Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

Size Price Stock Quantity  
USD 170 In stock
USD 370 In stock
USD 670 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NEjqNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn5dHhLUUN3ME2wMlAxODNyNjFOwG0> NEPpOVBUSU6JRWK=
OCUB-M NX7JNVN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;yTWM2OD1yLkCwNVk1KM7:TR?= NFrTVINUSU6JRWK=
DOHH-2 NGXPTmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\EeWlEPTB;MD6wNFIzPSEQvF2= Mn3rV2FPT0WU
NOS-1 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q0TGlEPTB;MD6wNFI1OiEQvF2= NE[wcFVUSU6JRWK=
L-363 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMECyPFQh|ryP NVPzVlJ1W0GQR1XS
RL95-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMECzNkDPxE1? NVLjT2NsW0GQR1XS
BL-70 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLOTWM2OD1yLkCwN|M4KM7:TR?= NEnoU|BUSU6JRWK=
TGBC1TKB NFHIcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV20d2g6UUN3ME2wMlAxOzd7IN88US=> NVzW[2c1W0GQR1XS
697 NYCzUVFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPmU4FKSzVyPUCuNFA3OzRizszN NFjHSnFUSU6JRWK=
RPMI-8226 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rDRmlEPTB;MD6wNFY2OSEQvF2= NXzCcHVYW0GQR1XS
BL-41 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEC2PVYh|ryP NIiybFRUSU6JRWK=
MRK-nu-1 NYDCVXFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzaTWM2OD1yLkCwO|A4KM7:TR?= M4nvVHNCVkeHUh?=
EW-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHOTWM2OD1yLkCwO|Q6KM7:TR?= MX7TRW5ITVJ?
EVSA-T NF;OO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm3[21KSzVyPUCuNFA5QTJizszN MXnTRW5ITVJ?
HUTU-80 NYKxXHhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDEN|ZKSzVyPUCuNFA6OjlizszN NFvKdoZUSU6JRWK=
VA-ES-BJ NELHOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF30cZlKSzVyPUCuNFA6QDRizszN M2f6PHNCVkeHUh?=
GCIY MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3Qe4RKSzVyPUCuNFExODdizszN MVXTRW5ITVJ?
ES6 NWCyVo9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLw[XNKSzVyPUCuNFExQDNizszN M{DKcHNCVkeHUh?=
NALM-6 M{j6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILJNGlKSzVyPUCuNFEyODJizszN Mo\jV2FPT0WU
LB996-RCC NYW3bGJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrrTWM2OD1yLkCxNVM4KM7:TR?= M3[4fHNCVkeHUh?=
EW-16 NGS3cVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rvT2lEPTB;MD6wNVE6OiEQvF2= MWLTRW5ITVJ?
KALS-1 M3XZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL4[WVoUUN3ME2wMlAyOTl6IN88US=> MmflV2FPT0WU
OPM-2 M1jPXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnVPYdRUUN3ME2wMlAyOjlizszN MYLTRW5ITVJ?
KU812 NVLHeWc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEGyPVYh|ryP MUjTRW5ITVJ?
A4-Fuk MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEGzNVkh|ryP NFfFenZUSU6JRWK=
KGN NUXOOW1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDEXIpKSzVyPUCuNFE{PTlizszN M1nhdHNCVkeHUh?=
KS-1 M2fPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEGzPVIh|ryP NGDmRmpUSU6JRWK=
no-11 M{W4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEGzPVUh|ryP M1fITnNCVkeHUh?=
PSN1 MlrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEG0NFkh|ryP NIXnVohUSU6JRWK=
SK-LMS-1 M2jmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMEG0NVMh|ryP NGPkeJdUSU6JRWK=
LS-411N MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3hbWJKSzVyPUCuNFE1OzlizszN NYXITphnW0GQR1XS
HT-144 M4\4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEG0OVEh|ryP MUjTRW5ITVJ?
ACN M4\uNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHOTo9KSzVyPUCuNFE2KM7:TR?= MVPTRW5ITVJ?
RKO NVjIdFJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zKTmlEPTB;MD6wNVU{OyEQvF2= Mne0V2FPT0WU
CMK MnmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLoeoVKSzVyPUCuNFE2PDNizszN NYe3dZJSW0GQR1XS
GB-1 NGPjT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT2TWM2OD1yLkCxOVU{KM7:TR?= NXnie3JiW0GQR1XS
KE-37 M3nEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXkTJZKSzVyPUCuNFE2PzNizszN NFPLcHBUSU6JRWK=
no-10 NEm4TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvlTWM2OD1yLkCxOVg1KM7:TR?= MYnTRW5ITVJ?
MOLT-16 NIK5NVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEG2NlIh|ryP NXiycJNWW0GQR1XS
HEL NHfI[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\zTGlEPTB;MD6wNVY1KM7:TR?= MkHRV2FPT0WU
NCI-H1355 NFXzN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTWTWM2OD1yLkCxOlQ3KM7:TR?= M{HKN3NCVkeHUh?=
IST-MEL1 NVPIfGk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK0TWM2OD1yLkCxO|c1KM7:TR?= MoCzV2FPT0WU
MHH-PREB-1 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LyWWlEPTB;MD6wNVgyQCEQvF2= NYDuS2QzW0GQR1XS
ES8 NIPGZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorJTWM2OD1yLkCxPFQ1KM7:TR?= M2iyUXNCVkeHUh?=
LC-2-ad M17jWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfyTWM2OD1yLkCyNVM4KM7:TR?= NGnKTndUSU6JRWK=
LAMA-84 NX3BeI1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEKxOlch|ryP NHnGW4hUSU6JRWK=
BV-173 NHfRV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEKyNFMh|ryP NVW2TG5qW0GQR1XS
SW872 M4j4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrObVNbUUN3ME2wMlAzOjR5IN88US=> MlzKV2FPT0WU
SK-UT-1 M3vRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEKyOlEh|ryP NWX1U3N{W0GQR1XS
OS-RC-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMEKzNlMh|ryP MYHTRW5ITVJ?
NCI-H747 NFzvc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1yLkCyN|Mh|ryP Mlm2V2FPT0WU
MZ2-MEL MnWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDVTWM2OD1yLkCyN|M4KM7:TR?= NHq2dGlUSU6JRWK=
TE-11 NWK5V4NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEKzO|Ih|ryP MV\TRW5ITVJ?
KURAMOCHI NYjz[|hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jQ[mlEPTB;MD6wNlQyPCEQvF2= M{\XXXNCVkeHUh?=
HD-MY-Z MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz0PXdKSzVyPUCuNFI1OjZizszN NWfzfG1bW0GQR1XS
GI-1 NVvUWVZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknuTWM2OD1yLkCyOFY6KM7:TR?= NUDuXYxwW0GQR1XS
LB1047-RCC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSxTYcyUUN3ME2wMlAzPDh6IN88US=> M3P0W3NCVkeHUh?=
TE-12 NFfmZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nSemlEPTB;MD6wNlU2KM7:TR?= MU\TRW5ITVJ?
MZ7-mel NHHvc4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHTTWM2OD1yLkCyOlA6KM7:TR?= MU\TRW5ITVJ?
MMAC-SF MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OxemlEPTB;MD6wNlY{OyEQvF2= MXPTRW5ITVJ?
A101D MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfETWM2OD1yLkCyOlUh|ryP NV;5OZpXW0GQR1XS
GR-ST M1fXZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEK2OVUh|ryP M2qwfnNCVkeHUh?=
MC116 Mn;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPHRnJIUUN3ME2wMlAzPjhizszN NV7oVJhxW0GQR1XS
Ramos-2G6-4C10 NUnGOWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXsTWM2OD1yLkCyO|Uh|ryP NV\Ido9LW0GQR1XS
ATN-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzWTWM2OD1yLkCyO|g6KM7:TR?= M4TKT3NCVkeHUh?=
MFH-ino MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnsNlNKSzVyPUCuNFI5OTJizszN MmjSV2FPT0WU
DEL M2jLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XiSWlEPTB;MD6wNlgyPSEQvF2= NXX4SYM6W0GQR1XS
OCI-AML2 NV\MZ|d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPzZZE3UUN3ME2wMlAzQDdzIN88US=> MYrTRW5ITVJ?
LXF-289 M17u[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEK4O|Ih|ryP Mnr1V2FPT0WU
IA-LM NIrIZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvOSnBKSzVyPUCuNFI6OTdizszN NH7qe29USU6JRWK=
EoL-1-cell NWLk[VN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEK5PVYh|ryP NHWzNmFUSU6JRWK=
OVCAR-4 M1zUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEOwPVQh|ryP Mn74V2FPT0WU
ES1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLUTWM2OD1yLkCzNFk4KM7:TR?= MlPaV2FPT0WU
CESS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEOwPVkh|ryP MmnIV2FPT0WU
GAK MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTOfXBKSzVyPUCuNFMyQDZizszN NETvVHpUSU6JRWK=
NTERA-S-cl-D1 NFLESmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEOyNlYh|ryP MXrTRW5ITVJ?
TE-10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPBTWM2OD1yLkCzN|EyKM7:TR?= MnuzV2FPT0WU
CCRF-CEM Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEOzO|Eh|ryP M2WzNXNCVkeHUh?=
NMC-G1 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULuVXdtUUN3ME2wMlA{PDR6IN88US=> Ml6xV2FPT0WU
HOP-62 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf0VW9QUUN3ME2wMlA{PTV4IN88US=> NEPidVNUSU6JRWK=
SH-4 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULieFh3UUN3ME2wMlA{PTh{IN88US=> NU\LTo92W0GQR1XS
NCI-H1648 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDXndrUUN3ME2wMlA{PjJ{IN88US=> Mk\RV2FPT0WU
EB-3 M2ryR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4WxdWlEPTB;MD6wN|Y1OyEQvF2= M3rheXNCVkeHUh?=
BB65-RCC M32zemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f2S2lEPTB;MD6wN|Y6OSEQvF2= MlH5V2FPT0WU
BE-13 NHHaVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEO3OVkh|ryP MojIV2FPT0WU
CP67-MEL M4TBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[1UWlEPTB;MD6wN|c2QSEQvF2= MkPtV2FPT0WU
SW954 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3td3NzUUN3ME2wMlA{PzlizszN NFLRXZhUSU6JRWK=
TE-5 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknWTWM2OD1yLkCzPFU1KM7:TR?= MU\TRW5ITVJ?
HCE-4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP5TWM2OD1yLkCzPFU2KM7:TR?= M4j3W3NCVkeHUh?=
LC-1F NHnDRpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULiSpB2UUN3ME2wMlA{QTh7IN88US=> NUHPTmJOW0GQR1XS
TK10 MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPKTWM2OD1yLkC0NFE6KM7:TR?= MnXYV2FPT0WU
SJSA-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMESxPFgh|ryP M3vyTXNCVkeHUh?=
Daudi MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHG[pNQUUN3ME2wMlA1OjJ3IN88US=> Mom5V2FPT0WU
SW982 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXTZmdDUUN3ME2wMlA1OjR4IN88US=> MmHWV2FPT0WU
SF126 NXzZO3k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnlU2NKSzVyPUCuNFQ{PjFizszN NHfvOFFUSU6JRWK=
TE-15 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fnSWlEPTB;MD6wOFQ{PSEQvF2= NFvae|hUSU6JRWK=
COLO-684 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXzU25KSzVyPUCuNFQ2PjFizszN NXHl[3NSW0GQR1XS
8-MG-BA NGq5fXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMES2Nlkh|ryP MYHTRW5ITVJ?
NB13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMES3O|Yh|ryP MVfTRW5ITVJ?
HCC1599 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLHWW1rUUN3ME2wMlA1QDd7IN88US=> NX\qOY1EW0GQR1XS
SK-PN-DW NGfxW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMES5OFkh|ryP MlrvV2FPT0WU
ALL-PO M4\UeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMES5OVYh|ryP MVPTRW5ITVJ?
NB6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PHZWlEPTB;MD6wOVI4OSEQvF2= MljhV2FPT0WU
IST-SL2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj5fJhsUUN3ME2wMlA2OzZ{IN88US=> MY\TRW5ITVJ?
BB30-HNC NI\pcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;nWHhKSzVyPUCuNFU4OyEQvF2= MmSxV2FPT0WU
SW962 M4e1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XscWlEPTB;MD6wOVc3OyEQvF2= MlHGV2FPT0WU
TGBC24TKB MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O1eWlEPTB;MD6wOVc6QSEQvF2= MkHTV2FPT0WU
KINGS-1 NFjjc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofaTWM2OD1yLkC1PFA{KM7:TR?= NET2OnZUSU6JRWK=
HC-1 NX7BNoYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrDTWM2OD1yLkC1PFI4KM7:TR?= NYrhRpZ1W0GQR1XS
RS4-11 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XOXmlEPTB;MD6wOVk{QCEQvF2= M2j1OHNCVkeHUh?=
LS-123 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDRV|dMUUN3ME2wMlA2QTR{IN88US=> Ml7jV2FPT0WU
A3-KAW NIfkdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XzUWlEPTB;MD6wOlIzPSEQvF2= NInFcWxUSU6JRWK=
SNB75 NG\kd|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jZN2lEPTB;MD6wOlM1OSEQvF2= M1f6WHNCVkeHUh?=
SR NGHI[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTTTWM2OD1yLkC2N|c1KM7:TR?= NEH4UWxUSU6JRWK=
LOUCY Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5ZmlEPTB;MD6wOlM6PCEQvF2= NHzJWIlUSU6JRWK=
K5 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwME[0NFMh|ryP NHzoWXNUSU6JRWK=
Becker NUXibYtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TEe2lEPTB;MD6wOlQzKM7:TR?= NXvJclB6W0GQR1XS
CTV-1 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm3fnhkUUN3ME2wMlA3PTR6IN88US=> NH3mW25USU6JRWK=
KLE MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzUTWM2OD1yLkC2OVg1KM7:TR?= NHTjbJZUSU6JRWK=
MZ1-PC MnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXrTWM2OD1yLkC2OVk5KM7:TR?= NX\ZcIRoW0GQR1XS
MOLT-4 Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvUTWM2OD1yLkC2OlA2KM7:TR?= M1;MZnNCVkeHUh?=
MLMA NFzXeY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvIVGRpUUN3ME2wMlA3PzhizszN NYr3bm1nW0GQR1XS
A388 NITEZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnzWnRmUUN3ME2wMlA3QDl|IN88US=> MonvV2FPT0WU
MV-4-11 NIDPUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjIOnIzUUN3ME2wMlA3QTl3IN88US=> MX3TRW5ITVJ?
DSH1 NGPIUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjaTWM2OD1yLkC3NVc{KM7:TR?= MV\TRW5ITVJ?
MONO-MAC-6 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXbYNKSzVyPUCuNFczOTJizszN M{D2cHNCVkeHUh?=
ARH-77 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm3TWM2OD1yLkC3Nlc5KM7:TR?= M1fWV3NCVkeHUh?=
LB771-HNC NV\TV21lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHO0cXhKSzVyPUCuNFc2PDlizszN M4OyTnNCVkeHUh?=
PF-382 M1nKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfaXo1KSzVyPUCuNFc2PjlizszN M4mwV3NCVkeHUh?=
KM12 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\4bWlEPTB;MD6wO|Y1KM7:TR?= MX7TRW5ITVJ?
HAL-01 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W4bmlEPTB;MD6wO|Y2QCEQvF2= M4[yWXNCVkeHUh?=
RPMI-8402 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljiTWM2OD1yLkC3O|g6KM7:TR?= MoXPV2FPT0WU
OMC-1 NIPiUItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\6PGlEPTB;MD6wO|gxPCEQvF2= M3XZd3NCVkeHUh?=
HT MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnG3TWM2OD1yLkC4JO69VQ>? MYjTRW5ITVJ?
QIMR-WIL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULS[VdQUUN3ME2wMlA5ODV3IN88US=> NFHsSIxUSU6JRWK=
KNS-42 NF\iXoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfYWGNjUUN3ME2wMlA5OjB|IN88US=> NGDq[25USU6JRWK=
BC-3 MmDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nSO2lEPTB;MD6wPFIxPCEQvF2= NWrkO4tjW0GQR1XS
ES4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPUZXJKSzVyPUCuNFgzQTZizszN MnfvV2FPT0WU
NCI-H23 M2O2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvwTWM2OD1yLkC4OFQh|ryP NGPXZZBUSU6JRWK=
LB2518-MEL M{K0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPFSotKSzVyPUCuNFg3QTZizszN NGfDb4JUSU6JRWK=
LC4-1 NV6xco9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33LOWlEPTB;MD6wPFc{QCEQvF2= MnT4V2FPT0WU
SIG-M5 NFvSN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC0V2ZVUUN3ME2wMlA5QTB2IN88US=> M1WzV3NCVkeHUh?=
LP-1 NEGx[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7wZnBKSzVyPUCuNFg6OzhizszN MYnTRW5ITVJ?
TE-8 NVXFdYYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEmwNVYh|ryP MVfTRW5ITVJ?
K-562 M3nZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LpVmlEPTB;MD6wPVEzKM7:TR?= NV\ycHZWW0GQR1XS
J-RT3-T3-5 NUDZVZZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEmxOVMh|ryP NUXUNWllW0GQR1XS
DU-4475 MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\hOGlEPTB;MD6wPVE3PSEQvF2= NWPCRZhCW0GQR1XS
RXF393 NF3T[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEm0OlIh|ryP NGPLRVRUSU6JRWK=
NB5 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTnTWM2OD1yLkC5OlI2KM7:TR?= M{OxUXNCVkeHUh?=
A704 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3vTWM2OD1yLkC5O|QyKM7:TR?= NEHjfnFUSU6JRWK=
SF268 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEm4NlUh|ryP NIjPR5RUSU6JRWK=
UACC-257 NX[1fFNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTaSo91UUN3ME2wMlA6QDN|IN88US=> NHK4e3lUSU6JRWK=
L-428 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\CeVRKSzVyPUCuNVA{OiEQvF2= NVi2R|RxW0GQR1XS
ST486 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2GxeWlEPTB;MD6xNFYxPiEQvF2= MUnTRW5ITVJ?
SK-MM-2 NIDDZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[4bXpKSzVyPUCuNVA4ODlizszN MUfTRW5ITVJ?
COR-L279 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjpPIRKSzVyPUCuNVA5OzJizszN MV;TRW5ITVJ?
JiyoyeP-2003 NWO3RlV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rkTGlEPTB;MD6xNFg1OyEQvF2= MYjTRW5ITVJ?
GT3TKB NV[3[JFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ibmlEPTB;MD6xNFkyQCEQvF2= MVHTRW5ITVJ?
HCE-T NFjkNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:3UpBIUUN3ME2wMlExQTRizszN MXvTRW5ITVJ?
SBC-1 NYDXXpFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rPeGlEPTB;MD6xNVEyQSEQvF2= M4HjZnNCVkeHUh?=
KNS-81-FD MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTicGlKSzVyPUCuNVEzPzNizszN MYfTRW5ITVJ?
NCI-H2126 M{fsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C1UGlEPTB;MD6xNVM6PCEQvF2= MmHBV2FPT0WU
EM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M36yeGlEPTB;MD6xNVUzQSEQvF2= MVjTRW5ITVJ?
JAR M4XJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnWbWlpUUN3ME2wMlEyPTl6IN88US=> NG\BNnJUSU6JRWK=
NB17 Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:2RmlEPTB;MD6xNVY2OiEQvF2= MWnTRW5ITVJ?
LB647-SCLC M4DJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzqUY1KSzVyPUCuNVE4ODVizszN Ml7JV2FPT0WU
CAL-148 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfZ[3pKSzVyPUCuNVE5KM7:TR?= M{TLbnNCVkeHUh?=
K052 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjnTWM2OD1yLkGxPFUyKM7:TR?= NFTzbnFUSU6JRWK=
KARPAS-299 M1[0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3YZ2VZUUN3ME2wMlEzOjN|IN88US=> NYXoWXByW0GQR1XS
KARPAS-422 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj5coFKSzVyPUCuNVI1OzJizszN MnGyV2FPT0WU
LOXIMVI M2jNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXQdYdKSzVyPUCuNVI2OTVizszN MmnwV2FPT0WU
SCC-3 M2PxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PU[2lEPTB;MD6xNlg2OSEQvF2= Mlm3V2FPT0WU
LU-139 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLiWpR5UUN3ME2wMlEzQTd3IN88US=> MXXTRW5ITVJ?
COLO-320-HSR NGTLPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7UTWM2OD1yLkGzNFg3KM7:TR?= MWXTRW5ITVJ?
ONS-76 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDD[lNKSzVyPUCuNVMyOyEQvF2= MmPVV2FPT0WU
U-266 M2r6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HPOGlEPTB;MD6xN|I1PSEQvF2= M3vlUHNCVkeHUh?=
HH MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu4ZoFNUUN3ME2wMlE{PTN3IN88US=> M4PZ[XNCVkeHUh?=
BB49-HNC NWC2dpBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUO1PFch|ryP MYLTRW5ITVJ?
NCI-SNU-5 NGO2fJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL3TWM2OD1yLkGzOVk3KM7:TR?= MWTTRW5ITVJ?
C2BBe1 NEm1Um9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TXWWlEPTB;MD6xN|c1PiEQvF2= NV7LZ|djW0GQR1XS
ML-2 NWnsNmNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\W[2lEPTB;MD6xN|k2OyEQvF2= NYjW[5g1W0GQR1XS
SCH NH\RSHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTDTWM2OD1yLkGzPVc1KM7:TR?= MlPQV2FPT0WU
NCI-H82 NX;kRpRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rlUWlEPTB;MD6xOFExPCEQvF2= NV71TJZyW0GQR1XS
MDA-MB-134-VI MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMUSyOVIh|ryP M3XhNnNCVkeHUh?=
SK-N-DZ MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXuTWM2OD1yLkG0O|E6KM7:TR?= NXLVW3NmW0GQR1XS
HL-60 NUHteo1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMUS5NkDPxE1? MY\TRW5ITVJ?
LB373-MEL-D M{L1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GxOGlEPTB;MD6xOVU{QSEQvF2= MUXTRW5ITVJ?
LB831-BLC NUHEOI5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fmV2lEPTB;MD6xOlA4PiEQvF2= M{LnfnNCVkeHUh?=
SK-NEP-1 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMU[xNFEh|ryP M3nZd3NCVkeHUh?=
IMR-5 NHrTb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjO[ZFKSzVyPUCuNVY1QDNizszN M{DLO3NCVkeHUh?=
Calu-6 NYj4TYJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuxZ29pUUN3ME2wMlE3PTN5IN88US=> NWH1[IMxW0GQR1XS
NCI-H1882 NHroUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK4TGsyUUN3ME2wMlE3PzJ6IN88US=> M2P4dHNCVkeHUh?=
NCI-H446 NGXKTG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITpWpFKSzVyPUCuNVY5QTFizszN NGnqSHFUSU6JRWK=
GI-ME-N Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfVTWM2OD1yLkG4NFIh|ryP MknJV2FPT0WU
MPP-89 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS4XXJ2UUN3ME2wMlE5OTJzIN88US=> NYrp[4xpW0GQR1XS
CGTH-W-1 NWn1dpJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7KV3M6UUN3ME2wMlE5PDN4IN88US=> M1jt[HNCVkeHUh?=
MEG-01 M3HiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\XXmdKSzVyPUCuNVg3OjhizszN NVLGdIF[W0GQR1XS
NCI-H748 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLtTVlKSzVyPUCuNVg6OTFizszN MnKxV2FPT0WU
COLO-829 NIjCOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jLWWlEPTB;MD6yNFY4OyEQvF2= MX3TRW5ITVJ?
GOTO NFXFTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLuUZl3UUN3ME2wMlIxPzNizszN MY\TRW5ITVJ?
EW-3 NVOwc2s4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LhWmlEPTB;MD6yNVcyQCEQvF2= NV;uVGF6W0GQR1XS
KY821 NVLoW2o4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ibmlEPTB;MD6yNlA1PSEQvF2= NXnONGN6W0GQR1XS
CTB-1 NH;0UXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljpTWM2OD1yLkKyNlI5KM7:TR?= M4XGU3NCVkeHUh?=
TALL-1 NF[wTI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zSNWlEPTB;MD6yNlkzOSEQvF2= NEjXRoRUSU6JRWK=
NCI-H209 M1XYN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnlVJJKSzVyPUCuNlI6PjJizszN M4S4W3NCVkeHUh?=
IST-MES1 NETDUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln1TWM2OD1yLkKzOVEh|ryP MVrTRW5ITVJ?
DMS-114 NVjuW2xPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;hTWM2OD1yLkKzPVk{KM7:TR?= M1;KRXNCVkeHUh?=
SNU-C2B MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInqdnpKSzVyPUCuNlQ{OTZizszN M1vHNHNCVkeHUh?=
DG-75 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXnTWM2OD1yLkK2NVk2KM7:TR?= MnHkV2FPT0WU
D-336MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi1O5NKSzVyPUCuNlY2PTdizszN M2XkS3NCVkeHUh?=
KMOE-2 NV70V4ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfnTWM2OD1yLkK3OVM5KM7:TR?= M33WcXNCVkeHUh?=
NB1 NY\jU5ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rKcmlEPTB;MD6yO|kzPiEQvF2= NVi0SGNOW0GQR1XS
RH-1 Mm\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrHTWM2OD1yLkK3PVg6KM7:TR?= NWriVpJsW0GQR1XS
TE-1 NVyycJl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17CcGlEPTB;MD6yPFQ4QSEQvF2= M1XxNXNCVkeHUh?=
RPMI-6666 M3H5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfyR45KSzVyPUCuNlg5PCEQvF2= NE\PfmtUSU6JRWK=
TE-9 M4HXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMki5PFUh|ryP NHPrTplUSU6JRWK=
BT-474 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMkmzN|Qh|ryP NFvz[YZUSU6JRWK=
COLO-668 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXuSm5TUUN3ME2wMlI6PDJ7IN88US=> MmrEV2FPT0WU
NCI-H1581 NX[4WnNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPacWRKSzVyPUCuNlk3QDlizszN MUTTRW5ITVJ?
MN-60 NXPrZlBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnVTWM2OD1yLkK5PVA2KM7:TR?= MoPFV2FPT0WU
L-540 NUHwZo97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fWfWlEPTB;MD6zNFA5OSEQvF2= M4D6e3NCVkeHUh?=
MOLT-13 NEXDV3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDlTWM2OD1yLkOwNVg{KM7:TR?= Mo\nV2FPT0WU
NCI-SNU-16 NFjzeWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LYbmlEPTB;MD6zNFIxPSEQvF2= MXrTRW5ITVJ?
NCI-H64 NXTPUpZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDuTIhKSzVyPUCuN|A{OzFizszN MlHIV2FPT0WU
CP66-MEL MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GdXNoUUN3ME2wMlMyPDF3IN88US=> MkTvV2FPT0WU
NB69 NYPNUVF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O1PWlEPTB;MD6zNlE5QCEQvF2= MX3TRW5ITVJ?
NCI-H2196 NUS5cYRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLyXYhUUUN3ME2wMlM{ODN4IN88US=> NUjXVZc6W0GQR1XS
MHH-CALL-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7oTWM2OD1yLkOzOFY5KM7:TR?= Mn;wV2FPT0WU
HCC2157 M2LJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfFTZRKSzVyPUCuN|M6PTRizszN NW\mR3VHW0GQR1XS
LS-1034 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK1T2JKSzVyPUCuN|Y{QDhizszN MkfsV2FPT0WU
BOKU NHy1OW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwM{exPVkh|ryP NVLSfWpNW0GQR1XS
GDM-1 MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTOTWM2OD1yLkO3NlM1KM7:TR?= MlLTV2FPT0WU
TGW NGWyRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xld2lEPTB;MD6zO|Q2OyEQvF2= MofKV2FPT0WU
SNU-C1 M2DvOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXr[ZVDUUN3ME2wMlM5OjF3IN88US=> MWnTRW5ITVJ?
LS-513 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\GTWM2OD1yLkO5NFcyKM7:TR?= MXvTRW5ITVJ?
NOMO-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPFcmpKSzVyPUCuN|k6PzFizszN NX64eJB1W0GQR1XS
MS-1 NFXWbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNECxO|ch|ryP NHzRbWdUSU6JRWK=
EKVX MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNES0OlEh|ryP M{SzNnNCVkeHUh?=
SK-MEL-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGyTWM2OD1yLkS2OEDPxE1? NGrYfXdUSU6JRWK=
HCC1187 M3XaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LhU2lEPTB;MD60Olc3QCEQvF2= NXrNbZZXW0GQR1XS
HCC2218 NGLpOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\SW2ZKSzVyPUCuOFczOjdizszN Ml3iV2FPT0WU
NCI-H187 M2K1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwNEe4OEDPxE1? M2rES3NCVkeHUh?=
DB Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\kT|VKSzVyPUCuOVAxPTVizszN MlPSV2FPT0WU
NCI-H69 MmnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvnTIZPUUN3ME2wMlUxOjR5IN88US=> NEDvbGJUSU6JRWK=
NCI-H1694 NWnWdoFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HYOmlEPTB;MD61NFY6PyEQvF2= NIPoW4hUSU6JRWK=
CA46 M17POmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwNUC5NVch|ryP NWHCV41WW0GQR1XS
EHEB NU\qV|ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNUGxPVMh|ryP M3TRcHNCVkeHUh?=
NCCIT MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m4XGlEPTB;MD61OFMzOSEQvF2= NVzzXGR{W0GQR1XS
NCI-H720 Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r4dWlEPTB;MD61OFk3OiEQvF2= NWnwc4NjW0GQR1XS
LU-134-A M37KfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rveWlEPTB;MD61OVI6PiEQvF2= MnTjV2FPT0WU
MC-CAR NVz3XINOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNUW0N|Eh|ryP M{GyRnNCVkeHUh?=
NEC8 M174W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{e3WmlEPTB;MD61OlE4OiEQvF2= NEK1fWZUSU6JRWK=
NCI-H524 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\tc2pKSzVyPUCuOVg4PDhizszN NUP6To9iW0GQR1XS
NCI-H1963 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK4TWM2OD1yLk[yOVgh|ryP M4rLVHNCVkeHUh?=
SU-DHL-1 MorjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjlNZZDUUN3ME2wMlY1PTJ4IN88US=> NYTJfoxUW0GQR1XS
NCI-H1522 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf4R2xEUUN3ME2wMlY1QDh|IN88US=> MkHPV2FPT0WU
NCI-H1155 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwNkWzOUDPxE1? NYGxbGd7W0GQR1XS
D-263MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP1cI43UUN3ME2wMlY3OTBzIN88US=> MV7TRW5ITVJ?
TE-6 NXjjXVBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNkixNFQh|ryP MUfTRW5ITVJ?
NCI-H1417 NFj6d5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNkm3NVEh|ryP NU\rW|FYW0GQR1XS
NCI-H510A NUXDTJRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwN{eyN|Yh|ryP NIHNUIlUSU6JRWK=
KARPAS-45 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrYTWM2OD1yLke4NlM2KM7:TR?= NHO0NG1USU6JRWK=
IST-SL1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG2bmFKSzVyPUCuPFU5OjVizszN NHm0[WpUSU6JRWK=
COLO-824 NHPG[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwOEe4N|Uh|ryP MUfTRW5ITVJ?
NCI-H526 M2LhRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwOUC5OVgh|ryP NH:0TodUSU6JRWK=
NCI-H719 M17MWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwOU[2OVch|ryP MkTwV2FPT0WU
SF539 M{H5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHQblVKSzVyPUCuPVg{QTZizszN Mnz6V2FPT0WU
NKM-1 NHXtdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwOUi2OlMh|ryP NI\SOphUSU6JRWK=
A253 NVzXOlJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHqTWM2OD1yLkm4PFg2KM7:TR?= NF;DTWFUSU6JRWK=
TE-441-T NFjDR4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz4TWM2OD1zLkC0N|Uh|ryP MV;TRW5ITVJ?
COR-L88 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESxSXdKSzVyPUGuNVE{PTRizszN NVns[3NTW0GQR1XS
CPC-N Moi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDFTWM2OD1zLkG1PFg5KM7:TR?= NIXhU|BUSU6JRWK=
NCI-H2107 NGLyVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3hdWxlUUN3ME2xMlE4OjZzIN88US=> NIXteoxUSU6JRWK=
ECC4 NEGxSJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzISGNKSzVyPUGuNVg3QTNizszN NGLLNohUSU6JRWK=
NCI-H2141 NV\xWYxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PzSWlEPTB;MT6xPVI6QSEQvF2= M33XPHNCVkeHUh?=
NCI-H1770 NHjyflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzYUHlKSzVyPUGuN|I6OjhizszN M1y2TXNCVkeHUh?=
NCI-SNU-1 M3XJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLwZ5FKSzVyPUGuN|MxPCEQvF2= MonTV2FPT0WU
LU-165 NVriVmhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4OwPGlEPTB;MT60OVQ3PyEQvF2= M4HaOnNCVkeHUh?=
Raji M2OxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPvb2lRUUN3ME2xMlQ4OjV7IN88US=> M4TGNnNCVkeHUh?=
EW-24 M2HV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzMZVhKSzVyPUGuOVQ3OTlizszN M4T0UHNCVkeHUh?=
KP-N-RT-BM-1 NYfHdmI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnicXZlUUN3ME2xMlU3PTVzIN88US=> MljsV2FPT0WU
SK-MEL-1 NHnQS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwNkS4O|ch|ryP NXHPbJlqW0GQR1XS
SCLC-21H MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrTTWM2OD1zLk[2OlUyKM7:TR?= MVfTRW5ITVJ?
SIMA NFzFNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILsdlRKSzVyPUGuOlgzOzNizszN NHTiZlZUSU6JRWK=
NCI-H1304 NEG5OotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[xN5pFUUN3ME2xMlcxPzZ3IN88US=> NXTUfm5XW0GQR1XS
REH NGTqTXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPCTWM2OD1zLkexNFc5KM7:TR?= MlvTV2FPT0WU
KP-N-YS NEPLbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vyXmlEPTB;MT65N|U2OSEQvF2= M{X3TXNCVkeHUh?=
DMS-153 NUfNO4NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXQdnZKSzVyPUGuPVc2QSEQvF2= M4\ieHNCVkeHUh?=
NB10 NETN[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7GXYRKSzVyPUKuNlA5PzhizszN M3;IXnNCVkeHUh?=
NCI-H345 MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPGempKSzVyPUKuOlE6ODVizszN MWPTRW5ITVJ?
SK-N-FI MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7mTWM2OD1{Lke1N|gyKM7:TR?= NHLaUYhUSU6JRWK=
NCI-H1092 NF3xNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPWW2hKSzVyPUKuPVU{QTRizszN MmizV2FPT0WU
KM-H2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwNkWzPVYh|ryP MYTTRW5ITVJ?
KG-1 NIPpOpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H2dGlEPTB;Mz63NVY5QCEQvF2= NV3QOYFOW0GQR1XS
D-283MED MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zVdmlEPTB;Mz63OVg4KM7:TR?= MXXTRW5ITVJ?
LU-65 MlH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvVTWM2OD12LkGxOFg2KM7:TR?= MnrLV2FPT0WU
MSTO-211H MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjyTWM2OD12LkG4PFk5KM7:TR?= MUDTRW5ITVJ?
NCI-H2081 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrHOoFKSzVyPUSuNlkyPzRizszN MU\TRW5ITVJ?
D-247MG M37BUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LYSmlEPTB;ND60N|E6OSEQvF2= M3i0ZnNCVkeHUh?=
P31-FUJ NUT2cJFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PGOWlEPTB;ND60OVAyQSEQvF2= MXTTRW5ITVJ?
DMS-79 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XMcWlEPTB;ND65N|E5OyEQvF2= M37ES3NCVkeHUh?=
KASUMI-1 NYDmZYhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTRwOUe1NFkh|ryP NX;nNVExW0GQR1XS
JVM-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnvOIJKSzVyPUWuNlUxOTRizszN NWW4c|JGW0GQR1XS
LAN-6 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjV5VLUUN3ME21MlUyPzN4IN88US=> NXnzRXEzW0GQR1XS
DJM-1 Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHZRodEUUN3ME21MlU3ODJ7IN88US=> Mn\vV2FPT0WU
JVM-2 NIXFdWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\oTHM5UUN3ME21MlY4ODl{IN88US=> MlHSV2FPT0WU
U-87-MG MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTVwOEm5OlQh|ryP MXjTRW5ITVJ?
SHP-77 NIS0XY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHDOWlKUUN3ME21Mlk1QTJ6IN88US=> NHPIW5NUSU6JRWK=
RPMI-8866 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjFcFZKSzVyPU[uNlcxOTNizszN MlLjV2FPT0WU
ES7 NHH3VJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzpVnRKSzVyPU[uN|k6OjRizszN NGTvR|dUSU6JRWK=
WSU-NHL MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTZwNUG2NFkh|ryP M3LvNnNCVkeHUh?=
CAS-1 NEDBT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXOTWM2OD15LkC5O|Q6KM7:TR?= NV7uWWhZW0GQR1XS
MHH-NB-11 NWL6c|V{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nyVGlEPTB;OD6yN|E2OiEQvF2= NH22bmtUSU6JRWK=
ES5 M2jVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrlZYh[UUN3ME25MlUzOjh4IN88US=> NEjlcJhUSU6JRWK=
HDLM-2 NUDwfHFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn24TWM2OD17Lkm1PVAzKM7:TR?= M3PYU3NCVkeHUh?=
NCI-H2171 M2PtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG5dW1KSzVyPUGwMlU6OjdizszN NGHoNnhUSU6JRWK=
LNCaP-Clone-FGC NIryR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFzLkO3NVgh|ryP Mln5V2FPT0WU
NCI-H1395 NFPyToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3Lc3hKSzVyPUGyMlI3QTlizszN NWjxVW5oW0GQR1XS
NCI-H1436 NXnvTZhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;4cGlEPTB;MUOuN|E6PSEQvF2= NXeyNI9EW0GQR1XS
RCC10RGB MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vEeWlEPTB;MUOuN|IzOSEQvF2= NYLScmpTW0GQR1XS
SW684 NXrRPWtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzZcJRKSzVyPUGzMlk4QTdizszN MX;TRW5ITVJ?
NCI-H1650 NUjZcJAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HEeGlEPTB;MUWuNFQ1PyEQvF2= NU\0W2ZTW0GQR1XS
EW-13 NHrGcWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfrcWlKSzVyPUG1MlIxOjFizszN MlTIV2FPT0WU
EC-GI-10 M1j6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF3Lki2OFQh|ryP NXLONFFNW0GQR1XS
CHP-126 NXfCdJhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TSNmlEPTB;MUeuNVkyQCEQvF2= NHnCPHVUSU6JRWK=
NCI-H226 NUX1e3hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF6LkC0NFMh|ryP M1TXVXNCVkeHUh?=
NCI-H1838 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISzPHpKSzVyPUKwMlE5PDhizszN M1TxTXNCVkeHUh?=
EW-11 NEf6eotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rRc2lEPTB;MkSuNlcyQCEQvF2= NX;JWlBoW0GQR1XS
EB2 NE\FcHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS4TWM2OD1|MT61N|E5KM7:TR?= NHniOVBUSU6JRWK=
D-502MG NVrLUmNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW5TWM2OD12Mz65NlI6KM7:TR?= NUfUcZp6W0GQR1XS
U-698-M MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLD[nRFUUN3ME20PE45PjdzIN88US=> M3qxWnNCVkeHUh?=
ES3 NUH3O5JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rveWlEPTB;NEmuN|g6OyEQvF2= M1vV[XNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo Add solvents individually and in order:
30% PEG 400+0.5% Tween80+5% Propylene glycol
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Related mTOR Products

Tags: buy Torin 1 | Torin 1 supplier | purchase Torin 1 | Torin 1 cost | Torin 1 manufacturer | order Torin 1 | Torin 1 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID