Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 Mom1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHVcW1KSzVyPUCuNFAxOzB4IN88US=> M3:wUnNCVkeHUh?=
OCUB-M MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1za[GlEPTB;MD6wNFE6PCEQvF2= MVnTRW5ITVJ?
DOHH-2 NVW2cWU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDDNXBKSzVyPUCuNFAzOjVizszN NYPsU2c5W0GQR1XS
NOS-1 NVfOVpFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fmU2lEPTB;MD6wNFI1OiEQvF2= MonPV2FPT0WU
L-363 M4nKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[1Zph2UUN3ME2wMlAxOjh2IN88US=> NH7yOYNUSU6JRWK=
RL95-2 NHXIW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrzN2pKSzVyPUCuNFA{OiEQvF2= M{DINXNCVkeHUh?=
BL-70 M{nt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XPOmlEPTB;MD6wNFM{PyEQvF2= Mme4V2FPT0WU
TGBC1TKB M3HVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMECzO|kh|ryP MlX1V2FPT0WU
697 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z6ZWlEPTB;MD6wNFY{PCEQvF2= M3zCenNCVkeHUh?=
RPMI-8226 NEL5N2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOyd4FKSzVyPUCuNFA3PTFizszN Ml7RV2FPT0WU
BL-41 M1vsTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILGTJBKSzVyPUCuNFA3QTZizszN NYf6cXhsW0GQR1XS
MRK-nu-1 NEXRdnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEC3NFch|ryP NH63co1USU6JRWK=
EW-1 NH;mO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK2NXZpUUN3ME2wMlAxPzR7IN88US=> NX3zTVZ1W0GQR1XS
EVSA-T NV7rZZZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\XdW1KSzVyPUCuNFA5QTJizszN M3zzbnNCVkeHUh?=
HUTU-80 NYjUWJU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPnSHRTUUN3ME2wMlAxQTJ7IN88US=> MWLTRW5ITVJ?
VA-ES-BJ NFzUdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHFTWM2OD1yLkCwPVg1KM7:TR?= MnOyV2FPT0WU
GCIY NWPKUVRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfETWM2OD1yLkCxNFA4KM7:TR?= M3y5WHNCVkeHUh?=
ES6 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF2xbGhKSzVyPUCuNFExQDNizszN MlTSV2FPT0WU
NALM-6 MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TvcWlEPTB;MD6wNVExOiEQvF2= M17uUHNCVkeHUh?=
LB996-RCC MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXFSodLUUN3ME2wMlAyOTN5IN88US=> MlrLV2FPT0WU
EW-16 NWP5NWlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnocmI6UUN3ME2wMlAyOTl{IN88US=> NXe1UHJpW0GQR1XS
KALS-1 NWrXPXF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG2TWM2OD1yLkCxNVk5KM7:TR?= MV\TRW5ITVJ?
OPM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMEGyPUDPxE1? NF7uZlFUSU6JRWK=
KU812 M{m5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEGyPVYh|ryP MXvTRW5ITVJ?
A4-Fuk MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEGzNVkh|ryP MknDV2FPT0WU
KGN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEGzOVkh|ryP NF3jNVVUSU6JRWK=
KS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj0TWFKSzVyPUCuNFE{QTJizszN M4C4ZXNCVkeHUh?=
no-11 NH\S[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13j[mlEPTB;MD6wNVM6PSEQvF2= NEnTVWdUSU6JRWK=
PSN1 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rySWlEPTB;MD6wNVQxQSEQvF2= MmXFV2FPT0WU
SK-LMS-1 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NID2UXFKSzVyPUCuNFE1OTNizszN MVXTRW5ITVJ?
LS-411N MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\jSlJRUUN3ME2wMlAyPDN7IN88US=> M{C5U3NCVkeHUh?=
HT-144 NXLFOVJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYflcYxEUUN3ME2wMlAyPDVzIN88US=> Mn;pV2FPT0WU
ACN MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEG1JO69VQ>? M33leXNCVkeHUh?=
RKO M3LNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XQU2lEPTB;MD6wNVU{OyEQvF2= MVfTRW5ITVJ?
CMK MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfrSGw1UUN3ME2wMlAyPTR|IN88US=> M1rSdnNCVkeHUh?=
GB-1 M2XBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzxTWM2OD1yLkCxOVU{KM7:TR?= NF3hSXBUSU6JRWK=
KE-37 M1fFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEG1O|Mh|ryP MW\TRW5ITVJ?
no-10 M4X2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jvd2lEPTB;MD6wNVU5PCEQvF2= NUO0W5Y2W0GQR1XS
MOLT-16 NEHyWFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTDTWM2OD1yLkCxOlIzKM7:TR?= M{Oxc3NCVkeHUh?=
HEL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HEeWlEPTB;MD6wNVY1KM7:TR?= MorOV2FPT0WU
NCI-H1355 NGXaNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEG2OFYh|ryP M1zqdXNCVkeHUh?=
IST-MEL1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XWcWlEPTB;MD6wNVc4PCEQvF2= M{XBPHNCVkeHUh?=
MHH-PREB-1 M{DVPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTpTWM2OD1yLkCxPFE5KM7:TR?= M2\ud3NCVkeHUh?=
ES8 NGjtO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEG4OFQh|ryP M{LkO3NCVkeHUh?=
LC-2-ad MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLsXJVKSzVyPUCuNFIyOzdizszN NX\NZpBvW0GQR1XS
LAMA-84 NVKwO3VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\semlEPTB;MD6wNlE3PyEQvF2= M2Pu[nNCVkeHUh?=
BV-173 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnftTWM2OD1yLkCyNlA{KM7:TR?= MnjNV2FPT0WU
SW872 NVH0bndZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\aSWJnUUN3ME2wMlAzOjR5IN88US=> NYK0cWw6W0GQR1XS
SK-UT-1 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XSUGlEPTB;MD6wNlI3OSEQvF2= Mkn1V2FPT0WU
OS-RC-2 M3TKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqxSHpKSzVyPUCuNFI{OjNizszN M4ex[XNCVkeHUh?=
NCI-H747 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHITWM2OD1yLkCyN|Mh|ryP M2LtfnNCVkeHUh?=
MZ2-MEL MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Po[mlEPTB;MD6wNlM{PyEQvF2= Mmj6V2FPT0WU
TE-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\VTWM2OD1yLkCyN|czKM7:TR?= MlfDV2FPT0WU
KURAMOCHI NFfGSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nMNWlEPTB;MD6wNlQyPCEQvF2= NHn2PY1USU6JRWK=
HD-MY-Z NI\pb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DrcWlEPTB;MD6wNlQzPiEQvF2= M{nlZnNCVkeHUh?=
GI-1 M3XzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\TTWM2OD1yLkCyOFY6KM7:TR?= MWnTRW5ITVJ?
LB1047-RCC NViydnhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX6e4lKSzVyPUCuNFI1QDhizszN M3PaeHNCVkeHUh?=
TE-12 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[wTWM2OD1yLkCyOVUh|ryP NIHBNYNUSU6JRWK=
MZ7-mel NIPvSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMEK2NFkh|ryP NHTNdINUSU6JRWK=
MMAC-SF M{jvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12zNGlEPTB;MD6wNlY{OyEQvF2= MX;TRW5ITVJ?
A101D NFPQeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTLTWM2OD1yLkCyOlUh|ryP NF\RZXBUSU6JRWK=
GR-ST Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEK2OVUh|ryP NELmSGJUSU6JRWK=
MC116 NUDQVVJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DNUmlEPTB;MD6wNlY5KM7:TR?= NFLJcHBUSU6JRWK=
Ramos-2G6-4C10 NGXWOWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEK3OUDPxE1? NIG5SmxUSU6JRWK=
ATN-1 MmPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv2TWM2OD1yLkCyO|g6KM7:TR?= NHfxWlZUSU6JRWK=
MFH-ino MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojqTWM2OD1yLkCyPFEzKM7:TR?= MkPGV2FPT0WU
DEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i5cmlEPTB;MD6wNlgyPSEQvF2= M1rwbXNCVkeHUh?=
OCI-AML2 NH\MVZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PsemlEPTB;MD6wNlg4OSEQvF2= M1fRN3NCVkeHUh?=
LXF-289 NHjqTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PwbGlEPTB;MD6wNlg4OiEQvF2= NV\FdmlCW0GQR1XS
IA-LM Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEK5NVch|ryP M1P2VHNCVkeHUh?=
EoL-1-cell M1fYO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NESydVVKSzVyPUCuNFI6QTZizszN MYDTRW5ITVJ?
OVCAR-4 M4LG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\YTWM2OD1yLkCzNFk1KM7:TR?= Mnu5V2FPT0WU
ES1 NWDwN4tDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD6fm03UUN3ME2wMlA{ODl5IN88US=> NYfhVIJwW0GQR1XS
CESS MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjiTWM2OD1yLkCzNFk6KM7:TR?= M1HQRXNCVkeHUh?=
GAK NGe2dI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLZTWM2OD1yLkCzNVg3KM7:TR?= NFntfXdUSU6JRWK=
NTERA-S-cl-D1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTLUldKSzVyPUCuNFMzOjZizszN NXHXTGZ[W0GQR1XS
TE-10 NF3pOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEOzNVEh|ryP NYXs[HZ5W0GQR1XS
CCRF-CEM NGPFbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnxUGRkUUN3ME2wMlA{OzdzIN88US=> NFTSTohUSU6JRWK=
NMC-G1 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV2xNHhqUUN3ME2wMlA{PDR6IN88US=> NXv3U2F{W0GQR1XS
HOP-62 NInob|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\GfIw1UUN3ME2wMlA{PTV4IN88US=> MV3TRW5ITVJ?
SH-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\hXotNUUN3ME2wMlA{PTh{IN88US=> Mk\tV2FPT0WU
NCI-H1648 NYj0SHBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLVXnNKSzVyPUCuNFM3OjJizszN Mn20V2FPT0WU
EB-3 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLvdlBKSzVyPUCuNFM3PDNizszN NGfGR3NUSU6JRWK=
BB65-RCC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEO2PVEh|ryP M1HaXHNCVkeHUh?=
BE-13 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEO3OVkh|ryP M1XzT3NCVkeHUh?=
CP67-MEL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Xm[2lEPTB;MD6wN|c2QSEQvF2= NVzXTlU2W0GQR1XS
SW954 NVnneFAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7FTWM2OD1yLkCzO|kh|ryP MkTzV2FPT0WU
TE-5 M{fq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjkNo1KSzVyPUCuNFM5PTRizszN M3XKRnNCVkeHUh?=
HCE-4 NIjKVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j4R2lEPTB;MD6wN|g2PSEQvF2= MoLOV2FPT0WU
LC-1F M2rOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne2TWM2OD1yLkCzPVg6KM7:TR?= NHfxNmxUSU6JRWK=
TK10 M2jVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMESwNVkh|ryP MkH3V2FPT0WU
SJSA-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFmxXlFKSzVyPUCuNFQyQDhizszN M1G5[3NCVkeHUh?=
Daudi MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMESyNlUh|ryP MWjTRW5ITVJ?
SW982 Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMESyOFYh|ryP NHPYWVNUSU6JRWK=
SF126 M{jNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMESzOlEh|ryP MorTV2FPT0WU
TE-15 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\tNmtKSzVyPUCuNFQ1OzVizszN MoXXV2FPT0WU
COLO-684 NXnsR21jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK3SVl6UUN3ME2wMlA1PTZzIN88US=> M1fwd3NCVkeHUh?=
8-MG-BA NUnTWVI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPNT2pKSzVyPUCuNFQ3OjlizszN MWHTRW5ITVJ?
NB13 NXnwXlFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXP[nVWUUN3ME2wMlA1Pzd4IN88US=> NX\GWlFQW0GQR1XS
HCC1599 NFnSfoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMES4O|kh|ryP M33mfnNCVkeHUh?=
SK-PN-DW NWjM[2ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTieXpKSzVyPUCuNFQ6PDlizszN NHrK[ZBUSU6JRWK=
ALL-PO NV7WW2F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnezTWM2OD1yLkC0PVU3KM7:TR?= NE\qRYNUSU6JRWK=
NB6 M1m0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHFTWM2OD1yLkC1NlcyKM7:TR?= Ml3KV2FPT0WU
IST-SL2 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7wTWM2OD1yLkC1N|YzKM7:TR?= NHn5OHBUSU6JRWK=
BB30-HNC MmGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEW3N{DPxE1? Mmq5V2FPT0WU
SW962 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWzTWM2OD1yLkC1O|Y{KM7:TR?= MmDhV2FPT0WU
TGBC24TKB M2S4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGX2TVhKSzVyPUCuNFU4QTlizszN MXHTRW5ITVJ?
KINGS-1 NVPMPVgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHPTWM2OD1yLkC1PFA{KM7:TR?= MV3TRW5ITVJ?
HC-1 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEW4Nlch|ryP MX3TRW5ITVJ?
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LS-123 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEW5OFIh|ryP NVm2WGY1W0GQR1XS
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EKVX MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNES0OlEh|ryP NFjaUI1USU6JRWK=
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HCC1187 MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn4O|lKSzVyPUCuOFY4PjhizszN NVexVpNwW0GQR1XS
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DB NF3vRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnsTWM2OD1yLkWwNFU2KM7:TR?= MVrTRW5ITVJ?
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LU-134-A NHfuUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPtW4NrUUN3ME2wMlU2Ojl4IN88US=> MoT5V2FPT0WU
MC-CAR M3PreWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7pTWM2OD1yLkW1OFMyKM7:TR?= NGO3S|VUSU6JRWK=
NEC8 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HoeGlEPTB;MD61OlE4OiEQvF2= MVHTRW5ITVJ?
NCI-H524 NVX1UVk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNUi3OFgh|ryP NELze4RUSU6JRWK=
NCI-H1963 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zMdGlEPTB;MD62NlU5KM7:TR?= MXnTRW5ITVJ?
SU-DHL-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq0eFRKSzVyPUCuOlQ2OjZizszN NEnuZ41USU6JRWK=
NCI-H1522 NWPzfpdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WzdWlEPTB;MD62OFg5OyEQvF2= NULaNZdpW0GQR1XS
NCI-H1155 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPMW4xKSzVyPUCuOlU{PSEQvF2= M4PZXHNCVkeHUh?=
D-263MG NYjRdGliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS5TWM2OD1yLk[2NVAyKM7:TR?= MX7TRW5ITVJ?
TE-6 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\YTJdiUUN3ME2wMlY5OTB2IN88US=> NGO5TGdUSU6JRWK=
NCI-H1417 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LTSWlEPTB;MD62PVcyOSEQvF2= MV\TRW5ITVJ?
NCI-H510A MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrxdZpKSzVyPUCuO|czOzZizszN MUnTRW5ITVJ?
KARPAS-45 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzaNJhKSzVyPUCuO|gzOzVizszN MWjTRW5ITVJ?
IST-SL1 NF;HUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn2TWM2OD1yLki1PFI2KM7:TR?= NIf2VodUSU6JRWK=
COLO-824 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwOEe4N|Uh|ryP MkXPV2FPT0WU
NCI-H526 M1:3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXiTWM2OD1yLkmwPVU5KM7:TR?= MX7TRW5ITVJ?
NCI-H719 NIj3NFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXSZph6UUN3ME2wMlk3PjV5IN88US=> NEHlZmhUSU6JRWK=
SF539 NVzr[|YyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXJdmpKSzVyPUCuPVg{QTZizszN MW\TRW5ITVJ?
NKM-1 M13XWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW3TWM2OD1yLkm4OlY{KM7:TR?= MXjTRW5ITVJ?
A253 NXrFdlNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwOUi4PFUh|ryP NVPNbYlFW0GQR1XS
TE-441-T NGfOSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETWTW1KSzVyPUGuNFQ{PSEQvF2= NVP0fm1KW0GQR1XS
COR-L88 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{G3VGlEPTB;MT6xNVM2PCEQvF2= NGDPUnNUSU6JRWK=
CPC-N MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrZfIZoUUN3ME2xMlE2QDh6IN88US=> M1TmWHNCVkeHUh?=
NCI-H2107 NH\EXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzTcnRXUUN3ME2xMlE4OjZzIN88US=> MVrTRW5ITVJ?
ECC4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzTPIVKSzVyPUGuNVg3QTNizszN NWjsU5ZnW0GQR1XS
NCI-H2141 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P3eWlEPTB;MT6xPVI6QSEQvF2= NFvVPVBUSU6JRWK=
NCI-H1770 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf3[FdKSzVyPUGuN|I6OjhizszN MkmxV2FPT0WU
NCI-SNU-1 M2TvXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzaTWM2OD1zLkOzNFQh|ryP MVfTRW5ITVJ?
LU-165 NHS5c4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwNEW0Olch|ryP MXzTRW5ITVJ?
Raji Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyR2lEPTB;MT60O|I2QSEQvF2= Mn\UV2FPT0WU
EW-24 NFrScmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\weVV4UUN3ME2xMlU1PjF7IN88US=> MXTTRW5ITVJ?
KP-N-RT-BM-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwNU[1OVEh|ryP M2m4d3NCVkeHUh?=
SK-MEL-1 NGjOendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW2R|dWUUN3ME2xMlY1QDd5IN88US=> M16zS3NCVkeHUh?=
SCLC-21H MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\xOWlEPTB;MT62OlY2OSEQvF2= NW\6dVlkW0GQR1XS
SIMA M2rU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXid4dKSzVyPUGuOlgzOzNizszN MoHZV2FPT0WU
NCI-H1304 NUjs[VlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTOVIpyUUN3ME2xMlcxPzZ3IN88US=> NX3Tc4tMW0GQR1XS
REH M1nwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLFTWM2OD1zLkexNFc5KM7:TR?= MmP2V2FPT0WU
KP-N-YS M{PP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXoTWM2OD1zLkmzOVUyKM7:TR?= MkjRV2FPT0WU
DMS-153 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3TbpFKSzVyPUGuPVc2QSEQvF2= NGGyZ2VUSU6JRWK=
NB10 NFOwNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2T6T2lEPTB;Mj6yNFg4QCEQvF2= M1XHOXNCVkeHUh?=
NCI-H345 M1rB[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPJ[WtKSzVyPUKuOlE6ODVizszN M{\EN3NCVkeHUh?=
SK-N-FI NEj0PFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJwN{WzPFEh|ryP NIrYPIpUSU6JRWK=
NCI-H1092 NXTlV|c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2OzNWlEPTB;Mj65OVM6PCEQvF2= Mk\vV2FPT0WU
KM-H2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwNkWzPVYh|ryP M4LwR3NCVkeHUh?=
KG-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwN{G2PFgh|ryP NETHU3hUSU6JRWK=
D-283MED MlnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTNwN{W4O{DPxE1? MnvLV2FPT0WU
LU-65 NGjGN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPhTWM2OD12LkGxOFg2KM7:TR?= NXrQdVlxW0GQR1XS
MSTO-211H NXTLNVNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3uTWM2OD12LkG4PFk5KM7:TR?= NIG5UXRUSU6JRWK=
NCI-H2081 NHPxeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHXWJBKSzVyPUSuNlkyPzRizszN M2TJRnNCVkeHUh?=
D-247MG MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\TS4pKSzVyPUSuOFMyQTFizszN MmX3V2FPT0WU
P31-FUJ MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzrSI1VUUN3ME20MlQ2ODF7IN88US=> NUDKRY4zW0GQR1XS
DMS-79 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTRwOUOxPFMh|ryP MlHVV2FPT0WU
KASUMI-1 NXn0cnoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3OyPGlEPTB;ND65O|UxQSEQvF2= NXywb4FMW0GQR1XS
JVM-3 M1T4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorDTWM2OD13LkK1NFE1KM7:TR?= NEWzeGRUSU6JRWK=
LAN-6 NUjXPFdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTVwNUG3N|Yh|ryP M1S5eXNCVkeHUh?=
DJM-1 NEPXTJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M374[GlEPTB;NT61OlAzQSEQvF2= MUDTRW5ITVJ?
JVM-2 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37wcGlEPTB;NT62O|A6OiEQvF2= NHP0R4xUSU6JRWK=
U-87-MG M1XNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETjWY5KSzVyPUWuPFk6PjRizszN M4LlSXNCVkeHUh?=
SHP-77 M3n2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\lNWNKSzVyPUWuPVQ6OjhizszN NYT0b5N[W0GQR1XS
RPMI-8866 M12yZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jDbWlEPTB;Nj6yO|AyOyEQvF2= NH7vN4FUSU6JRWK=
ES7 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrJ[pJKSzVyPU[uN|k6OjRizszN MkLPV2FPT0WU
WSU-NHL NIfNOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTZwNUG2NFkh|ryP MmqwV2FPT0WU
CAS-1 M2XGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn5TWM2OD15LkC5O|Q6KM7:TR?= M1\RNHNCVkeHUh?=
MHH-NB-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH1S2FKSzVyPUiuNlMyPTJizszN NFK5[ItUSU6JRWK=
ES5 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf2TWM2OD17LkWyNlg3KM7:TR?= MlzEV2FPT0WU
HDLM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTlwOUW5NFIh|ryP M1KxUXNCVkeHUh?=
NCI-H2171 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXhTWM2OD1zMD61PVI4KM7:TR?= MnjkV2FPT0WU
LNCaP-Clone-FGC Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\FTmlEPTB;MUGuN|cyQCEQvF2= M1;zNHNCVkeHUh?=
NCI-H1395 NVzCdoNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjBfHNXUUN3ME2xNk4zPjl7IN88US=> MWnTRW5ITVJ?
NCI-H1436 NHH4N|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF|LkOxPVUh|ryP NYjqUVg3W0GQR1XS
RCC10RGB MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLyTWM2OD1zMz6zNlIyKM7:TR?= NH[2Z4FUSU6JRWK=
SW684 NF;LVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLY[YNKSzVyPUGzMlk4QTdizszN NFyzV|VUSU6JRWK=
NCI-H1650 NHH6PWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PSdGlEPTB;MUWuNFQ1PyEQvF2= MlrvV2FPT0WU
EW-13 M4\GVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPuPIdkUUN3ME2xOU4zODJzIN88US=> NYDw[oFiW0GQR1XS
EC-GI-10 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3VVJhjUUN3ME2xOU45PjR2IN88US=> Mny5V2FPT0WU
CHP-126 NX\4SZBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG5OZRSUUN3ME2xO{4yQTF6IN88US=> M4XUOXNCVkeHUh?=
NCI-H226 NXnNXXBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF6LkC0NFMh|ryP Mly5V2FPT0WU
NCI-H1838 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPwTlNKSzVyPUKwMlE5PDhizszN NFP0fodUSU6JRWK=
EW-11 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ2LkK3NVgh|ryP NXu1fGw4W0GQR1XS
EB2 NImwRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjmTWM2OD1|MT61N|E5KM7:TR?= Mkn6V2FPT0WU
D-502MG M4XZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3lWGxEUUN3ME20N{46OjJ7IN88US=> NUfsNo97W0GQR1XS
U-698-M NEO5eGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjtVnZKSzVyPUS4Mlg3PzFizszN MXPTRW5ITVJ?
ES3 NXTRXnBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknCTWM2OD12OT6zPFk{KM7:TR?= MoTNV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG 400+0.5% Tween80+5% Propylene glycol 30mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID