MG-132

Catalog No.S2619

MG-132 Chemical Structure

Molecular Weight(MW): 475.62

MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.

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In DMSO USD 100 In stock
USD 50 In stock
USD 170 In stock
USD 470 In stock

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Cited by 46 Publications

9 Customer Reviews

  • MDA-MB-231 cells were treated with 10 uM MG132 and incubated under normoxia or hypoxia for 4 h. Endogenous interaction between LATS2 and SIAH2 was analysed by immunoprecipitation.

    Nat Cell Biol 2015 17(1), 95-103. MG-132 purchased from Selleck.

    HeLa cells were transfected with control mimic, RMND5A siRNA or miR-138 mimic. After transfection for 36 h, cells were treated with proteasome inhibitor MG132 (20 uM) or Dimethyl sulfoxide (DMSO) for 8 h. Endogenous Exportin-5 protein and RMND5A protein expression was measured by western blotting.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

  • HeLa cells were transfected with negative control mimic, miR-138 mimic or RMND5A siRNA. After transfection for 36 h, cells were treated with MG132 (20 uM) or DMSO for 8 h. RMND5A and Exportin-5 protein expression were analyzed by immunocytochemistry. Nuclei were counterstained with DAPI.

    Nucleic Acids Res 2014 42(1), 458-74. MG-132 purchased from Selleck.

     

    TFEB induced autophagy dependent ATZ clearance in vitro. MEF transiently co-transfected with either ATZ plus GFP expressing plasmids or ATZ plus TFEB expressing plasmids were incubated with proteasome inhibitor MG132 or with DMSO for 6 h. Upon MG132 treatment, steady state levels of 52 kDa ATZ band increased in both cells transfected with ATZ plus GFP and with ATZ plus TFEB expressing plasmids. Quantification of band intensities showed a 48% reduction of ATZ in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP, in the absence of the proteasome inhibitor. In MG132 treated cells, a 61% decrease of ATZ was detected in cells transfected with ATZ plus TFEB compared to cells transfected with ATZ plus GFP.

    EMBO Mol Med 2013 5, 397-412. MG-132 purchased from Selleck.

  • JAK1 expression was analyzed in A375 cells expressing scrambled shRNA or shRNF125 (#2) and treated with MG132 (5 uM, 10 hr), and in Lu1205 cells expressing WT RNF125 and treated with MG132.

    Cell Rep 2015 11(9), 1458-73. MG-132 purchased from Selleck.

    LRB1 and LRB2 regulate phyB protein levels. PhyB protein levels in crude extracts from the wild type (WT) and the indicated mutant backgrounds were assayed by immunoblot analysis with anti-phyB monoclonal antibodies. Anti-PBA1 and anti-histone H3 antibodies were used to confirm equal protein loading. Rc-induced loss of phyB in the wild type is inhibited by 100 uM MG132.

    Plant Physiol 2012 60(1), 118-34. MG-132 purchased from Selleck.

  • Representative images for γ-H2AX-stained cells treated with 100 uM FA for 3 h without or with MG132. Fluorescence was measured in at least 50 nuclei in each of three experiments.

    Toxicol Appl Pharmacol 2015 286(2), 135-41. MG-132 purchased from Selleck.

    GSK-3β phosphorylation at Ser9 is enhanced in NOK-overexpressed stable cell lines. The proteasome inhibitor, MG132, was added in medium of HeLa-HA and HeLa-NOK-HA cells for 12 h and then the p-GSK-3b(Ser9) was assayed by western blotting.

    FEBS Lett 2012 586, 3787–3792. MG-132 purchased from Selleck.

  • Truncated mouse Period2 (Per2) protein was expressed in NIH3T3 cells, treated by cycloheximide with or without MG132 for 1-4 hours.Per2 was reported to be degraded by the proteasome proteolysis. By adding MG132 (25 μM), a proteasome inhibitor, the degradation of Per2 was dramatically decreased within 4 hours treatment (shown by western blot).

    2012 Dr. Edison DUKE-NUS Graduate Medical School Singapore.. MG-132 purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description MG-132 is an inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 μM.
Targets
Proteasome [1]
(Cell-free assay)
100 nM
In vitro

MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. [1] MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. [2] MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [3] Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. [4] MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). [5] MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LPS-stimulated RAW264.7 cells MUTGeY5kfGmxbjDBd5NigQ>? MUGyOUDPxE1? M3v0dmROW09? M4X0W2lvcGmkaYTzJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjFizszN MojYNlQ3QTd2OU[=
HL-60 NGLVcJNEgXSxdH;4bYMhSXO|YYm= NE\4THY1OCEQvF2= MYK0PEBp MWrEUXNQ MonOTWM2ODxzMDFOwG0> M1PsUlI1Pjl5NEm2
SMMC-7721 M3zYeGN6fG:2b4jpZ{BCe3OjeR?= NYTrV3YxPDBizszN NYHafmpPPDhiaB?= MnPOSG1UVw>? NU\LflBrUUN3ME23MlEh|ryP M1nPNVI1Pjl5NEm2
A-549 MkjER5l1d3SxeHnjJGF{e2G7 NWnxdFE2PDBizszN MnLWOFghcA>? NXvvTHhzTE2VTx?= Ml7UTWM2ODxzMDFOwG0> M{LXNFI1Pjl5NEm2
MCF-7 MkG0R5l1d3SxeHnjJGF{e2G7 M4TFeFQxKM7:TR?= MmPmOFghcA>? MofKSG1UVw>? NXO5dnNQUUN3ME23MlMh|ryP NFrVXoUzPDZ7N{S5Oi=>
SW-480 MkT0R5l1d3SxeHnjJGF{e2G7 M3LGSFQxKM7:TR?= NYnwc5RKPDhiaB?= MlzuSG1UVw>? M1HtVWlEPTB;NDFOwG0> NFnObI4zPDZ7N{S5Oi=>
NCI-H929 NELJcW5EgXSxdH;4bYMhSXO|YYm= NUDqRotMOSEQvF2= MoHwO|IhcA>? NFLlbW9FVVOR M17FfGlEPTB;MD6xO{DPxE1? M1fRRlI1PjJ3MEi4
293T NIrJeJhEgXSxdH;4bYMhSXO|YYm= MnjWNVAh|ryP MUO3NkBp NH\IZ|lFVVOR NGLGSnFKSzVyPEKg{txO NGGzVnQzPDZ{NUC4PC=>
293T MkG0SpVv[3Srb36gRZN{[Xl? M{n1cFExKM7:TR?= M3yzTFI1KGh? NV3rfVJYTE2VTx?= M2qyWm1w\GW{YYTlcJkhcW6mdXPld{Bp\WG2LYPoc4NsKCB? M4DESVI1PjJ3MEi4
HeLa NYTq[2lPU2mwYYPlJGF{e2G7 MnLqNVAh|ryP NEHpdFIyKGh? NWTMT|N3TE2VTx?= NFfF[mFKdmS3Y3XzJHBCWlBiY3zlZZZi\2ViYomgbY5pcWKrdHnu[{Bxem:|ZXHzc41mKGGldHn2bZR6 NInLd2gzPDN{MUizNy=>
MDA-MB-231 NYrrbJp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnqNUDPxE1? MkfCO|IhcA>? MVjEUXNQ Mn7ETWM2OD1yLkG4JO69VQ>? NI\VTmozPDF3M{KwOi=>
MCF-7 NXSy[WhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP6S4kyKM7:TR?= NX\ib4N7PzJiaB?= MU\EUXNQ M{jrNWlEPTB;MD6xN{DPxE1? MVGyOFE2OzJyNh?=
MCF10A MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVyxJO69VQ>? NGDQTVE4OiCq MmrSSG1UVw>? MoHvTWM2OD1yLkK5JO69VQ>? NEfRNVkzPDF3M{KwOi=>
HEK-293 MVTLbY5ie2ViQYPzZZk> NISxNJEzKGGwZDCyNEDPxE1? NGrSbHIzKGh? NF2yVGRFVVOR MUHJcohq[mm2czDDbHQuVCCjY4Tpeol1gSC5aYToJGlEPTBib3[gPUBvVSB? NYW4OmM3OjN3NEC3PVA>
Calu6 MnjxSpVv[3Srb36gRZN{[Xl? M2H0N|ExKM7:TR?= NIHUcXUyQCCq M4WyOGROW09? MlzoV4lodmmoaXPhcpRtgSCjY3P1cZVt[XSnczDmdoF1[XirbjDwdoVkfXK|b4K= MoTBNlM2ODZ2OE[=
IFN-gamma-induced RAW264.7 NITmbIxHfW6ldHnvckBCe3OjeR?= M3\0emROW09? NF\HWYRKdmirYnn0d{BvcXS{aXOgc5hq\GVicILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOC5yN{eg{txO M{TlU|IzOjd5Mke3
IPC227F MW\DfZRwfG:6aXOgRZN{[Xl? M1P4PFEh|ryP MUO0PEBp NFvyNG9FVVOR MWnJR|UxRTBwMEe3JO69VQ>? MUCyNVkzPDV{OB?=
Hepa-1c1c7 MnvSSpVv[3Srb36gRZN{[Xl? NFfrUFUzPSEQvF2= NWT4OpRsPiCq NFTvRVlFVVOR M1HxSWlv[3KnYYPld{BPemZ{IIDyc5RmcW5ibHX2[Yw> NVP6TYxNOjB|OUK1OFQ>
COS-7 MVfDfZRwfG:6aXOgRZN{[Xl? MX2xNEDPxE1? MWLEUXNQ MoHGTWM2ODxzMDFOwG0> NXW3NJNGOThyOEiwPVc>
HuH-7 M4nKXWN6fG:2b4jpZ{BCe3OjeR?= MWOxNEDPxE1? MknFSG1UVw>? NY[4OFlPUUN3MEyxNEDPxE1? NX3qUIxsOThyOEiwPVc>
OCI-Ly3 NFvmXotHfW6ldHnvckBCe3OjeR?= MUixNEDPxE4EoB?= NXfuOZdmPCCq MV;EUXNQ MWrJcoR2[2W|IHj1cYFvKEmtYYDwZWJidHCqYTDzeIFjcWyrenH0bY9vKHerdHigSWM2OCCxZjCxJO69VQ>? NUC0SmNiOThyMkSxNVM>
A2780 cDDP MVjBdI9xfG:|aYOgRZN{[Xl? NIPTbWQzPCCq NYXPPXZYTE2VTx?= M1THc2lv\HWlZYOgZZBweHSxc3nzJIJ6KGmwaHnibZRqdmdiUGTFUkBl\We{YXTheIlwdg>? NGTMepYyPzZ6NECxPC=>
LPS-stimulated RAW264.7 cells M4XOOGZ2dmO2aX;uJGF{e2G7 MVfEUXNQ M4HxOGlvcGmkaYTzJG5HNWujcIDhRkBFVkFiYnnu[Ilv\w>? MkjKNVc1ODd{N{e=
PC12 NXPpToNiTnWwY4Tpc44hSXO|YYm= M320bFExOCEQvF5CpC=> NHT5TXczPCCq NXHxendkTE2VTx?= NU\ZOI12UW6qaXLpeJMhPi2RSFTBMUBidmRiSELPNk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gQ>? MnP3NVcyPTh2NUS=
PC3 MmOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke3NlAh|ryP MV:0PEBp NXfE[HV6TE2VTx?= NY\WbnBpUUN3ME2wMlYh|ryP Mny0NVY3QDZ3M{e=
LP-1 NUnxTmNKSXCxcITvd4l{KEG|c3H5 MlvaN|AxKG6P M1jhUlI1KGh? MlnnSG1UVw>? Mk\RTY5lfWOnczDhdI9xfG:|aYOgZpkhcW6lcnXhd4lv\yClbHXheoVlKFCDUmCgcIV3\WxiYX7kJJJm\HWlaX7nJG1kdC1zIIDyc5RmcW5ibHX2[Yw> MorDNVU6PTh3OEm=
ES6 M4nmc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEGzNFYh|ryP NHftXXpUSU6JRWK=
A101D MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NImwWVVKSzVyPUCuNFMzPzlizszN M2riSnNCVkeHUh?=
OCUB-M Mk\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLFTWM2OD1yLkCzO|M4KM7:TR?= Mo[wV2FPT0WU
LB2518-MEL NGHTUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTCOHVKSzVyPUCuNFM4PiEQvF2= NV;uWpM2W0GQR1XS
SH-4 NVvxXlR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz6S3plUUN3ME2wMlA1OzFizszN MmDQV2FPT0WU
KNS-42 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjCOXlNUUN3ME2wMlA1PDRzIN88US=> Mn7pV2FPT0WU
DSH1 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zNTWlEPTB;MD6wOVI5QSEQvF2= NUK0OWZJW0GQR1XS
NTERA-S-cl-D1 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\4OZFKSzVyPUCuNFU4PzJizszN NWnzNY06W0GQR1XS
D-542MG MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DoZWlEPTB;MD6wOVk2PyEQvF2= M1zVWHNCVkeHUh?=
KS-1 NWjNdZF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4npdWlEPTB;MD6wOlQ2QCEQvF2= NVXkfGtDW0GQR1XS
BL-41 NEnOXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwME[5OFch|ryP Mn\ZV2FPT0WU
LXF-289 NWHnNZpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEewOlYh|ryP NU[yUYhUW0GQR1XS
D-247MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[3TWM2OD1yLkC3NlA6KM7:TR?= M{\oWHNCVkeHUh?=
MMAC-SF NXzndpRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPpNXU5UUN3ME2wMlA4OjZ6IN88US=> NFL3dI1USU6JRWK=
CP66-MEL NXv1cppUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37WU2lEPTB;MD6wO|Uh|ryP MmXtV2FPT0WU
LB771-HNC NYjRdGtqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm1PIlzUUN3ME2wMlA5ODN4IN88US=> NUjzTlVRW0GQR1XS
no-10 NGrwZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLyOnFKSzVyPUCuNFg6ODlizszN MnXoV2FPT0WU
A388 NXi3VoNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u4emlEPTB;MD6wPVA3PSEQvF2= NFHYNo9USU6JRWK=
OPM-2 NHPkU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMUC0O|Qh|ryP NFvIbJNUSU6JRWK=
OVCAR-4 M4PPNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fNXGlEPTB;MD6xNFk{QCEQvF2= NYPPXVQ4W0GQR1XS
HOP-62 M17OTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTzTWM2OD1yLkGwPVQ6KM7:TR?= NIX5NIZUSU6JRWK=
ML-2 NFP4eXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLsflVKSzVyPUCuNVE5ODZizszN NIH0dmtUSU6JRWK=
UACC-257 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OwU2lEPTB;MD6xNVkzPyEQvF2= NGDBTllUSU6JRWK=
NEC8 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPLTWM2OD1yLkGxPVk2KM7:TR?= MXTTRW5ITVJ?
ONS-76 M4TmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHKRXpKSzVyPUCuNVI6OzVizszN NHHyeIJUSU6JRWK=
KE-37 M2e2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6T2lEPTB;MD6xN|I4QCEQvF2= NXn0XItTW0GQR1XS
HT-144 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMUO4PVUh|ryP MoTBV2FPT0WU
LB2241-RCC M2j3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfPTWM2OD1yLkG0NlQ4KM7:TR?= NHOy[G1USU6JRWK=
TE-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETVV|BKSzVyPUCuNVQzPzhizszN MXTTRW5ITVJ?
KINGS-1 M3XN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NICyNXlKSzVyPUCuNVQ4QSEQvF2= MoHFV2FPT0WU
NCI-H69 NV\UXpZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;NOmlEPTB;MD6xOVE1OSEQvF2= NELC[WdUSU6JRWK=
CAS-1 NUjGfYZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkezTWM2OD1yLkG1OFgzKM7:TR?= MkXNV2FPT0WU
D-263MG NWHwcXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMU[wNFYh|ryP NI\LXpJUSU6JRWK=
A253 M2TwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPWO49YUUN3ME2wMlE3OTJ6IN88US=> NWnTfYRvW0GQR1XS
PF-382 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi2VFdKSzVyPUCuNVY4ODZizszN MWDTRW5ITVJ?
CESS NGXkdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX65TFNCUUN3ME2wMlE4ODZizszN MlW5V2FPT0WU
MZ2-MEL MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml64TWM2OD1yLkG3OVU6KM7:TR?= NFzKVJdUSU6JRWK=
HEL MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q3SGlEPTB;MD6xPFUyPyEQvF2= M1LteXNCVkeHUh?=
D-392MG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f3N2lEPTB;MD6xPVEyPSEQvF2= MVLTRW5ITVJ?
SK-LMS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUmzNFMh|ryP NHz3XHhUSU6JRWK=
GI-ME-N NIHSS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H2V2lEPTB;MD6xPVMxPiEQvF2= M3P4S3NCVkeHUh?=
LB831-BLC NH[4R4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTYPY9KSzVyPUCuNVk{PCEQvF2= NUn0bok2W0GQR1XS
DU-4475 NHLvSnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMUm2OVgh|ryP M{O3S3NCVkeHUh?=
IST-SL1 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzycpRbUUN3ME2wMlIxODl2IN88US=> MXXTRW5ITVJ?
GAK NWrXdHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMkC1N|Qh|ryP NEPZNHpUSU6JRWK=
EW-1 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMkGwOFch|ryP MVvTRW5ITVJ?
LAMA-84 M{XWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjRNXY1UUN3ME2wMlIyQDVzIN88US=> NH;XTnJUSU6JRWK=
SK-UT-1 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nyT2lEPTB;MD6yNlA1QSEQvF2= M1LGPHNCVkeHUh?=
VA-ES-BJ M3Tse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOzcIRKSzVyPUCuNlIzPTdizszN MYXTRW5ITVJ?
ACN M1jZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;nTWM2OD1yLkKyOlM5KM7:TR?= NFzreGxUSU6JRWK=
SK-PN-DW MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L1VGlEPTB;MD6yN|E6KM7:TR?= MVzTRW5ITVJ?
HD-MY-Z MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMkOzNFMh|ryP NEW0bY5USU6JRWK=
LB373-MEL-D NHTJRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzjTWM2OD1yLkK0NVk5KM7:TR?= NWPZcppZW0GQR1XS
COLO-829 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX1fG91UUN3ME2wMlI1OjV5IN88US=> MmXDV2FPT0WU
ES8 M3i2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMkS3OlMh|ryP NH7zWGhUSU6JRWK=
RXF393 NXTGUY9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGzTWM2OD1yLkK1NFE2KM7:TR?= NEHR[pRUSU6JRWK=
TK10 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMkW0N|Uh|ryP MoPTV2FPT0WU
LOUCY MmeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMkW0OVYh|ryP NYjOOFVHW0GQR1XS
MZ7-mel M1jIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:0ZnFKSzVyPUCuNlY{PzRizszN NV;0Z2VOW0GQR1XS
CP67-MEL NFr3clVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3QTWM2OD1yLkK2O|Mh|ryP MUfTRW5ITVJ?
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NCI-H128 M1Hrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X2bGlEPTB;MT6zOVgyPCEQvF2= MUjTRW5ITVJ?
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NCI-H2227 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnmTWM2OD1zLk[xOVYyKM7:TR?= NWrZbXdPW0GQR1XS
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NCI-H748 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTQRVdmUUN3ME2zMlQ1OjZ4IN88US=> NVT0THZzW0GQR1XS
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A4-Fuk MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHwbmRiUUN3ME22MlA5OTF6IN88US=> NWnyPZBHW0GQR1XS
NCI-H1581 M4PaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTZwMkO4OFkh|ryP NUTlV2Q{W0GQR1XS
HUTU-80 NFvuSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f3V2lEPTB;Nj6zOlg6PyEQvF2= NF\1T3NUSU6JRWK=
TGW Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHQSFRKSzVyPU[uOFU2QTNizszN NFKz[JhUSU6JRWK=
SK-N-FI MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLwWJdJUUN3ME22MlQ2QDV2IN88US=> MYHTRW5ITVJ?
U-266 NGPjNm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTjOYo4UUN3ME22MlUyQTJ4IN88US=> NYO3bGhNW0GQR1XS
EM-2 NF;ycI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnGTYMxUUN3ME22MlY4ODl7IN88US=> NFzoZZBUSU6JRWK=
NMC-G1 NFXucJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfGSopUUUN3ME22MlcyQDl3IN88US=> MXTTRW5ITVJ?
KASUMI-1 NGPZZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7hc5hKSzVyPU[uPFQ4QDdizszN NE\F[5ZUSU6JRWK=
NALM-6 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjOnpKSzVyPU[uPFY4PTRizszN MVLTRW5ITVJ?
OCI-AML2 NHLEPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXRTWM2OD15LkCwN|I3KM7:TR?= NUHYO5JQW0GQR1XS
SHP-77 NX7CboUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy2NoJJUUN3ME23MlIzPDNizszN NIrq[2ZUSU6JRWK=
NOMO-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzON2ZjUUN3ME23MlI1OjV2IN88US=> NXnKb|AzW0GQR1XS
SK-N-DZ NX;EeHlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTdwN{GwPFkh|ryP NEnWVIdUSU6JRWK=
LB1047-RCC NGPnRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTdwN{KyN|Eh|ryP M3u5fXNCVkeHUh?=
MZ1-PC NEnqPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfsTWM2OD15Lki2OVU5KM7:TR?= M4np[nNCVkeHUh?=
NB10 NH3wPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXUcGppUUN3ME23Mlk6PTV4IN88US=> NH;BUnlUSU6JRWK=
RL95-2 NVqxN282T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrzUow4UUN3ME24MlExQDR{IN88US=> NU\PR2M1W0GQR1XS
OMC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW3TWM2OD16LkWyNVkyKM7:TR?= MlzCV2FPT0WU
D-283MED NXnBNmhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRThwOUG3NVkh|ryP M33MVHNCVkeHUh?=
MC116 NUnKWWY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy2OVVUUUN3ME24Mlk4QTRizszN M{[4[3NCVkeHUh?=
SJSA-1 NHS2XHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLzTWM2OD17LkC5NFkyKM7:TR?= NYfxcW1LW0GQR1XS
JiyoyeP-2003 NFnX[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfpPVlKSzVyPUmuNlk{OTdizszN M1rPd3NCVkeHUh?=
IST-MEL1 MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTlwN{SxPVgh|ryP MWjTRW5ITVJ?
CTV-1 MonhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTFyLkC5O|kh|ryP M1;KTXNCVkeHUh?=
NH-12 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELuZ4VKSzVyPUGwMlI1OzNizszN NFHtTHZUSU6JRWK=
CA46 M3;RN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\tTWM2OD1zMD6zOlEh|ryP NH[xT3dUSU6JRWK=
NCI-SNU-1 NULSOG1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTFyLkS5Olkh|ryP Mni3V2FPT0WU
SCLC-21H NGfSW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XXVGlEPTB;MUCuOlU6PiEQvF2= NWW2[IRuW0GQR1XS
EC-GI-10 M1yxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTFyLkewN|Eh|ryP MX3TRW5ITVJ?
SR MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H3NmlEPTB;MUGuNFE5PSEQvF2= NInkRWNUSU6JRWK=
NCI-H1648 M4XCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzZVnlKSzVyPUGxMlA6PjVizszN MY\TRW5ITVJ?
TGBC1TKB NUKw[ZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF60eIRKSzVyPUGxMlQyODJizszN MUXTRW5ITVJ?
EW-11 NGTrNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme4TWM2OD1zMT61NVg3KM7:TR?= MXvTRW5ITVJ?
SK-MM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFzLkiwOlEh|ryP MkDaV2FPT0WU
NCI-H524 M1:0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFzLkm4NlIh|ryP NF\ZbopUSU6JRWK=
NOS-1 NInjXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP1TWM2OD1zMj6wN|Q2KM7:TR?= MmnwV2FPT0WU
AM-38 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3zb5ZKSzVyPUGyMlU3OzNizszN M2DYPHNCVkeHUh?=
A498 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v3[mlEPTB;MUKuO|A3QSEQvF2= NH3CT4tUSU6JRWK=
KARPAS-422 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDHTWM2OD1zMj63OFk3KM7:TR?= NXPacGtZW0GQR1XS
LU-139 NFPYeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInlNGNKSzVyPUGyMlkxOjZizszN MnToV2FPT0WU
COR-L88 M3Hkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzjeIJKSzVyPUGyMlk{QDJizszN NX2yOHIzW0GQR1XS
K5 M4DoUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF{Lkm0OlIh|ryP MWjTRW5ITVJ?
NB13 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF{Lkm3PFMh|ryP M3HXRnNCVkeHUh?=
MRK-nu-1 NWXSOVlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHyeXZjUUN3ME2xN{4yQTVizszN MVnTRW5ITVJ?
MHH-NB-11 M4nUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF|LkK5NFIh|ryP NGjKPGpUSU6JRWK=
KU812 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF|Lk[xNlQh|ryP NYT0TVJyW0GQR1XS
TE-12 NWf1dJB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojTTWM2OD1zMz62PVk1KM7:TR?= NHjRZplUSU6JRWK=
NCI-N87 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ZdGlEPTB;MUOuO|M3KM7:TR?= NIjYOJhUSU6JRWK=
EB2 M1XITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPVTWM2OD1zMz64OVA2KM7:TR?= NHnrZpJUSU6JRWK=
DB MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17zW2lEPTB;MUOuPVg5PSEQvF2= NHy3VY5USU6JRWK=
697 M1mzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULhblNoUUN3ME2xOE41PTFzIN88US=> NYO1bGF2W0GQR1XS
MSTO-211H M2nWZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rVdGlEPTB;MUSuO|Q1QCEQvF2= MULTRW5ITVJ?
JVM-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;WXFJEUUN3ME2xOE44PzN3IN88US=> MXPTRW5ITVJ?
COLO-824 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LlRmlEPTB;MUSuO|k6PCEQvF2= NWDQXmx5W0GQR1XS
BC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLwPGxKSzVyPUG1MlM6QCEQvF2= NHfBPJFUSU6JRWK=
BOKU NIXnUXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqyTWM2OD1zNT65OlA5KM7:TR?= MVzTRW5ITVJ?
GOTO NH3MUpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL6PI9KSzVyPUG2Mlk3OTdizszN NYrQSJF[W0GQR1XS
HCC2157 M{TCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnQO5RTUUN3ME2xO{41PzV3IN88US=> Mnu0V2FPT0WU
LS-1034 NF6yWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\nNWNKSzVyPUG3MlY5OThizszN NXrwfY9MW0GQR1XS
CAL-148 Ml;sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDYUlFiUUN3ME2xO{46Pzl4IN88US=> MWjTRW5ITVJ?
MOLT-4 M1\hdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHHdWNlUUN3ME2xPE45OjB6IN88US=> NVO3eJh3W0GQR1XS
Daudi NIezWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;CeXFKSzVyPUG4MlkzOzFizszN M2S3XHNCVkeHUh?=
J-RT3-T3-5 MlvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF7LkSwOlYh|ryP NFLNSpRUSU6JRWK=
KMOE-2 NID2OIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv2TWM2OD1zOT62OFgzKM7:TR?= MnHnV2FPT0WU
HL-60 M{Hk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJyLkG5OlUh|ryP MmnmV2FPT0WU
P31-FUJ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r3d2lEPTB;MkCuOFc2OyEQvF2= NFO4coZUSU6JRWK=
IM-9 M2C3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17wSWlEPTB;MkCuOlIzPCEQvF2= NYraXo1kW0GQR1XS
HDLM-2 M1LITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2G4WWlEPTB;MkCuPFgzOSEQvF2= M13BSXNCVkeHUh?=
NCI-H1304 M3nlXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfvTWM2OD1{MT6wN|EyKM7:TR?= MUHTRW5ITVJ?
NCI-H345 NWPlfFB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;J[2lEPTB;MkGuNFY1OyEQvF2= NHPq[phUSU6JRWK=
RPMI-6666 M2DCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjLNIlKSzVyPUKxMlM3ODJizszN MVvTRW5ITVJ?
GR-ST NHjo[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HReGlEPTB;MkGuOFE4KM7:TR?= MVzTRW5ITVJ?
CHP-126 NYqwd2NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHC[mNKSzVyPUKxMlYyQDFizszN NXHW[FgzW0GQR1XS
EHEB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXQdGppUUN3ME2yNU43PzNzIN88US=> MkC4V2FPT0WU
CPC-N MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnBZmFFUUN3ME2yOE4xOjBzIN88US=> M4nSeXNCVkeHUh?=
NB1 M1f2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXLcmZOUUN3ME2yOE43QTN7IN88US=> NWGzPYQ4W0GQR1XS
LS-123 NEfreJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ2LkmwNVIh|ryP M2HQVnNCVkeHUh?=
ST486 NVvwZWh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi5[oVKSzVyPUK1MlEyOTNizszN MUPTRW5ITVJ?
NCI-H1963 NYDOdXppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe1[HlUUUN3ME2yOk4xPjJ|IN88US=> MVfTRW5ITVJ?
U-87-MG M4i0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrBXFdoUUN3ME2yOk44PjR2IN88US=> MVXTRW5ITVJ?
COR-L279 NGG4b5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3lRZB{UUN3ME2yOk44QTJ{IN88US=> MlLxV2FPT0WU
LU-165 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ6LkC4OlEh|ryP MYfTRW5ITVJ?
COLO-800 NXPySpJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLlTWM2OD1{OD6yPVU3KM7:TR?= MX;TRW5ITVJ?
ETK-1 MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fVcmlEPTB;MkiuN|Q1PiEQvF2= NVyzVmRCW0GQR1XS
LNCaP-Clone-FGC NX22WmVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ7LkmyPFEh|ryP MWTTRW5ITVJ?
SIG-M5 NWXIZ4tMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmraTWM2OD1|MD63PVUzKM7:TR?= MXzTRW5ITVJ?
NB6 NV;oSlZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF72WJFKSzVyPUOwMlk2ODNizszN M3jsPXNCVkeHUh?=
NCI-H2107 NV\Ucm5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrK[YR{UUN3ME2zNU4zOzN6IN88US=> MUHTRW5ITVJ?
SNU-C1 Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ftd2lEPTB;M{GuN|EzPiEQvF2= NWruZ2JOW0GQR1XS
JAR NH;LXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNzLkO3PVkh|ryP M2HlUHNCVkeHUh?=
L-363 M4O2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN{LkKxOFQh|ryP NYHmNVlPW0GQR1XS
EW-24 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:3TWM2OD1|Mj6zOFc1KM7:TR?= M4XHc3NCVkeHUh?=
NB69 NELlNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLGPFN5UUN3ME2zN{43PDV2IN88US=> NFu0OFVUSU6JRWK=
EW-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7TTWM2OD1|Mz64PVY6KM7:TR?= MVXTRW5ITVJ?
Ramos-2G6-4C10 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN2LkK5PVMh|ryP MVrTRW5ITVJ?
TE-11 NX7Uc5htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fnN2lEPTB;M{SuOFgzOiEQvF2= M3fpSHNCVkeHUh?=
L-428 MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL4[3lKSzVyPUO0Mlc2OzZizszN NYDhbY4xW0GQR1XS
KP-N-YN NVTYPFZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTN2LkmwOVch|ryP NXnoTm1oW0GQR1XS
CGTH-W-1 M33aTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX1OYVkUUN3ME2zOk46ODR6IN88US=> MkTJV2FPT0WU
K-562 M1LvSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjTco9GUUN3ME2zO{4xQDZ2IN88US=> NXLU[FdCW0GQR1XS
NCI-H1299 M1f1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED5d5ZKSzVyPUO4MlE3ODNizszN NXHNTpNsW0GQR1XS
RCC10RGB NXi5Z5h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfLR|VKSzVyPUO4MlIxQDNizszN Ml\YV2FPT0WU
NCI-SNU-16 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknoTWM2OD1|OD61OlU{KM7:TR?= NFi0UmFUSU6JRWK=
LC-2-ad NX;0TGxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoS4TWM2OD1|OT60N|M4KM7:TR?= NXu5WpIyW0GQR1XS
MHH-PREB-1 M{HqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rifGlEPTB;M{muO|M5QCEQvF2= MofWV2FPT0WU
NCI-H64 NHfhcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XpcGlEPTB;NECuNFk1QCEQvF2= NX;VdmpzW0GQR1XS
LB996-RCC NV3X[5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTRyLki3NVYh|ryP MVXTRW5ITVJ?
DEL NFvYUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTUbW9KSzVyPUSxMlQ1ODVizszN MlPrV2FPT0WU
MLMA MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTRzLke1PVUh|ryP NITzNodUSU6JRWK=
SBC-1 NFe1dI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TVcGlEPTB;NEKuNVgxPiEQvF2= MVnTRW5ITVJ?
MPP-89 NELsRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofSTWM2OD12Mj61PFc2KM7:TR?= NHi1bnVUSU6JRWK=
MV-4-11 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDaTWM2OD12Mj65NFY4KM7:TR?= M1i2RnNCVkeHUh?=
EoL-1- MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTR2LkG1Olgh|ryP MlryV2FPT0WU
CW-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP3WFhKSzVyPUS0Mlg{PDJizszN M{ftc3NCVkeHUh?=
HT M1\YU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLEb5J1UUN3ME20OU44ODB5IN88US=> NIfEOlRUSU6JRWK=
SW954 NGPMOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK2TWM2OD12Nz60NVI5KM7:TR?= NV31folLW0GQR1XS
A3-KAW MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTEOnA{UUN3ME20PU45ODZzIN88US=> MkLtV2FPT0WU
TC-YIK NYPwOGpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfBfGxKSzVyPUWwMlA{PjNizszN MWLTRW5ITVJ?
SW962 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XnWGlEPTB;NUSuPFM2PyEQvF2= Mn7aV2FPT0WU
KP-N-RT-BM-1 NUmzZXZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiyepJJUUN3ME21Ok43PjN6IN88US=> NW\xR|R3W0GQR1XS
NCI-H1395 NYrQT21lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jKSmlEPTB;NUiuPFE4OiEQvF2= MlHVV2FPT0WU
RPMI-8402 M4TFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\rfWpKSzVyPUW4Mlk2OjZizszN MmL2V2FPT0WU
SCH MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fVfmlEPTB;NkCuPVY{QCEQvF2= MoHxV2FPT0WU
NCI-H2196 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHXTWM2OD14MT6yN|Eh|ryP MoHoV2FPT0WU
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NCI-H1694 M{nMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\IWlZKSzVyPUexMlA{OiEQvF2= NHmyOWRUSU6JRWK=
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NCI-H2171 M1vCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PaOmlEPTB;N{muOFE{PiEQvF2= MYrTRW5ITVJ?
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NCI-H446 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTl7Lke1PFgh|ryP NGnGNpRUSU6JRWK=
NCI-H889 M{SyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFyND6yOFIh|ryP M4f5eHNCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. [7] MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA. [8]

Protocol

Kinase Assay:

[1]

+ Expand

Measurement of inhibitory activities of MG-132 against 20S proteasome:

The reaction mixture for the 20S proteasome inhibitory assay contains 0.1 M Tris-acetate, pH 7.0, 20S proteasome, MG-132, and 25 μM substrate dissolved in dimethyl sulfoxide in a final volume of 1 mL. After incuba tion at 37 °C for 15 minutes, the reaction is stopped by the addition of 0.1 mL of 10% SDS and 0.9 mL of 0.1M Tris acetate, pH 9.0. The fluorescence of the reaction products is measured. To determine the IC50 against 20S proteasome, various concentrations of MG-132 are included in the assay mixture.
Cell Research:

[3]

+ Expand
  • Cell lines: KIM-2, HC11, and ES
  • Concentrations: Dissolved in DMSO, final concentrations ~25 μM
  • Incubation Time: 24, and 48 hours
  • Method:

    Cells are exposed to various concentrations of MG-132 for 24, and 48 hours. Supernatant and monolayer cells are harvested by centrifugation and fixed in 70% ethanol in PBS for staining with acridine orange. Equal volumes of cells and acridine orange (5 mg/mL in PBS) are mixed on a microscope slide and examined by fluorescence microscopy. For annexin V analysis, cells are harvested by centrifugation and stained with annexin V and propidium iodide. For cell cycle analysis, cells are rehydrated in PBS at room temperature for 10 minutes, followed by staining with propidium iodide (5 mg/mL). All samples are analyzed using a Coulter Epics XL flow cytometer.


    (Only for Reference)
Animal Research:

[7]

+ Expand
  • Animal Models: Male mdx (C57BL/10ScSn DMD mdx) mice
  • Formulation: Dissolved in DMSO, and diluted in PBS
  • Dosages: ~10 μg/kg/day
  • Administration: Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (199.73 mM)
Ethanol 95 mg/mL (199.73 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+20% propylene glycol+ddH2O 2mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 475.62
Formula

C26H41N3O5

CAS No. 133407-82-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID