Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NELJVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[5NolKSzVyPUCuNFAxOzB4IN88US=> NGLhelFUSU6JRWK=
OCUB-M MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\LUGlEPTB;MD6wNFE6PCEQvF2= NXToTJVTW0GQR1XS
DOHH-2 NHe4b2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTMVFJKSzVyPUCuNFAzOjVizszN NEmxWZZUSU6JRWK=
NOS-1 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPRTWM2OD1yLkCwNlQzKM7:TR?= MkjIV2FPT0WU
L-363 M2PDbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMECyPFQh|ryP MXjTRW5ITVJ?
RL95-2 NYTIc4hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3ITWM2OD1yLkCwN|Ih|ryP MoOwV2FPT0WU
BL-70 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3X1PGlEPTB;MD6wNFM{PyEQvF2= M1PmeHNCVkeHUh?=
TGBC1TKB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzYTWM2OD1yLkCwN|c6KM7:TR?= MXjTRW5ITVJ?
697 MlvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMEC2N|Qh|ryP NFvmWmJUSU6JRWK=
RPMI-8226 M3u2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTXdmZKUUN3ME2wMlAxPjVzIN88US=> MY\TRW5ITVJ?
BL-41 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPjTWM2OD1yLkCwOlk3KM7:TR?= NELWclJUSU6JRWK=
MRK-nu-1 M1fXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofQTWM2OD1yLkCwO|A4KM7:TR?= NHTKd|dUSU6JRWK=
EW-1 NX3rRpp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK3ZoJ4UUN3ME2wMlAxPzR7IN88US=> NY\GcZBqW0GQR1XS
EVSA-T NVu4bXgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M376RmlEPTB;MD6wNFg6OiEQvF2= M2L2dnNCVkeHUh?=
HUTU-80 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjkbpZ{UUN3ME2wMlAxQTJ7IN88US=> NXrlWWJPW0GQR1XS
VA-ES-BJ NVe1dHdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DNemlEPTB;MD6wNFk5PCEQvF2= MmnBV2FPT0WU
GCIY NUL2W5J7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzIV5ZsUUN3ME2wMlAyODB5IN88US=> MlzlV2FPT0WU
ES6 NFf4ZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vyPGlEPTB;MD6wNVA5OyEQvF2= M4\oUHNCVkeHUh?=
NALM-6 NXjoVG5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEGxNFIh|ryP M1uzdXNCVkeHUh?=
LB996-RCC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr1TWM2OD1yLkCxNVM4KM7:TR?= MUfTRW5ITVJ?
EW-16 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITQSZNKSzVyPUCuNFEyQTJizszN M4SycHNCVkeHUh?=
KALS-1 NUOzflFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEGxPVgh|ryP NHPueYZUSU6JRWK=
OPM-2 NF;Rb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnPOZBKSzVyPUCuNFEzQSEQvF2= MmjHV2FPT0WU
KU812 NWnaboJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\XR|gzUUN3ME2wMlAyOjl4IN88US=> NVvNUVhpW0GQR1XS
A4-Fuk M4jLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEGzNVkh|ryP M1TCWXNCVkeHUh?=
KGN MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIS0b|FKSzVyPUCuNFE{PTlizszN MoewV2FPT0WU
KS-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEGzPVIh|ryP NGnmcI1USU6JRWK=
no-11 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEGzPVUh|ryP NUPI[3JnW0GQR1XS
PSN1 NWn5SZN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvXOZFKSzVyPUCuNFE1ODlizszN MofqV2FPT0WU
SK-LMS-1 NVvRXXNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEG0NVMh|ryP NXLp[2NiW0GQR1XS
LS-411N M3rUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPqdmlKSzVyPUCuNFE1OzlizszN NYjSNmpsW0GQR1XS
HT-144 NF3zdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7IN4NIUUN3ME2wMlAyPDVzIN88US=> Mm\0V2FPT0WU
ACN NGq5bHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETrbnpKSzVyPUCuNFE2KM7:TR?= NHH4bW1USU6JRWK=
RKO M{fRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEG1N|Mh|ryP MmLKV2FPT0WU
CMK NUHBUoRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEG1OFMh|ryP NXrpbmRFW0GQR1XS
GB-1 NGnNUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXTUGNKSzVyPUCuNFE2PTNizszN NX20[mVOW0GQR1XS
KE-37 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEG1O|Mh|ryP NEfDWmFUSU6JRWK=
no-10 NHLBXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr0UGNKSzVyPUCuNFE2QDRizszN Ml;HV2FPT0WU
MOLT-16 NHe4RWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPPT|J6UUN3ME2wMlAyPjJ{IN88US=> MlvTV2FPT0WU
HEL MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEG2OEDPxE1? M1zaUnNCVkeHUh?=
NCI-H1355 M3\EZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C5UmlEPTB;MD6wNVY1PiEQvF2= MkPwV2FPT0WU
IST-MEL1 M4K4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrPTGtwUUN3ME2wMlAyPzd2IN88US=> NHH2TWRUSU6JRWK=
MHH-PREB-1 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHOe5VKSzVyPUCuNFE5OThizszN NIDo[|RUSU6JRWK=
ES8 NHzVTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ryWmlEPTB;MD6wNVg1PCEQvF2= NGHIVZNUSU6JRWK=
LC-2-ad Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfLTWM2OD1yLkCyNVM4KM7:TR?= M{OzenNCVkeHUh?=
LAMA-84 NGXJO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrP[odWUUN3ME2wMlAzOTZ5IN88US=> M3LSR3NCVkeHUh?=
BV-173 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjLTWM2OD1yLkCyNlA{KM7:TR?= NEnVe3pUSU6JRWK=
SW872 NYXHfYJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEKyOFch|ryP MmPYV2FPT0WU
SK-UT-1 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HhNmlEPTB;MD6wNlI3OSEQvF2= NHnvOGZUSU6JRWK=
OS-RC-2 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vBZWlEPTB;MD6wNlMzOyEQvF2= M4rr[XNCVkeHUh?=
NCI-H747 Ml7SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jSPGlEPTB;MD6wNlM{KM7:TR?= M4fy[3NCVkeHUh?=
MZ2-MEL NWn3To9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ad2lEPTB;MD6wNlM{PyEQvF2= MXjTRW5ITVJ?
TE-11 NG\FR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjRUJhZUUN3ME2wMlAzOzd{IN88US=> NYrVVlFGW0GQR1XS
KURAMOCHI M2PtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYizb4JjUUN3ME2wMlAzPDF2IN88US=> Mlq3V2FPT0WU
HD-MY-Z NELZ[G5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEK0NlYh|ryP MWnTRW5ITVJ?
GI-1 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEK0Olkh|ryP MonsV2FPT0WU
LB1047-RCC NFu4VIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGz[Fd1UUN3ME2wMlAzPDh6IN88US=> NHXZenBUSU6JRWK=
TE-12 Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEK1OUDPxE1? NV7U[3Z[W0GQR1XS
MZ7-mel MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DidmlEPTB;MD6wNlYxQSEQvF2= NV[xdYR{W0GQR1XS
MMAC-SF NGTIfXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkSzTWM2OD1yLkCyOlM{KM7:TR?= Moq5V2FPT0WU
A101D NVKwepU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHP[WRKSzVyPUCuNFI3PSEQvF2= Mne5V2FPT0WU
GR-ST MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvlTWM2OD1yLkCyOlU2KM7:TR?= NEXpfVdUSU6JRWK=
MC116 NIXsNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7EXVhKSzVyPUCuNFI3QCEQvF2= NYm1NHRFW0GQR1XS
Ramos-2G6-4C10 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILPZmhKSzVyPUCuNFI4PSEQvF2= M1zObnNCVkeHUh?=
ATN-1 NHPvSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvTZopKSzVyPUCuNFI4QDlizszN M4jFWHNCVkeHUh?=
MFH-ino NVT3WJUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTiTWM2OD1yLkCyPFEzKM7:TR?= NGPIVFlUSU6JRWK=
DEL M4[1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHzd2NHUUN3ME2wMlAzQDF3IN88US=> MmPBV2FPT0WU
OCI-AML2 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\3UGlEPTB;MD6wNlg4OSEQvF2= MorOV2FPT0WU
LXF-289 MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPLRlFKSzVyPUCuNFI5PzJizszN NXLFeGJTW0GQR1XS
IA-LM M{PYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m0XGlEPTB;MD6wNlkyPyEQvF2= NHnG[GpUSU6JRWK=
EoL-1-cell MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL0T25KSzVyPUCuNFI6QTZizszN MnSyV2FPT0WU
OVCAR-4 NYfo[|YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Fe4ZKSzVyPUCuNFMxQTRizszN M{PyVnNCVkeHUh?=
ES1 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjkS4ZKSzVyPUCuNFMxQTdizszN NH\GO2lUSU6JRWK=
CESS NHWw[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXSTWM2OD1yLkCzNFk6KM7:TR?= NYDMe|duW0GQR1XS
GAK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEOxPFYh|ryP M1PWUnNCVkeHUh?=
NTERA-S-cl-D1 M{HZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\oZWlEPTB;MD6wN|IzPiEQvF2= Mn;JV2FPT0WU
TE-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfDbYxKSzVyPUCuNFM{OTFizszN M3\XVXNCVkeHUh?=
CCRF-CEM NVTDe2ttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rTXGlEPTB;MD6wN|M4OSEQvF2= MlqwV2FPT0WU
NMC-G1 M2frcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ZTWM2OD1yLkCzOFQ5KM7:TR?= MUDTRW5ITVJ?
HOP-62 M1XBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3P6bWlEPTB;MD6wN|U2PiEQvF2= M2PR[nNCVkeHUh?=
SH-4 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiwd3l4UUN3ME2wMlA{PTh{IN88US=> M3rzTHNCVkeHUh?=
NCI-H1648 NV64[HBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvBTWM2OD1yLkCzOlIzKM7:TR?= NXP2TGs4W0GQR1XS
EB-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrNSHZKSzVyPUCuNFM3PDNizszN NY[5SHdjW0GQR1XS
BB65-RCC NGPFdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrWTWM2OD1yLkCzOlkyKM7:TR?= NGjUdGxUSU6JRWK=
BE-13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP4TWM2OD1yLkCzO|U6KM7:TR?= NYrBUmxTW0GQR1XS
CP67-MEL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPlTWM2OD1yLkCzO|U6KM7:TR?= M3z6SXNCVkeHUh?=
SW954 NEjLVGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEO3PUDPxE1? Mm\pV2FPT0WU
TE-5 Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEO4OVQh|ryP M1nLcnNCVkeHUh?=
HCE-4 NEj6eG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\LNHdbUUN3ME2wMlA{QDV3IN88US=> NEH1e|FUSU6JRWK=
LC-1F MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEO5PFkh|ryP NV7QXmNmW0GQR1XS
TK10 NXXHZ483T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTaUpByUUN3ME2wMlA1ODF7IN88US=> NI\FOFNUSU6JRWK=
SJSA-1 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELu[lJKSzVyPUCuNFQyQDhizszN NVvNTnNPW0GQR1XS
Daudi NGfRVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMESyNlUh|ryP NYHGN294W0GQR1XS
SW982 M4HPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fhc2lEPTB;MD6wOFI1PiEQvF2= MoDzV2FPT0WU
SF126 NHHUe|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTCc3dlUUN3ME2wMlA1OzZzIN88US=> NGfndHhUSU6JRWK=
TE-15 NHPHfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\RTWM2OD1yLkC0OFM2KM7:TR?= MoXQV2FPT0WU
COLO-684 M4q5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvtTHRKSzVyPUCuNFQ2PjFizszN NGDpT5BUSU6JRWK=
8-MG-BA MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\PTWM2OD1yLkC0OlI6KM7:TR?= NWPkTphCW0GQR1XS
NB13 NYHMdpAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPLTWM2OD1yLkC0O|c3KM7:TR?= NXf5S3lXW0GQR1XS
HCC1599 M1uxbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j5R2lEPTB;MD6wOFg4QSEQvF2= MUfTRW5ITVJ?
SK-PN-DW MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLvTWM2OD1yLkC0PVQ6KM7:TR?= NV\hbnNXW0GQR1XS
ALL-PO MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW0TWM2OD1yLkC0PVU3KM7:TR?= MlvNV2FPT0WU
NB6 NFPPR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PLZWlEPTB;MD6wOVI4OSEQvF2= MXLTRW5ITVJ?
IST-SL2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:1TWM2OD1yLkC1N|YzKM7:TR?= MYXTRW5ITVJ?
BB30-HNC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGycGhKSzVyPUCuNFU4OyEQvF2= MWPTRW5ITVJ?
SW962 NUPrNI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEW3OlMh|ryP MW\TRW5ITVJ?
TGBC24TKB M2H0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXHdlNKSzVyPUCuNFU4QTlizszN NH7GdZdUSU6JRWK=
KINGS-1 Mn7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jIVWlEPTB;MD6wOVgxOyEQvF2= NIiwbXBUSU6JRWK=
HC-1 NXfub|R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TVN2lEPTB;MD6wOVgzPyEQvF2= M{jYXnNCVkeHUh?=
RS4-11 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLB[2JoUUN3ME2wMlA2QTN6IN88US=> MnuxV2FPT0WU
LS-123 NXPZZWllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDSTWM2OD1yLkC1PVQzKM7:TR?= MmfKV2FPT0WU
A3-KAW NUG4UGVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwME[yNlUh|ryP MU\TRW5ITVJ?
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Raji MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zUSGlEPTB;MT60O|I2QSEQvF2= MofOV2FPT0WU
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SIMA NHO1WVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\KWo9KSzVyPUGuOlgzOzNizszN MofoV2FPT0WU
NCI-H1304 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH6TWM2OD1zLkewO|Y2KM7:TR?= MlTWV2FPT0WU
REH NYP3XIdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljpTWM2OD1zLkexNFc5KM7:TR?= NHXLPYxUSU6JRWK=
KP-N-YS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHsPJlKSzVyPUGuPVM2PTFizszN M1G2TXNCVkeHUh?=
DMS-153 NFGzWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnFRpZ[UUN3ME2xMlk4PTlizszN MmfTV2FPT0WU
NB10 NVTRXJA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnlTWM2OD1{LkKwPFc5KM7:TR?= MlzCV2FPT0WU
NCI-H345 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWW3T|A{UUN3ME2yMlYyQTB3IN88US=> NXnwbJFoW0GQR1XS
SK-N-FI MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrVWGxKSzVyPUKuO|U{QDFizszN M2rpN3NCVkeHUh?=
NCI-H1092 NHrFTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITIRW5KSzVyPUKuPVU{QTRizszN NYfQToxrW0GQR1XS
KM-H2 NU\tOHpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHXTWM2OD1|Lk[1N|k3KM7:TR?= NEfOcndUSU6JRWK=
KG-1 MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr1b3hSUUN3ME2zMlcyPjh6IN88US=> NFq0[ZJUSU6JRWK=
D-283MED NIPifmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCwcIlKSzVyPUOuO|U5PyEQvF2= M3HuZnNCVkeHUh?=
LU-65 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH1XXNKSzVyPUSuNVE1QDVizszN MX3TRW5ITVJ?
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NCI-H2081 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS0TWM2OD12LkK5NVc1KM7:TR?= NEC1Z2tUSU6JRWK=
D-247MG Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\5co15UUN3ME20MlQ{OTlzIN88US=> MUPTRW5ITVJ?
P31-FUJ NWXLN2pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGmzW|RKSzVyPUSuOFUxOTlizszN NX7mVmFrW0GQR1XS
DMS-79 NYTETVhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHwTWM2OD12LkmzNVg{KM7:TR?= NGD1bpdUSU6JRWK=
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JVM-3 NHLhPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml35TWM2OD13LkK1NFE1KM7:TR?= MnHoV2FPT0WU
LAN-6 NHftUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTVwNUG3N|Yh|ryP MXvTRW5ITVJ?
DJM-1 NH\v[ZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTVwNU[wNlkh|ryP MU\TRW5ITVJ?
JVM-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[1emlEPTB;NT62O|A6OiEQvF2= M{i1enNCVkeHUh?=
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SHP-77 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7wTWM2OD13Lkm0PVI5KM7:TR?= M2GyUXNCVkeHUh?=
RPMI-8866 M3XMXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTZwMkewNVMh|ryP NXXRVFN4W0GQR1XS
ES7 NEPsZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH2PIRnUUN3ME22MlM6QTJ2IN88US=> MYPTRW5ITVJ?
WSU-NHL Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWydIlKSzVyPU[uOVE3ODlizszN M{TjTXNCVkeHUh?=
CAS-1 NG\0c|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK1bVN6UUN3ME23MlA6PzR7IN88US=> MV7TRW5ITVJ?
MHH-NB-11 MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRThwMkOxOVIh|ryP NHnVdplUSU6JRWK=
ES5 NFy1[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnyOodxUUN3ME25MlUzOjh4IN88US=> MkH6V2FPT0WU
HDLM-2 NULIOnozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe1[nlKSzVyPUmuPVU6ODJizszN MnT5V2FPT0WU
NCI-H2171 NXnMdIF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHT5NIZKSzVyPUGwMlU6OjdizszN MlrJV2FPT0WU
LNCaP-Clone-FGC MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLkXGJKSzVyPUGxMlM4OThizszN MojxV2FPT0WU
NCI-H1395 NHS4dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XENWlEPTB;MUKuNlY6QSEQvF2= NVfkXod2W0GQR1XS
NCI-H1436 M37HWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C4UWlEPTB;MUOuN|E6PSEQvF2= MWfTRW5ITVJ?
RCC10RGB NVX4[lF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\0WWlEPTB;MUOuN|IzOSEQvF2= NXvSdVBWW0GQR1XS
SW684 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzEe5I4UUN3ME2xN{46Pzl5IN88US=> M3iyfnNCVkeHUh?=
NCI-H1650 M37vWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\ZPGlEPTB;MUWuNFQ1PyEQvF2= M361dHNCVkeHUh?=
EW-13 NVv6VnBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXGwWGNmUUN3ME2xOU4zODJzIN88US=> NWDQTFZDW0GQR1XS
EC-GI-10 M3fDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF3Lki2OFQh|ryP MVfTRW5ITVJ?
CHP-126 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jyNGlEPTB;MUeuNVkyQCEQvF2= M13T[3NCVkeHUh?=
NCI-H226 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPjTWM2OD1zOD6wOFA{KM7:TR?= Ml\MV2FPT0WU
NCI-H1838 NVr1O21LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLxW5lqUUN3ME2yNE4yQDR6IN88US=> MkGwV2FPT0WU
EW-11 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zjS2lEPTB;MkSuNlcyQCEQvF2= NU\Db|UzW0GQR1XS
EB2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTCdZp5UUN3ME2zNU42OzF6IN88US=> M3WzWnNCVkeHUh?=
D-502MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrZR4lKSzVyPUSzMlkzOjlizszN NHzMOnhUSU6JRWK=
U-698-M Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrKc4FKSzVyPUS4Mlg3PzFizszN NX;NS4Q4W0GQR1XS
ES3 NUPRTFVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTo[GxRUUN3ME20PU4{QDl|IN88US=> M1zLXnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID