Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NFqyc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfmSFlKSzVyPUCuNFAxOzB4IN88US=> NX7kTFlsW0GQR1XS
OCUB-M NF;nNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfrVXFKSzVyPUCuNFAyQTRizszN M2\oeHNCVkeHUh?=
DOHH-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMECyNlUh|ryP Mn7DV2FPT0WU
NOS-1 NIXzVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M333dGlEPTB;MD6wNFI1OiEQvF2= MX7TRW5ITVJ?
L-363 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomzTWM2OD1yLkCwNlg1KM7:TR?= MW\TRW5ITVJ?
RL95-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHYTWM2OD1yLkCwN|Ih|ryP MmTPV2FPT0WU
BL-70 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD1coFKSzVyPUCuNFA{OzdizszN MUHTRW5ITVJ?
TGBC1TKB NIjYPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\lSlQyUUN3ME2wMlAxOzd7IN88US=> M1nPd3NCVkeHUh?=
697 NXHOfXJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEC2N|Qh|ryP MnfVV2FPT0WU
RPMI-8226 M2jBdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITOZ3BKSzVyPUCuNFA3PTFizszN NYntc414W0GQR1XS
BL-41 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPzW4lKSzVyPUCuNFA3QTZizszN NIe1dG1USU6JRWK=
MRK-nu-1 NFzUVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFeyUYJKSzVyPUCuNFA4ODdizszN MWLTRW5ITVJ?
EW-1 NIfNU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPKXJJKSzVyPUCuNFA4PDlizszN NV3BW4p3W0GQR1XS
EVSA-T MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT6TWM2OD1yLkCwPFkzKM7:TR?= NILQNGlUSU6JRWK=
HUTU-80 NHvhcpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELaNpVKSzVyPUCuNFA6OjlizszN NH:0b3BUSU6JRWK=
VA-ES-BJ NWK2b5RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXUOm9KSzVyPUCuNFA6QDRizszN M2LsXHNCVkeHUh?=
GCIY NEHldoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;2RWl{UUN3ME2wMlAyODB5IN88US=> NHXjfm9USU6JRWK=
ES6 NYDUeIk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHucGdMUUN3ME2wMlAyODh|IN88US=> MULTRW5ITVJ?
NALM-6 NIS0WVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEGxNFIh|ryP Moq1V2FPT0WU
LB996-RCC M3izdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEGxN|ch|ryP NUTmSJRiW0GQR1XS
EW-16 NFTQd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe3dmdKSzVyPUCuNFEyQTJizszN Mo\oV2FPT0WU
KALS-1 NWjib4ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LCWmlEPTB;MD6wNVE6QCEQvF2= NVXWcJNRW0GQR1XS
OPM-2 NInyc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLYTWM2OD1yLkCxNlkh|ryP M2LKdHNCVkeHUh?=
KU812 NX3teIhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEGyPVYh|ryP M4TsPXNCVkeHUh?=
A4-Fuk M1u0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEGzNVkh|ryP NWHHZllVW0GQR1XS
KGN M{G0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PQc2lEPTB;MD6wNVM2QSEQvF2= MkfEV2FPT0WU
KS-1 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1mwfGlEPTB;MD6wNVM6OiEQvF2= M{L1PHNCVkeHUh?=
no-11 NHvmUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqyTWM2OD1yLkCxN|k2KM7:TR?= NYTCN4VIW0GQR1XS
PSN1 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLUU5JKSzVyPUCuNFE1ODlizszN NIriblhUSU6JRWK=
SK-LMS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XmWGlEPTB;MD6wNVQyOyEQvF2= MWPTRW5ITVJ?
LS-411N NIC5TJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET0[W1KSzVyPUCuNFE1OzlizszN NFjONpRUSU6JRWK=
HT-144 Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\SN2lEPTB;MD6wNVQ2OSEQvF2= MV3TRW5ITVJ?
ACN Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HFZ2lEPTB;MD6wNVUh|ryP MlXIV2FPT0WU
RKO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:zZo1kUUN3ME2wMlAyPTN|IN88US=> Mo\mV2FPT0WU
CMK MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rUbmlEPTB;MD6wNVU1OyEQvF2= MnrvV2FPT0WU
GB-1 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33BVmlEPTB;MD6wNVU2OyEQvF2= M4\3R3NCVkeHUh?=
KE-37 M3\2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfXXIs1UUN3ME2wMlAyPTd|IN88US=> NVHZd29wW0GQR1XS
no-10 NUnCOYxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEG1PFQh|ryP NH;6T4tUSU6JRWK=
MOLT-16 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTJSlBKSzVyPUCuNFE3OjJizszN M{nLd3NCVkeHUh?=
HEL M{POSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEG2OEDPxE1? NHz0[JlUSU6JRWK=
NCI-H1355 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnK[5BwUUN3ME2wMlAyPjR4IN88US=> MkGxV2FPT0WU
IST-MEL1 NUnqUW9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvnTWM2OD1yLkCxO|c1KM7:TR?= NVnGbGtWW0GQR1XS
MHH-PREB-1 M4PIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu1c|BZUUN3ME2wMlAyQDF6IN88US=> NELQWlZUSU6JRWK=
ES8 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXDdpFwUUN3ME2wMlAyQDR2IN88US=> MnO1V2FPT0WU
LC-2-ad MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Hvb2lEPTB;MD6wNlE{PyEQvF2= M3z1UXNCVkeHUh?=
LAMA-84 NIi1OoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrJTWM2OD1yLkCyNVY4KM7:TR?= MYDTRW5ITVJ?
BV-173 NYDlTlRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP0foY4UUN3ME2wMlAzOjB|IN88US=> M3z4[HNCVkeHUh?=
SW872 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\H[VJVUUN3ME2wMlAzOjR5IN88US=> MkLvV2FPT0WU
SK-UT-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\qTWM2OD1yLkCyNlYyKM7:TR?= MkK4V2FPT0WU
OS-RC-2 NFzWS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O4eWlEPTB;MD6wNlMzOyEQvF2= Mkn0V2FPT0WU
NCI-H747 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPRRZhKSzVyPUCuNFI{OyEQvF2= M{PBUXNCVkeHUh?=
MZ2-MEL MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HQcmlEPTB;MD6wNlM{PyEQvF2= NFLnSZNUSU6JRWK=
TE-11 NHPoTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nON2lEPTB;MD6wNlM4OiEQvF2= M3TUNnNCVkeHUh?=
KURAMOCHI NIjRcmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEK0NVQh|ryP M1rXSnNCVkeHUh?=
HD-MY-Z M1Hs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEK0NlYh|ryP MofCV2FPT0WU
GI-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjOTWM2OD1yLkCyOFY6KM7:TR?= NITqVGZUSU6JRWK=
LB1047-RCC NGPq[IxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXzUlRKSzVyPUCuNFI1QDhizszN NEPX[XBUSU6JRWK=
TE-12 M1PuVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke3TWM2OD1yLkCyOVUh|ryP NWf3NnJSW0GQR1XS
MZ7-mel NYLPU|NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW2TWM2OD1yLkCyOlA6KM7:TR?= M{PzcHNCVkeHUh?=
MMAC-SF NEjnOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEK2N|Mh|ryP MWPTRW5ITVJ?
A101D NGDoXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH4NmZKSzVyPUCuNFI3PSEQvF2= NILEO5JUSU6JRWK=
GR-ST NX21[GtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Xv[2lEPTB;MD6wNlY2PSEQvF2= MlTqV2FPT0WU
MC116 NXXqbJF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDGU|BKSzVyPUCuNFI3QCEQvF2= MYHTRW5ITVJ?
Ramos-2G6-4C10 NI\IdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPW[pVKSzVyPUCuNFI4PSEQvF2= NXyyPYtxW0GQR1XS
ATN-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEK3PFkh|ryP NH3BSY1USU6JRWK=
MFH-ino NV;wXIVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{K1XmlEPTB;MD6wNlgyOiEQvF2= MmLyV2FPT0WU
DEL NILLWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\JRY85UUN3ME2wMlAzQDF3IN88US=> NUDMT3pGW0GQR1XS
OCI-AML2 M3zXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEK4O|Eh|ryP NGDuTXFUSU6JRWK=
LXF-289 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXWwZ5lVUUN3ME2wMlAzQDd{IN88US=> MUnTRW5ITVJ?
IA-LM NUS1TlVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEK5NVch|ryP MVzTRW5ITVJ?
EoL-1-cell MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nZPGlEPTB;MD6wNlk6PiEQvF2= NX3tfJZJW0GQR1XS
OVCAR-4 M4\HNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnGSWtvUUN3ME2wMlA{ODl2IN88US=> M2jxb3NCVkeHUh?=
ES1 M1rKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHNNVBKSzVyPUCuNFMxQTdizszN NVvrXHl3W0GQR1XS
CESS NEfiVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEOwPVkh|ryP MXXTRW5ITVJ?
GAK NH3rWZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LaXGlEPTB;MD6wN|E5PiEQvF2= NEPYZ2lUSU6JRWK=
NTERA-S-cl-D1 NIfVUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPTVHhKSzVyPUCuNFMzOjZizszN MmWxV2FPT0WU
TE-10 NY\WT2o6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEOzNVEh|ryP NFX0T2hUSU6JRWK=
CCRF-CEM Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrSb5M3UUN3ME2wMlA{OzdzIN88US=> NHjtcYFUSU6JRWK=
NMC-G1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u3UmlEPTB;MD6wN|Q1QCEQvF2= Mn3vV2FPT0WU
HOP-62 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fPbmlEPTB;MD6wN|U2PiEQvF2= M3OzN3NCVkeHUh?=
SH-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vkXGlEPTB;MD6wN|U5OiEQvF2= MU\TRW5ITVJ?
NCI-H1648 M1X2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnLVZpKSzVyPUCuNFM3OjJizszN MV;TRW5ITVJ?
EB-3 NGr6ZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnhWZJGUUN3ME2wMlA{PjR|IN88US=> M3T3UXNCVkeHUh?=
BB65-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KTWM2OD1yLkCzOlkyKM7:TR?= MVPTRW5ITVJ?
BE-13 M{HMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rSVmlEPTB;MD6wN|c2QSEQvF2= NH:4XopUSU6JRWK=
CP67-MEL M4fvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD3TWM2OD1yLkCzO|U6KM7:TR?= MVTTRW5ITVJ?
SW954 NWPrb4VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OzVmlEPTB;MD6wN|c6KM7:TR?= NXnvSIZUW0GQR1XS
TE-5 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEO4OVQh|ryP MlTGV2FPT0WU
HCE-4 M4nHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LPbWlEPTB;MD6wN|g2PSEQvF2= NUPtR5QxW0GQR1XS
LC-1F M3XwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnG0TWM2OD1yLkCzPVg6KM7:TR?= NYPWWGc5W0GQR1XS
TK10 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMESwNVkh|ryP NH62[WxUSU6JRWK=
SJSA-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fxWmlEPTB;MD6wOFE5QCEQvF2= MYTTRW5ITVJ?
Daudi NHi4UVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfHWYFDUUN3ME2wMlA1OjJ3IN88US=> M1;LSHNCVkeHUh?=
SW982 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfNb3ZKSzVyPUCuNFQzPDZizszN NIHDRWFUSU6JRWK=
SF126 NGj5W4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMESzOlEh|ryP NF7BNndUSU6JRWK=
TE-15 NE\NO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\mZmlEPTB;MD6wOFQ{PSEQvF2= MYnTRW5ITVJ?
COLO-684 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMES1OlEh|ryP MUnTRW5ITVJ?
8-MG-BA NFy2UXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj2TWM2OD1yLkC0OlI6KM7:TR?= NVfoNnhDW0GQR1XS
NB13 M3jkcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMES3O|Yh|ryP Mn;TV2FPT0WU
HCC1599 M2DyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPtTWM2OD1yLkC0PFc6KM7:TR?= M1TU[XNCVkeHUh?=
SK-PN-DW M2LkRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrGTWM2OD1yLkC0PVQ6KM7:TR?= M2j4UXNCVkeHUh?=
ALL-PO NX6zbXA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMES5OVYh|ryP NYHBfIpzW0GQR1XS
NB6 Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z1S2lEPTB;MD6wOVI4OSEQvF2= M4\meXNCVkeHUh?=
IST-SL2 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LhbGlEPTB;MD6wOVM3OiEQvF2= M1zrfnNCVkeHUh?=
BB30-HNC NF70Z3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjmNWxKSzVyPUCuNFU4OyEQvF2= M2X2bXNCVkeHUh?=
SW962 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf6[GtKSzVyPUCuNFU4PjNizszN Mn7rV2FPT0WU
TGBC24TKB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDEPJdKSzVyPUCuNFU4QTlizszN M2HrR3NCVkeHUh?=
KINGS-1 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEW4NFMh|ryP MYXTRW5ITVJ?
HC-1 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCzTWM2OD1yLkC1PFI4KM7:TR?= M3;ibHNCVkeHUh?=
RS4-11 NHjoZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEW5N|gh|ryP MYrTRW5ITVJ?
LS-123 NX74fmU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzKTVhKSzVyPUCuNFU6PDJizszN M4HNOnNCVkeHUh?=
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SNU-C1 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUexUpVRUUN3ME2wMlM5OjF3IN88US=> NIrQNoNUSU6JRWK=
LS-513 M1nDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TMd2lEPTB;MD6zPVA4OSEQvF2= NETHSWNUSU6JRWK=
NOMO-1 M3L6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXrVop1UUN3ME2wMlM6QTdzIN88US=> NVe5eYtMW0GQR1XS
MS-1 NIrpT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj4SlNKSzVyPUCuOFAyPzdizszN MoL2V2FPT0WU
EKVX NGrXeoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHETWM2OD1yLkS0OFYyKM7:TR?= M4S0NHNCVkeHUh?=
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HCC1187 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;YTmlEPTB;MD60Olc3QCEQvF2= MXjTRW5ITVJ?
HCC2218 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXUNHpKSzVyPUCuOFczOjdizszN NUHLb|VEW0GQR1XS
NCI-H187 NFv1Zm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\NTWM2OD1yLkS3PFQh|ryP NW\BcHFwW0GQR1XS
DB M3;PT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnvTWM2OD1yLkWwNFU2KM7:TR?= MX3TRW5ITVJ?
NCI-H69 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1naeGlEPTB;MD61NFI1PyEQvF2= Ml3MV2FPT0WU
NCI-H1694 M1LqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvXbHVSUUN3ME2wMlUxPjl5IN88US=> Mm\OV2FPT0WU
CA46 NVjMR5NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L2WGlEPTB;MD61NFkyPyEQvF2= M4LwfnNCVkeHUh?=
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NCI-H720 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz0VI5KSzVyPUCuOVQ6PjJizszN MnPZV2FPT0WU
LU-134-A M2rGUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jOfWlEPTB;MD61OVI6PiEQvF2= Mn75V2FPT0WU
MC-CAR NGD6TnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\STWM2OD1yLkW1OFMyKM7:TR?= M4HXeXNCVkeHUh?=
NEC8 NYfq[pVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHaemFKSzVyPUCuOVYyPzJizszN NY\T[otNW0GQR1XS
NCI-H524 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PuWWlEPTB;MD61PFc1QCEQvF2= MWTTRW5ITVJ?
NCI-H1963 MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDYc2FUUUN3ME2wMlYzPThizszN M1LpZ3NCVkeHUh?=
SU-DHL-1 NXXRVo9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7ITWM2OD1yLk[0OVI3KM7:TR?= NGG0[ZlUSU6JRWK=
NCI-H1522 M2PJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwNkS4PFMh|ryP NITmUm9USU6JRWK=
NCI-H1155 NHXKPIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXO[YtzUUN3ME2wMlY2OzVizszN MYPTRW5ITVJ?
D-263MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L0bGlEPTB;MD62OlExOSEQvF2= Mn7UV2FPT0WU
TE-6 M{Hmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;hTWM2OD1yLk[4NVA1KM7:TR?= MoDyV2FPT0WU
NCI-H1417 M2PNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17wSGlEPTB;MD62PVcyOSEQvF2= NFvQTFNUSU6JRWK=
NCI-H510A MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nmcGlEPTB;MD63O|I{PiEQvF2= MnX6V2FPT0WU
KARPAS-45 M2fh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwN{iyN|Uh|ryP NVzTOIRZW0GQR1XS
IST-SL1 M{nKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLlZ4FKSzVyPUCuPFU5OjVizszN NV72cVNbW0GQR1XS
COLO-824 NH71R4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXERlBKSzVyPUCuPFc5OzVizszN NGPDPFRUSU6JRWK=
NCI-H526 NIq2SJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL6TWM2OD1yLkmwPVU5KM7:TR?= NVfxZWdVW0GQR1XS
NCI-H719 NIroZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e4Z2lEPTB;MD65OlY2PyEQvF2= NXrCUHpoW0GQR1XS
SF539 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfyTVl7UUN3ME2wMlk5Ozl4IN88US=> MnW4V2FPT0WU
NKM-1 NYjtTmpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH2eXI4UUN3ME2wMlk5PjZ|IN88US=> MofGV2FPT0WU
A253 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorUTWM2OD1yLkm4PFg2KM7:TR?= M1TLbXNCVkeHUh?=
TE-441-T MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL4TWM2OD1zLkC0N|Uh|ryP MlfWV2FPT0WU
COR-L88 M2CyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXERWNKSzVyPUGuNVE{PTRizszN NWTzbVJNW0GQR1XS
CPC-N MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXN[mFWUUN3ME2xMlE2QDh6IN88US=> M3T5fnNCVkeHUh?=
NCI-H2107 NH3PXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vifmlEPTB;MT6xO|I3OSEQvF2= MYHTRW5ITVJ?
ECC4 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFwMUi2PVMh|ryP NUXhb5ZqW0GQR1XS
NCI-H2141 NFfKdGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTFwMUmyPVkh|ryP MYHTRW5ITVJ?
NCI-H1770 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL3WHhKSzVyPUGuN|I6OjhizszN MVvTRW5ITVJ?
NCI-SNU-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXz3[ZFbUUN3ME2xMlM{ODRizszN MkLnV2FPT0WU
LU-165 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K0T2lEPTB;MT60OVQ3PyEQvF2= NEnONVVUSU6JRWK=
Raji NGftbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13qbmlEPTB;MT60O|I2QSEQvF2= MVjTRW5ITVJ?
EW-24 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTFwNUS2NVkh|ryP MXTTRW5ITVJ?
KP-N-RT-BM-1 NIL5WXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwNU[1OVEh|ryP NGLtOVJUSU6JRWK=
SK-MEL-1 M1HZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zqUmlEPTB;MT62OFg4PyEQvF2= NWnGPI9CW0GQR1XS
SCLC-21H MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPVWmNVUUN3ME2xMlY3PjVzIN88US=> MlXBV2FPT0WU
SIMA MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnLTWM2OD1zLk[4NlM{KM7:TR?= NUDFdYxIW0GQR1XS
NCI-H1304 NGXwSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwN{C3OlUh|ryP MWfTRW5ITVJ?
REH Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TKbWlEPTB;MT63NVA4QCEQvF2= NH\2VoRUSU6JRWK=
KP-N-YS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTtTWM2OD1zLkmzOVUyKM7:TR?= M2Dib3NCVkeHUh?=
DMS-153 NYL5fHdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof5TWM2OD1zLkm3OVkh|ryP MXLTRW5ITVJ?
NB10 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTCTWM2OD1{LkKwPFc5KM7:TR?= MX7TRW5ITVJ?
NCI-H345 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf1SGNQUUN3ME2yMlYyQTB3IN88US=> NFr3ZodUSU6JRWK=
SK-N-FI MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e2cmlEPTB;Mj63OVM5OSEQvF2= NYXHU4d2W0GQR1XS
NCI-H1092 NXHqbGVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPaTWM2OD1{Lkm1N|k1KM7:TR?= MVnTRW5ITVJ?
KM-H2 NUnI[XhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTwTWM2OD1|Lk[1N|k3KM7:TR?= NEn4dVFUSU6JRWK=
KG-1 M33Sb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTNwN{G2PFgh|ryP M17vZnNCVkeHUh?=
D-283MED Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrTb21KSzVyPUOuO|U5PyEQvF2= NVXX[ow2W0GQR1XS
LU-65 NVnxTotQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTRwMUG0PFUh|ryP MVXTRW5ITVJ?
MSTO-211H NVKzW5p[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRwMUi4PVgh|ryP NF7kbIxUSU6JRWK=
NCI-H2081 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXtZpZnUUN3ME20MlI6OTd2IN88US=> NXXGdXI2W0GQR1XS
D-247MG MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3vTWM2OD12LkSzNVkyKM7:TR?= NIPtXWxUSU6JRWK=
P31-FUJ MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTRwNEWwNVkh|ryP NE\jUnZUSU6JRWK=
DMS-79 Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LU[GlEPTB;ND65N|E5OyEQvF2= M4CyW3NCVkeHUh?=
KASUMI-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITHcI5KSzVyPUSuPVc2ODlizszN NF7Bd4dUSU6JRWK=
JVM-3 NFHjZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3d|dzUUN3ME21MlI2ODF2IN88US=> MXrTRW5ITVJ?
LAN-6 NV7BfYptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7wWnNHUUN3ME21MlUyPzN4IN88US=> M4rSUXNCVkeHUh?=
DJM-1 NF;WRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTVwNU[wNlkh|ryP NYrETYpPW0GQR1XS
JVM-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXLVXJKSzVyPUWuOlcxQTJizszN MknDV2FPT0WU
U-87-MG MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLrSHhKSzVyPUWuPFk6PjRizszN NGW1PJpUSU6JRWK=
SHP-77 NEOwUZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfXTWM2OD13Lkm0PVI5KM7:TR?= MlvpV2FPT0WU
RPMI-8866 NHjRdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonwTWM2OD14LkK3NFE{KM7:TR?= MmfXV2FPT0WU
ES7 M4fGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTZwM{m5NlQh|ryP M4G1WHNCVkeHUh?=
WSU-NHL NYTtboZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSxSVJKSzVyPU[uOVE3ODlizszN NX7DUIFHW0GQR1XS
CAS-1 M2jYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjGcGI6UUN3ME23MlA6PzR7IN88US=> NHu3[|BUSU6JRWK=
MHH-NB-11 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TMOmlEPTB;OD6yN|E2OiEQvF2= M1vnfXNCVkeHUh?=
ES5 NIrybYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPYd5ZKSzVyPUmuOVIzQDZizszN MnTpV2FPT0WU
HDLM-2 NVuzdmZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n1e2lEPTB;OT65OVkxOiEQvF2= MnvBV2FPT0WU
NCI-H2171 NEfHOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT5TWM2OD1zMD61PVI4KM7:TR?= MWLTRW5ITVJ?
LNCaP-Clone-FGC M3PxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFzLkO3NVgh|ryP MnzGV2FPT0WU
NCI-H1395 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LCTGlEPTB;MUKuNlY6QSEQvF2= MVXTRW5ITVJ?
NCI-H1436 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX0XpZPUUN3ME2xN{4{OTl3IN88US=> NHTCR4tUSU6JRWK=
RCC10RGB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHnTWM2OD1zMz6zNlIyKM7:TR?= M3zPeHNCVkeHUh?=
SW684 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DCTGlEPTB;MUOuPVc6PyEQvF2= NUK4[282W0GQR1XS
NCI-H1650 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17XcmlEPTB;MUWuNFQ1PyEQvF2= MoDqV2FPT0WU
EW-13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jZOWlEPTB;MUWuNlAzOSEQvF2= MWHTRW5ITVJ?
EC-GI-10 M3\3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3aTWM2OD1zNT64OlQ1KM7:TR?= M1\vUHNCVkeHUh?=
CHP-126 M4LGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO5dnZWUUN3ME2xO{4yQTF6IN88US=> NWLnT|NXW0GQR1XS
NCI-H226 NU\WUmFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLaTWM2OD1zOD6wOFA{KM7:TR?= MVrTRW5ITVJ?
NCI-H1838 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojJTWM2OD1{MD6xPFQ5KM7:TR?= NGTvVnFUSU6JRWK=
EW-11 M4KyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfPSXhKSzVyPUK0MlI4OThizszN Mle3V2FPT0WU
EB2 M1fofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLYTpRKSzVyPUOxMlU{OThizszN NGnHb21USU6JRWK=
D-502MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi1TWM2OD12Mz65NlI6KM7:TR?= MnXJV2FPT0WU
U-698-M M2DvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4O3ZKSzVyPUS4Mlg3PzFizszN MlfEV2FPT0WU
ES3 NX64dGNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDlUldKSzVyPUS5MlM5QTNizszN NIDVVGFUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG 400+0.5% Tween80+5% Propylene glycol 30mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID