Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHXV4VUUUN3ME2wMlAxODNyNjFOwG0> NYHMN4NVW0GQR1XS
OCUB-M NY\vSlg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv0ephKSzVyPUCuNFAyQTRizszN MVXTRW5ITVJ?
DOHH-2 NGPXdFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3uTWM2OD1yLkCwNlI2KM7:TR?= NF\0SndUSU6JRWK=
NOS-1 NX;Q[ox3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjzdldKSzVyPUCuNFAzPDJizszN MmXoV2FPT0WU
L-363 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC1[XpKSzVyPUCuNFAzQDRizszN NVHZZXd4W0GQR1XS
RL95-2 NYLhToc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonNTWM2OD1yLkCwN|Ih|ryP NXO2dGVrW0GQR1XS
BL-70 NHHjZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMECzN|ch|ryP MXvTRW5ITVJ?
TGBC1TKB NWPLUJNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL3[|BKSzVyPUCuNFA{PzlizszN MmPZV2FPT0WU
697 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjMTWM2OD1yLkCwOlM1KM7:TR?= MojEV2FPT0WU
RPMI-8226 NVTLXWRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEC2OVEh|ryP Mo\BV2FPT0WU
BL-41 NIjCRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEC2PVYh|ryP NUPpTpNwW0GQR1XS
MRK-nu-1 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGq2d5FKSzVyPUCuNFA4ODdizszN NIW5VpVUSU6JRWK=
EW-1 NFXI[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{P0ZWlEPTB;MD6wNFc1QSEQvF2= MYrTRW5ITVJ?
EVSA-T MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\ONXpKSzVyPUCuNFA5QTJizszN NUTLfItCW0GQR1XS
HUTU-80 NVfCNWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfDTWM2OD1yLkCwPVI6KM7:TR?= NXrBPIg5W0GQR1XS
VA-ES-BJ NFTDXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvkSIlKSzVyPUCuNFA6QDRizszN MnzNV2FPT0WU
GCIY NHfaZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfRdJdVUUN3ME2wMlAyODB5IN88US=> NGizbFNUSU6JRWK=
ES6 NV;ZU4RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ThUmlEPTB;MD6wNVA5OyEQvF2= MX3TRW5ITVJ?
NALM-6 NIDBUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zMRmlEPTB;MD6wNVExOiEQvF2= MX7TRW5ITVJ?
LB996-RCC MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly4TWM2OD1yLkCxNVM4KM7:TR?= MYjTRW5ITVJ?
EW-16 M3zLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEGxPVIh|ryP M{i0RnNCVkeHUh?=
KALS-1 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfHcolLUUN3ME2wMlAyOTl6IN88US=> MXPTRW5ITVJ?
OPM-2 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK3WWVKSzVyPUCuNFEzQSEQvF2= M4LQenNCVkeHUh?=
KU812 NWPKfWtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPaZ2dKSzVyPUCuNFEzQTZizszN MXXTRW5ITVJ?
A4-Fuk M2j0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mwVmlEPTB;MD6wNVMyQSEQvF2= MnX2V2FPT0WU
KGN M{PkNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\oTWM2OD1yLkCxN|U6KM7:TR?= M4HMR3NCVkeHUh?=
KS-1 M33lbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXOXZN6UUN3ME2wMlAyOzl{IN88US=> MnO4V2FPT0WU
no-11 M3XwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDocXhKSzVyPUCuNFE{QTVizszN M4nsenNCVkeHUh?=
PSN1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3Q[WpiUUN3ME2wMlAyPDB7IN88US=> NVHwboZyW0GQR1XS
SK-LMS-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr2TlBTUUN3ME2wMlAyPDF|IN88US=> M1nld3NCVkeHUh?=
LS-411N NXKyOIE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfJcY9KSzVyPUCuNFE1OzlizszN NWPL[mxzW0GQR1XS
HT-144 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfxVGtKSzVyPUCuNFE1PTFizszN MXjTRW5ITVJ?
ACN NUTZZnNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFq5VHFKSzVyPUCuNFE2KM7:TR?= MWXTRW5ITVJ?
RKO NH;WTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;1TWM2OD1yLkCxOVM{KM7:TR?= MlG1V2FPT0WU
CMK NGfzbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm3TWM2OD1yLkCxOVQ{KM7:TR?= NHfTbohUSU6JRWK=
GB-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;FN5RXUUN3ME2wMlAyPTV|IN88US=> M4DWbHNCVkeHUh?=
KE-37 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\TN2lEPTB;MD6wNVU4OyEQvF2= NYnSfGdjW0GQR1XS
no-10 NWHrdFl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rjSWlEPTB;MD6wNVU5PCEQvF2= MYrTRW5ITVJ?
MOLT-16 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoUpdqUUN3ME2wMlAyPjJ{IN88US=> M3u0[XNCVkeHUh?=
HEL MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3xepdCUUN3ME2wMlAyPjRizszN MUfTRW5ITVJ?
NCI-H1355 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PldmlEPTB;MD6wNVY1PiEQvF2= MmO5V2FPT0WU
IST-MEL1 NWPGXXJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK1W2JKSzVyPUCuNFE4PzRizszN MoSwV2FPT0WU
MHH-PREB-1 NWHSPXVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHkTWM2OD1yLkCxPFE5KM7:TR?= Mmj2V2FPT0WU
ES8 MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\pdJQ4UUN3ME2wMlAyQDR2IN88US=> M1H5VHNCVkeHUh?=
LC-2-ad NEH5UIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfLWGNKSzVyPUCuNFIyOzdizszN MYrTRW5ITVJ?
LAMA-84 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S5XWlEPTB;MD6wNlE3PyEQvF2= NGHkOVBUSU6JRWK=
BV-173 NWK4fWVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXOXHNKSzVyPUCuNFIzODNizszN NXrRS482W0GQR1XS
SW872 MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLL[nIyUUN3ME2wMlAzOjR5IN88US=> MXfTRW5ITVJ?
SK-UT-1 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3vUohKSzVyPUCuNFIzPjFizszN NWnxWHFKW0GQR1XS
OS-RC-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\rboZKSzVyPUCuNFI{OjNizszN NV\UcGczW0GQR1XS
NCI-H747 NF\qR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjaTG52UUN3ME2wMlAzOzNizszN NHjYPJVUSU6JRWK=
MZ2-MEL NV3KSotTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLNTYJKSzVyPUCuNFI{OzdizszN NWH6c45{W0GQR1XS
TE-11 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHVVmVHUUN3ME2wMlAzOzd{IN88US=> NIrXT3RUSU6JRWK=
KURAMOCHI MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwMEK0NVQh|ryP NXfWdml7W0GQR1XS
HD-MY-Z NGHtWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTTVGNoUUN3ME2wMlAzPDJ4IN88US=> NIHrPGpUSU6JRWK=
GI-1 NEHSSIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPXTWM2OD1yLkCyOFY6KM7:TR?= MorFV2FPT0WU
LB1047-RCC M2LtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLa[|ZKSzVyPUCuNFI1QDhizszN NULPXnA6W0GQR1XS
TE-12 M3nD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPiS45GUUN3ME2wMlAzPTVizszN MkfwV2FPT0WU
MZ7-mel MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GxSGlEPTB;MD6wNlYxQSEQvF2= MlXOV2FPT0WU
MMAC-SF MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDaTWM2OD1yLkCyOlM{KM7:TR?= NF\qVlZUSU6JRWK=
A101D M2D2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXXclcyUUN3ME2wMlAzPjVizszN NWTGZ2ZDW0GQR1XS
GR-ST M1TTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXviUpZzUUN3ME2wMlAzPjV3IN88US=> M{jkcnNCVkeHUh?=
MC116 M4[zO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDWcWJoUUN3ME2wMlAzPjhizszN MV\TRW5ITVJ?
Ramos-2G6-4C10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEK3OUDPxE1? NFf3dHBUSU6JRWK=
ATN-1 M1v3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PXSWlEPTB;MD6wNlc5QSEQvF2= NXX2fpYxW0GQR1XS
MFH-ino NXjDc4JXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELUenVKSzVyPUCuNFI5OTJizszN NWnGZ25CW0GQR1XS
DEL NU[zcHdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml2wTWM2OD1yLkCyPFE2KM7:TR?= NHHXO3hUSU6JRWK=
OCI-AML2 NVrOd|E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEK4O|Eh|ryP Mk\pV2FPT0WU
LXF-289 NV7BN4VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEK4O|Ih|ryP NGTX[|VUSU6JRWK=
IA-LM NXe4c4hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPoTW9KSzVyPUCuNFI6OTdizszN MljvV2FPT0WU
EoL-1-cell M3jk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXGbWx5UUN3ME2wMlAzQTl4IN88US=> NWrme446W0GQR1XS
OVCAR-4 MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHsb21KSzVyPUCuNFMxQTRizszN MVfTRW5ITVJ?
ES1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jyfGlEPTB;MD6wN|A6PyEQvF2= MonSV2FPT0WU
CESS NIHXTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PzZWlEPTB;MD6wN|A6QSEQvF2= NWrsS|V5W0GQR1XS
GAK NYH4OGUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrHTWM2OD1yLkCzNVg3KM7:TR?= MVHTRW5ITVJ?
NTERA-S-cl-D1 M2PWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\uTWM2OD1yLkCzNlI3KM7:TR?= M4LyXnNCVkeHUh?=
TE-10 MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEOzNVEh|ryP NYrzb21jW0GQR1XS
CCRF-CEM MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEOzO|Eh|ryP MoT4V2FPT0WU
NMC-G1 NXfzU3FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfqfJBDUUN3ME2wMlA{PDR6IN88US=> NFPWPGdUSU6JRWK=
HOP-62 NFO3bIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7mTWM2OD1yLkCzOVU3KM7:TR?= MUTTRW5ITVJ?
SH-4 MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfk[Y5KSzVyPUCuNFM2QDJizszN M3\0dnNCVkeHUh?=
NCI-H1648 MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmwTHF2UUN3ME2wMlA{PjJ{IN88US=> MY\TRW5ITVJ?
EB-3 NULNfJpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTfGlEPTB;MD6wN|Y1OyEQvF2= NUH6bVExW0GQR1XS
BB65-RCC NUTwOFRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj2[FZbUUN3ME2wMlA{PjlzIN88US=> MlTIV2FPT0WU
BE-13 M3rjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL3SGhbUUN3ME2wMlA{PzV7IN88US=> M{nlN3NCVkeHUh?=
CP67-MEL Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXXTWM2OD1yLkCzO|U6KM7:TR?= MnvLV2FPT0WU
SW954 NWnFNnNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILOZpFKSzVyPUCuNFM4QSEQvF2= NXTpNYJsW0GQR1XS
TE-5 MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nQNmlEPTB;MD6wN|g2PCEQvF2= NH;2VXhUSU6JRWK=
HCE-4 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;2O2lEPTB;MD6wN|g2PSEQvF2= MlHKV2FPT0WU
LC-1F MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TwXWlEPTB;MD6wN|k5QSEQvF2= NVHtfploW0GQR1XS
TK10 M4r5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD1yLkC0NFE6KM7:TR?= NEnXNodUSU6JRWK=
SJSA-1 NET6[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX5TWM2OD1yLkC0NVg5KM7:TR?= MWHTRW5ITVJ?
Daudi NYjJNplNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMESyNlUh|ryP MUPTRW5ITVJ?
SW982 MmnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LJbGlEPTB;MD6wOFI1PiEQvF2= NHLvOINUSU6JRWK=
SF126 NYLsSWxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nqemlEPTB;MD6wOFM3OSEQvF2= MUPTRW5ITVJ?
TE-15 NXO4coc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMES0N|Uh|ryP NETLeIJUSU6JRWK=
COLO-684 MkiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjSUIV5UUN3ME2wMlA1PTZzIN88US=> Mn\lV2FPT0WU
8-MG-BA MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvkTWM2OD1yLkC0OlI6KM7:TR?= NISzdYhUSU6JRWK=
NB13 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITxSWlKSzVyPUCuNFQ4PzZizszN NFHiNItUSU6JRWK=
HCC1599 NX7ZPYhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMES4O|kh|ryP NFq4[ZpUSU6JRWK=
SK-PN-DW NVjhOZZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{L1fWlEPTB;MD6wOFk1QSEQvF2= M1nsWHNCVkeHUh?=
ALL-PO NX61fY1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrHTWM2OD1yLkC0PVU3KM7:TR?= MmrIV2FPT0WU
NB6 M4m1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzYb5BvUUN3ME2wMlA2OjdzIN88US=> NIDWU|NUSU6JRWK=
IST-SL2 NFO2dZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjSNHhIUUN3ME2wMlA2OzZ{IN88US=> M3rJ[XNCVkeHUh?=
BB30-HNC NG\RO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[2dXVKSzVyPUCuNFU4OyEQvF2= NUnJRlVlW0GQR1XS
SW962 NWLLcGpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEW3OlMh|ryP MlvIV2FPT0WU
TGBC24TKB M4fYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HLUWlEPTB;MD6wOVc6QSEQvF2= M2PzdXNCVkeHUh?=
KINGS-1 NFvl[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzqTWM2OD1yLkC1PFA{KM7:TR?= NYHYd2xwW0GQR1XS
HC-1 M2\LSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M160c2lEPTB;MD6wOVgzPyEQvF2= NVv3WXFGW0GQR1XS
RS4-11 M4PwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e5[mlEPTB;MD6wOVk{QCEQvF2= MoSwV2FPT0WU
LS-123 Mn35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPUTWM2OD1yLkC1PVQzKM7:TR?= NXHxXmx1W0GQR1XS
A3-KAW M{n3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwME[yNlUh|ryP MlfoV2FPT0WU
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HCC1187 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LSOGlEPTB;MD60Olc3QCEQvF2= M4Hpd3NCVkeHUh?=
HCC2218 NXPoVoZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfnZ4VDUUN3ME2wMlQ4OjJ5IN88US=> M2PqTHNCVkeHUh?=
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NCI-H69 NILTSmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwNUCyOFch|ryP MVXTRW5ITVJ?
NCI-H1694 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HOZmlEPTB;MD61NFY6PyEQvF2= MU\TRW5ITVJ?
CA46 NWf5NXp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvoTWM2OD1yLkWwPVE4KM7:TR?= NH\WcJJUSU6JRWK=
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LU-134-A MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL3TWM2OD1yLkW1Nlk3KM7:TR?= M2C3PXNCVkeHUh?=
MC-CAR NYjFPIg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrZc2ZKSzVyPUCuOVU1OzFizszN MUXTRW5ITVJ?
NEC8 NX7wO|JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwNU[xO|Ih|ryP NFf1UZlUSU6JRWK=
NCI-H524 NIHUc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjXWWVZUUN3ME2wMlU5PzR6IN88US=> MUXTRW5ITVJ?
NCI-H1963 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL6TWM2OD1yLk[yOVgh|ryP NUS2RmN7W0GQR1XS
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NCI-H1155 NHu1T4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNkWzOUDPxE1? M3HrNHNCVkeHUh?=
D-263MG NF;0[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLCVI13UUN3ME2wMlY3OTBzIN88US=> NIPlXIRUSU6JRWK=
TE-6 NYLadIhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwNkixNFQh|ryP M4\2cHNCVkeHUh?=
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NCI-H510A NWG1PHRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwN{eyN|Yh|ryP Mo\zV2FPT0WU
KARPAS-45 NEXCPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1WyRmlEPTB;MD63PFI{PSEQvF2= NYH1SlJ4W0GQR1XS
IST-SL1 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[xR2dKSzVyPUCuPFU5OjVizszN M37yOHNCVkeHUh?=
COLO-824 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe5OZlKSzVyPUCuPFc5OzVizszN M37rOXNCVkeHUh?=
NCI-H526 NYLKXJR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:zXmlEPTB;MD65NFk2QCEQvF2= M37WV3NCVkeHUh?=
NCI-H719 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzQSllIUUN3ME2wMlk3PjV5IN88US=> MnHmV2FPT0WU
SF539 NUjZell7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwOUizPVYh|ryP MYPTRW5ITVJ?
NKM-1 NWLWTWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vE[2lEPTB;MD65PFY3OyEQvF2= MkjxV2FPT0WU
A253 M2D6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWraXGtQUUN3ME2wMlk5QDh3IN88US=> NYftWHczW0GQR1XS
TE-441-T M{PLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jkO2lEPTB;MT6wOFM2KM7:TR?= NF;ReZhUSU6JRWK=
COR-L88 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\kc3RKSzVyPUGuNVE{PTRizszN MWXTRW5ITVJ?
CPC-N MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFwMUW4PFgh|ryP NFzS[mZUSU6JRWK=
NCI-H2107 NELUVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW0cY9jUUN3ME2xMlE4OjZzIN88US=> M4e4TnNCVkeHUh?=
ECC4 M3fGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwMUi2PVMh|ryP M4DsfnNCVkeHUh?=
NCI-H2141 NHLUbYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITjbXFKSzVyPUGuNVkzQTlizszN M1LqZXNCVkeHUh?=
NCI-H1770 MkXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFwM{K5Nlgh|ryP MVTTRW5ITVJ?
NCI-SNU-1 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXjTWM2OD1zLkOzNFQh|ryP NFHBPGlUSU6JRWK=
LU-165 NHPReGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFwNEW0Olch|ryP NGL4dG5USU6JRWK=
Raji MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XrTWlEPTB;MT60O|I2QSEQvF2= NGe1T|lUSU6JRWK=
EW-24 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLCTWM2OD1zLkW0OlE6KM7:TR?= MmKxV2FPT0WU
KP-N-RT-BM-1 M4fQWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTNVmlEUUN3ME2xMlU3PTVzIN88US=> M1LjZnNCVkeHUh?=
SK-MEL-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUNWhKSzVyPUGuOlQ5PzdizszN NVy0XFdOW0GQR1XS
SCLC-21H NGLQ[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTRTWM2OD1zLk[2OlUyKM7:TR?= NFzwXIhUSU6JRWK=
SIMA MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLaTWM2OD1zLk[4NlM{KM7:TR?= NFHscHRUSU6JRWK=
NCI-H1304 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL4[JFKSzVyPUGuO|A4PjVizszN NGO2[5FUSU6JRWK=
REH MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwN{GwO|gh|ryP NWe1OYF[W0GQR1XS
KP-N-YS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG1TWM2OD1zLkmzOVUyKM7:TR?= NH3aTmlUSU6JRWK=
DMS-153 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknpTWM2OD1zLkm3OVkh|ryP M1HyS3NCVkeHUh?=
NB10 MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfCOnNKSzVyPUKuNlA5PzhizszN MYXTRW5ITVJ?
NCI-H345 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17kTmlEPTB;Mj62NVkxPSEQvF2= M3HF[nNCVkeHUh?=
SK-N-FI MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LUfGlEPTB;Mj63OVM5OSEQvF2= MlPGV2FPT0WU
NCI-H1092 NV3wV4RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTOVG9zUUN3ME2yMlk2Ozl2IN88US=> M4XJZnNCVkeHUh?=
KM-H2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTNwNkWzPVYh|ryP NGKwWGJUSU6JRWK=
KG-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHNTWM2OD1|LkexOlg5KM7:TR?= MXjTRW5ITVJ?
D-283MED NVXqd4VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuxdXRKSzVyPUOuO|U5PyEQvF2= M2rZW3NCVkeHUh?=
LU-65 M3HDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkTWM2OD12LkGxOFg2KM7:TR?= M4[3fXNCVkeHUh?=
MSTO-211H MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17NRWlEPTB;ND6xPFg6QCEQvF2= NXXXTIw5W0GQR1XS
NCI-H2081 NU\kWY9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTRwMkmxO|Qh|ryP M3y5RXNCVkeHUh?=
D-247MG M4LtSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRwNEOxPVEh|ryP MUHTRW5ITVJ?
P31-FUJ MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTRwNEWwNVkh|ryP MljxV2FPT0WU
DMS-79 M3zENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH6TWM2OD12LkmzNVg{KM7:TR?= NV;PcWpTW0GQR1XS
KASUMI-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrPVWpKSzVyPUSuPVc2ODlizszN NH3WdI1USU6JRWK=
JVM-3 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnD[G9KSzVyPUWuNlUxOTRizszN MnzQV2FPT0WU
LAN-6 M4n6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn5TWM2OD13LkWxO|M3KM7:TR?= NX64fmdTW0GQR1XS
DJM-1 NVvyfINmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\VTWM2OD13LkW2NFI6KM7:TR?= NH3GcHFUSU6JRWK=
JVM-2 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILEOIlKSzVyPUWuOlcxQTJizszN MXLTRW5ITVJ?
U-87-MG M1XrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrPTWM2OD13Lki5PVY1KM7:TR?= NIL5N4RUSU6JRWK=
SHP-77 M4nPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXNTWM2OD13Lkm0PVI5KM7:TR?= MoDtV2FPT0WU
RPMI-8866 MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTZwMkewNVMh|ryP MlHtV2FPT0WU
ES7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITLU2FKSzVyPU[uN|k6OjRizszN Mn\rV2FPT0WU
WSU-NHL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPOTWM2OD14LkWxOlA6KM7:TR?= NFO3RmtUSU6JRWK=
CAS-1 NGXIfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTdwMEm3OFkh|ryP NE\5eJdUSU6JRWK=
MHH-NB-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPhWFFKSzVyPUiuNlMyPTJizszN NYT5ZVQyW0GQR1XS
ES5 MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTlwNUKyPFYh|ryP MmCzV2FPT0WU
HDLM-2 NUSxWndzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTlwOUW5NFIh|ryP MXXTRW5ITVJ?
NCI-H2171 NHjNbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DXS2lEPTB;MUCuOVkzPyEQvF2= NEDaWYxUSU6JRWK=
LNCaP-Clone-FGC M1LOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;xfFdKSzVyPUGxMlM4OThizszN MYjTRW5ITVJ?
NCI-H1395 NGnZU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vUdmlEPTB;MUKuNlY6QSEQvF2= NXXJR281W0GQR1XS
NCI-H1436 NX[yToFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTF|LkOxPVUh|ryP NYjyW5pPW0GQR1XS
RCC10RGB M4G5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHUTWM2OD1zMz6zNlIyKM7:TR?= NHHCfJpUSU6JRWK=
SW684 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzrfHJKSzVyPUGzMlk4QTdizszN NGXhUWtUSU6JRWK=
NCI-H1650 NFfqRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT6emFDUUN3ME2xOU4xPDR5IN88US=> NHXkN3ZUSU6JRWK=
EW-13 MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;ycYxSUUN3ME2xOU4zODJzIN88US=> NEjFeW9USU6JRWK=
EC-GI-10 M2T5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3wbIM6UUN3ME2xOU45PjR2IN88US=> NHfZTXFUSU6JRWK=
CHP-126 NYe3VFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3Q[WNQUUN3ME2xO{4yQTF6IN88US=> NYW2[nJDW0GQR1XS
NCI-H226 NHj3VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXiNIV{UUN3ME2xPE4xPDB|IN88US=> M4f6bHNCVkeHUh?=
NCI-H1838 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTIT5RKSzVyPUKwMlE5PDhizszN MXPTRW5ITVJ?
EW-11 NEf4U2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHnOlVKSzVyPUK0MlI4OThizszN NGTqOoxUSU6JRWK=
EB2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjTTWM2OD1|MT61N|E5KM7:TR?= MlztV2FPT0WU
D-502MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnwTWM2OD12Mz65NlI6KM7:TR?= NVnkTHBMW0GQR1XS
U-698-M M{XDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD6cYt1UUN3ME20PE45PjdzIN88US=> MmTFV2FPT0WU
ES3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;lXlNMUUN3ME20PU4{QDl|IN88US=> MnXQV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG 400+0.5% Tween80+5% Propylene glycol
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID