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Palomid 529 (P529) Chemical Structure
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Biological Activity
Palomid 529 (P529) is a novel PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. Palomid 529 (P529) inhibits tumor growth, angiogenesis, and vascular permeability. However, Palomid 529 (P529) has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 (P529) inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. In addition, Palomid 529 (P529) significantly enhanced the antiproliferative effect of radiation in prostate cancer cells (PC-3). [1][2][3]
References on Palomid 529 (P529)
- [1] British Journal of Cancer 2009;100:932 – 940
- [1] Endocr Relat Cancer 2011 May 6;
- [3] Cancer Res 2008 November 15;68(22): 9551–9557
Chemical Information
| Molecular Weight (WM): | 406.43 |
|---|---|
| Formula: | C24H22O6 |
| CAS No.: | 914913-88-5 |
| Synonyms: |
P529
|
| Dissolve in (25°C): | DMSO ≥81mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Palomid529 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Palomid529 for 3h,followed by 20-minute stimolation of 100ng/ml EGF.
Data independently produced by Dr. Zhang of Tianjin Medical University Palomid 529 (P529) purchased from Selleck
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After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Palomid529 for 3h,followed by 20-minute stimolation of 100ng/ml EGF. |
Data independently produced by Dr. Zhang of Tianjin Medical University
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