Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NVfMWXFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v5TmlEPTB;MD6wNFA{ODZizszN MnrtV2FPT0WU
OCUB-M Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMECxPVQh|ryP NWex[phSW0GQR1XS
DOHH-2 NHvZN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMECyNlUh|ryP NIXsNYhUSU6JRWK=
NOS-1 NGSzUJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMECyOFIh|ryP MkDVV2FPT0WU
L-363 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHLTWM2OD1yLkCwNlg1KM7:TR?= Mm[yV2FPT0WU
RL95-2 M1rMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LPXmlEPTB;MD6wNFMzKM7:TR?= M3u5cHNCVkeHUh?=
BL-70 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn5TWM2OD1yLkCwN|M4KM7:TR?= MnP0V2FPT0WU
TGBC1TKB NYXwVFQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECzO|kh|ryP Mo\6V2FPT0WU
697 M2X5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEC2N|Qh|ryP M{fLfHNCVkeHUh?=
RPMI-8226 NFzMVYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PNZ2lEPTB;MD6wNFY2OSEQvF2= M3HSXnNCVkeHUh?=
BL-41 NFrM[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXRTWM2OD1yLkCwOlk3KM7:TR?= MlfkV2FPT0WU
MRK-nu-1 M1TGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3aTWM2OD1yLkCwO|A4KM7:TR?= MkLIV2FPT0WU
EW-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnBR3p1UUN3ME2wMlAxPzR7IN88US=> NYP1T2luW0GQR1XS
EVSA-T MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnwOZdOUUN3ME2wMlAxQDl{IN88US=> NUP5SVBwW0GQR1XS
HUTU-80 M{[5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV64bnlxUUN3ME2wMlAxQTJ7IN88US=> MmTuV2FPT0WU
VA-ES-BJ NIfPfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEi5TYZKSzVyPUCuNFA6QDRizszN M171VXNCVkeHUh?=
GCIY MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C2fWlEPTB;MD6wNVAxPyEQvF2= Mnu5V2FPT0WU
ES6 NV71RVZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13LemlEPTB;MD6wNVA5OyEQvF2= MVfTRW5ITVJ?
NALM-6 NGfCdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;mUGlEPTB;MD6wNVExOiEQvF2= NUfXbZNYW0GQR1XS
LB996-RCC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEGxN|ch|ryP MmfjV2FPT0WU
EW-16 NYnnNVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTuPHZmUUN3ME2wMlAyOTl{IN88US=> NXvuOYZVW0GQR1XS
KALS-1 NWDx[I9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLrTWM2OD1yLkCxNVk5KM7:TR?= M3PEb3NCVkeHUh?=
OPM-2 NHrUTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HYc2lEPTB;MD6wNVI6KM7:TR?= Ml;lV2FPT0WU
KU812 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rUSmlEPTB;MD6wNVI6PiEQvF2= M3;kOHNCVkeHUh?=
A4-Fuk NFzDRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjXRVhJUUN3ME2wMlAyOzF7IN88US=> M3uxT3NCVkeHUh?=
KGN NV3PboRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEGzOVkh|ryP NXnHVIhVW0GQR1XS
KS-1 M1rnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7wSI8{UUN3ME2wMlAyOzl{IN88US=> NXn3blBwW0GQR1XS
no-11 NX\kdWhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEGzPVUh|ryP MoX4V2FPT0WU
PSN1 M{fzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEG0NFkh|ryP NWLzfGx1W0GQR1XS
SK-LMS-1 NVfSRlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\3SpNWUUN3ME2wMlAyPDF|IN88US=> MV3TRW5ITVJ?
LS-411N NVzYbGZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLZXZNnUUN3ME2wMlAyPDN7IN88US=> M{TOU3NCVkeHUh?=
HT-144 NHvldI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLNNVJiUUN3ME2wMlAyPDVzIN88US=> NYPTeIkyW0GQR1XS
ACN NEXwUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEG1JO69VQ>? MYHTRW5ITVJ?
RKO M1fhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LiPWlEPTB;MD6wNVU{OyEQvF2= NEnMPWRUSU6JRWK=
CMK MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr0SGdKSzVyPUCuNFE2PDNizszN NH33S5JUSU6JRWK=
GB-1 NW\ycGJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW4TWM2OD1yLkCxOVU{KM7:TR?= NIjhTWZUSU6JRWK=
KE-37 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDJTWM2OD1yLkCxOVc{KM7:TR?= NGXmT4dUSU6JRWK=
no-10 NXPKPGxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTYTWM2OD1yLkCxOVg1KM7:TR?= MWHTRW5ITVJ?
MOLT-16 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEG2NlIh|ryP NYrvVop4W0GQR1XS
HEL NUjLdXUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTsZnRUUUN3ME2wMlAyPjRizszN Mo\JV2FPT0WU
NCI-H1355 MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETaUplKSzVyPUCuNFE3PDZizszN NXK2eXNCW0GQR1XS
IST-MEL1 NGOy[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;kfVVwUUN3ME2wMlAyPzd2IN88US=> Mmr3V2FPT0WU
MHH-PREB-1 M3v4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2yb5ZKSzVyPUCuNFE5OThizszN NGPBS5BUSU6JRWK=
ES8 NXjT[Gp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHOflRKSzVyPUCuNFE5PDRizszN MlOyV2FPT0WU
LC-2-ad NGPkVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDvW5pSUUN3ME2wMlAzOTN5IN88US=> NFjieGNUSU6JRWK=
LAMA-84 M3ixOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jSPGlEPTB;MD6wNlE3PyEQvF2= MUHTRW5ITVJ?
BV-173 NH\JboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluwTWM2OD1yLkCyNlA{KM7:TR?= M2DOUHNCVkeHUh?=
SW872 NHnINW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3JdJpKSzVyPUCuNFIzPDdizszN NUnkbZR6W0GQR1XS
SK-UT-1 NFnsW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPJTWM2OD1yLkCyNlYyKM7:TR?= MnTvV2FPT0WU
OS-RC-2 Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEKzNlMh|ryP M4LpeHNCVkeHUh?=
NCI-H747 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEKzN{DPxE1? M3PqWHNCVkeHUh?=
MZ2-MEL M1;EfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfSWZdKSzVyPUCuNFI{OzdizszN NVnBcoMzW0GQR1XS
TE-11 NYjhV5dCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;aS2lEPTB;MD6wNlM4OiEQvF2= M1XmfnNCVkeHUh?=
KURAMOCHI MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[wVYRKSzVyPUCuNFI1OTRizszN M{ThfnNCVkeHUh?=
HD-MY-Z MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEK0NlYh|ryP M3Oyd3NCVkeHUh?=
GI-1 NHL1d49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHR[3B7UUN3ME2wMlAzPDZ7IN88US=> NUHUb|ZXW0GQR1XS
LB1047-RCC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33iSmlEPTB;MD6wNlQ5QCEQvF2= M1jK[HNCVkeHUh?=
TE-12 NWqxTpp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX0TWM2OD1yLkCyOVUh|ryP M3HPPHNCVkeHUh?=
MZ7-mel M3r2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEK2NFkh|ryP NXG2OG9jW0GQR1XS
MMAC-SF NUnsWHNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILkZlNKSzVyPUCuNFI3OzNizszN M3XURnNCVkeHUh?=
A101D M1GyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HjW2lEPTB;MD6wNlY2KM7:TR?= MUnTRW5ITVJ?
GR-ST MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PGTGlEPTB;MD6wNlY2PSEQvF2= MmnJV2FPT0WU
MC116 M4PCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULNSZNKUUN3ME2wMlAzPjhizszN MWTTRW5ITVJ?
Ramos-2G6-4C10 M1fN[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjYcYlxUUN3ME2wMlAzPzVizszN Ml3mV2FPT0WU
ATN-1 NYrFO3ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjYTWM2OD1yLkCyO|g6KM7:TR?= M2jZSHNCVkeHUh?=
MFH-ino NXjaTmhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3qWm5KSzVyPUCuNFI5OTJizszN M1rxRXNCVkeHUh?=
DEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\iTWM2OD1yLkCyPFE2KM7:TR?= NGXS[ZZUSU6JRWK=
OCI-AML2 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEK4O|Eh|ryP MWjTRW5ITVJ?
LXF-289 NV:xeXg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXQenVKSzVyPUCuNFI5PzJizszN NFnvVVBUSU6JRWK=
IA-LM NGW2OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXl[WVKSzVyPUCuNFI6OTdizszN NH7UeWdUSU6JRWK=
EoL-1-cell NGW4cHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEK5PVYh|ryP NEDWWWpUSU6JRWK=
OVCAR-4 NI\SPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXH[mxKSzVyPUCuNFMxQTRizszN MX\TRW5ITVJ?
ES1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnntTWM2OD1yLkCzNFk4KM7:TR?= MmK2V2FPT0WU
CESS M2rrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG3TWM2OD1yLkCzNFk6KM7:TR?= NWHmXWh{W0GQR1XS
GAK MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEOxPFYh|ryP NIO2OIpUSU6JRWK=
NTERA-S-cl-D1 NEXvWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPkTWM2OD1yLkCzNlI3KM7:TR?= M2\CR3NCVkeHUh?=
TE-10 MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr0eVVKSzVyPUCuNFM{OTFizszN NYCw[2RUW0GQR1XS
CCRF-CEM M3nvXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfSTGxKSzVyPUCuNFM{PzFizszN NF;oc2FUSU6JRWK=
NMC-G1 NETpOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL5fItDUUN3ME2wMlA{PDR6IN88US=> NHHzUZFUSU6JRWK=
HOP-62 NEO5fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEO1OVYh|ryP NXvVWo1XW0GQR1XS
SH-4 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M375W2lEPTB;MD6wN|U5OiEQvF2= MoW1V2FPT0WU
NCI-H1648 NGGxOJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\TO3dKSzVyPUCuNFM3OjJizszN NUi5fYtGW0GQR1XS
EB-3 M37vRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfkOnV7UUN3ME2wMlA{PjR|IN88US=> MY\TRW5ITVJ?
BB65-RCC NUW4NlVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEO2PVEh|ryP MV;TRW5ITVJ?
BE-13 M3;UbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTZTWM2OD1yLkCzO|U6KM7:TR?= NVXySHgyW0GQR1XS
CP67-MEL NIrqeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TrRWlEPTB;MD6wN|c2QSEQvF2= NInEW2hUSU6JRWK=
SW954 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HEfmlEPTB;MD6wN|c6KM7:TR?= NYnicmN4W0GQR1XS
TE-5 NHHOUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[4TWM2OD1yLkCzPFU1KM7:TR?= NXfHfJBqW0GQR1XS
HCE-4 M1nnfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEO4OVUh|ryP NYSxVJh5W0GQR1XS
LC-1F MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\sTWM2OD1yLkCzPVg6KM7:TR?= NYH4SFA3W0GQR1XS
TK10 NYCzbmg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L6dmlEPTB;MD6wOFAyQSEQvF2= M4nwVHNCVkeHUh?=
SJSA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XydmlEPTB;MD6wOFE5QCEQvF2= NF;ZTlZUSU6JRWK=
Daudi M3SwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMESyNlUh|ryP MULTRW5ITVJ?
SW982 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7wOWJKSzVyPUCuNFQzPDZizszN NWnjN3JkW0GQR1XS
SF126 NYq0XnhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrlTWM2OD1yLkC0N|YyKM7:TR?= NW\QTYVKW0GQR1XS
TE-15 NHz1VYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL2TWM2OD1yLkC0OFM2KM7:TR?= MXvTRW5ITVJ?
COLO-684 NETXUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjoTWM2OD1yLkC0OVYyKM7:TR?= NUTrZ2NDW0GQR1XS
8-MG-BA MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj4TWM2OD1yLkC0OlI6KM7:TR?= MlXNV2FPT0WU
NB13 M33qOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT4c|ZKSzVyPUCuNFQ4PzZizszN M13KS3NCVkeHUh?=
HCC1599 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLXTWM2OD1yLkC0PFc6KM7:TR?= MmHuV2FPT0WU
SK-PN-DW MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInITnpKSzVyPUCuNFQ6PDlizszN NFH2SJVUSU6JRWK=
ALL-PO NWnib5p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXSfJlMUUN3ME2wMlA1QTV4IN88US=> NHnXdGpUSU6JRWK=
NB6 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fnemlEPTB;MD6wOVI4OSEQvF2= M4DFWnNCVkeHUh?=
IST-SL2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEWzOlIh|ryP NHGxTXNUSU6JRWK=
BB30-HNC MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfwTWM2OD1yLkC1O|Mh|ryP NFWyd4lUSU6JRWK=
SW962 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnJWWFKSzVyPUCuNFU4PjNizszN NVjze3h4W0GQR1XS
TGBC24TKB MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXWdpVuUUN3ME2wMlA2Pzl7IN88US=> MUTTRW5ITVJ?
KINGS-1 M3ntUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEW4NFMh|ryP MWfTRW5ITVJ?
HC-1 NXnRU3EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGyTWM2OD1yLkC1PFI4KM7:TR?= NV3iO5ZEW0GQR1XS
RS4-11 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fRUGlEPTB;MD6wOVk{QCEQvF2= M4[yUnNCVkeHUh?=
LS-123 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P3UGlEPTB;MD6wOVk1OiEQvF2= MofQV2FPT0WU
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NCI-H2107 M{L1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv0TWM2OD1zLkG3NlYyKM7:TR?= Ml;XV2FPT0WU
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NCI-H2141 M1vGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjpOWlKSzVyPUGuNVkzQTlizszN M4rvUXNCVkeHUh?=
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LU-165 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO3TWM2OD1zLkS1OFY4KM7:TR?= MX7TRW5ITVJ?
Raji MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\nTmlEPTB;MT60O|I2QSEQvF2= NHWzbYdUSU6JRWK=
EW-24 M4\Ubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi1WHNKSzVyPUGuOVQ3OTlizszN MlvGV2FPT0WU
KP-N-RT-BM-1 NVjqfmdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTFwNU[1OVEh|ryP NGfoOm5USU6JRWK=
SK-MEL-1 M{j6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwNkS4O|ch|ryP NY\pNWtQW0GQR1XS
SCLC-21H NXjkZ4R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTFwNk[2OVEh|ryP M{Puc3NCVkeHUh?=
SIMA NFjuS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn0XYJDUUN3ME2xMlY5OjN|IN88US=> MkP2V2FPT0WU
NCI-H1304 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X4fWlEPTB;MT63NFc3PSEQvF2= NGOyRpRUSU6JRWK=
REH Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5NGlEPTB;MT63NVA4QCEQvF2= NIS3R2pUSU6JRWK=
KP-N-YS NVPRSmxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z3eWlEPTB;MT65N|U2OSEQvF2= MWPTRW5ITVJ?
DMS-153 NXjnXYo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwOUe1PUDPxE1? M1jnNnNCVkeHUh?=
NB10 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnmRXVKSzVyPUKuNlA5PzhizszN M3LJdnNCVkeHUh?=
NCI-H345 NGK5S5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK5SnV3UUN3ME2yMlYyQTB3IN88US=> NWj4RY1QW0GQR1XS
SK-N-FI MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnINopKSzVyPUKuO|U{QDFizszN MYDTRW5ITVJ?
NCI-H1092 NWrQ[2o1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzOfGRDUUN3ME2yMlk2Ozl2IN88US=> NXPVNmtOW0GQR1XS
KM-H2 NVroflFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC3[m51UUN3ME2zMlY2Ozl4IN88US=> NVXGN29oW0GQR1XS
KG-1 NVP0eIdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{CweGlEPTB;Mz63NVY5QCEQvF2= MnHGV2FPT0WU
D-283MED NXPnTmxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLxTWM2OD1|Lke1PFch|ryP NWnuR2hbW0GQR1XS
LU-65 NEXyTIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTRwMUG0PFUh|ryP NITLTWhUSU6JRWK=
MSTO-211H NIXmd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ON2pKSzVyPUSuNVg5QThizszN MUjTRW5ITVJ?
NCI-H2081 M1H4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W0Z2lEPTB;ND6yPVE4PCEQvF2= MYDTRW5ITVJ?
D-247MG M2fQOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jT[mlEPTB;ND60N|E6OSEQvF2= NYPlUlRLW0GQR1XS
P31-FUJ M{\WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fXNWlEPTB;ND60OVAyQSEQvF2= MkTyV2FPT0WU
DMS-79 NHXU[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHpfWtKSzVyPUSuPVMyQDNizszN MlH5V2FPT0WU
KASUMI-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwOUe1NFkh|ryP M1PO[XNCVkeHUh?=
JVM-3 NUTlRYFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K0PGlEPTB;NT6yOVAyPCEQvF2= MWfTRW5ITVJ?
LAN-6 NWSycJQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LJPWlEPTB;NT61NVc{PiEQvF2= NIryNWZUSU6JRWK=
DJM-1 NFnwT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFe1Z41KSzVyPUWuOVYxOjlizszN MmDmV2FPT0WU
JVM-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;xcpoyUUN3ME21MlY4ODl{IN88US=> NVHsW2F1W0GQR1XS
U-87-MG NVPpNWZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfmPZBJUUN3ME21Mlg6QTZ2IN88US=> M3PWenNCVkeHUh?=
SHP-77 M3;sNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvxbpBKSzVyPUWuPVQ6OjhizszN MXnTRW5ITVJ?
RPMI-8866 M1zvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke1TWM2OD14LkK3NFE{KM7:TR?= MYfTRW5ITVJ?
ES7 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfIeVFKSzVyPU[uN|k6OjRizszN NYXMXHBzW0GQR1XS
WSU-NHL NWXrT3BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3BTWM2OD14LkWxOlA6KM7:TR?= MWTTRW5ITVJ?
CAS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHCOXNLUUN3ME23MlA6PzR7IN88US=> MoHWV2FPT0WU
MHH-NB-11 NHPqNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjMRmNlUUN3ME24MlI{OTV{IN88US=> NVL0bG95W0GQR1XS
ES5 M{[1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zWeGlEPTB;OT61NlI5PiEQvF2= Moi5V2FPT0WU
HDLM-2 M3fRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq4UY5KSzVyPUmuPVU6ODJizszN MVHTRW5ITVJ?
NCI-H2171 NHu3TnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnz[Ip5UUN3ME2xNE42QTJ5IN88US=> M2DKN3NCVkeHUh?=
LNCaP-Clone-FGC NVn4O5lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPkTWM2OD1zMT6zO|E5KM7:TR?= MmHZV2FPT0WU
NCI-H1395 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF{LkK2PVkh|ryP MULTRW5ITVJ?
NCI-H1436 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF|LkOxPVUh|ryP NFjMdmFUSU6JRWK=
RCC10RGB MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnR[HZKSzVyPUGzMlMzOjFizszN NHfE[|FUSU6JRWK=
SW684 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF|Lkm3PVch|ryP MljEV2FPT0WU
NCI-H1650 NXXrOVQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF3LkC0OFch|ryP NFLZXI1USU6JRWK=
EW-13 NETZeFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHJOY1rUUN3ME2xOU4zODJzIN88US=> MkXrV2FPT0WU
EC-GI-10 NVXsVJg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\2TWM2OD1zNT64OlQ1KM7:TR?= Ml\4V2FPT0WU
CHP-126 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTjTWM2OD1zNz6xPVE5KM7:TR?= MmP6V2FPT0WU
NCI-H226 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzl[nZCUUN3ME2xPE4xPDB|IN88US=> NW[yTmt7W0GQR1XS
NCI-H1838 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD1{MD6xPFQ5KM7:TR?= MonMV2FPT0WU
EW-11 NYfE[mZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfSRWhIUUN3ME2yOE4zPzF6IN88US=> MnzjV2FPT0WU
EB2 M{TvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PCWWlEPTB;M{GuOVMyQCEQvF2= MVnTRW5ITVJ?
D-502MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR|LkmyNlkh|ryP NXz6R4lxW0GQR1XS
U-698-M NFHudHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nYfGlEPTB;NEiuPFY4OSEQvF2= MoTsV2FPT0WU
ES3 NIGxfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PnSWlEPTB;NEmuN|g6OyEQvF2= MVrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG 400+0.5% Tween80+5% Propylene glycol
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID