Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M17Ddmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfYRpdKSzVyPUCuNFAxOzB4IN88US=> NEe4THZUSU6JRWK=
OCUB-M MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrVTWM2OD1yLkCwNVk1KM7:TR?= MXfTRW5ITVJ?
DOHH-2 NGPUT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECyNlUh|ryP MX3TRW5ITVJ?
NOS-1 NIHCVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfvOW11UUN3ME2wMlAxOjR{IN88US=> NGnXSHBUSU6JRWK=
L-363 NHXC[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMECyPFQh|ryP M4Xi[XNCVkeHUh?=
RL95-2 MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf4PJZkUUN3ME2wMlAxOzJizszN NVHqSHdpW0GQR1XS
BL-70 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrOTWM2OD1yLkCwN|M4KM7:TR?= M2HpcnNCVkeHUh?=
TGBC1TKB NHS3SHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMECzO|kh|ryP NIfmWlRUSU6JRWK=
697 NWPI[|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO4dHU3UUN3ME2wMlAxPjN2IN88US=> MlraV2FPT0WU
RPMI-8226 NUXJO|ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEC2OVEh|ryP MkL1V2FPT0WU
BL-41 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEC2PVYh|ryP NG\KcIRUSU6JRWK=
MRK-nu-1 NUXTUHFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LJ[mlEPTB;MD6wNFcxPyEQvF2= M17HfXNCVkeHUh?=
EW-1 M3\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjpbVdYUUN3ME2wMlAxPzR7IN88US=> MkT4V2FPT0WU
EVSA-T M3:xbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEC4PVIh|ryP M3nqXnNCVkeHUh?=
HUTU-80 M16wW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEC5Nlkh|ryP NELtSGNUSU6JRWK=
VA-ES-BJ NFu1SpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvaXohOUUN3ME2wMlAxQTh2IN88US=> MWDTRW5ITVJ?
GCIY MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnXZpFpUUN3ME2wMlAyODB5IN88US=> MlHrV2FPT0WU
ES6 MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqyTJdKSzVyPUCuNFExQDNizszN MWPTRW5ITVJ?
NALM-6 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvNTWM2OD1yLkCxNVAzKM7:TR?= M1rH[XNCVkeHUh?=
LB996-RCC NFG1XVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7kTWM2OD1yLkCxNVM4KM7:TR?= NXvJOYV[W0GQR1XS
EW-16 NXTtd5dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEGxPVIh|ryP NXuzNY5vW0GQR1XS
KALS-1 NISzUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\ZTWM2OD1yLkCxNVk5KM7:TR?= M1vyV3NCVkeHUh?=
OPM-2 NGHuNpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnLVFlKSzVyPUCuNFEzQSEQvF2= MY\TRW5ITVJ?
KU812 NInwbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILwSYNKSzVyPUCuNFEzQTZizszN MonsV2FPT0WU
A4-Fuk M4rmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PRR2lEPTB;MD6wNVMyQSEQvF2= NVjwVpg5W0GQR1XS
KGN NH\EPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjUeVlKSzVyPUCuNFE{PTlizszN M3OwVXNCVkeHUh?=
KS-1 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEGzPVIh|ryP NHrENG1USU6JRWK=
no-11 M1n5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEGzPVUh|ryP M4TFPHNCVkeHUh?=
PSN1 NHvjdo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPmS4ZrUUN3ME2wMlAyPDB7IN88US=> NEPoU5lUSU6JRWK=
SK-LMS-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3qTWM2OD1yLkCxOFE{KM7:TR?= NUDGZpczW0GQR1XS
LS-411N M{DUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTqTWM2OD1yLkCxOFM6KM7:TR?= MUPTRW5ITVJ?
HT-144 NWTybo9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPxTWM2OD1yLkCxOFUyKM7:TR?= MULTRW5ITVJ?
ACN NGT1SFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK0TWM2OD1yLkCxOUDPxE1? Mk\xV2FPT0WU
RKO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M330VmlEPTB;MD6wNVU{OyEQvF2= M2TuWXNCVkeHUh?=
CMK NFrMZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[wZ2lEPTB;MD6wNVU1OyEQvF2= NEC5R|NUSU6JRWK=
GB-1 M3vCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojpTWM2OD1yLkCxOVU{KM7:TR?= M{HXOHNCVkeHUh?=
KE-37 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfxO2NoUUN3ME2wMlAyPTd|IN88US=> NWWweWUzW0GQR1XS
no-10 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD6WGtKUUN3ME2wMlAyPTh2IN88US=> NH\WeZFUSU6JRWK=
MOLT-16 NXjVW|dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\SR3dKSzVyPUCuNFE3OjJizszN M2TPcnNCVkeHUh?=
HEL M2nJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPMW|BKSzVyPUCuNFE3PCEQvF2= MXjTRW5ITVJ?
NCI-H1355 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\pbWJYUUN3ME2wMlAyPjR4IN88US=> MkPuV2FPT0WU
IST-MEL1 NGHTTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEG3O|Qh|ryP NFXnTWxUSU6JRWK=
MHH-PREB-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEG4NVgh|ryP MYnTRW5ITVJ?
ES8 MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT0TWM2OD1yLkCxPFQ1KM7:TR?= MUXTRW5ITVJ?
LC-2-ad MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\JPIpKSzVyPUCuNFIyOzdizszN NGO2dnVUSU6JRWK=
LAMA-84 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEKxOlch|ryP NH70VmFUSU6JRWK=
BV-173 NGflTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEKyNFMh|ryP NGjhR|lUSU6JRWK=
SW872 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\ObmlEPTB;MD6wNlI1PyEQvF2= NFziR2ZUSU6JRWK=
SK-UT-1 M1rN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEKyOlEh|ryP MVTTRW5ITVJ?
OS-RC-2 NW\oOHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HOVWlEPTB;MD6wNlMzOyEQvF2= MlXkV2FPT0WU
NCI-H747 NEPzXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG1b4tSUUN3ME2wMlAzOzNizszN NFT0bJNUSU6JRWK=
MZ2-MEL NHrvbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLPWXFKSzVyPUCuNFI{OzdizszN MkDzV2FPT0WU
TE-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX31S3J1UUN3ME2wMlAzOzd{IN88US=> MoHuV2FPT0WU
KURAMOCHI M{fXOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\1Vow{UUN3ME2wMlAzPDF2IN88US=> MWLTRW5ITVJ?
HD-MY-Z NFj3VZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHqN2FKSzVyPUCuNFI1OjZizszN M3jHXXNCVkeHUh?=
GI-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfQTWM2OD1yLkCyOFY6KM7:TR?= NFHlSphUSU6JRWK=
LB1047-RCC M{L4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O1ZmlEPTB;MD6wNlQ5QCEQvF2= MXTTRW5ITVJ?
TE-12 NIHhPGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PhR2lEPTB;MD6wNlU2KM7:TR?= NYD4O2RUW0GQR1XS
MZ7-mel M2\YRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\VTWM2OD1yLkCyOlA6KM7:TR?= MmDwV2FPT0WU
MMAC-SF M3\TZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHvXYxKSzVyPUCuNFI3OzNizszN NGrpSZhUSU6JRWK=
A101D MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDXTWM2OD1yLkCyOlUh|ryP NEjFOWVUSU6JRWK=
GR-ST M1TzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT5[JpKSzVyPUCuNFI3PTVizszN Ml:xV2FPT0WU
MC116 M3ruOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXNTWM2OD1yLkCyOlgh|ryP NUDZPVMzW0GQR1XS
Ramos-2G6-4C10 NVLRb2RvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDI[oRKSzVyPUCuNFI4PSEQvF2= NITIeWdUSU6JRWK=
ATN-1 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mydWlEPTB;MD6wNlc5QSEQvF2= MoO4V2FPT0WU
MFH-ino MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjlO|RyUUN3ME2wMlAzQDF{IN88US=> NXHodJpVW0GQR1XS
DEL Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnJSnN7UUN3ME2wMlAzQDF3IN88US=> M{OyTXNCVkeHUh?=
OCI-AML2 NXPsSXo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrONWdbUUN3ME2wMlAzQDdzIN88US=> MYjTRW5ITVJ?
LXF-289 M1f3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M163[GlEPTB;MD6wNlg4OiEQvF2= NWXqcmJJW0GQR1XS
IA-LM MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\odpdXUUN3ME2wMlAzQTF5IN88US=> MlHWV2FPT0WU
EoL-1-cell M1jPeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j1NWlEPTB;MD6wNlk6PiEQvF2= MUTTRW5ITVJ?
OVCAR-4 NG\JfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEOwPVQh|ryP NY\nOolyW0GQR1XS
ES1 NH;tWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEOwPVch|ryP MXzTRW5ITVJ?
CESS M4PrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TDcGlEPTB;MD6wN|A6QSEQvF2= NVW0NnpXW0GQR1XS
GAK NVO1Sop5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEOxPFYh|ryP M3\Gb3NCVkeHUh?=
NTERA-S-cl-D1 M{TodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u5S2lEPTB;MD6wN|IzPiEQvF2= MXjTRW5ITVJ?
TE-10 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zrO2lEPTB;MD6wN|MyOSEQvF2= MlvsV2FPT0WU
CCRF-CEM MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjvWYJKSzVyPUCuNFM{PzFizszN NVzaeldrW0GQR1XS
NMC-G1 NI\nfm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXUbWhKSzVyPUCuNFM1PDhizszN NVjab|lVW0GQR1XS
HOP-62 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvDZZVKSzVyPUCuNFM2PTZizszN M2G5U3NCVkeHUh?=
SH-4 M{GwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH5TWM2OD1yLkCzOVgzKM7:TR?= MlXhV2FPT0WU
NCI-H1648 NIniVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C4bGlEPTB;MD6wN|YzOiEQvF2= M2HVXHNCVkeHUh?=
EB-3 NYfQeY5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEO2OFMh|ryP MnzEV2FPT0WU
BB65-RCC NWXhNII{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEO2PVEh|ryP M4K5XnNCVkeHUh?=
BE-13 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi0OFVKSzVyPUCuNFM4PTlizszN M1LKcHNCVkeHUh?=
CP67-MEL NFnWd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLxU|F1UUN3ME2wMlA{PzV7IN88US=> MUDTRW5ITVJ?
SW954 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPUUHlKSzVyPUCuNFM4QSEQvF2= MXzTRW5ITVJ?
TE-5 NUOze5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjlWIlKSzVyPUCuNFM5PTRizszN MnzkV2FPT0WU
HCE-4 NVuxW5A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO2ZXpLUUN3ME2wMlA{QDV3IN88US=> MV3TRW5ITVJ?
LC-1F MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojlTWM2OD1yLkCzPVg6KM7:TR?= NWrLZYdmW0GQR1XS
TK10 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPzTWM2OD1yLkC0NFE6KM7:TR?= NYnISFh{W0GQR1XS
SJSA-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnse4tMUUN3ME2wMlA1OTh6IN88US=> M{nFUXNCVkeHUh?=
Daudi NIfJOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LNcmlEPTB;MD6wOFIzPSEQvF2= MYjTRW5ITVJ?
SW982 NGfTSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH4[JVKSzVyPUCuNFQzPDZizszN MWTTRW5ITVJ?
SF126 NILKU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOyfJZKSzVyPUCuNFQ{PjFizszN M2P1PHNCVkeHUh?=
TE-15 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHQWGFNUUN3ME2wMlA1PDN3IN88US=> M13UTHNCVkeHUh?=
COLO-684 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMES1OlEh|ryP Ml7uV2FPT0WU
8-MG-BA M37a[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTvWGRmUUN3ME2wMlA1PjJ7IN88US=> MkXwV2FPT0WU
NB13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H4bmlEPTB;MD6wOFc4PiEQvF2= NYn5Z445W0GQR1XS
HCC1599 NWLDb4hjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jaVGlEPTB;MD6wOFg4QSEQvF2= NGDvbZdUSU6JRWK=
SK-PN-DW NV;sdXU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojkTWM2OD1yLkC0PVQ6KM7:TR?= MXfTRW5ITVJ?
ALL-PO NVWwPJRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTFT|NTUUN3ME2wMlA1QTV4IN88US=> MUfTRW5ITVJ?
NB6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PiXWlEPTB;MD6wOVI4OSEQvF2= M2my[XNCVkeHUh?=
IST-SL2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrkTWM2OD1yLkC1N|YzKM7:TR?= MX;TRW5ITVJ?
BB30-HNC NGPiR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHnTWM2OD1yLkC1O|Mh|ryP NVXTeHdsW0GQR1XS
SW962 NH3te4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPYOotKSzVyPUCuNFU4PjNizszN Ml;XV2FPT0WU
TGBC24TKB NUPJboF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrqVZNKSzVyPUCuNFU4QTlizszN NIHNVolUSU6JRWK=
KINGS-1 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEW4NFMh|ryP NEDx[3JUSU6JRWK=
HC-1 NXvnNWpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GwVWlEPTB;MD6wOVgzPyEQvF2= M3iyRnNCVkeHUh?=
RS4-11 NYrofGhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfyTWM2OD1yLkC1PVM5KM7:TR?= NGHMZYdUSU6JRWK=
LS-123 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLTTWM2OD1yLkC1PVQzKM7:TR?= MULTRW5ITVJ?
A3-KAW MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwME[yNlUh|ryP MlTaV2FPT0WU
SNB75 NVrB[m5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzzSVlKSzVyPUCuNFY{PDFizszN NEDIOVdUSU6JRWK=
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MS-1 NXzmNmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHX6VG9KSzVyPUCuOFAyPzdizszN MmTGV2FPT0WU
EKVX NV22d4pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TRPGlEPTB;MD60OFQ3OSEQvF2= M2PqWHNCVkeHUh?=
SK-MEL-2 MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF36dFhKSzVyPUCuOFY1KM7:TR?= MYrTRW5ITVJ?
HCC1187 NXrUeI8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\jdFRTUUN3ME2wMlQ3PzZ6IN88US=> NXHHSFdnW0GQR1XS
HCC2218 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\ITWM2OD1yLkS3NlI4KM7:TR?= MVfTRW5ITVJ?
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DB MnHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X6WmlEPTB;MD61NFA2PSEQvF2= M{DDb3NCVkeHUh?=
NCI-H69 M1T0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrwNGtKSzVyPUCuOVAzPDdizszN MkfvV2FPT0WU
NCI-H1694 Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXuTWM2OD1yLkWwOlk4KM7:TR?= M1OwTnNCVkeHUh?=
CA46 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3S4bWlEPTB;MD61NFkyPyEQvF2= M1XDVnNCVkeHUh?=
EHEB NFr1UlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS4cppKUUN3ME2wMlUyOTl|IN88US=> NIDWO|VUSU6JRWK=
NCCIT NILpeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNUSzNlEh|ryP M2PkfHNCVkeHUh?=
NCI-H720 NISxdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwNUS5OlIh|ryP NXjsXG16W0GQR1XS
LU-134-A M3jZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwNUWyPVYh|ryP NUjoTIxXW0GQR1XS
MC-CAR M2XZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW5XIJjUUN3ME2wMlU2PDNzIN88US=> NWTMUYUyW0GQR1XS
NEC8 NYC2WVY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jVZmlEPTB;MD61OlE4OiEQvF2= MVXTRW5ITVJ?
NCI-H524 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwNUi3OFgh|ryP NGPGclhUSU6JRWK=
NCI-H1963 NGm4VVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjXRXV[UUN3ME2wMlYzPThizszN NFrNNHZUSU6JRWK=
SU-DHL-1 MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfHO|dnUUN3ME2wMlY1PTJ4IN88US=> MknaV2FPT0WU
NCI-H1522 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnyemF{UUN3ME2wMlY1QDh|IN88US=> MUDTRW5ITVJ?
NCI-H1155 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHjN3JrUUN3ME2wMlY2OzVizszN NEfIbG5USU6JRWK=
D-263MG MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq3TWM2OD1yLk[2NVAyKM7:TR?= MXLTRW5ITVJ?
TE-6 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTHTWM2OD1yLk[4NVA1KM7:TR?= NHfwRXhUSU6JRWK=
NCI-H1417 M4n0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml36TWM2OD1yLk[5O|EyKM7:TR?= MXXTRW5ITVJ?
NCI-H510A NGO1OIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr0UHlKSzVyPUCuO|czOzZizszN NYq0SoRIW0GQR1XS
KARPAS-45 NH60dpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL1TWM2OD1yLke4NlM2KM7:TR?= M{DKeHNCVkeHUh?=
IST-SL1 MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwOEW4NlUh|ryP MYXTRW5ITVJ?
COLO-824 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DPPGlEPTB;MD64O|g{PSEQvF2= NF3TT4tUSU6JRWK=
NCI-H526 NEDwfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwOUC5OVgh|ryP M4m1U3NCVkeHUh?=
NCI-H719 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzbnpsUUN3ME2wMlk3PjV5IN88US=> MUXTRW5ITVJ?
SF539 MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrwTWM2OD1yLkm4N|k3KM7:TR?= NIDDZ3hUSU6JRWK=
NKM-1 NGTkW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m5SmlEPTB;MD65PFY3OyEQvF2= NWf6d4x[W0GQR1XS
A253 M{LmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu3N3hKSzVyPUCuPVg5QDVizszN M4LtTHNCVkeHUh?=
TE-441-T M1W5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFwMESzOUDPxE1? NVzoNpp1W0GQR1XS
COR-L88 NIDpVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwMUGzOVQh|ryP NVjtOpd3W0GQR1XS
CPC-N MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fsbGlEPTB;MT6xOVg5QCEQvF2= M2XRSnNCVkeHUh?=
NCI-H2107 M{DmcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TndWlEPTB;MT6xO|I3OSEQvF2= MkLmV2FPT0WU
ECC4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Kyd2lEPTB;MT6xPFY6OyEQvF2= MlTWV2FPT0WU
NCI-H2141 M2XweGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;PXog{UUN3ME2xMlE6Ojl7IN88US=> NIq3UWxUSU6JRWK=
NCI-H1770 NHjDWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrZTWM2OD1zLkOyPVI5KM7:TR?= MUnTRW5ITVJ?
NCI-SNU-1 M{LyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrjeW9YUUN3ME2xMlM{ODRizszN NIrITXJUSU6JRWK=
LU-165 NWPpXYpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInsd4xKSzVyPUGuOFU1PjdizszN NUXUfGpCW0GQR1XS
Raji NH3WUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:0bGlEPTB;MT60O|I2QSEQvF2= M1npRnNCVkeHUh?=
EW-24 Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPjTWM2OD1zLkW0OlE6KM7:TR?= MXrTRW5ITVJ?
KP-N-RT-BM-1 Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP5fot[UUN3ME2xMlU3PTVzIN88US=> Mn22V2FPT0WU
SK-MEL-1 NEDDRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HPZWlEPTB;MT62OFg4PyEQvF2= MVvTRW5ITVJ?
SCLC-21H Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXjXGhKSzVyPUGuOlY3PTFizszN NWm1PIMyW0GQR1XS
SIMA M4jRZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfncJlKSzVyPUGuOlgzOzNizszN NYLHbWhEW0GQR1XS
NCI-H1304 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLsTWM2OD1zLkewO|Y2KM7:TR?= NYSwPHlxW0GQR1XS
REH MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET3O|FKSzVyPUGuO|ExPzhizszN NWjVblNlW0GQR1XS
KP-N-YS MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTFwOUO1OVEh|ryP MXjTRW5ITVJ?
DMS-153 M332cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr2OXJkUUN3ME2xMlk4PTlizszN M1Tt[nNCVkeHUh?=
NB10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DUNGlEPTB;Mj6yNFg4QCEQvF2= NYHQNZQ3W0GQR1XS
NCI-H345 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfNTWM2OD1{Lk[xPVA2KM7:TR?= M1v0VHNCVkeHUh?=
SK-N-FI M4PTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJwN{WzPFEh|ryP MWHTRW5ITVJ?
NCI-H1092 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPNVItKSzVyPUKuPVU{QTRizszN MYTTRW5ITVJ?
KM-H2 M{TPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrWfINWUUN3ME2zMlY2Ozl4IN88US=> M1zZSnNCVkeHUh?=
KG-1 NVnWW2gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{naSGlEPTB;Mz63NVY5QCEQvF2= M3\jbnNCVkeHUh?=
D-283MED NHTCeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Tr[mlEPTB;Mz63OVg4KM7:TR?= NYSwXGJ3W0GQR1XS
LU-65 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHtN4dPUUN3ME20MlEyPDh3IN88US=> MXLTRW5ITVJ?
MSTO-211H NXLlXIN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvYdG5UUUN3ME20MlE5QDl6IN88US=> MXTTRW5ITVJ?
NCI-H2081 M2jGUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\aTWM2OD12LkK5NVc1KM7:TR?= Ml7RV2FPT0WU
D-247MG M{nJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfSfVNvUUN3ME20MlQ{OTlzIN88US=> MkX5V2FPT0WU
P31-FUJ MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL2OGRKSzVyPUSuOFUxOTlizszN NEfidGZUSU6JRWK=
DMS-79 M4jtc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjiTWM2OD12LkmzNVg{KM7:TR?= MUfTRW5ITVJ?
KASUMI-1 NW[0OGJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnOTWM2OD12Lkm3OVA6KM7:TR?= NVracoQ6W0GQR1XS
JVM-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PlWWlEPTB;NT6yOVAyPCEQvF2= MXrTRW5ITVJ?
LAN-6 NF3FOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD13LkWxO|M3KM7:TR?= MomwV2FPT0WU
DJM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTVwNU[wNlkh|ryP M{HkXHNCVkeHUh?=
JVM-2 NFv1WmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHEb49KSzVyPUWuOlcxQTJizszN NF\Xd4hUSU6JRWK=
U-87-MG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOxRmZKSzVyPUWuPFk6PjRizszN NVTIdo5YW0GQR1XS
SHP-77 M2LjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlryTWM2OD13Lkm0PVI5KM7:TR?= MkDvV2FPT0WU
RPMI-8866 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;pbGlEPTB;Nj6yO|AyOyEQvF2= M4j2Z3NCVkeHUh?=
ES7 M{XH[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qyXWlEPTB;Nj6zPVkzPCEQvF2= NILjdXdUSU6JRWK=
WSU-NHL M2PSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTZwNUG2NFkh|ryP NHPt[ldUSU6JRWK=
CAS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzTXpdoUUN3ME23MlA6PzR7IN88US=> NFGxVoFUSU6JRWK=
MHH-NB-11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW3eFBQUUN3ME24MlI{OTV{IN88US=> MoDqV2FPT0WU
ES5 NF63OGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTlwNUKyPFYh|ryP NETj[pRUSU6JRWK=
HDLM-2 M1XtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;ZWWlEPTB;OT65OVkxOiEQvF2= NX22emFoW0GQR1XS
NCI-H2171 NX7BelNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjXUY9KSzVyPUGwMlU6OjdizszN MmW5V2FPT0WU
LNCaP-Clone-FGC M3rCO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFzLkO3NVgh|ryP M1r4d3NCVkeHUh?=
NCI-H1395 MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz3TWM2OD1zMj6yOlk6KM7:TR?= M2rR[XNCVkeHUh?=
NCI-H1436 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf4c3VqUUN3ME2xN{4{OTl3IN88US=> MYjTRW5ITVJ?
RCC10RGB MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3wTWM2OD1zMz6zNlIyKM7:TR?= NVjlVoJFW0GQR1XS
SW684 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfJTWM2OD1zMz65O|k4KM7:TR?= M4DhfXNCVkeHUh?=
NCI-H1650 MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDCd2pKSzVyPUG1MlA1PDdizszN Mo\RV2FPT0WU
EW-13 M1zCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTuRVV4UUN3ME2xOU4zODJzIN88US=> NH3sT|hUSU6JRWK=
EC-GI-10 NGPuN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkexTWM2OD1zNT64OlQ1KM7:TR?= NYnod2V7W0GQR1XS
CHP-126 M{n4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXzTWM2OD1zNz6xPVE5KM7:TR?= MX\TRW5ITVJ?
NCI-H226 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEewZWpKSzVyPUG4MlA1ODNizszN MlftV2FPT0WU
NCI-H1838 M{XTbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJyLkG4OFgh|ryP M2XsOHNCVkeHUh?=
EW-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLMZXVkUUN3ME2yOE4zPzF6IN88US=> NFTQTFdUSU6JRWK=
EB2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2WVBKSzVyPUOxMlU{OThizszN NIHUSWRUSU6JRWK=
D-502MG MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTR|LkmyNlkh|ryP NUHCbItGW0GQR1XS
U-698-M M3;pTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K1dGlEPTB;NEiuPFY4OSEQvF2= NI\UUpFUSU6JRWK=
ES3 NWfZd2EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\hRmlEPTB;NEmuN|g6OyEQvF2= NHTUXZJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
20% NMP+50% PEG 400
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID