Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

    Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

  • Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

    Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M4\CN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS3SHB2UUN3ME2wMlAxODNyNjFOwG0> MlGzV2FPT0WU
OCUB-M NFHUTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXvTWM2OD1yLkCwNVk1KM7:TR?= NHjwN3BUSU6JRWK=
DOHH-2 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInQe2FKSzVyPUCuNFAzOjVizszN NHvLWHJUSU6JRWK=
NOS-1 NY\JOWlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\Te454UUN3ME2wMlAxOjR{IN88US=> MlTDV2FPT0WU
L-363 NILKS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\JS2lEPTB;MD6wNFI5PCEQvF2= MXjTRW5ITVJ?
RL95-2 NYTnZ25ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHhZlZvUUN3ME2wMlAxOzJizszN NWjiXHJuW0GQR1XS
BL-70 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\3fWlEPTB;MD6wNFM{PyEQvF2= MmnxV2FPT0WU
TGBC1TKB MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMECzO|kh|ryP NHfkOYVUSU6JRWK=
697 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nhVGlEPTB;MD6wNFY{PCEQvF2= NIi0UZJUSU6JRWK=
RPMI-8226 NHvYOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G4ZmlEPTB;MD6wNFY2OSEQvF2= MoTmV2FPT0WU
BL-41 NEC2UW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvRdnpKSzVyPUCuNFA3QTZizszN NV\uW3VDW0GQR1XS
MRK-nu-1 NEDDXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf4eHFKSzVyPUCuNFA4ODdizszN MVrTRW5ITVJ?
EW-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n2WWlEPTB;MD6wNFc1QSEQvF2= MYLTRW5ITVJ?
EVSA-T NUDsbVRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H6VGlEPTB;MD6wNFg6OiEQvF2= NUCxWYVjW0GQR1XS
HUTU-80 NUfmOoVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7aTm14UUN3ME2wMlAxQTJ7IN88US=> NXnPdnZbW0GQR1XS
VA-ES-BJ MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTkTWM2OD1yLkCwPVg1KM7:TR?= M37MSnNCVkeHUh?=
GCIY M3r4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLETWM2OD1yLkCxNFA4KM7:TR?= Mke2V2FPT0WU
ES6 M33VTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSxSGF2UUN3ME2wMlAyODh|IN88US=> Mnz3V2FPT0WU
NALM-6 MlHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\qTGlEPTB;MD6wNVExOiEQvF2= M3fnTHNCVkeHUh?=
LB996-RCC NWnaVoFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf0TIZKSzVyPUCuNFEyOzdizszN NHvhXG9USU6JRWK=
EW-16 M17ldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13NOmlEPTB;MD6wNVE6OiEQvF2= NITZ[4ZUSU6JRWK=
KALS-1 M2THWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFricWlKSzVyPUCuNFEyQThizszN NFS4NlBUSU6JRWK=
OPM-2 NXzadnF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX3TWM2OD1yLkCxNlkh|ryP MUnTRW5ITVJ?
KU812 NWXJeVhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNXFBQUUN3ME2wMlAyOjl4IN88US=> NE\ZSndUSU6JRWK=
A4-Fuk NHvXb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHX[XppUUN3ME2wMlAyOzF7IN88US=> MWPTRW5ITVJ?
KGN M1qyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPTT3hKSzVyPUCuNFE{PTlizszN MVzTRW5ITVJ?
KS-1 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEGzPVIh|ryP NXfZdmc6W0GQR1XS
no-11 M1Lq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnSbIhSUUN3ME2wMlAyOzl3IN88US=> M4LCT3NCVkeHUh?=
PSN1 NHXsTmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHtdotKSzVyPUCuNFE1ODlizszN NFnGOHFUSU6JRWK=
SK-LMS-1 NWjRRm9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13QeWlEPTB;MD6wNVQyOyEQvF2= MlfMV2FPT0WU
LS-411N NVHUW|lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMEG0N|kh|ryP NV:0[Fh1W0GQR1XS
HT-144 NH3KPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ToUGlEPTB;MD6wNVQ2OSEQvF2= Mn3wV2FPT0WU
ACN NVLTd4xET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzDTWM2OD1yLkCxOUDPxE1? NHXOclNUSU6JRWK=
RKO MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH3TWM2OD1yLkCxOVM{KM7:TR?= NVjDPGtYW0GQR1XS
CMK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LUd2lEPTB;MD6wNVU1OyEQvF2= M4L5W3NCVkeHUh?=
GB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMEG1OVMh|ryP NYjyWHA1W0GQR1XS
KE-37 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHBNVBHUUN3ME2wMlAyPTd|IN88US=> MnzZV2FPT0WU
no-10 NF7WcHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4N4s4UUN3ME2wMlAyPTh2IN88US=> MoPuV2FPT0WU
MOLT-16 NYjwdmltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvvTWM2OD1yLkCxOlIzKM7:TR?= NXHpNHA5W0GQR1XS
HEL NIC5TVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjveJBXUUN3ME2wMlAyPjRizszN MULTRW5ITVJ?
NCI-H1355 NET2Nm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHDTWM2OD1yLkCxOlQ3KM7:TR?= NHXZU4NUSU6JRWK=
IST-MEL1 NFXSR4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3kTWM2OD1yLkCxO|c1KM7:TR?= MoTyV2FPT0WU
MHH-PREB-1 M3P0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGixeVRKSzVyPUCuNFE5OThizszN MnXKV2FPT0WU
ES8 NGDpbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEG4OFQh|ryP MW\TRW5ITVJ?
LC-2-ad MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEKxN|ch|ryP MV3TRW5ITVJ?
LAMA-84 M3\rXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3juXGlEPTB;MD6wNlE3PyEQvF2= NX32VlVkW0GQR1XS
BV-173 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3v[FZKSzVyPUCuNFIzODNizszN MYPTRW5ITVJ?
SW872 NHvienBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2xO2ZKSzVyPUCuNFIzPDdizszN Mli4V2FPT0WU
SK-UT-1 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;mSmlEPTB;MD6wNlI3OSEQvF2= NG\0SYxUSU6JRWK=
OS-RC-2 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi0PI5OUUN3ME2wMlAzOzJ|IN88US=> MVHTRW5ITVJ?
NCI-H747 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDkOGdKSzVyPUCuNFI{OyEQvF2= M2q5PXNCVkeHUh?=
MZ2-MEL NUjSVmp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULvUGtCUUN3ME2wMlAzOzN5IN88US=> NXHXSlBoW0GQR1XS
TE-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEKzO|Ih|ryP NILmSFRUSU6JRWK=
KURAMOCHI NX3Pc4hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvFZ4tkUUN3ME2wMlAzPDF2IN88US=> NIH2OHVUSU6JRWK=
HD-MY-Z MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHvc|l4UUN3ME2wMlAzPDJ4IN88US=> NXLNTpZ1W0GQR1XS
GI-1 M2fNV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvubIpKSzVyPUCuNFI1PjlizszN NXrBZXRGW0GQR1XS
LB1047-RCC Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTk[mRlUUN3ME2wMlAzPDh6IN88US=> NHThVG5USU6JRWK=
TE-12 NGTiWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj0TWM2OD1yLkCyOVUh|ryP NHvITGZUSU6JRWK=
MZ7-mel MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpNmlEPTB;MD6wNlYxQSEQvF2= M1;JR3NCVkeHUh?=
MMAC-SF NU\UTZNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;rXGlEPTB;MD6wNlY{OyEQvF2= MXvTRW5ITVJ?
A101D M{T3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml33TWM2OD1yLkCyOlUh|ryP NF3P[pVUSU6JRWK=
GR-ST NITxdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTleJNUUUN3ME2wMlAzPjV3IN88US=> MmDGV2FPT0WU
MC116 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33l[WlEPTB;MD6wNlY5KM7:TR?= NXvDOo5QW0GQR1XS
Ramos-2G6-4C10 M3n3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWzN3RKSzVyPUCuNFI4PSEQvF2= MV3TRW5ITVJ?
ATN-1 M37ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTCTWM2OD1yLkCyO|g6KM7:TR?= MULTRW5ITVJ?
MFH-ino MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULvU3FrUUN3ME2wMlAzQDF{IN88US=> NYDqSpVVW0GQR1XS
DEL MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEK4NVUh|ryP NFXnXVNUSU6JRWK=
OCI-AML2 M2rKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInzT|BKSzVyPUCuNFI5PzFizszN M2DieHNCVkeHUh?=
LXF-289 NX\KVpJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD1yLkCyPFczKM7:TR?= NWezdZBLW0GQR1XS
IA-LM NW\zNpJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPhPIltUUN3ME2wMlAzQTF5IN88US=> NU\QbmpSW0GQR1XS
EoL-1-cell M4HtTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPVTlZKSzVyPUCuNFI6QTZizszN NIPXR2dUSU6JRWK=
OVCAR-4 NVLSN4dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEOwPVQh|ryP NFfvfWFUSU6JRWK=
ES1 M{\tcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorDTWM2OD1yLkCzNFk4KM7:TR?= NWHLV|V2W0GQR1XS
CESS M{m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sfWJ4UUN3ME2wMlA{ODl7IN88US=> MXzTRW5ITVJ?
GAK NYDPeIdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEOxPFYh|ryP MmL1V2FPT0WU
NTERA-S-cl-D1 M3;5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK4TWM2OD1yLkCzNlI3KM7:TR?= MoHaV2FPT0WU
TE-10 MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEOzNVEh|ryP M4OweXNCVkeHUh?=
CCRF-CEM M2nWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHCeIFjUUN3ME2wMlA{OzdzIN88US=> NGm2SlhUSU6JRWK=
NMC-G1 M3ztd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO0OFgh|ryP NV3QVWpiW0GQR1XS
HOP-62 Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEO1OVYh|ryP M4XYbnNCVkeHUh?=
SH-4 NUDlTVFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOyN3BKSzVyPUCuNFM2QDJizszN NYX0O4VLW0GQR1XS
NCI-H1648 Mk[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHGTWM2OD1yLkCzOlIzKM7:TR?= NVG0ZXhuW0GQR1XS
EB-3 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXoTWM2OD1yLkCzOlQ{KM7:TR?= MVvTRW5ITVJ?
BB65-RCC M1LCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjwcFN7UUN3ME2wMlA{PjlzIN88US=> Mn3hV2FPT0WU
BE-13 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjsTWM2OD1yLkCzO|U6KM7:TR?= Mm[zV2FPT0WU
CP67-MEL NH3XZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHlUFJKSzVyPUCuNFM4PTlizszN MUnTRW5ITVJ?
SW954 NFPTVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEO3PUDPxE1? M{noV3NCVkeHUh?=
TE-5 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEO4OVQh|ryP Ml\NV2FPT0WU
HCE-4 MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnlcoJKSzVyPUCuNFM5PTVizszN MUfTRW5ITVJ?
LC-1F NFroVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfqTWM2OD1yLkCzPVg6KM7:TR?= M3X6dnNCVkeHUh?=
TK10 NFK0[ZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMESwNVkh|ryP MXzTRW5ITVJ?
SJSA-1 M33PfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKN|RPUUN3ME2wMlA1OTh6IN88US=> NETFRZBUSU6JRWK=
Daudi MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnBXHhQUUN3ME2wMlA1OjJ3IN88US=> MYnTRW5ITVJ?
SW982 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrLVmhKSzVyPUCuNFQzPDZizszN MkfYV2FPT0WU
SF126 M3j2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMESzOlEh|ryP MlPXV2FPT0WU
TE-15 NYnybllOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMES0N|Uh|ryP M2PNNnNCVkeHUh?=
COLO-684 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\KTWM2OD1yLkC0OVYyKM7:TR?= NFXKUZpUSU6JRWK=
8-MG-BA MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrWXFhKSzVyPUCuNFQ3OjlizszN MXnTRW5ITVJ?
NB13 M3zjWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK4c45KSzVyPUCuNFQ4PzZizszN NULPOFQzW0GQR1XS
HCC1599 NXXKUVJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\pTWM2OD1yLkC0PFc6KM7:TR?= MknQV2FPT0WU
SK-PN-DW MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fB[WlEPTB;MD6wOFk1QSEQvF2= M1;KO3NCVkeHUh?=
ALL-PO MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnRTWM2OD1yLkC0PVU3KM7:TR?= MYTTRW5ITVJ?
NB6 NYTLVJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofrTWM2OD1yLkC1NlcyKM7:TR?= MWLTRW5ITVJ?
IST-SL2 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEWzOlIh|ryP MnntV2FPT0WU
BB30-HNC NWPnNoFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEW3N{DPxE1? NXKzbpRuW0GQR1XS
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTuT|BCUUN3ME2wMlA2PzZ|IN88US=> MlTjV2FPT0WU
TGBC24TKB NFTZNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEW3PVkh|ryP NX7vfWx2W0GQR1XS
KINGS-1 NUTONVhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL2TolKSzVyPUCuNFU5ODNizszN NH\NSlVUSU6JRWK=
HC-1 NVnKZ2NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX6SnpKSzVyPUCuNFU5OjdizszN MXnTRW5ITVJ?
RS4-11 NHzKb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTx[W03UUN3ME2wMlA2QTN6IN88US=> MW\TRW5ITVJ?
LS-123 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\seHdKSzVyPUCuNFU6PDJizszN MYPTRW5ITVJ?
A3-KAW MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOyW5RkUUN3ME2wMlA3OjJ3IN88US=> NHfDOVBUSU6JRWK=
SNB75 M{\jXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n6SWlEPTB;MD6wOlM1OSEQvF2= M4HJSnNCVkeHUh?=
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NOMO-1 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwM{m5O|Eh|ryP MlfRV2FPT0WU
MS-1 NIXTNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljUTWM2OD1yLkSwNVc4KM7:TR?= NHjRdW1USU6JRWK=
EKVX MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTVW|JKSzVyPUCuOFQ1PjFizszN NH7uVFRUSU6JRWK=
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HCC1187 NHXEeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\LTWM2OD1yLkS2O|Y5KM7:TR?= M1ztXXNCVkeHUh?=
HCC2218 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrPSpNFUUN3ME2wMlQ4OjJ5IN88US=> NXnWcphkW0GQR1XS
NCI-H187 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\PTWM2OD1yLkS3PFQh|ryP NHnpVGhUSU6JRWK=
DB NULLW|d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mwPGlEPTB;MD61NFA2PSEQvF2= M37pb3NCVkeHUh?=
NCI-H69 M1n1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwNUCyOFch|ryP MXjTRW5ITVJ?
NCI-H1694 NXjadYl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwNUC2PVch|ryP NHy2Wm1USU6JRWK=
CA46 NIO0SnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNUC5NVch|ryP NVPVSYx[W0GQR1XS
EHEB Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XlUmlEPTB;MD61NVE6OyEQvF2= MnHXV2FPT0WU
NCCIT NIj1SW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzqPHNuUUN3ME2wMlU1OzJzIN88US=> Mn;aV2FPT0WU
NCI-H720 NF7qUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n4OWlEPTB;MD61OFk3OiEQvF2= MV7TRW5ITVJ?
LU-134-A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH4TWM2OD1yLkW1Nlk3KM7:TR?= MUfTRW5ITVJ?
MC-CAR MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvZTWM2OD1yLkW1OFMyKM7:TR?= NGnERolUSU6JRWK=
NEC8 NFP4V3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHixblNKSzVyPUCuOVYyPzJizszN MmrCV2FPT0WU
NCI-H524 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXjVHB{UUN3ME2wMlU5PzR6IN88US=> M{DCNXNCVkeHUh?=
NCI-H1963 NIDETGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrJ[IVvUUN3ME2wMlYzPThizszN MlK2V2FPT0WU
SU-DHL-1 M371VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPJPIdQUUN3ME2wMlY1PTJ4IN88US=> NXvGc|NQW0GQR1XS
NCI-H1522 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNkS4PFMh|ryP NYT2UWJvW0GQR1XS
NCI-H1155 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwNkWzOUDPxE1? NGLhSYZUSU6JRWK=
D-263MG M3v5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm4NFBlUUN3ME2wMlY3OTBzIN88US=> NGfDZlJUSU6JRWK=
TE-6 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNkixNFQh|ryP M1PyV3NCVkeHUh?=
NCI-H1417 NX\t[JhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO1TWM2OD1yLk[5O|EyKM7:TR?= NVfZW2E{W0GQR1XS
NCI-H510A M{XEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\udopKSzVyPUCuO|czOzZizszN NH[4e2pUSU6JRWK=
KARPAS-45 M1vmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\jR4dKSzVyPUCuO|gzOzVizszN NHywbGNUSU6JRWK=
IST-SL1 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwOEW4NlUh|ryP MlvoV2FPT0WU
COLO-824 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi0OpNKSzVyPUCuPFc5OzVizszN MmKxV2FPT0WU
NCI-H526 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\JOGlEPTB;MD65NFk2QCEQvF2= M1nmc3NCVkeHUh?=
NCI-H719 M3L2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LjXGlEPTB;MD65OlY2PyEQvF2= Ml7YV2FPT0WU
SF539 M{Owdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkOyTWM2OD1yLkm4N|k3KM7:TR?= M3LRPXNCVkeHUh?=
NKM-1 M3;OSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwOUi2OlMh|ryP M2jC[3NCVkeHUh?=
A253 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTETWM2OD1yLkm4PFg2KM7:TR?= MlHLV2FPT0WU
TE-441-T MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwMESzOUDPxE1? NVfrWmNLW0GQR1XS
COR-L88 M{XMOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTxTWM2OD1zLkGxN|U1KM7:TR?= NWexOVJxW0GQR1XS
CPC-N NEXJRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwMUW4PFgh|ryP MYrTRW5ITVJ?
NCI-H2107 NEDuPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LZUGlEPTB;MT6xO|I3OSEQvF2= Mn7SV2FPT0WU
ECC4 NILXUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3Vm9UUUN3ME2xMlE5Pjl|IN88US=> NGq0XYZUSU6JRWK=
NCI-H2141 NYDoWIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nENWlEPTB;MT6xPVI6QSEQvF2= NFqwclFUSU6JRWK=
NCI-H1770 NWr4SZI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFwM{K5Nlgh|ryP NF;xZWZUSU6JRWK=
NCI-SNU-1 NIPYZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLBe5h4UUN3ME2xMlM{ODRizszN NI\hZnpUSU6JRWK=
LU-165 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwNEW0Olch|ryP M3W0THNCVkeHUh?=
Raji Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHmVYRXUUN3ME2xMlQ4OjV7IN88US=> NWPvNo1wW0GQR1XS
EW-24 M2L1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPFcWZKSzVyPUGuOVQ3OTlizszN NWTRXmdGW0GQR1XS
KP-N-RT-BM-1 NH3XV5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFwNU[1OVEh|ryP NYXHW2hnW0GQR1XS
SK-MEL-1 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jWR2lEPTB;MT62OFg4PyEQvF2= M2LOeXNCVkeHUh?=
SCLC-21H Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnt[HFKSzVyPUGuOlY3PTFizszN MVrTRW5ITVJ?
SIMA NXLDenZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjh[VZKSzVyPUGuOlgzOzNizszN MY\TRW5ITVJ?
NCI-H1304 NG\0dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnEN2tKSzVyPUGuO|A4PjVizszN MXvTRW5ITVJ?
REH MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHwTHNOUUN3ME2xMlcyODd6IN88US=> MlrNV2FPT0WU
KP-N-YS NGjxT4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HHbGlEPTB;MT65N|U2OSEQvF2= MUTTRW5ITVJ?
DMS-153 NF7TVmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;iTWM2OD1zLkm3OVkh|ryP MXzTRW5ITVJ?
NB10 NETyfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LuXGlEPTB;Mj6yNFg4QCEQvF2= M4jIOHNCVkeHUh?=
NCI-H345 M1m0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG2eIduUUN3ME2yMlYyQTB3IN88US=> NX3RWYp7W0GQR1XS
SK-N-FI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHpRVN[UUN3ME2yMlc2OzhzIN88US=> NF\aR5BUSU6JRWK=
NCI-H1092 NXHBSZFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzMTWM2OD1{Lkm1N|k1KM7:TR?= M1fNOnNCVkeHUh?=
KM-H2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwNkWzPVYh|ryP M2rFO3NCVkeHUh?=
KG-1 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITYcpRKSzVyPUOuO|E3QDhizszN M4HycnNCVkeHUh?=
D-283MED M37TSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNwN{W4O{DPxE1? NFjq[GRUSU6JRWK=
LU-65 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uydWlEPTB;ND6xNVQ5PSEQvF2= MYrTRW5ITVJ?
MSTO-211H NXHmc45pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\EU2lEPTB;ND6xPFg6QCEQvF2= NUftTZprW0GQR1XS
NCI-H2081 NXXyd2k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fWV2lEPTB;ND6yPVE4PCEQvF2= NFLrTlBUSU6JRWK=
D-247MG M2W5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTRwNEOxPVEh|ryP MUXTRW5ITVJ?
P31-FUJ Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTRwNEWwNVkh|ryP M4XnfnNCVkeHUh?=
DMS-79 NXfLbo5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LJ[2lEPTB;ND65N|E5OyEQvF2= M4LWXnNCVkeHUh?=
KASUMI-1 NHfPTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrCTWM2OD12Lkm3OVA6KM7:TR?= M1PIfXNCVkeHUh?=
JVM-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zR[GlEPTB;NT6yOVAyPCEQvF2= MXPTRW5ITVJ?
LAN-6 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTVwNUG3N|Yh|ryP MV3TRW5ITVJ?
DJM-1 NF20d4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LRZWlEPTB;NT61OlAzQSEQvF2= MoOzV2FPT0WU
JVM-2 MkLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\TVmkzUUN3ME21MlY4ODl{IN88US=> MX3TRW5ITVJ?
U-87-MG Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{iyUGlEPTB;NT64PVk3PCEQvF2= MoXqV2FPT0WU
SHP-77 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;mSGlEPTB;NT65OFkzQCEQvF2= M37NWHNCVkeHUh?=
RPMI-8866 M2nSWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DKZmlEPTB;Nj6yO|AyOyEQvF2= NX3aRXk4W0GQR1XS
ES7 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fp[GlEPTB;Nj6zPVkzPCEQvF2= MX3TRW5ITVJ?
WSU-NHL MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknvTWM2OD14LkWxOlA6KM7:TR?= M{PF[3NCVkeHUh?=
CAS-1 NHfCNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e2fmlEPTB;Nz6wPVc1QSEQvF2= NF7RSIxUSU6JRWK=
MHH-NB-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;S[mNSUUN3ME24MlI{OTV{IN88US=> MmTmV2FPT0WU
ES5 M2XqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFi2c5hKSzVyPUmuOVIzQDZizszN NH2xcXVUSU6JRWK=
HDLM-2 MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX3SJBKSzVyPUmuPVU6ODJizszN MXrTRW5ITVJ?
NCI-H2171 M4rs[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrCTWM2OD1zMD61PVI4KM7:TR?= MXfTRW5ITVJ?
LNCaP-Clone-FGC MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPU[4VKSzVyPUGxMlM4OThizszN MmHrV2FPT0WU
NCI-H1395 NYHI[VVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTDTWM2OD1zMj6yOlk6KM7:TR?= MlnPV2FPT0WU
NCI-H1436 NWTDOHhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7lRoUyUUN3ME2xN{4{OTl3IN88US=> MVLTRW5ITVJ?
RCC10RGB M37qfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF|LkOyNlEh|ryP MX\TRW5ITVJ?
SW684 NXPhfpRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF|Lkm3PVch|ryP NUP4Z|k5W0GQR1XS
NCI-H1650 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPUd5hKSzVyPUG1MlA1PDdizszN M3T2OHNCVkeHUh?=
EW-13 NUD5UGtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF3LkKwNlEh|ryP Mlr0V2FPT0WU
EC-GI-10 NXHmTZlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXufJlKSzVyPUG1Mlg3PDRizszN MWfTRW5ITVJ?
CHP-126 M4qxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDkTWM2OD1zNz6xPVE5KM7:TR?= NXP2WpNCW0GQR1XS
NCI-H226 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\MTWM2OD1zOD6wOFA{KM7:TR?= MlOzV2FPT0WU
NCI-H1838 NETvZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDse2luUUN3ME2yNE4yQDR6IN88US=> NVzTc4VKW0GQR1XS
EW-11 NHH1eYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJ2LkK3NVgh|ryP Mne0V2FPT0WU
EB2 NF;GSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNzLkWzNVgh|ryP MoSxV2FPT0WU
D-502MG M1L5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1V3hoUUN3ME20N{46OjJ7IN88US=> NV7jVHZvW0GQR1XS
U-698-M NVjGU5lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPkPFVKSzVyPUS4Mlg3PzFizszN MnP3V2FPT0WU
ES3 NVjEPWJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTR7LkO4PVMh|ryP M{PTNnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID