IST-MEL1 NIHDTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe5UFZRUUN3ME25Mlc1OTl6IN88US=> NXnHPY9uW0GQR1XS
CTV-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFyLkC5O|kh|ryP NFW0O5dUSU6JRWK=
NH-12 NUT6[ZNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFyLkK0N|Mh|ryP Mny5V2FPT0WU
CA46 MkSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\aOYh3UUN3ME2xNE4{PjFizszN MoX1V2FPT0WU
NCI-SNU-1 NITFbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPsO|hQUUN3ME2xNE41QTZ7IN88US=> MnHuV2FPT0WU
SCLC-21H MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH0TWM2OD1zMD62OVk3KM7:TR?= NEHnSpRUSU6JRWK=
EC-GI-10 NYjW[nQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP3clZKSzVyPUGwMlcxOzFizszN MXXTRW5ITVJ?
SR NXfXTZdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFzLkCxPFUh|ryP NUHFZpZKW0GQR1XS
NCI-H1648 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X1dmlEPTB;MUGuNFk3PSEQvF2= M3;FUnNCVkeHUh?=
TGBC1TKB M4PYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjoTWM2OD1zMT60NVAzKM7:TR?= NEnLVXVUSU6JRWK=
EW-11 NHjjd4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3VTWM2OD1zMT61NVg3KM7:TR?= MoT6V2FPT0WU
SK-MM-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXITWM2OD1zMT64NFYyKM7:TR?= NFv0bFlUSU6JRWK=
NCI-H524 NXy2cHRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\oXGlEPTB;MUGuPVgzOiEQvF2= M{P6OHNCVkeHUh?=
NOS-1 NG\DUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPtTpBKSzVyPUGyMlA{PDVizszN NGjKcZZUSU6JRWK=
AM-38 NFv5fYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\wU2lEPTB;MUKuOVY{OyEQvF2= MWrTRW5ITVJ?
A498 MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT5TWM2OD1zMj63NFY6KM7:TR?= M4rRXXNCVkeHUh?=
KARPAS-422 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\hN21KSzVyPUGyMlc1QTZizszN NFXlPWJUSU6JRWK=
LU-139 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX3cWJKSzVyPUGyMlkxOjZizszN MX\TRW5ITVJ?
COR-L88 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF{LkmzPFIh|ryP M{K5O3NCVkeHUh?=
K5 NFXvUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TUdmlEPTB;MUKuPVQ3OiEQvF2= MUHTRW5ITVJ?
NB13 NGDpO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS5TWM2OD1zMj65O|g{KM7:TR?= NF;sRZpUSU6JRWK=
MRK-nu-1 NF7rNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\pOWFKUUN3ME2xN{4yQTVizszN M3;r[XNCVkeHUh?=
MHH-NB-11 NIH5cIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLtTWM2OD1zMz6yPVAzKM7:TR?= MYLTRW5ITVJ?
KU812 NV;FbnJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTiXWNxUUN3ME2xN{43OTJ2IN88US=> MkX3V2FPT0WU
TE-12 M4HLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTsTWM2OD1zMz62PVk1KM7:TR?= NITPTGFUSU6JRWK=
NCI-N87 NVTyWIw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe0[ndQUUN3ME2xN{44OzZizszN M1e1ZXNCVkeHUh?=
EB2 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLOTWM2OD1zMz64OVA2KM7:TR?= M4e1PHNCVkeHUh?=
DB MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC4NnlKSzVyPUGzMlk5QDVizszN NFz5S3VUSU6JRWK=
697 M1fy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPG[WFFUUN3ME2xOE41PTFzIN88US=> M1PpVXNCVkeHUh?=
MSTO-211H NVP6R2lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrOUG1KSzVyPUG0Mlc1PDhizszN Mn6wV2FPT0WU
JVM-2 NFzDW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF2Lke3N|Uh|ryP NFLuPHZUSU6JRWK=
COLO-824 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXJ[ZZKSzVyPUG0Mlc6QTRizszN NHPYSXVUSU6JRWK=
BC-3 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzDTWM2OD1zNT6zPVgh|ryP M4HVO3NCVkeHUh?=
BOKU NWTXSm9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnF[m43UUN3ME2xOU46PjB6IN88US=> NHPleoVUSU6JRWK=
GOTO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[xWWVyUUN3ME2xOk46PjF5IN88US=> NXvYO4F2W0GQR1XS
HCC2157 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLpTWM2OD1zNz60O|U2KM7:TR?= NUXvPJB3W0GQR1XS
LS-1034 NWXkcm5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy2b5pbUUN3ME2xO{43QDF6IN88US=> NGe1fW9USU6JRWK=
CAL-148 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHkTWM2OD1zNz65O|k3KM7:TR?= MYDTRW5ITVJ?
MOLT-4 M16zeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlm5TWM2OD1zOD64NlA5KM7:TR?= MkLmV2FPT0WU
Daudi NFXDfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vKU2lEPTB;MUiuPVI{OSEQvF2= NHqySGJUSU6JRWK=
J-RT3-T3-5 NVX4VZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF7LkSwOlYh|ryP MkHxV2FPT0WU
KMOE-2 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHjS5VKSzVyPUG5MlY1QDJizszN MYTTRW5ITVJ?
HL-60 NIr5WnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH1TWM2OD1{MD6xPVY2KM7:TR?= M2O4fHNCVkeHUh?=
P31-FUJ NX6wZoV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Lr[WlEPTB;MkCuOFc2OyEQvF2= NXHoOlY1W0GQR1XS
IM-9 NYLhTlRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H1[mlEPTB;MkCuOlIzPCEQvF2= M3zGb3NCVkeHUh?=
HDLM-2 NVjQRppnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPyZ5RCUUN3ME2yNE45QDJzIN88US=> NU\aNmh{W0GQR1XS
NCI-H1304 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXZXZpKSzVyPUKxMlA{OTFizszN M4[2THNCVkeHUh?=
NCI-H345 M2XxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PYWmlEPTB;MkGuNFY1OyEQvF2= M2DKdHNCVkeHUh?=
RPMI-6666 MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDBdGFKSzVyPUKxMlM3ODJizszN MYDTRW5ITVJ?
GR-ST NI\INWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LYNWlEPTB;MkGuOFE4KM7:TR?= MWPTRW5ITVJ?
CHP-126 NEW5[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJzLk[xPFEh|ryP MoTCV2FPT0WU
EHEB MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJzLk[3N|Eh|ryP NIXvR4hUSU6JRWK=
CPC-N M3\LS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ2LkCyNFEh|ryP M3vTNHNCVkeHUh?=
NB1 NXjSWlZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ2Lk[5N|kh|ryP NYHOWZpvW0GQR1XS
LS-123 NGL6eHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;0VHNjUUN3ME2yOE46ODF{IN88US=> M2O5SHNCVkeHUh?=
ST486 NFfPdnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LGeGlEPTB;MkWuNVEyOyEQvF2= MkXLV2FPT0WU
NCI-H1963 NGjEfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2wTWM2OD1{Nj6wOlI{KM7:TR?= MofSV2FPT0WU
U-87-MG NUPrXFNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\uTWM2OD1{Nj63OlQ1KM7:TR?= NFL5fmdUSU6JRWK=
COR-L279 NH;xO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\aR2lEPTB;Mk[uO|kzOiEQvF2= M3nqS3NCVkeHUh?=
LU-165 NWLrSVBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnNO|VMUUN3ME2yPE4xQDZzIN88US=> MljJV2FPT0WU
COLO-800 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfIV45KSzVyPUK4MlI6PTZizszN NUPNbmU6W0GQR1XS
ETK-1 NIO4OJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1f3RmlEPTB;MkiuN|Q1PiEQvF2= Mn\IV2FPT0WU
LNCaP-Clone-FGC NX7qbG9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUix[WVsUUN3ME2yPU46OjhzIN88US=> NIqwOmVUSU6JRWK=
SIG-M5 NEDIVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTNyLke5OVIh|ryP NH7DNYdUSU6JRWK=
NB6 NGflWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD1c3hpUUN3ME2zNE46PTB|IN88US=> NIHrNmdUSU6JRWK=
NCI-H2107 M2PXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHWdZhKSzVyPUOxMlI{OzhizszN Mnf0V2FPT0WU
SNU-C1 M3TK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fs[GlEPTB;M{GuN|EzPiEQvF2= NHXqXGNUSU6JRWK=
JAR M2nS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:yNXN{UUN3ME2zNU4{Pzl7IN88US=> NV7RPIJJW0GQR1XS
L-363 NWTO[3ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXJTWM2OD1|Mj6yNVQ1KM7:TR?= MXjTRW5ITVJ?
EW-24 NWXmRlFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTN{LkO0O|Qh|ryP MYXTRW5ITVJ?
NB69 NXvSVY9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXDVVhnUUN3ME2zN{43PDV2IN88US=> MmrsV2FPT0WU
EW-13 M2POWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf4b|JKSzVyPUOzMlg6PjlizszN NVXwfZZ6W0GQR1XS
Ramos-2G6-4C10 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN2LkK5PVMh|ryP NVXSOm5JW0GQR1XS
TE-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjpcWNKSzVyPUO0MlQ5OjJizszN Ml73V2FPT0WU
L-428 NVjMcVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m3PGlEPTB;M{SuO|U{PiEQvF2= NVPVW|NnW0GQR1XS
KP-N-YN MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfN[XVKSzVyPUO0MlkxPTdizszN MWHTRW5ITVJ?
CGTH-W-1 NWXJcmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN4LkmwOFgh|ryP MoC1V2FPT0WU
K-562 M3v3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT2UYZKSzVyPUO3MlA5PjRizszN NEnVeXpUSU6JRWK=
NCI-H1299 NVXSeJo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTN6LkG2NFMh|ryP Ml71V2FPT0WU
RCC10RGB NYnxcoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7WTWM2OD1|OD6yNFg{KM7:TR?= NHTLTXJUSU6JRWK=
NCI-SNU-16 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjsUIg2UUN3ME2zPE42PjV|IN88US=> NHmwUpZUSU6JRWK=
LC-2-ad MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XBdmlEPTB;M{muOFM{PyEQvF2= MYfTRW5ITVJ?
MHH-PREB-1 NHHnelZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN7LkezPFgh|ryP NVfmOHF7W0GQR1XS
NCI-H64 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljrTWM2OD12MD6wPVQ5KM7:TR?= NXrxR3ZKW0GQR1XS
LB996-RCC NXr4XYJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PTeGlEPTB;NECuPFcyPiEQvF2= Mnz2V2FPT0WU
DEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NESxNIhKSzVyPUSxMlQ1ODVizszN M2LGXHNCVkeHUh?=
MLMA M1SzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTRzLke1PVUh|ryP MULTRW5ITVJ?
SBC-1 NEfveJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDlUmtSUUN3ME20Nk4yQDB4IN88US=> M{H0OnNCVkeHUh?=
MPP-89 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nlZWlEPTB;NEKuOVg4PSEQvF2= M2TxZnNCVkeHUh?=
MV-4-11 NY\Z[mdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TIfGlEPTB;NEKuPVA3PyEQvF2= MlXpV2FPT0WU
EoL-1- M{PSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO1TWM2OD12ND6xOVY5KM7:TR?= MX;TRW5ITVJ?
CW-2 NXfhZnJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S0T2lEPTB;NESuPFM1OiEQvF2= M2PscXNCVkeHUh?=
HT MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTR3LkewNFch|ryP NID1fnBUSU6JRWK=
SW954 M3X6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL3TYFKSzVyPUS3MlQyOjhizszN NVjKWmpQW0GQR1XS
A3-KAW M{POcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjObVRDUUN3ME20PU45ODZzIN88US=> NHHINYFUSU6JRWK=
TC-YIK M1z6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj2Um1JUUN3ME21NE4xOzZ|IN88US=> NWHESGh4W0GQR1XS
SW962 NWfG[GluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTV2LkizOVch|ryP MUnTRW5ITVJ?
KP-N-RT-BM-1 NIfaVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLsWZhZUUN3ME21Ok43PjN6IN88US=> MoHHV2FPT0WU
NCI-H1395 M2HhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fDXGlEPTB;NUiuPFE4OiEQvF2= MY\TRW5ITVJ?
RPMI-8402 NHjlNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDS[|lyUUN3ME21PE46PTJ4IN88US=> NWnSNGUyW0GQR1XS
SCH NGXRNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZyLkm2N|gh|ryP MV\TRW5ITVJ?
NCI-H2196 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLLd3lwUUN3ME22NU4zOzFizszN NUXTZppqW0GQR1XS
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TUR Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD1zNkeuPFch|ryP MWfTRW5ITVJ?
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REH NF\odXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPiTWM2OD1{M{[uOlI3KM7:TR?= M2HJUHNCVkeHUh?=
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P30-OHK NWTuW2JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn75TWM2OD1{OEOuPFQ4KM7:TR?= MWnTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Protocol

Kinase Assay
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Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research
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  • Cell lines: KIM-2, HC11, and ES
  • Concentrations: Dissolved in DMSO, final concentrations ~25 μM
  • Incubation Time: 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (Only for Reference)
Animal Research
+ Expand
  • Animal Models: Male mdx (C57BL/10ScSn DMD mdx) mice
  • Formulation: Dissolved in DMSO, and diluted in PBS
  • Dosages: ~10 μg/kg/day
  • Administration: Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+20% propylene glycol+ddH2O 2mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 475.62
Formula

C26H41N3O5

CAS No. 133407-82-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID