Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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4 Customer Reviews

  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uxTmlEPTB;MD6wNFA{ODZizszN Mn;mV2FPT0WU
OCUB-M MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HpXGlEPTB;MD6wNFE6PCEQvF2= NEHabFlUSU6JRWK=
DOHH-2 M2Pn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT5TWM2OD1yLkCwNlI2KM7:TR?= MUXTRW5ITVJ?
NOS-1 M4DmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfIe5FKSzVyPUCuNFAzPDJizszN NIraeYxUSU6JRWK=
L-363 NWKwUolLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H3c2lEPTB;MD6wNFI5PCEQvF2= NF70fXVUSU6JRWK=
RL95-2 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7CTWM2OD1yLkCwN|Ih|ryP NVH2Umg2W0GQR1XS
BL-70 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3jTWM2OD1yLkCwN|M4KM7:TR?= MnjzV2FPT0WU
TGBC1TKB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fzcGlEPTB;MD6wNFM4QSEQvF2= NHvYO|RUSU6JRWK=
697 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTJTWM2OD1yLkCwOlM1KM7:TR?= M2rsZXNCVkeHUh?=
RPMI-8226 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf6co5{UUN3ME2wMlAxPjVzIN88US=> NX3mUpVUW0GQR1XS
BL-41 Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7uTWM2OD1yLkCwOlk3KM7:TR?= MUDTRW5ITVJ?
MRK-nu-1 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMEC3NFch|ryP MU\TRW5ITVJ?
EW-1 NFvlcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\oRm9bUUN3ME2wMlAxPzR7IN88US=> MlT0V2FPT0WU
EVSA-T NEnLb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnaTWM2OD1yLkCwPFkzKM7:TR?= MmTmV2FPT0WU
HUTU-80 NX72Vo04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjYb|NmUUN3ME2wMlAxQTJ7IN88US=> NVrs[o96W0GQR1XS
VA-ES-BJ NFLhcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XQS2lEPTB;MD6wNFk5PCEQvF2= MWnTRW5ITVJ?
GCIY M{\IeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHKcFZMUUN3ME2wMlAyODB5IN88US=> M4XrOnNCVkeHUh?=
ES6 M2m3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr3Zmx[UUN3ME2wMlAyODh|IN88US=> NYHyZ2EyW0GQR1XS
NALM-6 M{XIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDqW|ZrUUN3ME2wMlAyOTB{IN88US=> NU[xcHd[W0GQR1XS
LB996-RCC NVn1UmtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXJNIwxUUN3ME2wMlAyOTN5IN88US=> MXTTRW5ITVJ?
EW-16 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfq[|ZKSzVyPUCuNFEyQTJizszN NX\kPXBmW0GQR1XS
KALS-1 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP5fWNxUUN3ME2wMlAyOTl6IN88US=> Mni5V2FPT0WU
OPM-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGyPUDPxE1? MoS0V2FPT0WU
KU812 NYTKW21ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PyXmlEPTB;MD6wNVI6PiEQvF2= MVLTRW5ITVJ?
A4-Fuk Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEGzNVkh|ryP MlG4V2FPT0WU
KGN MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL0dGZKSzVyPUCuNFE{PTlizszN NI\VSHVUSU6JRWK=
KS-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\FZlBKSzVyPUCuNFE{QTJizszN NXrTO2h7W0GQR1XS
no-11 NUDp[mtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHTOYRKSzVyPUCuNFE{QTVizszN MXvTRW5ITVJ?
PSN1 NEDnUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnDTWM2OD1yLkCxOFA6KM7:TR?= NFfJWJZUSU6JRWK=
SK-LMS-1 NHLneoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEG0NVMh|ryP MXzTRW5ITVJ?
LS-411N NF7ofo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjldoxKSzVyPUCuNFE1OzlizszN NV\JTlhwW0GQR1XS
HT-144 Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPifG9NUUN3ME2wMlAyPDVzIN88US=> NIXPdJdUSU6JRWK=
ACN NFPwZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHhbIJ5UUN3ME2wMlAyPSEQvF2= NYTGZWtuW0GQR1XS
RKO MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfmVFh[UUN3ME2wMlAyPTN|IN88US=> MX;TRW5ITVJ?
CMK MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rP[GlEPTB;MD6wNVU1OyEQvF2= MYfTRW5ITVJ?
GB-1 M1vkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPDe4p2UUN3ME2wMlAyPTV|IN88US=> NW\ZVW4yW0GQR1XS
KE-37 NHfHTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\xOWlEPTB;MD6wNVU4OyEQvF2= MkTnV2FPT0WU
no-10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLMTWM2OD1yLkCxOVg1KM7:TR?= MlXXV2FPT0WU
MOLT-16 NWDLPYw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\DTWM2OD1yLkCxOlIzKM7:TR?= M1;HenNCVkeHUh?=
HEL NIK5Z4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHFeXUxUUN3ME2wMlAyPjRizszN M4TRenNCVkeHUh?=
NCI-H1355 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nLPWlEPTB;MD6wNVY1PiEQvF2= NIfz[FlUSU6JRWK=
IST-MEL1 M3LBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEG3O|Qh|ryP M161PHNCVkeHUh?=
MHH-PREB-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G3TWlEPTB;MD6wNVgyQCEQvF2= MoHoV2FPT0WU
ES8 MmW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEewRY1KSzVyPUCuNFE5PDRizszN MYPTRW5ITVJ?
LC-2-ad MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jIU2lEPTB;MD6wNlE{PyEQvF2= M1L1T3NCVkeHUh?=
LAMA-84 MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u3XGlEPTB;MD6wNlE3PyEQvF2= M1THV3NCVkeHUh?=
BV-173 Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEKyNFMh|ryP MV;TRW5ITVJ?
SW872 NVPvemdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjTTWM2OD1yLkCyNlQ4KM7:TR?= MlHpV2FPT0WU
SK-UT-1 NVnJcnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfuUY16UUN3ME2wMlAzOjZzIN88US=> NXPRWm1{W0GQR1XS
OS-RC-2 NIjoW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEKzNlMh|ryP MmDLV2FPT0WU
NCI-H747 NV\mTWFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvFbYZ[UUN3ME2wMlAzOzNizszN NGi3NWRUSU6JRWK=
MZ2-MEL M{fjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTtWI54UUN3ME2wMlAzOzN5IN88US=> MnHmV2FPT0WU
TE-11 NWjhZZBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofPTWM2OD1yLkCyN|czKM7:TR?= MoHRV2FPT0WU
KURAMOCHI Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzkWWVKSzVyPUCuNFI1OTRizszN NUHEVllRW0GQR1XS
HD-MY-Z NG\aVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonoTWM2OD1yLkCyOFI3KM7:TR?= M4nFenNCVkeHUh?=
GI-1 NHeyOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkezTWM2OD1yLkCyOFY6KM7:TR?= M3LqcnNCVkeHUh?=
LB1047-RCC MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEK0PFgh|ryP MXXTRW5ITVJ?
TE-12 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjDb|BKSzVyPUCuNFI2PSEQvF2= M4S5UnNCVkeHUh?=
MZ7-mel NXPWe|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEK2NFkh|ryP MlPpV2FPT0WU
MMAC-SF M1S0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPvTWM2OD1yLkCyOlM{KM7:TR?= MlX2V2FPT0WU
A101D MnvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW0TWM2OD1yLkCyOlUh|ryP NX;2NHhnW0GQR1XS
GR-ST NIfmcYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDwNodKSzVyPUCuNFI3PTVizszN NUTZelh4W0GQR1XS
MC116 NWPmZ2dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSwWHdnUUN3ME2wMlAzPjhizszN MoDhV2FPT0WU
Ramos-2G6-4C10 M1:zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXFblVKSzVyPUCuNFI4PSEQvF2= M1jGZnNCVkeHUh?=
ATN-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEK3PFkh|ryP M4\KUHNCVkeHUh?=
MFH-ino NGDsTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LIfGlEPTB;MD6wNlgyOiEQvF2= NXTKTGpKW0GQR1XS
DEL NWH6PZRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNdHNSUUN3ME2wMlAzQDF3IN88US=> M1nFZ3NCVkeHUh?=
OCI-AML2 NFTyZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEK4O|Eh|ryP NGjWXoxUSU6JRWK=
LXF-289 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL0TFhKSzVyPUCuNFI5PzJizszN MoLPV2FPT0WU
IA-LM M4rXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZd4xvUUN3ME2wMlAzQTF5IN88US=> MmfXV2FPT0WU
EoL-1-cell MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHGXnpwUUN3ME2wMlAzQTl4IN88US=> M2PGfHNCVkeHUh?=
OVCAR-4 M2jicWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\JTWM2OD1yLkCzNFk1KM7:TR?= MUPTRW5ITVJ?
ES1 NHHydodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu3OXRKSzVyPUCuNFMxQTdizszN NWj3d4VqW0GQR1XS
CESS NH;Sd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEOwPVkh|ryP MkPJV2FPT0WU
GAK M4rDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEOxPFYh|ryP NX7mR255W0GQR1XS
NTERA-S-cl-D1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M176OGlEPTB;MD6wN|IzPiEQvF2= MVnTRW5ITVJ?
TE-10 M3fudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnQTWM2OD1yLkCzN|EyKM7:TR?= M{S3fXNCVkeHUh?=
CCRF-CEM MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XpdmlEPTB;MD6wN|M4OSEQvF2= NYD5cJQ6W0GQR1XS
NMC-G1 NXjIUnQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[yTWM2OD1yLkCzOFQ5KM7:TR?= NVzibopTW0GQR1XS
HOP-62 NE\aUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fhPWlEPTB;MD6wN|U2PiEQvF2= M1vyeHNCVkeHUh?=
SH-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjVb41rUUN3ME2wMlA{PTh{IN88US=> M{faSnNCVkeHUh?=
NCI-H1648 NWH0RWhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:5TWM2OD1yLkCzOlIzKM7:TR?= NHe3[3BUSU6JRWK=
EB-3 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEO2OFMh|ryP MX\TRW5ITVJ?
BB65-RCC MnzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[yOWlEPTB;MD6wN|Y6OSEQvF2= M1H0bnNCVkeHUh?=
BE-13 M1PnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEO3OVkh|ryP MVPTRW5ITVJ?
CP67-MEL NXrK[olPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fBeWlEPTB;MD6wN|c2QSEQvF2= MkfYV2FPT0WU
SW954 M2rvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEO3PUDPxE1? M{fWO3NCVkeHUh?=
TE-5 M4PCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPicnlKSzVyPUCuNFM5PTRizszN NEfBNI1USU6JRWK=
HCE-4 NHzlW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3sTWM2OD1yLkCzPFU2KM7:TR?= NHnmS5JUSU6JRWK=
LC-1F M1nVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfwUVJKSzVyPUCuNFM6QDlizszN NVPscGhbW0GQR1XS
TK10 Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rBTmlEPTB;MD6wOFAyQSEQvF2= NUT4UYVCW0GQR1XS
SJSA-1 NIjxdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorsTWM2OD1yLkC0NVg5KM7:TR?= NYqzbohDW0GQR1XS
Daudi M{TmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMESyNlUh|ryP MWPTRW5ITVJ?
SW982 NYjQXGoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr2TWM2OD1yLkC0NlQ3KM7:TR?= NWLuT5ZrW0GQR1XS
SF126 M3LTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMESzOlEh|ryP M36yR3NCVkeHUh?=
TE-15 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm4O2lKSzVyPUCuNFQ1OzVizszN NI\Ldo5USU6JRWK=
COLO-684 M{XZW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL4VYdKSzVyPUCuNFQ2PjFizszN NGTk[VhUSU6JRWK=
8-MG-BA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrFTWM2OD1yLkC0OlI6KM7:TR?= MVXTRW5ITVJ?
NB13 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL1OppKSzVyPUCuNFQ4PzZizszN MUPTRW5ITVJ?
HCC1599 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjQfWJKSzVyPUCuNFQ5PzlizszN NUDUNmpQW0GQR1XS
SK-PN-DW NH;ub|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mzPWlEPTB;MD6wOFk1QSEQvF2= MWjTRW5ITVJ?
ALL-PO MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr3UVVLUUN3ME2wMlA1QTV4IN88US=> M3HlSXNCVkeHUh?=
NB6 NX[3VWc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi4W5BKSzVyPUCuNFUzPzFizszN MlexV2FPT0WU
IST-SL2 NGjIPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTSTWM2OD1yLkC1N|YzKM7:TR?= NYi5eXNxW0GQR1XS
BB30-HNC NYHFUYg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jpemlEPTB;MD6wOVc{KM7:TR?= NH\rXGlUSU6JRWK=
SW962 NW\nT5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEW3OlMh|ryP NUX4[XN2W0GQR1XS
TGBC24TKB M3nRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnZTpdiUUN3ME2wMlA2Pzl7IN88US=> NYro[lNlW0GQR1XS
KINGS-1 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjOTWM2OD1yLkC1PFA{KM7:TR?= M2TCeXNCVkeHUh?=
HC-1 M4mzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonPTWM2OD1yLkC1PFI4KM7:TR?= MoS2V2FPT0WU
RS4-11 M4TLZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDZTo45UUN3ME2wMlA2QTN6IN88US=> M3;URXNCVkeHUh?=
LS-123 NUK2c3ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLvUm5KSzVyPUCuNFU6PDJizszN MUjTRW5ITVJ?
A3-KAW MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlziTWM2OD1yLkC2NlI2KM7:TR?= NWX0[lh3W0GQR1XS
SNB75 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwME[zOFEh|ryP NFvOSY5USU6JRWK=
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MS-1 NFPZV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP0eZVKSzVyPUCuOFAyPzdizszN MXTTRW5ITVJ?
EKVX MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LLRWlEPTB;MD60OFQ3OSEQvF2= MXrTRW5ITVJ?
SK-MEL-2 M4\OXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK1TWM2OD1yLkS2OEDPxE1? Mk\HV2FPT0WU
HCC1187 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HTPGlEPTB;MD60Olc3QCEQvF2= NXnYdopoW0GQR1XS
HCC2218 M1fIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXENZlKSzVyPUCuOFczOjdizszN MXLTRW5ITVJ?
NCI-H187 NH\EenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHGWI9[UUN3ME2wMlQ4QDRizszN MkP3V2FPT0WU
DB M37NTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHwN4hKSzVyPUCuOVAxPTVizszN M3TLUHNCVkeHUh?=
NCI-H69 NFm5W3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTtTWM2OD1yLkWwNlQ4KM7:TR?= NUXiPJRnW0GQR1XS
NCI-H1694 NFLh[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\EfZZJUUN3ME2wMlUxPjl5IN88US=> MYDTRW5ITVJ?
CA46 NVPaXnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L4OmlEPTB;MD61NFkyPyEQvF2= M3jYU3NCVkeHUh?=
EHEB NYL4fog4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwNUGxPVMh|ryP NUHRWW9uW0GQR1XS
NCCIT M2DLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2foc2lEPTB;MD61OFMzOSEQvF2= MVjTRW5ITVJ?
NCI-H720 M{HSfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPUTWM2OD1yLkW0PVYzKM7:TR?= MmDoV2FPT0WU
LU-134-A NIG0XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwNUWyPVYh|ryP NVLKZ45xW0GQR1XS
MC-CAR M{XYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;YTWM2OD1yLkW1OFMyKM7:TR?= MlvKV2FPT0WU
NEC8 NXrKb4d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLqboQ5UUN3ME2wMlU3OTd{IN88US=> NGX4bpNUSU6JRWK=
NCI-H524 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[2TWM2OD1yLkW4O|Q5KM7:TR?= NUnjSphDW0GQR1XS
NCI-H1963 NETPS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i1bmlEPTB;MD62NlU5KM7:TR?= NVj3[lBzW0GQR1XS
SU-DHL-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvYTWM2OD1yLk[0OVI3KM7:TR?= MkXLV2FPT0WU
NCI-H1522 NXT6VnkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnmS4t1UUN3ME2wMlY1QDh|IN88US=> NYDJflZ5W0GQR1XS
NCI-H1155 NFTsW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\KVGlEPTB;MD62OVM2KM7:TR?= MkD3V2FPT0WU
D-263MG MkjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjkcGNyUUN3ME2wMlY3OTBzIN88US=> MVHTRW5ITVJ?
TE-6 M1zJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zLbmlEPTB;MD62PFExPCEQvF2= M3\S[XNCVkeHUh?=
NCI-H1417 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP5TWM2OD1yLk[5O|EyKM7:TR?= NVvEeo1rW0GQR1XS
NCI-H510A NUHuS5ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mydGlEPTB;MD63O|I{PiEQvF2= NUPhfW5LW0GQR1XS
KARPAS-45 NXrPXZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwN{iyN|Uh|ryP MWrTRW5ITVJ?
IST-SL1 M1;4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:zdINKSzVyPUCuPFU5OjVizszN MlfIV2FPT0WU
COLO-824 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwOEe4N|Uh|ryP MoDFV2FPT0WU
NCI-H526 NGrFe4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjDbXEyUUN3ME2wMlkxQTV6IN88US=> NWnlXXgzW0GQR1XS
NCI-H719 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zhc2lEPTB;MD65OlY2PyEQvF2= NX\6d3pEW0GQR1XS
SF539 M4njSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwOUizPVYh|ryP M3XSfXNCVkeHUh?=
NKM-1 NYXVUnE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTxSJF1UUN3ME2wMlk5PjZ|IN88US=> Mof2V2FPT0WU
A253 NIP3U|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwOUi4PFUh|ryP NEPBO5pUSU6JRWK=
TE-441-T NH23[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPETWM2OD1zLkC0N|Uh|ryP MlH1V2FPT0WU
COR-L88 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvmTWM2OD1zLkGxN|U1KM7:TR?= M2XQUHNCVkeHUh?=
CPC-N M2LkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL0OFdEUUN3ME2xMlE2QDh6IN88US=> NH32cXFUSU6JRWK=
NCI-H2107 NIDGb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwMUeyOlEh|ryP NH73ZopUSU6JRWK=
ECC4 NH3RT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL0R2NKSzVyPUGuNVg3QTNizszN MmPDV2FPT0WU
NCI-H2141 NF;vS|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LZdWlEPTB;MT6xPVI6QSEQvF2= NVvGSZVsW0GQR1XS
NCI-H1770 NEi4d29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPUNoVKSzVyPUGuN|I6OjhizszN M3LEZ3NCVkeHUh?=
NCI-SNU-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwM{OwOEDPxE1? NGqzdoxUSU6JRWK=
LU-165 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnUO4pKSzVyPUGuOFU1PjdizszN NXH1fIxLW0GQR1XS
Raji NV\KU44{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH6bpVZUUN3ME2xMlQ4OjV7IN88US=> M4qxcXNCVkeHUh?=
EW-24 M4DNW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfjdmxIUUN3ME2xMlU1PjF7IN88US=> Mn\2V2FPT0WU
KP-N-RT-BM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfDfINlUUN3ME2xMlU3PTVzIN88US=> MYTTRW5ITVJ?
SK-MEL-1 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;ZTWM2OD1zLk[0PFc4KM7:TR?= NYD0WVhGW0GQR1XS
SCLC-21H M3u4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFwNk[2OVEh|ryP MlLjV2FPT0WU
SIMA NWjDfmYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzqTWM2OD1zLk[4NlM{KM7:TR?= NVz0UWtvW0GQR1XS
NCI-H1304 NU\CXFllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqxWoNKSzVyPUGuO|A4PjVizszN NF[0bpNUSU6JRWK=
REH MkPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCxOI5KSzVyPUGuO|ExPzhizszN M3jIdnNCVkeHUh?=
KP-N-YS M{TCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHsW2pKSzVyPUGuPVM2PTFizszN M4jJPHNCVkeHUh?=
DMS-153 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLEVW9SUUN3ME2xMlk4PTlizszN NXv3XWJWW0GQR1XS
NB10 NX3GT2Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7vdVVKSzVyPUKuNlA5PzhizszN MnrTV2FPT0WU
NCI-H345 NFPZd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTJwNkG5NFUh|ryP MlfpV2FPT0WU
SK-N-FI MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfpTWM2OD1{Lke1N|gyKM7:TR?= NIPKc|RUSU6JRWK=
NCI-H1092 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjsRZVFUUN3ME2yMlk2Ozl2IN88US=> NUX2THg2W0GQR1XS
KM-H2 M2Llfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu4TWM2OD1|Lk[1N|k3KM7:TR?= NHPTbWtUSU6JRWK=
KG-1 NETiTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS5flJZUUN3ME2zMlcyPjh6IN88US=> M1rSWXNCVkeHUh?=
D-283MED NWPyTI1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPPTWM2OD1|Lke1PFch|ryP NGrtVo1USU6JRWK=
LU-65 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rCSmlEPTB;ND6xNVQ5PSEQvF2= NE\YcYhUSU6JRWK=
MSTO-211H Mlv1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTRwMUi4PVgh|ryP NED6NXpUSU6JRWK=
NCI-H2081 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fiRWlEPTB;ND6yPVE4PCEQvF2= NEPtUXlUSU6JRWK=
D-247MG M2DzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M364OWlEPTB;ND60N|E6OSEQvF2= M1XE[3NCVkeHUh?=
P31-FUJ M3LsdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XqU2lEPTB;ND60OVAyQSEQvF2= Mme3V2FPT0WU
DMS-79 M{C4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTRwOUOxPFMh|ryP MnvqV2FPT0WU
KASUMI-1 NGDkRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWryPJpMUUN3ME20Mlk4PTB7IN88US=> M4[3T3NCVkeHUh?=
JVM-3 NEjRRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jRUGlEPTB;NT6yOVAyPCEQvF2= MVnTRW5ITVJ?
LAN-6 M3\XUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTVwNUG3N|Yh|ryP MVPTRW5ITVJ?
DJM-1 NEPxUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVwNU[wNlkh|ryP M2TlR3NCVkeHUh?=
JVM-2 NUfoWXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X2bWlEPTB;NT62O|A6OiEQvF2= NVPtSmJWW0GQR1XS
U-87-MG NFvUfXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j0UmlEPTB;NT64PVk3PCEQvF2= MknRV2FPT0WU
SHP-77 NX3uZ3E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTVwOUS5Nlgh|ryP MVXTRW5ITVJ?
RPMI-8866 NGm0[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[3TWM2OD14LkK3NFE{KM7:TR?= MXnTRW5ITVJ?
ES7 NX34V296T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHPXm9mUUN3ME22MlM6QTJ2IN88US=> NV7jO5hHW0GQR1XS
WSU-NHL NYjvTVR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r2UGlEPTB;Nj61NVYxQSEQvF2= MkXsV2FPT0WU
CAS-1 NYTT[mpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P6eWlEPTB;Nz6wPVc1QSEQvF2= M33vOnNCVkeHUh?=
MHH-NB-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRThwMkOxOVIh|ryP NVvIfnBzW0GQR1XS
ES5 NFruOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDI[ZY3UUN3ME25MlUzOjh4IN88US=> MV7TRW5ITVJ?
HDLM-2 M4XKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfkTWM2OD17Lkm1PVAzKM7:TR?= MXLTRW5ITVJ?
NCI-H2171 NV7NcFEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M376N2lEPTB;MUCuOVkzPyEQvF2= NF7MOGhUSU6JRWK=
LNCaP-Clone-FGC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;zUWhKSzVyPUGxMlM4OThizszN M13zbnNCVkeHUh?=
NCI-H1395 M2T3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPvTWM2OD1zMj6yOlk6KM7:TR?= M{jCPHNCVkeHUh?=
NCI-H1436 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULkTllGUUN3ME2xN{4{OTl3IN88US=> M1HrXnNCVkeHUh?=
RCC10RGB MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDJTWM2OD1zMz6zNlIyKM7:TR?= MlGwV2FPT0WU
SW684 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF|Lkm3PVch|ryP M1HtW3NCVkeHUh?=
NCI-H1650 Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF3LkC0OFch|ryP M1HSTXNCVkeHUh?=
EW-13 MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjiZlc3UUN3ME2xOU4zODJzIN88US=> MnXDV2FPT0WU
EC-GI-10 NHzsUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF3Lki2OFQh|ryP MofNV2FPT0WU
CHP-126 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K3WWlEPTB;MUeuNVkyQCEQvF2= M3jlbXNCVkeHUh?=
NCI-H226 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\IUVQ5UUN3ME2xPE4xPDB|IN88US=> M1TE[XNCVkeHUh?=
NCI-H1838 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTyVYxKSzVyPUKwMlE5PDhizszN MYDTRW5ITVJ?
EW-11 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7KTWM2OD1{ND6yO|E5KM7:TR?= Mn[3V2FPT0WU
EB2 Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fQdmlEPTB;M{GuOVMyQCEQvF2= M2j2THNCVkeHUh?=
D-502MG M{fRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XObWlEPTB;NEOuPVIzQSEQvF2= MVXTRW5ITVJ?
U-698-M Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;MWW9KSzVyPUS4Mlg3PzFizszN M4XGXXNCVkeHUh?=
ES3 NF[5ZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTR7LkO4PVMh|ryP MUHTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

mTOR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID