AZD8055

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.

AZD8055 Chemical Structure

AZD8055 Chemical Structure

CAS: 1009298-09-2

Selleck's AZD8055 has been cited by 245 publications

Purity & Quality Control

Batch: Purity: 99.84%
99.84

AZD8055 Related Products

Signaling Pathway

Choose Selective mTOR Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 Growth Inhibition Assay IC50=0.02331 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.02938 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.03371 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.04056 μM SANGER
SBC-1 Growth Inhibition Assay IC50=0.04581 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=0.05453 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=0.06569 μM SANGER
H9 Growth Inhibition Assay IC50=0.06692 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.07951 μM SANGER
HH Growth Inhibition Assay IC50=0.08009 μM SANGER
KU812 Growth Inhibition Assay IC50=0.08043 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.08047 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.08641 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.09061 μM SANGER
ES5 Growth Inhibition Assay IC50=0.0935 μM SANGER
G-402 Growth Inhibition Assay IC50=0.0998 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.10347 μM SANGER
NB69 Growth Inhibition Assay IC50=0.135 μM SANGER
EGI-1 Growth Inhibition Assay IC50=0.13531 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.14073 μM SANGER
ME-180 Growth Inhibition Assay IC50=0.14681 μM SANGER
D-283MED Growth Inhibition Assay IC50=0.14723 μM SANGER
NB14 Growth Inhibition Assay IC50=0.16447 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.16983 μM SANGER
NBsusSR Growth Inhibition Assay IC50=0.17019 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.18032 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=0.18966 μM SANGER
A204 Growth Inhibition Assay IC50=0.1897 μM SANGER
A549 Growth Inhibition Assay IC50=0.1955 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.19651 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.20029 μM SANGER
LoVo Growth Inhibition Assay IC50=0.20202 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.20297 μM SANGER
HCC2218 Growth Inhibition Assay IC50=0.20688 μM SANGER
BEN Growth Inhibition Assay IC50=0.21293 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.22084 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.25041 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.26414 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.26824 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.27215 μM SANGER
697 Growth Inhibition Assay IC50=0.27367 μM SANGER
ES7 Growth Inhibition Assay IC50=0.27383 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.27407 μM SANGER
T47D Growth Inhibition Assay IC50=0.27475 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.28589 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.29164 μM SANGER
HT Growth Inhibition Assay IC50=0.2938 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.2974 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.30198 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.30805 μM SANGER
G-401 Growth Inhibition Assay IC50=0.30986 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.31864 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.32331 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.32703 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.32705 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.33619 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.34047 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.34188 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.34268 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.34834 μM SANGER
ECC10 Growth Inhibition Assay IC50=0.35035 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.35314 μM SANGER
ES8 Growth Inhibition Assay IC50=0.36553 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.38379 μM SANGER
L-363 Growth Inhibition Assay IC50=0.39026 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.39208 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.4053 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.40667 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.40787 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.40882 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.41074 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.41695 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.42267 μM SANGER
MFM-223 Growth Inhibition Assay IC50=0.42617 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.42908 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.42933 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.43032 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.4307 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=0.43077 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.43247 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.43372 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.43697 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.43848 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.44554 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.4515 μM SANGER
ES4 Growth Inhibition Assay IC50=0.45336 μM SANGER
TI-73 Growth Inhibition Assay IC50=0.45686 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.45726 μM SANGER
GCIY Growth Inhibition Assay IC50=0.45754 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.46292 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.46947 μM SANGER
M14 Growth Inhibition Assay IC50=0.4717 μM SANGER
SW962 Growth Inhibition Assay IC50=0.4719 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.47286 μM SANGER
A101D Growth Inhibition Assay IC50=0.48968 μM SANGER
DB Growth Inhibition Assay IC50=0.50021 μM SANGER
KNS-62 Growth Inhibition Assay IC50=0.50568 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=0.50597 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.5087 μM SANGER
DOK Growth Inhibition Assay IC50=0.51333 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.52268 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.52543 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.53015 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.53195 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=0.53447 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.53878 μM SANGER
YH-13 Growth Inhibition Assay IC50=0.54938 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.55123 μM SANGER
ES1 Growth Inhibition Assay IC50=0.55518 μM SANGER
GAMG Growth Inhibition Assay IC50=0.55658 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=0.5591 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.56884 μM SANGER
HOS Growth Inhibition Assay IC50=0.57192 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.57389 μM SANGER
SW780 Growth Inhibition Assay IC50=0.57595 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.57741 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=0.57751 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.58478 μM SANGER
SCC-4 Growth Inhibition Assay IC50=0.58541 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=0.58645 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.58675 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.58791 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.5897 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.59162 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.59609 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.59851 μM SANGER
H4 Growth Inhibition Assay IC50=0.60094 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.60351 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.60619 μM SANGER
KGN Growth Inhibition Assay IC50=0.61049 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=0.61917 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.62126 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.62152 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.62502 μM SANGER
NCI-H522 Growth Inhibition Assay IC50=0.62992 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.63167 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.63639 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.64153 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.66186 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=0.66537 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=0.67187 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.6745 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.67689 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.67752 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.6781 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.67846 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.67979 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.68064 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.68405 μM SANGER
EW-22 Growth Inhibition Assay IC50=0.68444 μM SANGER
SW982 Growth Inhibition Assay IC50=0.68501 μM SANGER
SF295 Growth Inhibition Assay IC50=0.68507 μM SANGER
WM-115 Growth Inhibition Assay IC50=0.68924 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.69813 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.70063 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.70173 μM SANGER
NB5 Growth Inhibition Assay IC50=0.70319 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.7059 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=0.70691 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.70717 μM SANGER
8305C Growth Inhibition Assay IC50=0.70755 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.70847 μM SANGER
PC-3 Growth Inhibition Assay IC50=0.7223 μM SANGER
C32 Growth Inhibition Assay IC50=0.72484 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.72718 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.72738 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.73172 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.73533 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.73795 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.74629 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.74736 μM SANGER
HLE Growth Inhibition Assay IC50=0.74844 μM SANGER
A375 Growth Inhibition Assay IC50=0.75193 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.75943 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.7597 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.75991 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=0.76261 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.76922 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.77057 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.77649 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.78029 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.78168 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.78482 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.78736 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.78926 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.79144 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.7933 μM SANGER
OE33 Growth Inhibition Assay IC50=0.79914 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.79924 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.8021 μM SANGER
SN12C Growth Inhibition Assay IC50=0.80668 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.80794 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.81422 μM SANGER
A704 Growth Inhibition Assay IC50=0.81798 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.81911 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.82401 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.82675 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.82725 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.83039 μM SANGER
A431 Growth Inhibition Assay IC50=0.83116 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.83457 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.84092 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.84937 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.85121 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.85207 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.85822 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.86041 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.86495 μM SANGER
RKO Growth Inhibition Assay IC50=0.86817 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.86928 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.88384 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.88395 μM SANGER
SF126 Growth Inhibition Assay IC50=0.88714 μM SANGER
BHY Growth Inhibition Assay IC50=0.88734 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.88833 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.89372 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=0.90229 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.90442 μM SANGER
UACC-893 Growth Inhibition Assay IC50=0.92855 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.92897 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.92922 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.93256 μM SANGER
DMS-114 Growth Inhibition Assay IC50=0.93677 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.93845 μM SANGER
ACN Growth Inhibition Assay IC50=0.94277 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.95924 μM SANGER
A427 Growth Inhibition Assay IC50=0.96198 μM SANGER
DEL Growth Inhibition Assay IC50=0.96773 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.97101 μM SANGER
A2058 Growth Inhibition Assay IC50=0.9736 μM SANGER
SW13 Growth Inhibition Assay IC50=0.98392 μM SANGER
T98G Growth Inhibition Assay IC50=1.01364 μM SANGER
LU-134-A Growth Inhibition Assay IC50=1.02675 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=1.02827 μM SANGER
D-423MG Growth Inhibition Assay IC50=1.02963 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=1.03141 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=1.03406 μM SANGER
SCH Growth Inhibition Assay IC50=1.0345 μM SANGER
D-566MG Growth Inhibition Assay IC50=1.06726 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=1.0794 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=1.08021 μM SANGER
SH-4 Growth Inhibition Assay IC50=1.08431 μM SANGER
786-0 Growth Inhibition Assay IC50=1.08934 μM SANGER
Mewo Growth Inhibition Assay IC50=1.09248 μM SANGER
AGS Growth Inhibition Assay IC50=1.09459 μM SANGER
Daoy Growth Inhibition Assay IC50=1.09628 μM SANGER
SW48 Growth Inhibition Assay IC50=1.10911 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=1.11021 μM SANGER
NH-12 Growth Inhibition Assay IC50=1.11237 μM SANGER
BE-13 Growth Inhibition Assay IC50=1.11759 μM SANGER
ES3 Growth Inhibition Assay IC50=1.13171 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=1.134 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=1.13941 μM SANGER
EKVX Growth Inhibition Assay IC50=1.14001 μM SANGER
NB13 Growth Inhibition Assay IC50=1.1445 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=1.14574 μM SANGER
LS-411N Growth Inhibition Assay IC50=1.15017 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=1.15624 μM SANGER
SCC-15 Growth Inhibition Assay IC50=1.16956 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=1.17056 μM SANGER
HT-144 Growth Inhibition Assay IC50=1.1707 μM SANGER
HEC-1 Growth Inhibition Assay IC50=1.17627 μM SANGER
HCE-T Growth Inhibition Assay IC50=1.17983 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=1.19082 μM SANGER
Detroit562 Growth Inhibition Assay IC50=1.19439 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=1.20441 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=1.21326 μM SANGER
MKN7 Growth Inhibition Assay IC50=1.21702 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=1.21702 μM SANGER
BT-20 Growth Inhibition Assay IC50=1.22444 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=1.24106 μM SANGER
LS-123 Growth Inhibition Assay IC50=1.24753 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=1.24776 μM SANGER
KS-1 Growth Inhibition Assay IC50=1.25171 μM SANGER
LU-65 Growth Inhibition Assay IC50=1.25606 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=1.25929 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=1.27014 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=1.27167 μM SANGER
LN-405 Growth Inhibition Assay IC50=1.28021 μM SANGER
8505C Growth Inhibition Assay IC50=1.28823 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=1.29434 μM SANGER
OC-314 Growth Inhibition Assay IC50=1.29929 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=1.31135 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=1.31428 μM SANGER
GAK Growth Inhibition Assay IC50=1.31858 μM SANGER
D-263MG Growth Inhibition Assay IC50=1.32641 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=1.32902 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=1.32998 μM SANGER
GCT Growth Inhibition Assay IC50=1.34345 μM SANGER
COR-L23 Growth Inhibition Assay IC50=1.34845 μM SANGER
TK10 Growth Inhibition Assay IC50=1.35797 μM SANGER
ES6 Growth Inhibition Assay IC50=1.36376 μM SANGER
SW1088 Growth Inhibition Assay IC50=1.36612 μM SANGER
AM-38 Growth Inhibition Assay IC50=1.37199 μM SANGER
CHP-134 Growth Inhibition Assay IC50=1.37844 μM SANGER
SW872 Growth Inhibition Assay IC50=1.38555 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=1.39067 μM SANGER
TE-12 Growth Inhibition Assay IC50=1.40601 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=1.41046 μM SANGER
HCT-116 Growth Inhibition Assay IC50=1.42854 μM SANGER
ALL-PO Growth Inhibition Assay IC50=1.43774 μM SANGER
EW-16 Growth Inhibition Assay IC50=1.43842 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=1.44775 μM SANGER
TE-8 Growth Inhibition Assay IC50=1.4556 μM SANGER
TCCSUP Growth Inhibition Assay IC50=1.4696 μM SANGER
SW1990 Growth Inhibition Assay IC50=1.47533 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=1.47675 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=1.48607 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=1.50086 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=1.52081 μM SANGER
Becker Growth Inhibition Assay IC50=1.52187 μM SANGER
SNU-387 Growth Inhibition Assay IC50=1.52241 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=1.52599 μM SANGER
647-V Growth Inhibition Assay IC50=1.5388 μM SANGER
SBC-5 Growth Inhibition Assay IC50=1.54593 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=1.55714 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=1.55819 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=1.55908 μM SANGER
KM-H2 Growth Inhibition Assay IC50=1.56474 μM SANGER
KY821 Growth Inhibition Assay IC50=1.56617 μM SANGER
RH-1 Growth Inhibition Assay IC50=1.56762 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=1.57423 μM SANGER
SF539 Growth Inhibition Assay IC50=1.57969 μM SANGER
JEG-3 Growth Inhibition Assay IC50=1.58094 μM SANGER
SCC-25 Growth Inhibition Assay IC50=1.58432 μM SANGER
SW1573 Growth Inhibition Assay IC50=1.60158 μM SANGER
EW-1 Growth Inhibition Assay IC50=1.61351 μM SANGER
YKG-1 Growth Inhibition Assay IC50=1.61438 μM SANGER
EW-11 Growth Inhibition Assay IC50=1.61741 μM SANGER
DJM-1 Growth Inhibition Assay IC50=1.61825 μM SANGER
Calu-3 Growth Inhibition Assay IC50=1.65213 μM SANGER
HT-3 Growth Inhibition Assay IC50=1.6566 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=1.67343 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=1.67797 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=1.68317 μM SANGER
TE-6 Growth Inhibition Assay IC50=1.70874 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=1.71993 μM SANGER
A2780 Growth Inhibition Assay IC50=1.72207 μM SANGER
GOTO Growth Inhibition Assay IC50=1.7356 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=1.74442 μM SANGER
GMS-10 Growth Inhibition Assay IC50=1.74662 μM SANGER
CaR-1 Growth Inhibition Assay IC50=1.74812 μM SANGER
SW900 Growth Inhibition Assay IC50=1.74993 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.75168 μM SANGER
SNB75 Growth Inhibition Assay IC50=1.75492 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=1.75682 μM SANGER
5637 Growth Inhibition Assay IC50=1.77268 μM SANGER
BT-474 Growth Inhibition Assay IC50=1.78171 μM SANGER
KM12 Growth Inhibition Assay IC50=1.79741 μM SANGER
COLO-680N Growth Inhibition Assay IC50=1.82381 μM SANGER
Saos-2 Growth Inhibition Assay IC50=1.82445 μM SANGER
CAL-54 Growth Inhibition Assay IC50=1.83313 μM SANGER
U-118-MG Growth Inhibition Assay IC50=1.84622 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=1.85501 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=1.8641 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=1.86462 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=1.89165 μM SANGER
HN Growth Inhibition Assay IC50=1.89545 μM SANGER
ACHN Growth Inhibition Assay IC50=1.90786 μM SANGER
HSC-2 Growth Inhibition Assay IC50=1.91096 μM SANGER
HCC2998 Growth Inhibition Assay IC50=1.93325 μM SANGER
HEL Growth Inhibition Assay IC50=1.94184 μM SANGER
SW684 Growth Inhibition Assay IC50=1.97371 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=1.98086 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=1.9821 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=2.00295 μM SANGER
DSH1 Growth Inhibition Assay IC50=2.01774 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=2.02049 μM SANGER
GB-1 Growth Inhibition Assay IC50=2.02577 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=2.04871 μM SANGER
SW954 Growth Inhibition Assay IC50=2.05036 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=2.05568 μM SANGER
AU565 Growth Inhibition Assay IC50=2.05905 μM SANGER
CW-2 Growth Inhibition Assay IC50=2.06875 μM SANGER
TE-1 Growth Inhibition Assay IC50=2.09377 μM SANGER
KP-4 Growth Inhibition Assay IC50=2.10312 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=2.10823 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=2.10986 μM SANGER
CAS-1 Growth Inhibition Assay IC50=2.11546 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=2.2269 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=2.28181 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=2.30088 μM SANGER
ESS-1 Growth Inhibition Assay IC50=2.3051 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=2.37024 μM SANGER
HT-1376 Growth Inhibition Assay IC50=2.38708 μM SANGER
LS-513 Growth Inhibition Assay IC50=2.38874 μM SANGER
KNS-42 Growth Inhibition Assay IC50=2.39105 μM SANGER
639-V Growth Inhibition Assay IC50=2.42758 μM SANGER
SJRH30 Growth Inhibition Assay IC50=2.45161 μM SANGER
SW1783 Growth Inhibition Assay IC50=2.47078 μM SANGER
NB6 Growth Inhibition Assay IC50=2.4828 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=2.4883 μM SANGER
HCE-4 Growth Inhibition Assay IC50=2.49402 μM SANGER
NB10 Growth Inhibition Assay IC50=2.49429 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=2.5465 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=2.55236 μM SANGER
HCC1395 Growth Inhibition Assay IC50=2.55655 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=2.5639 μM SANGER
SiHa Growth Inhibition Assay IC50=2.58719 μM SANGER
EFO-21 Growth Inhibition Assay IC50=2.58764 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=2.59076 μM SANGER
UMC-11 Growth Inhibition Assay IC50=2.59868 μM SANGER
COLO-679 Growth Inhibition Assay IC50=2.61233 μM SANGER
A388 Growth Inhibition Assay IC50=2.65253 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=2.65408 μM SANGER
EW-13 Growth Inhibition Assay IC50=2.68768 μM SANGER
MLMA Growth Inhibition Assay IC50=2.68856 μM SANGER
HOP-92 Growth Inhibition Assay IC50=2.7011 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=2.71442 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=2.72198 μM SANGER
769-P Growth Inhibition Assay IC50=2.7228 μM SANGER
SAS Growth Inhibition Assay IC50=2.765 μM SANGER
M059J Growth Inhibition Assay IC50=2.78318 μM SANGER
RD Growth Inhibition Assay IC50=2.79471 μM SANGER
GT3TKB Growth Inhibition Assay IC50=2.83433 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=2.86502 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=2.89504 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=2.91807 μM SANGER
MKN1 Growth Inhibition Assay IC50=3.00163 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=3.00451 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=3.02115 μM SANGER
KLE Growth Inhibition Assay IC50=3.06812 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=3.09343 μM SANGER
MC116 Growth Inhibition Assay IC50=3.11112 μM SANGER
SCC-9 Growth Inhibition Assay IC50=3.11366 μM SANGER
U031 Growth Inhibition Assay IC50=3.12423 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=3.23894 μM SANGER
U-266 Growth Inhibition Assay IC50=3.27633 μM SANGER
JVM-2 Growth Inhibition Assay IC50=3.32164 μM SANGER
UACC-257 Growth Inhibition Assay IC50=3.46431 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=3.46502 μM SANGER
BT-549 Growth Inhibition Assay IC50=3.50209 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=3.54158 μM SANGER
RH-18 Growth Inhibition Assay IC50=3.61798 μM SANGER
SW626 Growth Inhibition Assay IC50=3.71128 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=3.73247 μM SANGER
IGR-1 Growth Inhibition Assay IC50=3.74248 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=3.75336 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=3.82433 μM SANGER
D-247MG Growth Inhibition Assay IC50=3.86031 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=3.91271 μM SANGER
A253 Growth Inhibition Assay IC50=3.91436 μM SANGER
HT55 Growth Inhibition Assay IC50=3.91773 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=3.95864 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=3.96525 μM SANGER
SF268 Growth Inhibition Assay IC50=4.12881 μM SANGER
RMG-I Growth Inhibition Assay IC50=4.21454 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=4.21685 μM SANGER
S-117 Growth Inhibition Assay IC50=4.22024 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=4.30931 μM SANGER
J82 Growth Inhibition Assay IC50=4.33441 μM SANGER
CAL-72 Growth Inhibition Assay IC50=4.35477 μM SANGER
GP5d Growth Inhibition Assay IC50=4.41298 μM SANGER
UACC-62 Growth Inhibition Assay IC50=4.46545 μM SANGER
MS-1 Growth Inhibition Assay IC50=4.49115 μM SANGER
RCM-1 Growth Inhibition Assay IC50=4.5292 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=4.65359 μM SANGER
SW756 Growth Inhibition Assay IC50=4.69135 μM SANGER
HCC38 Growth Inhibition Assay IC50=4.71197 μM SANGER
YAPC Growth Inhibition Assay IC50=4.71313 μM SANGER
DK-MG Growth Inhibition Assay IC50=4.78112 μM SANGER
HCC1937 Growth Inhibition Assay IC50=4.85125 μM SANGER
OAW-28 Growth Inhibition Assay IC50=4.92435 μM SANGER
MEG-01 Growth Inhibition Assay IC50=5.08328 μM SANGER
GI-1 Growth Inhibition Assay IC50=5.23486 μM SANGER
FADU Growth Inhibition Assay IC50=5.27837 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=5.39432 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=5.45786 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=5.5052 μM SANGER
ONS-76 Growth Inhibition Assay IC50=5.55801 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=5.62566 μM SANGER
COLO-741 Growth Inhibition Assay IC50=5.71995 μM SANGER
HT-29 Growth Inhibition Assay IC50=5.80475 μM SANGER
HCC1187 Growth Inhibition Assay IC50=5.81008 μM SANGER
Capan-2 Growth Inhibition Assay IC50=5.95994 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=6.11441 μM SANGER
COLO-678 Growth Inhibition Assay IC50=6.15092 μM SANGER
D-502MG Growth Inhibition Assay IC50=6.17336 μM SANGER
NB17 Growth Inhibition Assay IC50=6.24943 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=6.2649 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=6.27118 μM SANGER
D-392MG Growth Inhibition Assay IC50=6.33399 μM SANGER
A498 Growth Inhibition Assay IC50=6.40302 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=6.45445 μM SANGER
HCC2157 Growth Inhibition Assay IC50=6.45616 μM SANGER
C3A Growth Inhibition Assay IC50=6.52004 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=6.70522 μM SANGER
DU-145 Growth Inhibition Assay IC50=6.7703 μM SANGER
COLO-829 Growth Inhibition Assay IC50=6.77873 μM SANGER
LS-1034 Growth Inhibition Assay IC50=7.04412 μM SANGER
HCC1954 Growth Inhibition Assay IC50=7.48134 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=7.48533 μM SANGER
Mo-T Growth Inhibition Assay IC50=7.51498 μM SANGER
OE19 Growth Inhibition Assay IC50=7.65503 μM SANGER
COR-L105 Growth Inhibition Assay IC50=7.71421 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=7.71521 μM SANGER
U-87-MG Growth Inhibition Assay IC50=8.03334 μM SANGER
MKN28 Growth Inhibition Assay IC50=8.11515 μM SANGER
HT-1197 Growth Inhibition Assay IC50=8.25907 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=8.34245 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=8.44331 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=9.06759 μM SANGER
TE-11 Growth Inhibition Assay IC50=9.45588 μM SANGER
ZR-75-30 Growth Inhibition Assay IC50=9.92634 μM SANGER
SW837 Growth Inhibition Assay IC50=10.2293 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=10.2326 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=10.4495 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=10.8365 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=11.0434 μM SANGER
FTC-133 Growth Inhibition Assay IC50=11.4051 μM SANGER
LAN-6 Growth Inhibition Assay IC50=12.124 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=12.5151 μM SANGER
Calu-6 Growth Inhibition Assay IC50=14.1021 μM SANGER
HCC70 Growth Inhibition Assay IC50=14.451 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=15.2159 μM SANGER
CAL-27 Growth Inhibition Assay IC50=15.3843 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=15.532 μM SANGER
no-10 Growth Inhibition Assay IC50=15.938 μM SANGER
U251 Growth Inhibition Assay IC50=16.3675 μM SANGER
TE-9 Growth Inhibition Assay IC50=17.5166 μM SANGER
TE-10 Growth Inhibition Assay IC50=19.0607 μM SANGER
COLO-824 Growth Inhibition Assay IC50=20.9276 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=21.0748 μM SANGER
KALS-1 Growth Inhibition Assay IC50=21.175 μM SANGER
L-428 Growth Inhibition Assay IC50=21.4016 μM SANGER
JAR Growth Inhibition Assay IC50=21.502 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=23.8475 μM SANGER
ABC-1 Growth Inhibition Assay IC50=26.7957 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=33.3464 μM SANGER
SW1463 Growth Inhibition Assay IC50=33.983 μM SANGER
SW1417 Growth Inhibition Assay IC50=37.0952 μM SANGER
NB12 Growth Inhibition Assay IC50=39.4655 μM SANGER
NY Growth Inhibition Assay IC50=41.3201 μM SANGER
H1048 Apoptosis Assay 500 nM 72 h nhances ABT-263–induced apoptosis 25737542
H86 Apoptosis Assay 500 nM 72 h nhances ABT-263–induced apoptosis 25737542
H196 Apoptosis Assay 500 nM 72 h nhances ABT-263–induced apoptosis 25737542
H446 Apoptosis Assay 500 nM 72 h nhances ABT-263–induced apoptosis 25737542
TFK-1 Growth Inhibition Assay 72 h DMSO IC50=47 nM 25152244
EGI-1 Growth Inhibition Assay 72 h DMSO IC50=53 nM 25152244
OCI/AML3 Growth Inhibition Assay 0.2 μM 48 h enhances cell growth inhibition induced by selumetinib 24739393
U937 Growth Inhibition Assay 0.2 μM 48 h enhances cell growth inhibition induced by selumetinib 24739393
MOLM13 Growth Inhibition Assay 0.2 μM 48 h enhances cell growth inhibition induced by selumetinib 24739393
MCF7 Growth Inhibition Assay 20 nM 72 h FBS reduces the PELP1-mediated increase in cell viability 24688046
TamR Growth Inhibition Assay IC50=18 nM 24457069
MCF7-X  Growth Inhibition Assay IC50=24 nM 24457069
T47D-tamR  Growth Inhibition Assay IC50=19 nM 24457069
293T  Function Assay 20 nM 3 h disrupts Akt-mediated TIF-IA stability, translocation, and activity 24363449
SW620 Growth Inhibition Assay 0.001-10μM 24 h inhibits the cell proliferation as the concentration rises 24363449
Huh7  Growth Inhibition Assay 5-100 nM 0-24 h DMSO increases cell death in a concentration- and time-dependent manner 24297300
Hep3B  Growth Inhibition Assay 5-100 nM 0-24 h DMSO increases cell death in a concentration- and time-dependent manner 24297300
Huh7  Function Assay 100 nM 12 h DMSO induces autophagy  24297300
U87-MG  Growth Inhibition Assay 72 h GI50 = 79 nM  24249640
 L3.6pl Growth Inhibition Assay 1 μM 72 h inhibits the cell growth combined with BMS-777607 24233399
TE671 Apoptosis Assay 1 μM 48 h increases cell apoptosis induced by ABT-737 24133218
RD Apoptosis Assay 1 μM 48 h increases cell apoptosis induced by ABT-737 24133218
RMS13 Apoptosis Assay 1 μM 48 h increases cell apoptosis induced by ABT-737 24133218
RH30 Apoptosis Assay 1 μM 48 h increases cell apoptosis induced by ABT-737 24133218
Hep-2 Growth Inhibition Assay 0.01-1 μM 12-96 h increases cell death in a concentration- and time-dependent manner 24103749
SCC-9 Growth Inhibition Assay 0.01-1 μM 12-96 h increases cell death in a concentration- and time-dependent manner 24103749
Hep-2 Function Assay 0.1/0.5 μM 24 h blocks mTORC1 and mTORC2 activation 24103749
SCC-9 Function Assay 0.1/0.5 μM 24 h blocks mTORC1 and mTORC2 activation 24103749
PANC-1 Apoptosis Assay 500 nM 48 h sensitizes pancreatic cancer cells to radiotherapy 23886294
RMG2 Apoptosis Assay 1-1000 nM 72 h FBS inhibits the cell viability concentration dependently 23615631
HAC2 Apoptosis Assay 1-1000 nM 72 h FBS inhibits the cell viability concentration dependently 23615631
HT-29 Apoptosis Assay 1 μM 72 h attenuates 5-FU-induced cell death 21949121
DLD1 Apoptosis Assay 1 μM 72 h attenuates 5-FU-induced cell death 21949121
HT-29 Function Assay 1 μM 72 h induces autophagy to confer cytoprotection 21949121
DLD1 Function Assay 1 μM 72 h induces autophagy to confer cytoprotection 21949121
Rh41 Growth Inhibition Assay IC50=30.7 nM 21337679
Rh18 Growth Inhibition Assay IC50=41.4 nM 21337679
Rh30 Growth Inhibition Assay IC50=14 nM 21337679
BT-12 Growth Inhibition Assay IC50=24.7 nM 21337679
CHLA-266 Growth Inhibition Assay IC50=1.1 nM 21337679
TC-71 Growth Inhibition Assay IC50=46.5 nM 21337679
CHLA-9 Growth Inhibition Assay IC50=15.3 nM 21337679
CHLA-10 Growth Inhibition Assay IC50=3.9 nM 21337679
CHLA-258 Growth Inhibition Assay IC50=10.4 nM 21337679
GBM2 Growth Inhibition Assay IC50=40.7 nM 21337679
NB-1643 Growth Inhibition Assay IC50=33.8 nM 21337679
NB-EBc1 Growth Inhibition Assay IC50=27.1 nM 21337679
CHLA-90 Growth Inhibition Assay IC50=34.5 nM 21337679
CHLA-136 Growth Inhibition Assay IC50=162.6 nM 21337679
NALM-6 Growth Inhibition Assay IC50=32.9 nM 21337679
COG-LL-317 Growth Inhibition Assay IC50=1.3 nM 21337679
RS4;11 Growth Inhibition Assay IC50=35 nM 21337679
MOLT-4 Growth Inhibition Assay IC50=8.6 nM 21337679
CCRF-CEM Growth Inhibition Assay IC50=4.1 nM 21337679
Kasumi-1 Growth Inhibition Assay IC50=1.4 nM 21337679
Karpas-299 Growth Inhibition Assay IC50=21.7 nM 21337679
Ramos-RA1 Growth Inhibition Assay IC50=8.2 nM 21337679
H838 Function Assay 1 μM 48 h induces cell autophagy 20364113
H838 Growth Inhibition Assay 0-3 μM 72 h induces growth inhibition and autophagy 20028854
A549  Growth Inhibition Assay 0-3 μM 72 h induces growth inhibition and autophagy 20028854
Click to View More Cell Line Experimental Data

Biological Activity

Description AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
Features First drug to inhibit both types of mTOR protein.
Targets
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM
In vitro
In vitro AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. [1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. [2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. [3]
Kinase Assay Cell-based determinations of mTOR inhibition
A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research Cell lines U87MG, A549 and H838 cells
Concentrations 1 nM - 1 μM
Incubation Time 72 to 96 hours
Method Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting.
Experimental Result Images Methods Biomarkers Images PMID
Western blot p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40 p-EGFR / EGFR p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a 24457069
Immunofluorescence p-4EBP1 / EIF4E / mTOR LC3B / p62 24600487
Growth inhibition assay Cell viability 29263324
In Vivo
In vivo AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. [1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. [4]
Animal Research Animal Models U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk).
Dosages 2.5-20 mg/kg
Administration Oral gavage once or twice daily
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01316809 Completed
Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
March 4 2011 Phase 1
NCT00999882 Completed
Cancer|Advanced Hepatocellular Carcinoma
AstraZeneca
October 2009 Phase 1
NCT00973076 Completed
Cancer|Solid Tumors|Advanced Solid Malignancies
AstraZeneca
August 2009 Phase 1
NCT00731263 Completed
Solid Tumors
AstraZeneca
July 2008 Phase 1
NCT01194193 Withdrawn
Cancer|Advanced Solid Tumours|Lymphomas
AstraZeneca
Phase 1

Chemical Information & Solubility

Molecular Weight 465.54 Formula

C25H31N5O4

CAS No. 1009298-09-2 SDF Download AZD8055 SDF
Smiles CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 93 mg/mL ( (199.76 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 93 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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