Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

Size Price Stock Quantity  
USD 170 In stock
USD 370 In stock
USD 670 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NIHu[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMECwN|A3KM7:TR?= NV\WVHZ3W0GQR1XS
OCUB-M Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMECxPVQh|ryP MUnTRW5ITVJ?
DOHH-2 NYjoTpA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECyNlUh|ryP NG\pTYFUSU6JRWK=
NOS-1 NWLS[JVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LPNGlEPTB;MD6wNFI1OiEQvF2= NHXKUlRUSU6JRWK=
L-363 NFvaZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTSOGlKSzVyPUCuNFAzQDRizszN NE\mcYRUSU6JRWK=
RL95-2 M1qydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC1TWM2OD1yLkCwN|Ih|ryP NH;VU|VUSU6JRWK=
BL-70 NXTjepZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXENpBOUUN3ME2wMlAxOzN5IN88US=> NX;hd4ZVW0GQR1XS
TGBC1TKB Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfZVmNKSzVyPUCuNFA{PzlizszN NFq2WVVUSU6JRWK=
697 NEntWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS4XJFxUUN3ME2wMlAxPjN2IN88US=> NYXWOpRYW0GQR1XS
RPMI-8226 NWDENJZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLUTWM2OD1yLkCwOlUyKM7:TR?= Mn\KV2FPT0WU
BL-41 M4r5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XU[mlEPTB;MD6wNFY6PiEQvF2= M1jHZXNCVkeHUh?=
MRK-nu-1 NH;aNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PSOmlEPTB;MD6wNFcxPyEQvF2= NHrkUIpUSU6JRWK=
EW-1 NUTQOZJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD1eWJKSzVyPUCuNFA4PDlizszN MVTTRW5ITVJ?
EVSA-T MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\FS48zUUN3ME2wMlAxQDl{IN88US=> Ml\OV2FPT0WU
HUTU-80 NW[wflNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEC5Nlkh|ryP M1fkVHNCVkeHUh?=
VA-ES-BJ NG\2bJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WxPGlEPTB;MD6wNFk5PCEQvF2= NX7HZYc1W0GQR1XS
GCIY MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e0O2lEPTB;MD6wNVAxPyEQvF2= MVTTRW5ITVJ?
ES6 NFj4elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEGwPFMh|ryP NHPI[G9USU6JRWK=
NALM-6 M2HxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXtW3BKSzVyPUCuNFEyODJizszN NFL3[lhUSU6JRWK=
LB996-RCC NGG2V5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTieIN[UUN3ME2wMlAyOTN5IN88US=> M1j3SHNCVkeHUh?=
EW-16 NUPyPI9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETGRWlKSzVyPUCuNFEyQTJizszN M2rTdXNCVkeHUh?=
KALS-1 NIHr[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEGxPVgh|ryP NHHrTo5USU6JRWK=
OPM-2 M2PyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEGyPUDPxE1? M1;LR3NCVkeHUh?=
KU812 M3npRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\JTWM2OD1yLkCxNlk3KM7:TR?= MmX1V2FPT0WU
A4-Fuk M1jxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7qTWM2OD1yLkCxN|E6KM7:TR?= NUG4ZWYzW0GQR1XS
KGN NWnDd4ZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HsdmlEPTB;MD6wNVM2QSEQvF2= MV7TRW5ITVJ?
KS-1 NX64eJM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3CenRDUUN3ME2wMlAyOzl{IN88US=> M4rjbXNCVkeHUh?=
no-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrMOW5wUUN3ME2wMlAyOzl3IN88US=> MVXTRW5ITVJ?
PSN1 NH7IV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEG0NFkh|ryP MXzTRW5ITVJ?
SK-LMS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDyTWM2OD1yLkCxOFE{KM7:TR?= MmnVV2FPT0WU
LS-411N MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\tVGlEPTB;MD6wNVQ{QSEQvF2= MX;TRW5ITVJ?
HT-144 NX;mT4dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnZTYFKSzVyPUCuNFE1PTFizszN M3jxNHNCVkeHUh?=
ACN NVnqTJNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z5d2lEPTB;MD6wNVUh|ryP MmTPV2FPT0WU
RKO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXMTmN{UUN3ME2wMlAyPTN|IN88US=> NUPGfldwW0GQR1XS
CMK M3\ETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtcFV5UUN3ME2wMlAyPTR|IN88US=> M1XaeXNCVkeHUh?=
GB-1 NXrSU2RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEG1OVMh|ryP NUTjd4NZW0GQR1XS
KE-37 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEG1O|Mh|ryP M3vSZnNCVkeHUh?=
no-10 NFnyOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PSTWlEPTB;MD6wNVU5PCEQvF2= MV7TRW5ITVJ?
MOLT-16 M4jCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;SSIVKSzVyPUCuNFE3OjJizszN MUDTRW5ITVJ?
HEL NV7xZnRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEG2OEDPxE1? NGHXWWVUSU6JRWK=
NCI-H1355 NYLOeFR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET6bYJKSzVyPUCuNFE3PDZizszN M4nxdHNCVkeHUh?=
IST-MEL1 M3fO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEG3O|Qh|ryP M17mdXNCVkeHUh?=
MHH-PREB-1 NHTXS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInIVplKSzVyPUCuNFE5OThizszN NYDQS4FbW0GQR1XS
ES8 NEK0N|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyxTWM2OD1yLkCxPFQ1KM7:TR?= MnTJV2FPT0WU
LC-2-ad NVHwW41PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DocGlEPTB;MD6wNlE{PyEQvF2= MorBV2FPT0WU
LAMA-84 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\iWoRKSzVyPUCuNFIyPjdizszN NVTid|M6W0GQR1XS
BV-173 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXJdYFKSzVyPUCuNFIzODNizszN M2fEN3NCVkeHUh?=
SW872 M2qwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGW5UXBKSzVyPUCuNFIzPDdizszN NWP1S|VGW0GQR1XS
SK-UT-1 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nGfWlEPTB;MD6wNlI3OSEQvF2= NXPNe|R{W0GQR1XS
OS-RC-2 NGr4bGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSxPId[UUN3ME2wMlAzOzJ|IN88US=> NGnzdZhUSU6JRWK=
NCI-H747 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjxVlhPUUN3ME2wMlAzOzNizszN NVnmSVF1W0GQR1XS
MZ2-MEL MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTtWW92UUN3ME2wMlAzOzN5IN88US=> NHL3VFRUSU6JRWK=
TE-11 M135[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[3TWM2OD1yLkCyN|czKM7:TR?= NU[5N|RsW0GQR1XS
KURAMOCHI M1;hW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEK0NVQh|ryP M3T5[HNCVkeHUh?=
HD-MY-Z NHf3Um9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMEK0NlYh|ryP MU\TRW5ITVJ?
GI-1 NIHQNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;iTWM2OD1yLkCyOFY6KM7:TR?= MVPTRW5ITVJ?
LB1047-RCC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEK0PFgh|ryP NEPtPIVUSU6JRWK=
TE-12 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEK1OUDPxE1? NHLTeIpUSU6JRWK=
MZ7-mel M4PsZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LrbWlEPTB;MD6wNlYxQSEQvF2= M4f3eXNCVkeHUh?=
MMAC-SF NYrNbmZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEK2N|Mh|ryP NWG3N2hNW0GQR1XS
A101D Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHifVJKSzVyPUCuNFI3PSEQvF2= MXvTRW5ITVJ?
GR-ST MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETsS5VKSzVyPUCuNFI3PTVizszN NUT0cVlMW0GQR1XS
MC116 NWfMbHpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEK2PEDPxE1? MX;TRW5ITVJ?
Ramos-2G6-4C10 M{npR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjSR5AzUUN3ME2wMlAzPzVizszN MXPTRW5ITVJ?
ATN-1 NXvV[Wh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEK3PFkh|ryP NFjufpBUSU6JRWK=
MFH-ino M2LK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEK4NVIh|ryP MV3TRW5ITVJ?
DEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDJTWM2OD1yLkCyPFE2KM7:TR?= MmrxV2FPT0WU
OCI-AML2 NH\oZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPITWM2OD1yLkCyPFcyKM7:TR?= MUDTRW5ITVJ?
LXF-289 NFnCPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6zVopyUUN3ME2wMlAzQDd{IN88US=> MmXBV2FPT0WU
IA-LM NHfPWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nafWlEPTB;MD6wNlkyPyEQvF2= M3PLW3NCVkeHUh?=
EoL-1-cell NFW2VHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[wcVAxUUN3ME2wMlAzQTl4IN88US=> MUfTRW5ITVJ?
OVCAR-4 M{OzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEOwPVQh|ryP M1\INnNCVkeHUh?=
ES1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEOwPVch|ryP MoHSV2FPT0WU
CESS M4m1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvOTWM2OD1yLkCzNFk6KM7:TR?= MmrkV2FPT0WU
GAK MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEOxPFYh|ryP M{DhbHNCVkeHUh?=
NTERA-S-cl-D1 NEjBc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojSTWM2OD1yLkCzNlI3KM7:TR?= MorTV2FPT0WU
TE-10 NUfnR3QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD1yLkCzN|EyKM7:TR?= NF3XPHZUSU6JRWK=
CCRF-CEM M{nqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwMEOzO|Eh|ryP M{H3VXNCVkeHUh?=
NMC-G1 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm5TWM2OD1yLkCzOFQ5KM7:TR?= M1nUcXNCVkeHUh?=
HOP-62 NWPHTWtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLOV4FRUUN3ME2wMlA{PTV4IN88US=> MW\TRW5ITVJ?
SH-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEO1PFIh|ryP MVvTRW5ITVJ?
NCI-H1648 NI[1PVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXvTWM2OD1yLkCzOlIzKM7:TR?= M13INnNCVkeHUh?=
EB-3 NITnOmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjkPGJKSzVyPUCuNFM3PDNizszN M2LPb3NCVkeHUh?=
BB65-RCC NWfNbXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fNcWlEPTB;MD6wN|Y6OSEQvF2= MontV2FPT0WU
BE-13 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fITWlEPTB;MD6wN|c2QSEQvF2= M3HHNHNCVkeHUh?=
CP67-MEL Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH0TWM2OD1yLkCzO|U6KM7:TR?= M1XaWHNCVkeHUh?=
SW954 M3jz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILR[pZKSzVyPUCuNFM4QSEQvF2= MXTTRW5ITVJ?
TE-5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfpXZJMUUN3ME2wMlA{QDV2IN88US=> M2LpXnNCVkeHUh?=
HCE-4 NVzp[GV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXoTWM2OD1yLkCzPFU2KM7:TR?= MnG3V2FPT0WU
LC-1F NXPm[Gk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\tfFdKSzVyPUCuNFM6QDlizszN NH;1XnlUSU6JRWK=
TK10 M1\vc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXldoRKSzVyPUCuNFQxOTlizszN MXTTRW5ITVJ?
SJSA-1 NGjoe4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXsXlNKSzVyPUCuNFQyQDhizszN MYDTRW5ITVJ?
Daudi NWTIVpJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fQdGlEPTB;MD6wOFIzPSEQvF2= NHHzeohUSU6JRWK=
SW982 NEXpXXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDEUWRKSzVyPUCuNFQzPDZizszN NVTldZJtW0GQR1XS
SF126 NGqxPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMESzOlEh|ryP MWXTRW5ITVJ?
TE-15 M1PXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT4XVNKSzVyPUCuNFQ1OzVizszN MV;TRW5ITVJ?
COLO-684 NYDsUlhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMES1OlEh|ryP NGjibnhUSU6JRWK=
8-MG-BA NUTUdWd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HG[WlEPTB;MD6wOFYzQSEQvF2= MlPQV2FPT0WU
NB13 NVn3dGZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HMfWlEPTB;MD6wOFc4PiEQvF2= NVfMPI5uW0GQR1XS
HCC1599 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLlPWRmUUN3ME2wMlA1QDd7IN88US=> MoDrV2FPT0WU
SK-PN-DW M1HBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMES5OFkh|ryP M1\4c3NCVkeHUh?=
ALL-PO M1zsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMES5OVYh|ryP NF34eIxUSU6JRWK=
NB6 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPRTWM2OD1yLkC1NlcyKM7:TR?= NYDi[2pKW0GQR1XS
IST-SL2 NUjBWlNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj0U|hKSzVyPUCuNFU{PjJizszN NYHteI9YW0GQR1XS
BB30-HNC NGX1dndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Lhd2lEPTB;MD6wOVc{KM7:TR?= Mk\hV2FPT0WU
SW962 NX35OpI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn3b2w1UUN3ME2wMlA2PzZ|IN88US=> M4PEUnNCVkeHUh?=
TGBC24TKB MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXQZW1EUUN3ME2wMlA2Pzl7IN88US=> MmToV2FPT0WU
KINGS-1 NXT5cZVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW0PVZrUUN3ME2wMlA2QDB|IN88US=> NY[zTGxuW0GQR1XS
HC-1 NFPheZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjDRpl2UUN3ME2wMlA2QDJ5IN88US=> NVnyNXZFW0GQR1XS
RS4-11 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrVfJVKSzVyPUCuNFU6OzhizszN MXrTRW5ITVJ?
LS-123 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEW5OFIh|ryP NEPBfG1USU6JRWK=
A3-KAW MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\UbWlEPTB;MD6wOlIzPSEQvF2= M{HaSXNCVkeHUh?=
SNB75 M33q[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj0Z5VMUUN3ME2wMlA3OzRzIN88US=> M3HVPXNCVkeHUh?=
SR MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnjZldKSzVyPUCuNFY{PzRizszN NV7aVlZsW0GQR1XS
LOUCY MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPCTWM2OD1yLkC2N|k1KM7:TR?= M1[2U3NCVkeHUh?=
K5 NE\UOZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDwTWM2OD1yLkC2OFA{KM7:TR?= NYi3bpg2W0GQR1XS
Becker NYnFOY4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7tRXpSUUN3ME2wMlA3PDJizszN NV\sdWtoW0GQR1XS
CTV-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfuTWM2OD1yLkC2OVQ5KM7:TR?= NIDVVY5USU6JRWK=
KLE M4ryUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwME[1PFQh|ryP MUHTRW5ITVJ?
MZ1-PC M1nrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV72ZWd{UUN3ME2wMlA3PTl6IN88US=> MlzjV2FPT0WU
MOLT-4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\2TWM2OD1yLkC2OlA2KM7:TR?= MWjTRW5ITVJ?
MLMA NFfaSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\KblNKSzVyPUCuNFY4QCEQvF2= MoDHV2FPT0WU
A388 NV7H[pZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrWUWRXUUN3ME2wMlA3QDl|IN88US=> MXrTRW5ITVJ?
MV-4-11 NILRdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHFRZBNUUN3ME2wMlA3QTl3IN88US=> NXXaSnRIW0GQR1XS
DSH1 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW5TWM2OD1yLkC3NVc{KM7:TR?= NXTyTFhFW0GQR1XS
MONO-MAC-6 MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli4TWM2OD1yLkC3NlEzKM7:TR?= NVP0dnp4W0GQR1XS
ARH-77 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofHTWM2OD1yLkC3Nlc5KM7:TR?= M{X1dnNCVkeHUh?=
LB771-HNC M{j0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEe1OFkh|ryP M{LPdHNCVkeHUh?=
PF-382 NFTWRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrVfWdKSzVyPUCuNFc2PjlizszN NUDybXU3W0GQR1XS
KM12 NH7TR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEe2OEDPxE1? MVzTRW5ITVJ?
HAL-01 NVHOPFN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrTTWM2OD1yLkC3OlU5KM7:TR?= NXv0dHk2W0GQR1XS
RPMI-8402 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Lwc2lEPTB;MD6wO|c5QSEQvF2= M1znRnNCVkeHUh?=
OMC-1 NGW1[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;IU25IUUN3ME2wMlA4QDB2IN88US=> NXXHfpB6W0GQR1XS
HT MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICxZolKSzVyPUCuNFgh|ryP MoHoV2FPT0WU
QIMR-WIL Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rZd2lEPTB;MD6wPFA2PSEQvF2= NHjFbJFUSU6JRWK=
KNS-42 NGXMeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HpOWlEPTB;MD6wPFIxOyEQvF2= NF[0eGxUSU6JRWK=
BC-3 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfvRZBKSzVyPUCuNFgzODRizszN NH3PTlJUSU6JRWK=
ES4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\hTWM2OD1yLkC4Nlk3KM7:TR?= NVLCN2RkW0GQR1XS
NCI-H23 M2D5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLnTo9KSzVyPUCuNFg1PCEQvF2= NFfyZ2xUSU6JRWK=
LB2518-MEL NF\5b2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LTbmlEPTB;MD6wPFY6PiEQvF2= MoTSV2FPT0WU
LC4-1 NUPZT5ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzIWHpKSzVyPUCuNFg4OzhizszN M3;uTHNCVkeHUh?=
SIG-M5 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fkUWlEPTB;MD6wPFkxPCEQvF2= NV\S[HJNW0GQR1XS
LP-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKyV4dKSzVyPUCuNFg6OzhizszN MYXTRW5ITVJ?
TE-8 NW[xSGRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEmwNVYh|ryP Moj6V2FPT0WU
K-562 MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;sVmlEPTB;MD6wPVEzKM7:TR?= MoLpV2FPT0WU
J-RT3-T3-5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMEmxOVMh|ryP MUDTRW5ITVJ?
DU-4475 NW\uOYJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEmxOlUh|ryP MWfTRW5ITVJ?
RXF393 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEm0OlIh|ryP MVfTRW5ITVJ?
NB5 MojKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPjTWM2OD1yLkC5OlI2KM7:TR?= NXSyUld1W0GQR1XS
A704 M2rudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTxWoJxUUN3ME2wMlA6PzRzIN88US=> Mmj6V2FPT0WU
SF268 NYW3b5VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP6fXFKSzVyPUCuNFk5OjVizszN NW\VU2F3W0GQR1XS
UACC-257 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTDeodpUUN3ME2wMlA6QDN|IN88US=> MWTTRW5ITVJ?
L-428 NHHnT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUCzNkDPxE1? M1jVOHNCVkeHUh?=
ST486 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMUC2NFYh|ryP Mn7LV2FPT0WU
SK-MM-2 M4LH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7EOHRKSzVyPUCuNVA4ODlizszN NUHlcphJW0GQR1XS
COR-L279 NVfrR45TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET1NlBKSzVyPUCuNVA5OzJizszN M4KzbXNCVkeHUh?=
JiyoyeP-2003 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXXOXVKSzVyPUCuNVA5PDNizszN MnvJV2FPT0WU
GT3TKB NGHaeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3OXpVKSzVyPUCuNVA6OThizszN NILJTJdUSU6JRWK=
HCE-T NUXhPVJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMUC5OEDPxE1? M3PYU3NCVkeHUh?=
SBC-1 M1vWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fIfWlEPTB;MD6xNVEyQSEQvF2= M{HmU3NCVkeHUh?=
KNS-81-FD NGCzcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS0TW9KSzVyPUCuNVEzPzNizszN Ml7LV2FPT0WU
NCI-H2126 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfjZZFKSzVyPUCuNVE{QTRizszN MXLTRW5ITVJ?
EM-2 M2f0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XPbmlEPTB;MD6xNVUzQSEQvF2= M2P2[3NCVkeHUh?=
JAR M1;RTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTVWHFKSzVyPUCuNVE2QThizszN M{[2SnNCVkeHUh?=
NB17 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUG2OVIh|ryP M2fLSnNCVkeHUh?=
LB647-SCLC M2PvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHYfWlKSzVyPUCuNVE4ODVizszN NEDUWolUSU6JRWK=
CAL-148 Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHSzT|JKSzVyPUCuNVE5KM7:TR?= MojiV2FPT0WU
K052 NHfoU|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T4c2lEPTB;MD6xNVg2OSEQvF2= NIHNblhUSU6JRWK=
KARPAS-299 M3:0SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfCR5VKSzVyPUCuNVIzOzNizszN NYrye2hIW0GQR1XS
KARPAS-422 M1rDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2C3NGlEPTB;MD6xNlQ{OiEQvF2= Mlm2V2FPT0WU
LOXIMVI Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMUK1NVUh|ryP M2jWdnNCVkeHUh?=
SCC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jRfmlEPTB;MD6xNlg2OSEQvF2= NX;VTGMyW0GQR1XS
LU-139 M3fId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMUK5O|Uh|ryP M{HGU3NCVkeHUh?=
COLO-320-HSR M2ftXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fnT2lEPTB;MD6xN|A5PiEQvF2= MYrTRW5ITVJ?
ONS-76 MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrJNIprUUN3ME2wMlE{OTNizszN NWPMNWxkW0GQR1XS
U-266 MkC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M322UmlEPTB;MD6xN|I1PSEQvF2= M{XDc3NCVkeHUh?=
HH MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDhRpZGUUN3ME2wMlE{PTN3IN88US=> NGrW[JBUSU6JRWK=
BB49-HNC MmrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMUO1PFch|ryP MlzGV2FPT0WU
NCI-SNU-5 NXr6O485T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUO1PVYh|ryP Mor0V2FPT0WU
C2BBe1 M2HnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrBeZhKSzVyPUCuNVM4PDZizszN M1u4cnNCVkeHUh?=
ML-2 NXnRdFVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\6fXVKSzVyPUCuNVM6PTNizszN NITIOIdUSU6JRWK=
SCH NGHwV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMUO5O|Qh|ryP MkfqV2FPT0WU
NCI-H82 M4\Ob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[yfYJKSzVyPUCuNVQyODRizszN M{PmSnNCVkeHUh?=
MDA-MB-134-VI M4DXT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMUSyOVIh|ryP NWfac4k1W0GQR1XS
SK-N-DZ M2f2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjod4dGUUN3ME2wMlE1PzF7IN88US=> NHTkfWdUSU6JRWK=
HL-60 M3[xXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDHTWM2OD1yLkG0PVIh|ryP NGPoXXZUSU6JRWK=
LB373-MEL-D NWj3N5BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2faXGlEPTB;MD6xOVU{QSEQvF2= MY\TRW5ITVJ?
LB831-BLC NVTXblFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS5TWM2OD1yLkG2NFc3KM7:TR?= MYXTRW5ITVJ?
SK-NEP-1 NYjYZ2h1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fpfWlEPTB;MD6xOlExOSEQvF2= NVLWOGxOW0GQR1XS
IMR-5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMU[0PFMh|ryP NGLD[pFUSU6JRWK=
Calu-6 NGnFZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7xRmE1UUN3ME2wMlE3PTN5IN88US=> NF6wU4RUSU6JRWK=
NCI-H1882 M3HqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PEOWlEPTB;MD6xOlczQCEQvF2= Mo[4V2FPT0WU
NCI-H446 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMU[4PVEh|ryP MVLTRW5ITVJ?
GI-ME-N MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMUiwNkDPxE1? MXTTRW5ITVJ?
MPP-89 M2O5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUixNlEh|ryP NFexe3BUSU6JRWK=
CGTH-W-1 Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\FZ2lmUUN3ME2wMlE5PDN4IN88US=> M132dXNCVkeHUh?=
MEG-01 NV\N[nFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMUi2Nlgh|ryP NXXwUlhEW0GQR1XS
NCI-H748 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXuyVZlrUUN3ME2wMlE5QTFzIN88US=> M3PYb3NCVkeHUh?=
COLO-829 NEWzXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zuNGlEPTB;MD6yNFY4OyEQvF2= NGfmOplUSU6JRWK=
GOTO M1;aUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfzTWM2OD1yLkKwO|Mh|ryP NGW2XotUSU6JRWK=
EW-3 Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTiTWM2OD1yLkKxO|E5KM7:TR?= NUnScGJEW0GQR1XS
KY821 NVvCTWJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELacJRKSzVyPUCuNlIxPDVizszN MljWV2FPT0WU
CTB-1 NXrDXI1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3NTWM2OD1yLkKyNlI5KM7:TR?= MYTTRW5ITVJ?
TALL-1 NUL4Z4lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDVXodKSzVyPUCuNlI6OjFizszN M{D1[HNCVkeHUh?=
NCI-H209 NYW5d21sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMkK5OlIh|ryP MYXTRW5ITVJ?
IST-MES1 NYDlWG05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjLc|E5UUN3ME2wMlI{PTFizszN MmTuV2FPT0WU
DMS-114 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXWPJpsUUN3ME2wMlI{QTl|IN88US=> M3PHTnNCVkeHUh?=
SNU-C2B M13icWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfXelJKSzVyPUCuNlQ{OTZizszN MlXnV2FPT0WU
DG-75 MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\OWmlEPTB;MD6yOlE6PSEQvF2= NGTRXlFUSU6JRWK=
D-336MG NIDveHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLPTWM2OD1yLkK2OVU4KM7:TR?= MUfTRW5ITVJ?
KMOE-2 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD1yLkK3OVM5KM7:TR?= MoTvV2FPT0WU
NB1 NEjEbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLWdFNwUUN3ME2wMlI4QTJ4IN88US=> MV;TRW5ITVJ?
RH-1 MnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMke5PFkh|ryP MkLvV2FPT0WU
TE-1 M2K4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4CxdmlEPTB;MD6yPFQ4QSEQvF2= M3PwUHNCVkeHUh?=
RPMI-6666 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXnVXJlUUN3ME2wMlI5QDRizszN NEDXelJUSU6JRWK=
TE-9 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;CTWM2OD1yLkK4PVg2KM7:TR?= NGLT[YxUSU6JRWK=
BT-474 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fNdmlEPTB;MD6yPVM{PCEQvF2= NIfBbXlUSU6JRWK=
COLO-668 MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M321d2lEPTB;MD6yPVQzQSEQvF2= NVSxS4ZlW0GQR1XS
NCI-H1581 M3HwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zUT2lEPTB;MD6yPVY5QSEQvF2= NXL2PXhJW0GQR1XS
MN-60 MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X1V2lEPTB;MD6yPVkxPSEQvF2= NUWxWVFKW0GQR1XS
L-540 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rWN2lEPTB;MD6zNFA5OSEQvF2= NVr5XHdsW0GQR1XS
MOLT-13 NHvp[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljXTWM2OD1yLkOwNVg{KM7:TR?= MVjTRW5ITVJ?
NCI-SNU-16 NIXXZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHGTWM2OD1yLkOwNlA2KM7:TR?= MkDOV2FPT0WU
NCI-H64 NG\hO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\scYhKSzVyPUCuN|A{OzFizszN MW\TRW5ITVJ?
CP66-MEL NHHmSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnzTWM2OD1yLkOxOFE2KM7:TR?= MW\TRW5ITVJ?
NB69 M3vmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjo[WVrUUN3ME2wMlMzOTh6IN88US=> NGjNPXdUSU6JRWK=
NCI-H2196 NIPY[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\XTWM2OD1yLkOzNFM3KM7:TR?= MW\TRW5ITVJ?
MHH-CALL-2 M1fRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m3VWlEPTB;MD6zN|Q3QCEQvF2= M1HFV3NCVkeHUh?=
HCC2157 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFy0c49KSzVyPUCuN|M6PTRizszN NX6yNZZZW0GQR1XS
LS-1034 M4LaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrJTWM2OD1yLkO2N|g5KM7:TR?= NF;KepRUSU6JRWK=
BOKU MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\UT2NjUUN3ME2wMlM4OTl7IN88US=> MWHTRW5ITVJ?
GDM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i0[GlEPTB;MD6zO|I{PCEQvF2= MnX5V2FPT0WU
TGW Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvMbI1lUUN3ME2wMlM4PDV|IN88US=> MmPGV2FPT0WU
SNU-C1 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwM{iyNVUh|ryP NHvOU5dUSU6JRWK=
LS-513 NE\pVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwM{mwO|Eh|ryP NXvGTWl7W0GQR1XS
NOMO-1 NIjjT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\qZlBKSzVyPUCuN|k6PzFizszN M1nXSHNCVkeHUh?=
MS-1 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XBS2lEPTB;MD60NFE4PyEQvF2= MlrIV2FPT0WU
EKVX NVPBXJpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfVXGNlUUN3ME2wMlQ1PDZzIN88US=> MoHyV2FPT0WU
SK-MEL-2 M2HuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqwR3ZVUUN3ME2wMlQ3PCEQvF2= MkC4V2FPT0WU
HCC1187 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInyc|RKSzVyPUCuOFY4PjhizszN M1Lob3NCVkeHUh?=
HCC2218 M3q4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPMfZMzUUN3ME2wMlQ4OjJ5IN88US=> MUHTRW5ITVJ?
NCI-H187 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvrTWM2OD1yLkS3PFQh|ryP M4ezVnNCVkeHUh?=
DB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnJTWM2OD1yLkWwNFU2KM7:TR?= NYjjTpFnW0GQR1XS
NCI-H69 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\MOlFVUUN3ME2wMlUxOjR5IN88US=> NV73cpdIW0GQR1XS
NCI-H1694 MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn4dWZKSzVyPUCuOVA3QTdizszN MXnTRW5ITVJ?
CA46 NHXxOYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vyUGlEPTB;MD61NFkyPyEQvF2= M2K2UnNCVkeHUh?=
EHEB MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33YVmlEPTB;MD61NVE6OyEQvF2= NE\CSplUSU6JRWK=
NCCIT MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLwZlVKSzVyPUCuOVQ{OjFizszN MknZV2FPT0WU
NCI-H720 M1K0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jabGlEPTB;MD61OFk3OiEQvF2= MVXTRW5ITVJ?
LU-134-A NWjUN|JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq1Xo1sUUN3ME2wMlU2Ojl4IN88US=> NI\jcZlUSU6JRWK=
MC-CAR NH;BXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjDTWM2OD1yLkW1OFMyKM7:TR?= MkS5V2FPT0WU
NEC8 M3PqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml21TWM2OD1yLkW2NVczKM7:TR?= MVXTRW5ITVJ?
NCI-H524 NGDZZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoezTWM2OD1yLkW4O|Q5KM7:TR?= MXPTRW5ITVJ?
NCI-H1963 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwNkK1PEDPxE1? MonMV2FPT0WU
SU-DHL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGSGlEPTB;MD62OFUzPiEQvF2= M4DObHNCVkeHUh?=
NCI-H1522 NFLqTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwNkS4PFMh|ryP Mm\PV2FPT0WU
NCI-H1155 NI\R[m9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqy[IRKSzVyPUCuOlU{PSEQvF2= MUXTRW5ITVJ?
D-263MG NXHDcJhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwNk[xNFEh|ryP MWfTRW5ITVJ?
TE-6 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PtcmlEPTB;MD62PFExPCEQvF2= Ml;4V2FPT0WU
NCI-H1417 M3j1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LDe2lEPTB;MD62PVcyOSEQvF2= M3;BfnNCVkeHUh?=
NCI-H510A M4HLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwN{eyN|Yh|ryP NVrEXFZ7W0GQR1XS
KARPAS-45 NI\FV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;NTWM2OD1yLke4NlM2KM7:TR?= NYHsZ5VbW0GQR1XS
IST-SL1 M{jJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXYWVlKSzVyPUCuPFU5OjVizszN MX\TRW5ITVJ?
COLO-824 MmLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjJSIY5UUN3ME2wMlg4QDN3IN88US=> NFTyRlZUSU6JRWK=
NCI-H526 M3fRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnFdVBGUUN3ME2wMlkxQTV6IN88US=> NFHWdphUSU6JRWK=
NCI-H719 NHftZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjXTWM2OD1yLkm2OlU4KM7:TR?= MonCV2FPT0WU
SF539 MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\Gfol4UUN3ME2wMlk5Ozl4IN88US=> NHPpd2JUSU6JRWK=
NKM-1 M2S3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XHU2lEPTB;MD65PFY3OyEQvF2= Mni3V2FPT0WU
A253 M3nhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnKOW5SUUN3ME2wMlk5QDh3IN88US=> NWOyeI4yW0GQR1XS
TE-441-T M2DrPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwMESzOUDPxE1? MkHvV2FPT0WU
COR-L88 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\OSIxjUUN3ME2xMlEyOzV2IN88US=> MV3TRW5ITVJ?
CPC-N M2e0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nXb2lEPTB;MT6xOVg5QCEQvF2= MoHCV2FPT0WU
NCI-H2107 NH\wXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nhRmlEPTB;MT6xO|I3OSEQvF2= NWHxXoszW0GQR1XS
ECC4 M{Tubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHFXGg4UUN3ME2xMlE5Pjl|IN88US=> NGLFeHpUSU6JRWK=
NCI-H2141 NFjGU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlUphWUUN3ME2xMlE6Ojl7IN88US=> M{f5c3NCVkeHUh?=
NCI-H1770 M3zhSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDyTWM2OD1zLkOyPVI5KM7:TR?= NUjQ[VFTW0GQR1XS
NCI-SNU-1 M2HScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwM{OwOEDPxE1? NX7vRYQ6W0GQR1XS
LU-165 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfrTWM2OD1zLkS1OFY4KM7:TR?= NEn3NHhUSU6JRWK=
Raji MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELuZXVKSzVyPUGuOFczPTlizszN NIr3N3FUSU6JRWK=
EW-24 MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfRVIpKSzVyPUGuOVQ3OTlizszN MkLwV2FPT0WU
KP-N-RT-BM-1 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T1NWlEPTB;MT61OlU2OSEQvF2= M3uwOXNCVkeHUh?=
SK-MEL-1 NUnmXoNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwNkS4O|ch|ryP Ml\rV2FPT0WU
SCLC-21H NVToRVNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrDWVBKSzVyPUGuOlY3PTFizszN Mn72V2FPT0WU
SIMA MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H1T2lEPTB;MT62PFI{OyEQvF2= NXjjd2pEW0GQR1XS
NCI-H1304 NF\Rc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXYNHhTUUN3ME2xMlcxPzZ3IN88US=> M4flRXNCVkeHUh?=
REH NFvSWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnsfopYUUN3ME2xMlcyODd6IN88US=> NVvRRop3W0GQR1XS
KP-N-YS MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDVR2hKSzVyPUGuPVM2PTFizszN MWPTRW5ITVJ?
DMS-153 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnFTWM2OD1zLkm3OVkh|ryP NEfwSZhUSU6JRWK=
NB10 NFLp[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrBeYlnUUN3ME2yMlIxQDd6IN88US=> NVzlTmJ5W0GQR1XS
NCI-H345 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O5dWlEPTB;Mj62NVkxPSEQvF2= NYLTZYYyW0GQR1XS
SK-N-FI NYWweGQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwN{WzPFEh|ryP NFu5UYRUSU6JRWK=
NCI-H1092 NW[0N3RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\qZ2lEPTB;Mj65OVM6PCEQvF2= MWXTRW5ITVJ?
KM-H2 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f0emlEPTB;Mz62OVM6PiEQvF2= NFroSo9USU6JRWK=
KG-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rXVmlEPTB;Mz63NVY5QCEQvF2= NWqy[VhEW0GQR1XS
D-283MED NHXr[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\0TWM2OD1|Lke1PFch|ryP M2L3bnNCVkeHUh?=
LU-65 MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vQeWlEPTB;ND6xNVQ5PSEQvF2= MUnTRW5ITVJ?
MSTO-211H NWPUd|QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PVW2lEPTB;ND6xPFg6QCEQvF2= NIO2SZhUSU6JRWK=
NCI-H2081 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO0endKSzVyPUSuNlkyPzRizszN NWO3dJRRW0GQR1XS
D-247MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[xS4hKSzVyPUSuOFMyQTFizszN NYTGPYNtW0GQR1XS
P31-FUJ MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\MdYdKSzVyPUSuOFUxOTlizszN NIWy[4pUSU6JRWK=
DMS-79 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLwOVNKSzVyPUSuPVMyQDNizszN MU\TRW5ITVJ?
KASUMI-1 NHHsXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jvbmlEPTB;ND65O|UxQSEQvF2= MmDBV2FPT0WU
JVM-3 MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\nZVl4UUN3ME21MlI2ODF2IN88US=> Mki5V2FPT0WU
LAN-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTVwNUG3N|Yh|ryP NF\rNnlUSU6JRWK=
DJM-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\Vd4RKSzVyPUWuOVYxOjlizszN MmezV2FPT0WU
JVM-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjtfYJ{UUN3ME21MlY4ODl{IN88US=> NXnzTYxOW0GQR1XS
U-87-MG NFrRd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36wSWlEPTB;NT64PVk3PCEQvF2= MXPTRW5ITVJ?
SHP-77 NGjUOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2K2eGlEPTB;NT65OFkzQCEQvF2= NGDpdHFUSU6JRWK=
RPMI-8866 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrZbJZKSzVyPU[uNlcxOTNizszN MWTTRW5ITVJ?
ES7 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHGeodiUUN3ME22MlM6QTJ2IN88US=> MYjTRW5ITVJ?
WSU-NHL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvrS2U5UUN3ME22MlUyPjB7IN88US=> MXnTRW5ITVJ?
CAS-1 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\3XXFKSzVyPUeuNFk4PDlizszN M{W5RXNCVkeHUh?=
MHH-NB-11 NETacGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPnUllRUUN3ME24MlI{OTV{IN88US=> MoPxV2FPT0WU
ES5 NXjKeXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPvdYNKSzVyPUmuOVIzQDZizszN MVvTRW5ITVJ?
HDLM-2 NH;XZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r1[WlEPTB;OT65OVkxOiEQvF2= M2W3[XNCVkeHUh?=
NCI-H2171 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonqTWM2OD1zMD61PVI4KM7:TR?= MoLxV2FPT0WU
LNCaP-Clone-FGC M13Fc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nTU2lEPTB;MUGuN|cyQCEQvF2= NV[4WplxW0GQR1XS
NCI-H1395 M1XTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PnSWlEPTB;MUKuNlY6QSEQvF2= NUnJ[pVsW0GQR1XS
NCI-H1436 NWLWb|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXmTWM2OD1zMz6zNVk2KM7:TR?= Mne4V2FPT0WU
RCC10RGB M1;3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C5N2lEPTB;MUOuN|IzOSEQvF2= MWnTRW5ITVJ?
SW684 M13ZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7xTWM2OD1zMz65O|k4KM7:TR?= M2nXbXNCVkeHUh?=
NCI-H1650 M13kWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF3LkC0OFch|ryP M1frfnNCVkeHUh?=
EW-13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPsN4pKSzVyPUG1MlIxOjFizszN MXnTRW5ITVJ?
EC-GI-10 M1e3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDnUmdyUUN3ME2xOU45PjR2IN88US=> M4\hdXNCVkeHUh?=
CHP-126 NVztW4hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[3flN4UUN3ME2xO{4yQTF6IN88US=> M1nuWnNCVkeHUh?=
NCI-H226 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fBV2lEPTB;MUiuNFQxOyEQvF2= MX\TRW5ITVJ?
NCI-H1838 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXtTWM2OD1{MD6xPFQ5KM7:TR?= NWfzVYJPW0GQR1XS
EW-11 NVXmT45KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HpN2lEPTB;MkSuNlcyQCEQvF2= NIHJb41USU6JRWK=
EB2 NXvYWGI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTNzLkWzNVgh|ryP NHTZRXJUSU6JRWK=
D-502MG MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETFbo5KSzVyPUSzMlkzOjlizszN MoTFV2FPT0WU
U-698-M Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4r3N2lEPTB;NEiuPFY4OSEQvF2= M4e4T3NCVkeHUh?=
ES3 NXXPTJZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDvT3NtUUN3ME20PU4{QDl|IN88US=> NX7yVIU3W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Related mTOR Products

Tags: buy Torin 1 | Torin 1 supplier | purchase Torin 1 | Torin 1 cost | Torin 1 manufacturer | order Torin 1 | Torin 1 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID