AZD8055

Catalog No.S1555

AZD8055 Chemical Structure

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

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In DMSO USD 156 In stock
USD 120 In stock
USD 370 In stock
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Cited by 38 Publications

8 Customer Reviews

  • PC3-LN4 cells were treated with GSK690693 (5 uM) alone, or in combination with PP242 (2 uM) or AZD8055 (1 uM) for 24 h, and immunoblotting performed.

    Cancer Res 2013 73(11), 3402-11. AZD8055 purchased from Selleck.

    HUVEC were treated with either RAD001 or AZD8055 before PA treatment. p53, GPX1, p53 acetylation, and subcellular PTEN were analyzed with corresponding antibodies. The blot is a representative of the results of three experiments. Values (mean盨D) are expressed as fold over untreated control. *p<0.05 versus their corresponding control groups in the one-way ANOVA.

    Antioxid Redox Signal 2014 20(9), 1382-95. AZD8055 purchased from Selleck.

  • (A) HCT116 or MDA-MB-468 cells were treated with 500 nM AZD8055 for the indicated times. Cell lysates were immunoblotted with the indicated antibodies. (B) HCT116 or MDA-MB-468 cells were treated with 50 nM rapamycin. 500 nM AZD8055, 1 uM MK2206 or dimethyl sulfoxide (DMSO) as control for 12 h. Cell lysates were immunoblotted with the indicated antibodies.

    Oncotarget 2014 5(15), 6015-27. AZD8055 purchased from Selleck.

    CSCs+24/44/ESA at 5,000 cells per well with stem cell culture media in triplicate in an ultra-low adhesion plate were treated with 5 umol/L BMS-777607, 1 umol/L AZD8055 alone, or in their different combinations. Cells were cultured for 72 hours. Cell viability was determined by the MTS assay. Percentages of polyploid cells were determined by counting 300 cells from two different regions. Results shown here were from one of two experiments with similar results.

    Mol Cancer Ther 2014 13(1), 37-48. AZD8055 purchased from Selleck.

  • mTOR kinase inhibitor AZD8055 activates PI3K accompanied with induction of expression of EGFR, HER2, HER3 and IRS1. Serum-deprived CHO-EGFP-AKT cells were incubated with 50 nM AZD8055 for 24 hr. The EGFP signal was detected using confocal microscopy. The white arrows indicate EGFP-AKT located on cellular membrane.

    Int J Cancer 2014 135(10), 2462-74. AZD8055 purchased from Selleck.

    mTOR, P70S6K1, 4E-BP1 and PCNA activation in the basilar artery of SAH. Top, Western blotting bands of antibodies, bottom, density of the protein band from each group. A, mTOR activation in the basilar artery demonstrated an elevated expression of mTOR on day 7 following SAH in SAH and SAH+DMSO animals. The mTOR inhibitors, Rapamycin and AZD8055 reduced the enhanced expression of mTOR (pb0.05, ANOVA). B. P70S6K1 activation. C. 4E-BP1 activation. D. PCNA activation. Rapamycin and AZD8055 significantly decreased the expression of P70S6K1, 4E-BP1 and PCNA compared with the SAH and SAH+DMSO (pb0.05, respectively; ANOVA). There was no significant difference between the two inhibitors in mTOR, P70S6K1, 4E-BP1 and PCNA expression.

    Exp Neurol 2012 233, 799-806. AZD8055 purchased from Selleck.

  • Induction of TCTP expression through 5-FU or oxaliplatin is inhibited by mTOR kinase inhibitors. HCT116 cells were treated for 48 h with 5-FU or oxaliplatin at the indicated concentrations. Where indicated, AZD 8055 (100 nM) or PP242 (1 μM) were added. TCTP levels were assessed by western blotting; signals were quantified and normalised against α-tubulin as a loading control. As a readout of mTOR activity, phosphorylation of the ribosomal protein S6 at Ser 240/244 was assessed using a phospho-specific antibody. a. Representative western blots demonstrating the alteration of the levels of TCTP protein and of phospho-ribosomal protein S6, respectively, in relation to the drug concentration.

    Cell Commun Signal, 2017.. AZD8055 purchased from Selleck.

    After starved in serum-free medium for 24h , A549 cells incubated with the indicated concentrations of AZD8055 for 3h , followed by 20-minute stimolation of 100ng/ml EGF

     
     

     

    Dr. Zhang of Tianjin Medical University. AZD8055 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.
Features First drug to inhibit both types of mTOR protein.
Targets
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM
In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. [1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. [2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 M3HxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXu1OG5yUUN3ME2wMlAzOzNzIN88US=> MlTMV2FPT0WU
NCI-H720 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzETWM2OD1yLkCyPVM5KM7:TR?= NYnRfJlVW0GQR1XS
KARPAS-45 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvlXVlKSzVyPUCuNFM{PzFizszN MUXTRW5ITVJ?
EW-3 NWTv[5FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PROmlEPTB;MD6wOFA2PiEQvF2= MlvjV2FPT0WU
SBC-1 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMES1PFEh|ryP MXLTRW5ITVJ?
NCI-H209 NUfHRXVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEW0OVMh|ryP M3nzUHNCVkeHUh?=
EoL-1-cell M2nZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXJSpFKSzVyPUCuNFY2PjlizszN NXzCN29uW0GQR1XS
H9 M3yzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjYR|dKSzVyPUCuNFY3QTJizszN M4\ofHNCVkeHUh?=
AN3-CA M37hRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEe5OVEh|ryP M2rFWnNCVkeHUh?=
HH MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLIdmFLUUN3ME2wMlA5ODB7IN88US=> M1Tp[nNCVkeHUh?=
KU812 NI\sboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEiwOFMh|ryP MnfOV2FPT0WU
DU-4475 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[3TYZmUUN3ME2wMlA5ODR5IN88US=> NWjjS3d5W0GQR1XS
CTV-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzOPVhVUUN3ME2wMlA5PjRzIN88US=> Mk\VV2FPT0WU
BV-173 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofoTWM2OD1yLkC5NFYyKM7:TR?= Mln0V2FPT0WU
ES5 NIL5WIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\FTWM2OD1yLkC5N|Uh|ryP MWLTRW5ITVJ?
G-402 NXjSUnlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W4VGlEPTB;MD6wPVk5KM7:TR?= MYDTRW5ITVJ?
MV-4-11 NIjVTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLwTWM2OD1yLkGwN|Q4KM7:TR?= Mlr2V2FPT0WU
NB69 NWXpdJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXSW3lsUUN3ME2wMlE{PSEQvF2= MkXnV2FPT0WU
EGI-1 NX[xTWpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFft[mVKSzVyPUCuNVM2OzFizszN MnH0V2FPT0WU
EW-18 NVfYfFRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMUSwO|Mh|ryP MWfTRW5ITVJ?
ME-180 M1zRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMUS2PFEh|ryP NXH0OWFLW0GQR1XS
D-283MED MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\TTWM2OD1yLkG0O|I{KM7:TR?= Mlq0V2FPT0WU
NB14 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTjdo9KSzVyPUCuNVY1PDdizszN Mnm4V2FPT0WU
Ramos-2G6-4C10 NFO4[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\PN2lEPTB;MD6xOlk5OyEQvF2= MWHTRW5ITVJ?
NBsusSR MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPBO3JKSzVyPUCuNVcxOTlizszN M3W3PHNCVkeHUh?=
LAMA-84 M1Tidmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXwcpRKSzVyPUCuNVgxOzJizszN NUnsOXJ{W0GQR1XS
NCI-H1581 NHHXe|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:2V2lEPTB;MD6xPFk3PiEQvF2= MV3TRW5ITVJ?
A204 NVfDW4g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCRmlOUUN3ME2wMlE5QTdizszN NHe3VHpUSU6JRWK=
A549 NHjqR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMUm1OUDPxE1? NIHi[4lUSU6JRWK=
CAL-51 NVLJNXUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17vR2lEPTB;MD6xPVY2OSEQvF2= MlzaV2FPT0WU
NKM-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXrTWM2OD1yLkKwNFI6KM7:TR?= MVPTRW5ITVJ?
LoVo NWHsVJpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjHVlNwUUN3ME2wMlIxOjB{IN88US=> Ml3jV2FPT0WU
HAL-01 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j3SGlEPTB;MD6yNFI6PyEQvF2= NYH2WGFvW0GQR1XS
HCC2218 NEDJeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqyTWM2OD1yLkKwOlg5KM7:TR?= MVHTRW5ITVJ?
BEN NFO4fWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPITWM2OD1yLkKxNlk{KM7:TR?= MWPTRW5ITVJ?
LC-2-ad MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPld|VKSzVyPUCuNlIxQDRizszN MkCxV2FPT0WU
LXF-289 NHv2WVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PNeWlEPTB;MD6yOVA1OSEQvF2= M3HRWHNCVkeHUh?=
HGC-27 M{fjcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6XWlEPTB;MD6yOlQyPCEQvF2= M3HMb3NCVkeHUh?=
LK-2 NEi1OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITT[HlKSzVyPUCuNlY5OjRizszN M1zlR3NCVkeHUh?=
CTB-1 M4TzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDRRYI5UUN3ME2wMlI4OjF3IN88US=> Mnf6V2FPT0WU
697 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1e3cGlEPTB;MD6yO|M3PyEQvF2= NX;TV5lPW0GQR1XS
ES7 NV7PSoR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHaTWM2OD1yLkK3N|g{KM7:TR?= MUnTRW5ITVJ?
MG-63 MknyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HVdmlEPTB;MD6yO|QxPyEQvF2= M1zjXXNCVkeHUh?=
T47D MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTtVFFmUUN3ME2wMlI4PDd3IN88US=> MULTRW5ITVJ?
RPMI-8226 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fnVWlEPTB;MD6yPFU5QSEQvF2= MlPSV2FPT0WU
NCI-H292 M164Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXMU5F2UUN3ME2wMlI6OTZ2IN88US=> M171XnNCVkeHUh?=
HT NXHwN3hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnUTWM2OD1yLkK5N|gh|ryP M3r0WXNCVkeHUh?=
A3-KAW NYrwNplZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TUbWlEPTB;MD6yPVc1KM7:TR?= MoW0V2FPT0WU
LB2241-RCC NE\kXlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW2WY1JUUN3ME2wMlMxOTl6IN88US=> NELXSI5USU6JRWK=
BB65-RCC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfoTWM2OD1yLkOwPFA2KM7:TR?= NGjHT5lUSU6JRWK=
G-401 MlHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPPUmtvUUN3ME2wMlMxQTh4IN88US=> NUHuRoRkW0GQR1XS
TYK-nu MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vZPGlEPTB;MD6zNVg3PCEQvF2= MlfhV2FPT0WU
NCI-SNU-1 NE\Cc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{KzN|Eh|ryP NYjNTJBZW0GQR1XS
CHL-1 NVjZOWZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPITWM2OD1yLkOyO|A{KM7:TR?= M{jrb3NCVkeHUh?=
P30-OHK NVe0W5JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrxTWM2OD1yLkOyO|A2KM7:TR?= Mo\FV2FPT0WU
PA-1 NYH3XHo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPSbWpnUUN3ME2wMlM{PjF7IN88US=> MnPVV2FPT0WU
LB1047-RCC NIO1fJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvLTWM2OD1yLkO0NFQ4KM7:TR?= MXLTRW5ITVJ?
EM-2 NWfPRmk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm1TWM2OD1yLkO0NVg5KM7:TR?= M1;ke3NCVkeHUh?=
VA-ES-BJ M4nBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm1[5ZKSzVyPUCuN|QzPjhizszN NIm5[I5USU6JRWK=
NCI-H520 NWLI[3RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfDTFhKSzVyPUCuN|Q5OzRizszN MYHTRW5ITVJ?
ECC10 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\6O|lEUUN3ME2wMlM2ODN3IN88US=> MoHTV2FPT0WU
LNCaP-Clone-FGC NISy[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV73OZI6UUN3ME2wMlM2OzF2IN88US=> NXzUPWl6W0GQR1XS
ES8 NVT6NXo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTzSllOUUN3ME2wMlM3PTV|IN88US=> NUnrXGdNW0GQR1XS
HuO-3N1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PQT2lEPTB;MD6zPFM4QSEQvF2= NEHTZ2NUSU6JRWK=
L-363 MmnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;v[45KSzVyPUCuN|kxOjZizszN MWjTRW5ITVJ?
SK-LU-1 NVXJeWM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3nUZVKSzVyPUCuN|kzODhizszN MYrTRW5ITVJ?
MCF7 M3[0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjZNZVyUUN3ME2wMlQxPTNizszN MVTTRW5ITVJ?
HuO9 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzpTWM2OD1yLkSwOlY4KM7:TR?= NHu1dWlUSU6JRWK=
BHT-101 NF73cplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjYTFQzUUN3ME2wMlQxPzh5IN88US=> M3jUeXNCVkeHUh?=
MZ2-MEL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljsTWM2OD1yLkSwPFgzKM7:TR?= MVvTRW5ITVJ?
NOS-1 Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M124NmlEPTB;MD60NVA4PCEQvF2= MUTTRW5ITVJ?
NEC8 NHHvdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwNEG2PVUh|ryP NGPUV41USU6JRWK=
COR-L88 NVHjTXh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwNEKyOlch|ryP MYnTRW5ITVJ?
MFM-223 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwNEK2NVch|ryP NELOe2NUSU6JRWK=
HSC-3 NIPHNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M165bWlEPTB;MD60NlkxQCEQvF2= NIPDbVVUSU6JRWK=
OVCAR-5 M2fkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULicnVXUUN3ME2wMlQzQTN|IN88US=> M4f4VHNCVkeHUh?=
MFE-280 NUnZTZFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\xdGlEPTB;MD60N|A{OiEQvF2= MnG0V2FPT0WU
KP-N-YS NVjS[WJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;xTWM2OD1yLkSzNFch|ryP M{nTTnNCVkeHUh?=
EPLC-272H Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fnNmlEPTB;MD60N|A4PyEQvF2= NIXCfnlUSU6JRWK=
KE-37 NHPkTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwNEOyOFch|ryP M4rMN3NCVkeHUh?=
HuH-7 NGHOeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7KTWM2OD1yLkSzN|czKM7:TR?= NH\kSIdUSU6JRWK=
CHP-212 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:2WGlEPTB;MD60N|Y6PyEQvF2= M32xU3NCVkeHUh?=
SK-MES-1 MofQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;wTWtXUUN3ME2wMlQ{QDR6IN88US=> M3XvdHNCVkeHUh?=
SJSA-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNES1OVQh|ryP Ml3xV2FPT0WU
QIMR-WIL M3XwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TY[2lEPTB;MD60OVE2KM7:TR?= NEi3T5dUSU6JRWK=
ES4 M1ewN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNEWzN|Yh|ryP NGfaWJpUSU6JRWK=
TI-73 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HIZWlEPTB;MD60OVY5PiEQvF2= M1m0W3NCVkeHUh?=
COLO-684 NUXpZnhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HhTWlEPTB;MD60OVczPiEQvF2= MmT5V2FPT0WU
GCIY MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUToNiUUN3ME2wMlQ2PzV2IN88US=> M3fLVXNCVkeHUh?=
JVM-3 NGLaXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zEO2lEPTB;MD60OlI6OiEQvF2= NHT1WmxUSU6JRWK=
MPP-89 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfmT3BKSzVyPUCuOFY6PDdizszN M1PDRXNCVkeHUh?=
M14 M1r6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiyUW5KSzVyPUCuOFcyPyEQvF2= NUTlRWNwW0GQR1XS
SW962 M2rzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnYTItKSzVyPUCuOFcyQSEQvF2= MXfTRW5ITVJ?
VM-CUB-1 M4\RTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:2TWM2OD1yLkS3Nlg3KM7:TR?= MWDTRW5ITVJ?
A101D NUn0Upd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXWVlV[UUN3ME2wMlQ5QTZ6IN88US=> NUHjXIZSW0GQR1XS
DB MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzE[GJKSzVyPUCuOVAxOjFizszN MXjTRW5ITVJ?
KNS-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[0SGZ5UUN3ME2wMlUxPTZ6IN88US=> M{nhd3NCVkeHUh?=
NCI-H460 M1jyXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jSOWlEPTB;MD61NFU6PyEQvF2= M2fKRXNCVkeHUh?=
MDA-MB-361 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPpZYsxUUN3ME2wMlUxQDdizszN MnfYV2FPT0WU
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SNB75 NF;JOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrpTWM2OD1zLke1OFkzKM7:TR?= MnnPV2FPT0WU
SK-PN-DW NV;tPJJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO1TWM2OD1zLke1OlgzKM7:TR?= MofNV2FPT0WU
5637 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwN{eyOlgh|ryP MVXTRW5ITVJ?
BT-474 NWLC[o9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwN{ixO|Eh|ryP M1\1d3NCVkeHUh?=
KM12 NHexeZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1zLke5O|QyKM7:TR?= M1nhRXNCVkeHUh?=
COLO-680N NUH1SoxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrNTmNOUUN3ME2xMlgzOzhzIN88US=> M4r0cHNCVkeHUh?=
Saos-2 M3r4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\Hb3pKSzVyPUGuPFI1PDVizszN MVfTRW5ITVJ?
CAL-54 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwOEOzNVMh|ryP MWPTRW5ITVJ?
U-118-MG M{Ha[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLYNZFLUUN3ME2xMlg1PjJ{IN88US=> M1zwTnNCVkeHUh?=
TGBC24TKB M3\Tb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDufYJYUUN3ME2xMlg2PTBzIN88US=> M3v1c3NCVkeHUh?=
NCI-H2052 M4DzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwOE[0NUDPxE1? MWDTRW5ITVJ?
BB30-HNC M3u4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGzTWM2OD1zLki2OFYzKM7:TR?= NE[2fopUSU6JRWK=
KNS-81-FD MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHBZ4dKSzVyPUGuPFkyPjVizszN M3X4c3NCVkeHUh?=
HN NWrSZoZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDmTWM2OD1zLki5OVQ2KM7:TR?= NEO3UXFUSU6JRWK=
ACHN NF:yRVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXKO|BKSzVyPUGuPVA4QDZizszN MYDTRW5ITVJ?
HSC-2 NUjQeHpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrXNGJFUUN3ME2xMlkyODl4IN88US=> M1jubXNCVkeHUh?=
HCC2998 NF[3emxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DEd2lEPTB;MT65N|MzPSEQvF2= NE\MVHdUSU6JRWK=
HEL NFXRVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWzd5NKSzVyPUGuPVQyQDRizszN M3;hPXNCVkeHUh?=
SW684 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPPd4trUUN3ME2xMlk4OzdzIN88US=> NYjldFJGW0GQR1XS
NCI-H1693 NUjzRXZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTFwOUiwPFYh|ryP M{Kzb3NCVkeHUh?=
8-MG-BA MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rKbWlEPTB;MT65PFIyKM7:TR?= NXLjRY1bW0GQR1XS
OVCAR-8 NHL5VVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETPTlJKSzVyPUKuNFAzQTVizszN NUXCfI9HW0GQR1XS
DSH1 M1PxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHUTWM2OD1{LkCxO|c1KM7:TR?= NUPSU5hEW0GQR1XS
KYSE-520 NXrHfGVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTFNmxKSzVyPUKuNFIxPDlizszN NXfodGFJW0GQR1XS
GB-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XMUGlEPTB;Mj6wNlU4PyEQvF2= NGjLSmlUSU6JRWK=
RCC10RGB MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[3TWM2OD1{LkC0PFcyKM7:TR?= M{jGOHNCVkeHUh?=
SW954 NEn3fohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\WZ2lEPTB;Mj6wOVA{PiEQvF2= Mm\TV2FPT0WU
IST-MES1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXaTWM2OD1{LkC1OVY5KM7:TR?= M1nSRXNCVkeHUh?=
AU565 NUnVNYpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M123UmlEPTB;Mj6wOVkxPSEQvF2= NWPYPIR3W0GQR1XS
CW-2 M{nXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Lyd2lEPTB;Mj6wOlg4PSEQvF2= M4\FUHNCVkeHUh?=
TE-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwMEmzO|ch|ryP M2nDSHNCVkeHUh?=
KP-4 M4HMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJwMUCzNVIh|ryP MVXTRW5ITVJ?
SNU-C2B NFvHeXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJwMUC4NlMh|ryP MYLTRW5ITVJ?
NCI-H1395 NHWzRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPwdZhDUUN3ME2yMlExQTh4IN88US=> MnvvV2FPT0WU
CAS-1 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPCUXNKSzVyPUKuNVE2PDZizszN MYjTRW5ITVJ?
NCI-H1155 Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ITopKSzVyPUKuNlI3QSEQvF2= MUXTRW5ITVJ?
SK-MEL-1 NFzm[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPPTo5QUUN3ME2yMlI5OThzIN88US=> NVPZZ3VqW0GQR1XS
KINGS-1 MmDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwM{CwPFgh|ryP M4LEb3NCVkeHUh?=
ESS-1 NI\HOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTyTWM2OD1{LkOwOVEh|ryP MkHLV2FPT0WU
PANC-10-05 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHkZ2N7UUN3ME2yMlM4ODJ2IN88US=> Mk\oV2FPT0WU
HT-1376 Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHk[4d{UUN3ME2yMlM5PzB6IN88US=> MWXTRW5ITVJ?
LS-513 NV3sS4xlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvPN5NQUUN3ME2yMlM5QDd2IN88US=> MofGV2FPT0WU
KNS-42 NIHmR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrtTWM2OD1{LkO5NVA2KM7:TR?= M4i5fnNCVkeHUh?=
639-V NF7zNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzjTWM2OD1{LkSyO|U5KM7:TR?= MV;TRW5ITVJ?
SJRH30 NVrkXXNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHDTWM2OD1{LkS1NVYyKM7:TR?= MmqwV2FPT0WU
SW1783 NVjxOYVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfK[49KSzVyPUKuOFcxPzhizszN MlLaV2FPT0WU
NB6 NIDEUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7UPGRKSzVyPUKuOFgzQCEQvF2= NVfLVJgyW0GQR1XS
SK-MEL-30 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqzTWM2OD1{LkS4PFMh|ryP MY\TRW5ITVJ?
HCE-4 NX7oWWhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwNEm0NFIh|ryP NFn0XFlUSU6JRWK=
NB10 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv6b|NkUUN3ME2yMlQ6PDJ7IN88US=> M1\wbnNCVkeHUh?=
H-EMC-SS NHfP[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3PTWM2OD1{LkW0OlUh|ryP MnSxV2FPT0WU
SK-HEP-1 Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnqTHBKSzVyPUKuOVUzOzZizszN NYnjfo14W0GQR1XS
HCC1395 NEX6c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTGUHkxUUN3ME2yMlU2PjV3IN88US=> NH:3c5BUSU6JRWK=
HuCCT1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJwNU[zPUDPxE1? M1\NfnNCVkeHUh?=
SiHa MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjtTWM2OD1{LkW4O|E6KM7:TR?= MVjTRW5ITVJ?
EFO-21 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[wTWM2OD1{LkW4O|Y1KM7:TR?= MmLkV2FPT0WU
NCI-H1666 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPsTZlKSzVyPUKuOVkxPzZizszN MWnTRW5ITVJ?
UMC-11 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnzN3pKSzVyPUKuOVk5PjhizszN NYjtfIJnW0GQR1XS
COLO-679 NHHPXGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT6SY1KSzVyPUKuOlEzOzNizszN NFzjO5NUSU6JRWK=
A388 M{PocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmxcYVHUUN3ME2yMlY2OjV|IN88US=> MUXTRW5ITVJ?
LB2518-MEL NUS1SI11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rLbGlEPTB;Mj62OVQxQCEQvF2= NHThc|lUSU6JRWK=
EW-13 NFe2[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\1XFVEUUN3ME2yMlY5PzZ6IN88US=> MkPqV2FPT0WU
MLMA MkjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHxTWM2OD1{Lk[4PFU3KM7:TR?= NX74bFU5W0GQR1XS
HOP-92 M3PmPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwN{CxNUDPxE1? MV7TRW5ITVJ?
NOMO-1 M17Ufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJwN{G0OFIh|ryP M1q1[nNCVkeHUh?=
NCI-H810 MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDBTWM2OD1{LkeyNVk5KM7:TR?= MV\TRW5ITVJ?
769-P NV\6OIdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37hSGlEPTB;Mj63NlI5KM7:TR?= MY\TRW5ITVJ?
SAS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwN{[1JO69VQ>? MX3TRW5ITVJ?
M059J MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwN{izNVgh|ryP NH\J[pRUSU6JRWK=
RD M3;XTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwN{m0O|Eh|ryP MnSzV2FPT0WU
GT3TKB MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j1UWlEPTB;Mj64N|Q{OyEQvF2= Mm\CV2FPT0WU
MZ7-mel MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;NbZFKSzVyPUKuPFY2ODJizszN M1WzR3NCVkeHUh?=
KYSE-510 NF;LfphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXWWXFKSzVyPUKuPFk2ODRizszN NVOycoNJW0GQR1XS
NCI-N87 NVe0VHZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfrNlBKSzVyPUKuPVE5ODdizszN NUTJNIZ3W0GQR1XS
MKN1 NXHlVYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwMECxOlMh|ryP M4nWeHNCVkeHUh?=
NCI-H2170 MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rLS2lEPTB;Mz6wNFQ2OSEQvF2= M1vmS3NCVkeHUh?=
OVCAR-3 M4nhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXvTWM2OD1|LkCyNVE2KM7:TR?= M{O1ZXNCVkeHUh?=
KLE NYLKN4FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmyTWM2OD1|LkC2PFEzKM7:TR?= NVLrUIVYW0GQR1XS
LB771-HNC NWHqRYhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrEOpBKSzVyPUOuNFk{PDNizszN NYPvcW9wW0GQR1XS
MC116 NH7ROmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTQSnd[UUN3ME2zMlEyOTF{IN88US=> NHHXO3hUSU6JRWK=
SCC-9 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jmU2lEPTB;Mz6xNVM3PiEQvF2= MkT2V2FPT0WU
U031 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\qSYJKSzVyPUOuNVI1OjNizszN M{fsTHNCVkeHUh?=
LCLC-103H NXn5[nMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\TTWM2OD1|LkKzPFk1KM7:TR?= NWnJR5F7W0GQR1XS
U-266 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTNwMke2N|Mh|ryP NV;wbHhkW0GQR1XS
JVM-2 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNwM{KxOlQh|ryP Ml;sV2FPT0WU
UACC-257 NGK0NHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe5c|N3UUN3ME2zMlQ3PDNzIN88US=> M2nkN3NCVkeHUh?=
LB996-RCC M3rNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;kS|RKSzVyPUOuOFY2ODJizszN NHHTXVdUSU6JRWK=
BT-549 Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XQWmlEPTB;Mz61NFIxQSEQvF2= M4jRW3NCVkeHUh?=
NCI-H526 NVLnbm9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX3TWM2OD1|LkW0NVU5KM7:TR?= M{jDXXNCVkeHUh?=
RH-18 NWWyNlVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDwfnlXUUN3ME2zMlYyPzl6IN88US=> M{P1T3NCVkeHUh?=
SW626 M133Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPYWHZRUUN3ME2zMlcyOTJ6IN88US=> MkTCV2FPT0WU
SK-N-AS M2fvcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[z[mlEPTB;Mz63N|I1PyEQvF2= MULTRW5ITVJ?
IGR-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULKbpJXUUN3ME2zMlc1OjR6IN88US=> NYXQS3JNW0GQR1XS
NCI-H2291 NH;HXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\GdY9qUUN3ME2zMlc2OzN4IN88US=> NYj6NmdSW0GQR1XS
NCI-H441 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{j2SmlEPTB;Mz64NlQ{OyEQvF2= MUfTRW5ITVJ?
D-247MG M{HrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrXdYpKSzVyPUOuPFYxOzFizszN MYLTRW5ITVJ?
COLO-320-HSR M2DxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HhSWlEPTB;Mz65NVI4OSEQvF2= MXHTRW5ITVJ?
A253 NYnVeHFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwOUG0N|Yh|ryP NHvKVoVUSU6JRWK=
HT55 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jKbGlEPTB;Mz65NVc4OyEQvF2= M1jGfHNCVkeHUh?=
MZ1-PC NIS1flVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjWTWM2OD1|Lkm1PFY1KM7:TR?= Ml7BV2FPT0WU
RERF-LC-MS MkW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTmNmdKSzVyPUOuPVY2OjVizszN NUf6V|I4W0GQR1XS
SF268 M3jrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjJUGNKSzVyPUSuNVI5QDFizszN NUDU[W1qW0GQR1XS
RMG-I NH7SN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXaTWM2OD12LkKxOFU1KM7:TR?= MnLiV2FPT0WU
CFPAC-1 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3FUlJKSzVyPUSuNlE3QDVizszN M1\j[3NCVkeHUh?=
S-117 NEnIfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjWPIpZUUN3ME20MlIzODJ2IN88US=> NYrFcJY3W0GQR1XS
NCI-H2122 M3X6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXMTWM2OD12LkOwPVMyKM7:TR?= NXTGO4FIW0GQR1XS
J82 NWOxNW93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDkTWM2OD12LkOzOFQyKM7:TR?= NYP6O5d{W0GQR1XS
CAL-72 NELjeYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETVU4ZKSzVyPUSuN|U1PzdizszN MVzTRW5ITVJ?
GP5d NWXOcG9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K4N2lEPTB;ND60NVI6QCEQvF2= MWnTRW5ITVJ?
UACC-62 NXm5T5Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPLZW9KSzVyPUSuOFY2PDVizszN NXm4XpJUW0GQR1XS
MS-1 NH7tOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG4endKSzVyPUSuOFkyOTVizszN MYXTRW5ITVJ?
RCM-1 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjOUoFKSzVyPUSuOVI6OiEQvF2= Mo\LV2FPT0WU
IST-SL1 NIH1XodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH1dG1KSzVyPUSuOlU{PTlizszN NWj5VpBoW0GQR1XS
SW756 M4PGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTRwNkmxN|Uh|ryP MmXBV2FPT0WU
HCC38 NE\4dIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XuXmlEPTB;ND63NVE6PyEQvF2= MYrTRW5ITVJ?
YAPC NVLqTIQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTRwN{GzNVMh|ryP M3jC[HNCVkeHUh?=
DK-MG M1HEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTRwN{ixNVIh|ryP M37hU3NCVkeHUh?=
HCC1937 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTRwOEWxNlUh|ryP NWPsWI1wW0GQR1XS
OAW-28 M2LmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\sTWM2OD12LkmyOFM2KM7:TR?= NUTKXFZDW0GQR1XS
MEG-01 NXHpT2YxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTVwMEizNlgh|ryP Mn7vV2FPT0WU
GI-1 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TxVGlEPTB;NT6yN|Q5PiEQvF2= NX;tNndqW0GQR1XS
FADU NXfIUIpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K4ZWlEPTB;NT6yO|g{PyEQvF2= MUfTRW5ITVJ?
CAPAN-1 NEjocVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKxT4dNUUN3ME21MlM6PDN{IN88US=> NY\jbYhDW0GQR1XS
TGBC11TKB MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG1Nm9KSzVyPUWuOFU4QDZizszN NWq4WosyW0GQR1XS
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NCI-H2029 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTlwME[3OVkh|ryP Ml;NV2FPT0WU
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NCI-H727 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFyLkS0PVUh|ryP MYfTRW5ITVJ?
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NCI-H2087 M4frWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\3VXhyUUN3ME2xNU4xPDN2IN88US=> NELBTmhUSU6JRWK=
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KARPAS-299 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3LdFFKSzVyPUG1MlIyPTlizszN MnK2V2FPT0WU
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NCI-H82 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzP[3ZMUUN3ME2xOU42OzJizszN MnLYV2FPT0WU
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T47D-tamR  M3\MWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHkTWM2OD1zOTDuUS=> MlG3NlQ1PTdyNkm=
293T  Mn7zSpVv[3Srb36gRZN{[Xl? MVGyNEBvVQ>? NYf3S|dpOyCq NETmXFFlcXO{dYD0d{BCc3RvbXXkbYF1\WRiVFnGMWlCKHO2YXLpcIl1gSxidILhcpNtd2OjdHnvckwh[W6mIHHjeIl3cXS7 M2THd|I1OzZ|NES5
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Huh7  NVrPfmtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPWbVY2NTFyMDDuUS=> M3Oxe|AuOjRiaB?= MkLYSG1UVw>? Ml[4bY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz Ml\HNlQzQTd|MEC=
Hep3B  NUK3TJlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqwflk2NTFyMDDuUS=> M4m5dVAuOjRiaB?= M1;XcGROW09? NH7XeYlqdmO{ZXHz[ZMh[2WubDDk[YF1cCCrbjDhJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? NGjoUFAzPDJ7N{OwNC=>
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Hep-2 M4nPdmZ2dmO2aX;uJGF{e2G7 NGfnS4UxNjFxMD61JO69VQ>? MXSyOEBp NX\CVFBP[myxY3vzJI1VV1KFMTDhcoQhdVSRUlOyJIFkfGm4YYTpc44> M{HCb|I1OTB|N{S5
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HT-29 NFfESJhCeG:ydH;zbZMhSXO|YYm= M4q4NVEh|ryP NH;HO5E4OiCq MYTheJRmdnWjdHXzJFUuTlVvaX7keYNm\CClZXzsJIRm[XSq NYf1XZpMOjF7NEmxNlE>
DLD1 MUnBdI9xfG:|aYOgRZN{[Xl? MXGxJO69VQ>? MVu3NkBp MYjheJRmdnWjdHXzJFUuTlVvaX7keYNm\CClZXzsJIRm[XSq M3yyOVIyQTR7MUKx
HT-29 MnjWSpVv[3Srb36gRZN{[Xl? MYexJO69VQ>? M{fPSlczKGh? NUPOOmQycW6mdXPld{BifXSxcHjh[5khfG9iY3;u[oVzKGO7dH;wdo91\WO2aX;u NHTPVFkzOTl2OUGyNS=>
DLD1 M3z3NmZ2dmO2aX;uJGF{e2G7 MkTwNUDPxE1? MkPXO|IhcA>? M3P1T4lv\HWlZYOgZZV1d3CqYXf5JJRwKGOxbn\ldkBkgXSxcILveIVkfGmxbh?= MUWyNVk1QTF{MR?=
Rh41 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DIXWlEPTB;M{CuO{BvVQ>? M3rmRlIyOzN5Nke5
Rh18 NYP3OmNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy3RoQ3UUN3ME20NU41KG6P M2HCZlIyOzN5Nke5
Rh30 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPCN|RXUUN3ME2xOEBvVQ>? NFizU|AzOTN|N{[3PS=>
BT-12 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\JeJFmUUN3ME2yOE44KG6P NIjodWszOTN|N{[3PS=>
CHLA-266 M3L5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvSTWM2OD1zLkGgcm0> NX74b5dJOjF|M{e2O|k>
TC-71 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7ZTWM2OD12Nj61JI5O MUmyNVM{PzZ5OR?=
CHLA-9 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC3OGxKSzVyPUG1MlMhdk1? NFe2PFYzOTN|N{[3PS=>
CHLA-10 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwOTDuUS=> NVW0U2p5OjF|M{e2O|k>
CHLA-258 NFqzTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6O|N7UUN3ME2xNE41KG6P NFPjfmkzOTN|N{[3PS=>
GBM2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHkWHROUUN3ME20NE44KG6P NV\DTnNFOjF|M{e2O|k>
NB-1643 M{TORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTN|Lkigcm0> MVOyNVM{PzZ5OR?=
NB-EBc1 NEnjOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LIcmlEPTB;MkeuNUBvVQ>? NVPrU3BUOjF|M{e2O|k>
CHLA-90 NHvp[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL3TWM2OD1|ND61JI5O Mmq3NlE{Ozd4N{m=
CHLA-136 NXLq[nQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnHclF[UUN3ME2xOlIvPiCwTR?= NYi2NZBbOjF|M{e2O|k>
NALM-6 NHHuS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L5SWlEPTB;M{KuPUBvVQ>? M{PqZVIyOzN5Nke5
COG-LL-317 NH;wWIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwMzDuUS=> MmHTNlE{Ozd4N{m=
RS4;11 NIT1UIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN3IH7N MV[yNVM{PzZ5OR?=
MOLT-4 NEn2SpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRThwNjDuUS=> M1j5b|IyOzN5Nke5
CCRF-CEM NUnTcotUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfXSo9KSzVyPUSuNUBvVQ>? MX:yNVM{PzZ5OR?=
Kasumi-1 M3rNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXBTWM2OD1zLkSgcm0> MYmyNVM{PzZ5OR?=
Karpas-299 NXPzO49HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLPNYJKSzVyPUKxMlchdk1? MX6yNVM{PzZ5OR?=
Ramos-RA1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfUTJRKSzVyPUiuNkBvVQ>? MUiyNVM{PzZ5OR?=
H838 NVjEfmx6TnWwY4Tpc44hSXO|YYm= NFjFWpAyKM7:TR?= MVq0PEBp NHrPO2xqdmS3Y3XzJINmdGxiYYX0c5Bp[We7 NYXZ[ZlOOjB|NkSxNVM>
H838 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1:3SFAuOyEQvF2= NIHQdpY4OiCq NIfETG9qdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l? M{HKdFIxODJ6OEW0
A549  NWTKOotwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f2dFAuOyEQvF2= NYr3NnRWPzJiaB?= NX\DWIRGcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7 MWKyNFAzQDh3NB?=

... Click to View More Cell Line Experimental Data

In vivo AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. [1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. [4]

Protocol

Kinase Assay:[1]
+ Expand

Cell-based determinations of mTOR inhibition:

A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:[1]
+ Expand
  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 1 nM - 1 μM
  • Incubation Time: 72 to 96 hours
  • Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk).
  • Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v)
  • Dosages: 2.5-20 mg/kg
  • Administration: Oral gavage once or twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL warmed (107.4 mM)
Ethanol 3 mg/mL (6.44 mM)
Water Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C25H31N5O4

CAS No. 1009298-09-2
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01316809 Completed Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 4, 2011 Phase 1
NCT00999882 Completed Cancer|Advanced Hepatocellular Carcinoma AstraZeneca October 2009 Phase 1
NCT00973076 Completed Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca August 2009 Phase 1
NCT00731263 Completed Solid Tumors AstraZeneca July 2008 Phase 1
NCT01194193 Withdrawn Cancer|Advanced Solid Tumours|Lymphomas AstraZeneca null Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID