Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NGHtUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTMVmlKSzVyPUCuNFAxOzB4IN88US=> NFO2R5BUSU6JRWK=
OCUB-M M1LZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjtbXBzUUN3ME2wMlAxOTl2IN88US=> M3rGcXNCVkeHUh?=
DOHH-2 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYj3c3VLUUN3ME2wMlAxOjJ3IN88US=> NYO2XoRMW0GQR1XS
NOS-1 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMECyOFIh|ryP NXzDR5lJW0GQR1XS
L-363 M2HxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvOTXRKSzVyPUCuNFAzQDRizszN MnLOV2FPT0WU
RL95-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMECzNkDPxE1? NUm3NJJPW0GQR1XS
BL-70 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLNPZNKSzVyPUCuNFA{OzdizszN MUTTRW5ITVJ?
TGBC1TKB MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWewNm5KUUN3ME2wMlAxOzd7IN88US=> MV;TRW5ITVJ?
697 NF\yellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZTINKSzVyPUCuNFA3OzRizszN MlvHV2FPT0WU
RPMI-8226 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEC2OVEh|ryP NX[yXG03W0GQR1XS
BL-41 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuzPGtKSzVyPUCuNFA3QTZizszN NHnHdlhUSU6JRWK=
MRK-nu-1 NGTLcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O5UmlEPTB;MD6wNFcxPyEQvF2= NYnET3dtW0GQR1XS
EW-1 NEP0VnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXJ[VFWUUN3ME2wMlAxPzR7IN88US=> NY\3NVJZW0GQR1XS
EVSA-T M2LKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTGTWM2OD1yLkCwPFkzKM7:TR?= NWfjWGJ5W0GQR1XS
HUTU-80 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6xTWM2OD1yLkCwPVI6KM7:TR?= MlfnV2FPT0WU
VA-ES-BJ NXHpdVg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXywU5BmUUN3ME2wMlAxQTh2IN88US=> NHywfHBUSU6JRWK=
GCIY MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13ZW2lEPTB;MD6wNVAxPyEQvF2= M3LQN3NCVkeHUh?=
ES6 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Hw[WlEPTB;MD6wNVA5OyEQvF2= MofQV2FPT0WU
NALM-6 NUOzNIdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXlTY9KSzVyPUCuNFEyODJizszN MVPTRW5ITVJ?
LB996-RCC NHfUNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEGxN|ch|ryP NFznOHBUSU6JRWK=
EW-16 NUn3Vox5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEGxPVIh|ryP M4fjVnNCVkeHUh?=
KALS-1 NUm2VIx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\Gdm9KSzVyPUCuNFEyQThizszN MoTzV2FPT0WU
OPM-2 M1nufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjkNIpKSzVyPUCuNFEzQSEQvF2= M3\sU3NCVkeHUh?=
KU812 NVr1O5p7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T4Z2lEPTB;MD6wNVI6PiEQvF2= MVLTRW5ITVJ?
A4-Fuk M3nTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S3OWlEPTB;MD6wNVMyQSEQvF2= MXPTRW5ITVJ?
KGN NXn5fVY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEGzOVkh|ryP NYD4fmNpW0GQR1XS
KS-1 NFPyO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn4TWM2OD1yLkCxN|kzKM7:TR?= NHHqUWlUSU6JRWK=
no-11 NUCzXVU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEGzPVUh|ryP MofuV2FPT0WU
PSN1 NF3uO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjSN4FMUUN3ME2wMlAyPDB7IN88US=> NXrWWWFOW0GQR1XS
SK-LMS-1 NYe1O4MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEG0NVMh|ryP MU\TRW5ITVJ?
LS-411N NHixOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LMe2lEPTB;MD6wNVQ{QSEQvF2= NHn4b2NUSU6JRWK=
HT-144 NGHwclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7TTWM2OD1yLkCxOFUyKM7:TR?= NIrwZnFUSU6JRWK=
ACN NETJbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMEG1JO69VQ>? MVvTRW5ITVJ?
RKO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnCeIRKSzVyPUCuNFE2OzNizszN NIjST2JUSU6JRWK=
CMK Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfnbohKSzVyPUCuNFE2PDNizszN M1XUT3NCVkeHUh?=
GB-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEG1OVMh|ryP M{LOPXNCVkeHUh?=
KE-37 NEL6VGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;x[IRVUUN3ME2wMlAyPTd|IN88US=> MXrTRW5ITVJ?
no-10 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDKTWM2OD1yLkCxOVg1KM7:TR?= MoLKV2FPT0WU
MOLT-16 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m4NmlEPTB;MD6wNVYzOiEQvF2= MkDUV2FPT0WU
HEL Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\MTWM2OD1yLkCxOlQh|ryP NWXMW5c3W0GQR1XS
NCI-H1355 M4r1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm2c|FKSzVyPUCuNFE3PDZizszN NH3wZnhUSU6JRWK=
IST-MEL1 M3HPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUS1Sot4UUN3ME2wMlAyPzd2IN88US=> MlHBV2FPT0WU
MHH-PREB-1 M2PlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnPWVM{UUN3ME2wMlAyQDF6IN88US=> M1Hve3NCVkeHUh?=
ES8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEG4OFQh|ryP MlWwV2FPT0WU
LC-2-ad NFzRWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEKxN|ch|ryP NF;NNm9USU6JRWK=
LAMA-84 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDmbVdPUUN3ME2wMlAzOTZ5IN88US=> M2f4XnNCVkeHUh?=
BV-173 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HXTmlEPTB;MD6wNlIxOyEQvF2= MVzTRW5ITVJ?
SW872 NXzBbFlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMEKyOFch|ryP NH35V|lUSU6JRWK=
SK-UT-1 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEKyOlEh|ryP M4LIZXNCVkeHUh?=
OS-RC-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEKzNlMh|ryP NF\BeFVUSU6JRWK=
NCI-H747 NGH5RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHFd|R4UUN3ME2wMlAzOzNizszN M1e4XHNCVkeHUh?=
MZ2-MEL MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv5bFBKSzVyPUCuNFI{OzdizszN NG\LVlRUSU6JRWK=
TE-11 NGrPfVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEKzO|Ih|ryP NEmw[YtUSU6JRWK=
KURAMOCHI M1fVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\FUpM2UUN3ME2wMlAzPDF2IN88US=> MX7TRW5ITVJ?
HD-MY-Z Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f3TWlEPTB;MD6wNlQzPiEQvF2= M4ezS3NCVkeHUh?=
GI-1 NGDkVGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C1NGlEPTB;MD6wNlQ3QSEQvF2= NUXmSVQ4W0GQR1XS
LB1047-RCC NID6[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG5eZBKSzVyPUCuNFI1QDhizszN NX\ITG1oW0GQR1XS
TE-12 MmfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljSTWM2OD1yLkCyOVUh|ryP NX:4NFVyW0GQR1XS
MZ7-mel NF7zSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[xZWRKSzVyPUCuNFI3ODlizszN NV3RVXRqW0GQR1XS
MMAC-SF NEK2Uo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorITWM2OD1yLkCyOlM{KM7:TR?= MUjTRW5ITVJ?
A101D NYnvNlRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPrTWM2OD1yLkCyOlUh|ryP M2DhTXNCVkeHUh?=
GR-ST NGLIbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTQTWM2OD1yLkCyOlU2KM7:TR?= MVHTRW5ITVJ?
MC116 M1HFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n3Z2lEPTB;MD6wNlY5KM7:TR?= MnjyV2FPT0WU
Ramos-2G6-4C10 NVm5PGZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj4PYs{UUN3ME2wMlAzPzVizszN MXvTRW5ITVJ?
ATN-1 MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEK3PFkh|ryP MoPMV2FPT0WU
MFH-ino Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r3[WlEPTB;MD6wNlgyOiEQvF2= M3XSTnNCVkeHUh?=
DEL NYHIcHFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m1WGlEPTB;MD6wNlgyPSEQvF2= MmfwV2FPT0WU
OCI-AML2 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\re4hbUUN3ME2wMlAzQDdzIN88US=> MUPTRW5ITVJ?
LXF-289 NWjZNWtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TqUGlEPTB;MD6wNlg4OiEQvF2= Mmj3V2FPT0WU
IA-LM MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEK5NVch|ryP MUjTRW5ITVJ?
EoL-1-cell NVzSUWxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzmUYdJUUN3ME2wMlAzQTl4IN88US=> MYTTRW5ITVJ?
OVCAR-4 NEK4PWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXiXXhKSzVyPUCuNFMxQTRizszN M3rjNHNCVkeHUh?=
ES1 M4HoVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrhXG9KSzVyPUCuNFMxQTdizszN MYnTRW5ITVJ?
CESS M1z4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPXTWM2OD1yLkCzNFk6KM7:TR?= M1HG[nNCVkeHUh?=
GAK MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13KdWlEPTB;MD6wN|E5PiEQvF2= NIXnNXVUSU6JRWK=
NTERA-S-cl-D1 NX;yT5NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmwTWM2OD1yLkCzNlI3KM7:TR?= NFvjSlZUSU6JRWK=
TE-10 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEOzNVEh|ryP MV3TRW5ITVJ?
CCRF-CEM MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEOzO|Eh|ryP NYrufHdVW0GQR1XS
NMC-G1 M4XqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KxXWlEPTB;MD6wN|Q1QCEQvF2= NFKxN2lUSU6JRWK=
HOP-62 MnLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjjTWM2OD1yLkCzOVU3KM7:TR?= NHrMNFhUSU6JRWK=
SH-4 NVTFS3VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64TWM2OD1yLkCzOVgzKM7:TR?= MlHEV2FPT0WU
NCI-H1648 NHXROG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvkWFM{UUN3ME2wMlA{PjJ{IN88US=> NWXLVG41W0GQR1XS
EB-3 NVPMUXNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi5TWM2OD1yLkCzOlQ{KM7:TR?= NGjhR|hUSU6JRWK=
BB65-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjEcpNHUUN3ME2wMlA{PjlzIN88US=> MW\TRW5ITVJ?
BE-13 NYLQNY9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHzZ45KSzVyPUCuNFM4PTlizszN MXjTRW5ITVJ?
CP67-MEL NXfpd|JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnPeHI1UUN3ME2wMlA{PzV7IN88US=> MW\TRW5ITVJ?
SW954 M{nObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXGTWM2OD1yLkCzO|kh|ryP NXfqeW92W0GQR1XS
TE-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjqXplqUUN3ME2wMlA{QDV2IN88US=> MmLVV2FPT0WU
HCE-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\DPGlEPTB;MD6wN|g2PSEQvF2= MVjTRW5ITVJ?
LC-1F Mo\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jYO2lEPTB;MD6wN|k5QSEQvF2= NF60OYJUSU6JRWK=
TK10 NEm2enRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMESwNVkh|ryP NFfVVZhUSU6JRWK=
SJSA-1 MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\nXppKSzVyPUCuNFQyQDhizszN MnLNV2FPT0WU
Daudi MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7zZYV4UUN3ME2wMlA1OjJ3IN88US=> NV7XcY1qW0GQR1XS
SW982 NH:5dGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjrO3lSUUN3ME2wMlA1OjR4IN88US=> MlLmV2FPT0WU
SF126 M1;HZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMESzOlEh|ryP Mlf2V2FPT0WU
TE-15 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP2SmpKSzVyPUCuNFQ1OzVizszN MmrmV2FPT0WU
COLO-684 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMES1OlEh|ryP NYrQSYRlW0GQR1XS
8-MG-BA M2W1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMES2Nlkh|ryP MVnTRW5ITVJ?
NB13 NWLMcGc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq5Z2dKSzVyPUCuNFQ4PzZizszN MmfiV2FPT0WU
HCC1599 M1HZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K0WWlEPTB;MD6wOFg4QSEQvF2= Ml3KV2FPT0WU
SK-PN-DW NVzKR5RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMES5OFkh|ryP MVLTRW5ITVJ?
ALL-PO MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjYfphKSzVyPUCuNFQ6PTZizszN NYO5UI94W0GQR1XS
NB6 M{nMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PFXWlEPTB;MD6wOVI4OSEQvF2= NHHXTnFUSU6JRWK=
IST-SL2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL1XlRUUUN3ME2wMlA2OzZ{IN88US=> NX7GTJNiW0GQR1XS
BB30-HNC NXX6foVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrON5h6UUN3ME2wMlA2PzNizszN NWi5NHJRW0GQR1XS
SW962 NWnvNWt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H2fmlEPTB;MD6wOVc3OyEQvF2= MV;TRW5ITVJ?
TGBC24TKB NGf3TolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEW3PVkh|ryP NYTD[GV{W0GQR1XS
KINGS-1 M4O3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnFTWM2OD1yLkC1PFA{KM7:TR?= NWXvZVloW0GQR1XS
HC-1 M3;iNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj2VVFKSzVyPUCuNFU5OjdizszN M{\GdHNCVkeHUh?=
RS4-11 M4PRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\LTWlEPTB;MD6wOVk{QCEQvF2= MkHzV2FPT0WU
LS-123 Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;pdmlEPTB;MD6wOVk1OiEQvF2= NWPub2JDW0GQR1XS
A3-KAW MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGxPIhjUUN3ME2wMlA3OjJ3IN88US=> NX;aSmJ6W0GQR1XS
SNB75 NGLnbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorvTWM2OD1yLkC2N|QyKM7:TR?= NXfZT|RrW0GQR1XS
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DB NVfqPG1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwNUCwOVUh|ryP M1fVSHNCVkeHUh?=
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LU-134-A M3S3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pu[2lEPTB;MD61OVI6PiEQvF2= M{njbnNCVkeHUh?=
MC-CAR NV7tSpVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP3TI95UUN3ME2wMlU2PDNzIN88US=> NGXqT49USU6JRWK=
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NCI-H1522 M1\Bd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fxTWlEPTB;MD62OFg5OyEQvF2= NH36eoNUSU6JRWK=
NCI-H1155 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nGdGlEPTB;MD62OVM2KM7:TR?= NFX1PI5USU6JRWK=
D-263MG M3zLOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XNPWlEPTB;MD62OlExOSEQvF2= M13SR3NCVkeHUh?=
TE-6 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXCOW9zUUN3ME2wMlY5OTB2IN88US=> NFH5e2hUSU6JRWK=
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NCI-H510A M1\BVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;vOGlEPTB;MD63O|I{PiEQvF2= MV;TRW5ITVJ?
KARPAS-45 MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PjXmlEPTB;MD63PFI{PSEQvF2= NH[5fHRUSU6JRWK=
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NCI-H526 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwOUC5OVgh|ryP NFi0PXFUSU6JRWK=
NCI-H719 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwOU[2OVch|ryP MYTTRW5ITVJ?
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A253 NVK1cHo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nj[2lEPTB;MD65PFg5PSEQvF2= NYPjW4N{W0GQR1XS
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CPC-N MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjGUmpKSzVyPUGuNVU5QDhizszN MkLnV2FPT0WU
NCI-H2107 NE\hSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfWTGhqUUN3ME2xMlE4OjZzIN88US=> M13kOXNCVkeHUh?=
ECC4 MmjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnlbpFKSzVyPUGuNVg3QTNizszN MofVV2FPT0WU
NCI-H2141 NGHQPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwMUmyPVkh|ryP M4K4OXNCVkeHUh?=
NCI-H1770 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwM{K5Nlgh|ryP MYLTRW5ITVJ?
NCI-SNU-1 NUfrVndST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFwM{OwOEDPxE1? MYXTRW5ITVJ?
LU-165 M1P2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWCxRpN4UUN3ME2xMlQ2PDZ5IN88US=> NHjZe4ZUSU6JRWK=
Raji NFzubWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrITGxKSzVyPUGuOFczPTlizszN M2LFW3NCVkeHUh?=
EW-24 MoC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFwNUS2NVkh|ryP NIjqS3NUSU6JRWK=
KP-N-RT-BM-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK4TWM2OD1zLkW2OVUyKM7:TR?= MVzTRW5ITVJ?
SK-MEL-1 NYDWWoYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLCcI1lUUN3ME2xMlY1QDd5IN88US=> NIrTdXBUSU6JRWK=
SCLC-21H MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO4ZmRlUUN3ME2xMlY3PjVzIN88US=> M3nrPXNCVkeHUh?=
SIMA MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLDTWM2OD1zLk[4NlM{KM7:TR?= MXLTRW5ITVJ?
NCI-H1304 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XPeWlEPTB;MT63NFc3PSEQvF2= NVvkfZBEW0GQR1XS
REH MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILaTGhKSzVyPUGuO|ExPzhizszN NXG5NW9qW0GQR1XS
KP-N-YS M3O3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnGOlY6UUN3ME2xMlk{PTVzIN88US=> M2LnfnNCVkeHUh?=
DMS-153 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f4cmlEPTB;MT65O|U6KM7:TR?= NXX6Um5IW0GQR1XS
NB10 NHP4WVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHDTWM2OD1{LkKwPFc5KM7:TR?= MWLTRW5ITVJ?
NCI-H345 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\3d4tjUUN3ME2yMlYyQTB3IN88US=> MXnTRW5ITVJ?
SK-N-FI NF3STo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M330cGlEPTB;Mj63OVM5OSEQvF2= NY\XZ5VqW0GQR1XS
NCI-H1092 M2TNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJwOUWzPVQh|ryP NXjJfFZJW0GQR1XS
KM-H2 M3XJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfNPHk5UUN3ME2zMlY2Ozl4IN88US=> NFHFPYJUSU6JRWK=
KG-1 NHvSRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33zfWlEPTB;Mz63NVY5QCEQvF2= MWXTRW5ITVJ?
D-283MED NGjXOXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLac4lKSzVyPUOuO|U5PyEQvF2= MUXTRW5ITVJ?
LU-65 M{fsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y1ZmlEPTB;ND6xNVQ5PSEQvF2= MoLSV2FPT0WU
MSTO-211H MoDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrPTphKSzVyPUSuNVg5QThizszN NHXHfFdUSU6JRWK=
NCI-H2081 M3fsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC1TWM2OD12LkK5NVc1KM7:TR?= NHrzWFhUSU6JRWK=
D-247MG Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHqb5pKSzVyPUSuOFMyQTFizszN MVPTRW5ITVJ?
P31-FUJ MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTRN4dtUUN3ME20MlQ2ODF7IN88US=> MVLTRW5ITVJ?
DMS-79 NUX3eo8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3rOXh{UUN3ME20Mlk{OTh|IN88US=> M4PvcHNCVkeHUh?=
KASUMI-1 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjUTWM2OD12Lkm3OVA6KM7:TR?= NYTEUHp[W0GQR1XS
JVM-3 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYroUGRJUUN3ME21MlI2ODF2IN88US=> NE\uTVRUSU6JRWK=
LAN-6 NF;vcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHLTWM2OD13LkWxO|M3KM7:TR?= M2LIR3NCVkeHUh?=
DJM-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTVwNU[wNlkh|ryP Mli0V2FPT0WU
JVM-2 NFrZOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;VS4JKSzVyPUWuOlcxQTJizszN MX;TRW5ITVJ?
U-87-MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrHTYdGUUN3ME21Mlg6QTZ2IN88US=> MVTTRW5ITVJ?
SHP-77 NYq0T5BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTVwOUS5Nlgh|ryP MXXTRW5ITVJ?
RPMI-8866 NFHvNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTZwMkewNVMh|ryP MlmwV2FPT0WU
ES7 NHjWTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\xVmlEPTB;Nj6zPVkzPCEQvF2= MVTTRW5ITVJ?
WSU-NHL Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGyTWM2OD14LkWxOlA6KM7:TR?= NED5co1USU6JRWK=
CAS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;Ddll6UUN3ME23MlA6PzR7IN88US=> NV;S[5ptW0GQR1XS
MHH-NB-11 NFLjdGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HBPWlEPTB;OD6yN|E2OiEQvF2= NICxXINUSU6JRWK=
ES5 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTlwNUKyPFYh|ryP M4jWN3NCVkeHUh?=
HDLM-2 NGL1SVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2xbm9KSzVyPUmuPVU6ODJizszN NWO2NoJiW0GQR1XS
NCI-H2171 NHvuc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjsWndYUUN3ME2xNE42QTJ5IN88US=> Ml\RV2FPT0WU
LNCaP-Clone-FGC M1O5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\0dpVKSzVyPUGxMlM4OThizszN NEPJblhUSU6JRWK=
NCI-H1395 NIfIdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETZRWNKSzVyPUGyMlI3QTlizszN MYLTRW5ITVJ?
NCI-H1436 NU\O[GNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17PUGlEPTB;MUOuN|E6PSEQvF2= NUD2ZnZ{W0GQR1XS
RCC10RGB NWPQeI4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e1bmlEPTB;MUOuN|IzOSEQvF2= NIS4bmJUSU6JRWK=
SW684 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PieGlEPTB;MUOuPVc6PyEQvF2= NFjqTlZUSU6JRWK=
NCI-H1650 Mnv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\uTWM2OD1zNT6wOFQ4KM7:TR?= NWf0eYR5W0GQR1XS
EW-13 NXHkbpFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXQUGVpUUN3ME2xOU4zODJzIN88US=> MmHIV2FPT0WU
EC-GI-10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;ZTW9KSzVyPUG1Mlg3PDRizszN NVTRepp1W0GQR1XS
CHP-126 NHnqTlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWwRnVwUUN3ME2xO{4yQTF6IN88US=> NULLT4c3W0GQR1XS
NCI-H226 M{TCcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX3WXVyUUN3ME2xPE4xPDB|IN88US=> MlTsV2FPT0WU
NCI-H1838 NIL3PJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLDXpBXUUN3ME2yNE4yQDR6IN88US=> MVzTRW5ITVJ?
EW-11 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjjR3ZKSzVyPUK0MlI4OThizszN NXHTOVFSW0GQR1XS
EB2 M4nkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNzLkWzNVgh|ryP MYHTRW5ITVJ?
D-502MG MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLCdmFKSzVyPUSzMlkzOjlizszN MWrTRW5ITVJ?
U-698-M M4TxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DQZmlEPTB;NEiuPFY4OSEQvF2= NYPCNIpqW0GQR1XS
ES3 NUHIRWN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\HXGczUUN3ME20PU4{QDl|IN88US=> NIH5VmJUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG 400+0.5% Tween80+5% Propylene glycol 30mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID