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MG-132 Chemical Structure
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Biological Activity
MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively. The Ki of MG132 is 4 nM. MG132 inhibits TNF-α-induced NF-κB activation and IκBα degradation with an IC50 of 3 µM and prevents β-secretase cleavage. MG132 induces neurite outgrowth in PC12 cells and has anticancer properties in vitro. MG132 reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. [1][2][3]
References on MG-132
- [1] J. Biochem 1996;119:, 572-576
- [2] http://en.wikipedia.org/wiki/MG132 ;
- [3] J BiolChem. 2001 Feb 9;276(6):4476-84.
Chemical Information
| Molecular Weight (WM): | 475.62 |
|---|---|
| Formula: | C26H41N3O5 |
| CAS No.: | 133407-82-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥95mg/mL |
| Water <1mg/mL | |
| Ethanol ≥95mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Selleck's high quality products have been used in several published research findings, including the following:
miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma.
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Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1 – 4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 mM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot). - Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1 – 4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 mM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).
Data independently produced by Dr. Edison DUKE-NUS Graduate Medical School Singapore. MG-132 purchased from Selleck
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| Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1 – 4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 mM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot). |
Data independently produced by Dr. Edison DUKE-NUS Graduate Medical School Singapore.
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