AZD8055

Catalog No.S1555

AZD8055 Chemical Structure

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

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In DMSO USD 156 In stock
USD 120 In stock
USD 370 In stock

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Cited by 37 Publications

7 Customer Reviews

  • PC3-LN4 cells were treated with GSK690693 (5 uM) alone, or in combination with PP242 (2 uM) or AZD8055 (1 uM) for 24 h, and immunoblotting performed.

    Cancer Res 2013 73(11), 3402-11. AZD8055 purchased from Selleck.

    HUVEC were treated with either RAD001 or AZD8055 before PA treatment. p53, GPX1, p53 acetylation, and subcellular PTEN were analyzed with corresponding antibodies. The blot is a representative of the results of three experiments. Values (mean盨D) are expressed as fold over untreated control. *p<0.05 versus their corresponding control groups in the one-way ANOVA.

    Antioxid Redox Signal 2014 20(9), 1382-95. AZD8055 purchased from Selleck.

  • (A) HCT116 or MDA-MB-468 cells were treated with 500 nM AZD8055 for the indicated times. Cell lysates were immunoblotted with the indicated antibodies. (B) HCT116 or MDA-MB-468 cells were treated with 50 nM rapamycin. 500 nM AZD8055, 1 uM MK2206 or dimethyl sulfoxide (DMSO) as control for 12 h. Cell lysates were immunoblotted with the indicated antibodies.

    Oncotarget 2014 5(15), 6015-27. AZD8055 purchased from Selleck.

    CSCs+24/44/ESA at 5,000 cells per well with stem cell culture media in triplicate in an ultra-low adhesion plate were treated with 5 umol/L BMS-777607, 1 umol/L AZD8055 alone, or in their different combinations. Cells were cultured for 72 hours. Cell viability was determined by the MTS assay. Percentages of polyploid cells were determined by counting 300 cells from two different regions. Results shown here were from one of two experiments with similar results.

    Mol Cancer Ther 2014 13(1), 37-48. AZD8055 purchased from Selleck.

  • mTOR kinase inhibitor AZD8055 activates PI3K accompanied with induction of expression of EGFR, HER2, HER3 and IRS1. Serum-deprived CHO-EGFP-AKT cells were incubated with 50 nM AZD8055 for 24 hr. The EGFP signal was detected using confocal microscopy. The white arrows indicate EGFP-AKT located on cellular membrane.

    Int J Cancer 2014 135(10), 2462-74. AZD8055 purchased from Selleck.

    mTOR, P70S6K1, 4E-BP1 and PCNA activation in the basilar artery of SAH. Top, Western blotting bands of antibodies, bottom, density of the protein band from each group. A, mTOR activation in the basilar artery demonstrated an elevated expression of mTOR on day 7 following SAH in SAH and SAH+DMSO animals. The mTOR inhibitors, Rapamycin and AZD8055 reduced the enhanced expression of mTOR (pb0.05, ANOVA). B. P70S6K1 activation. C. 4E-BP1 activation. D. PCNA activation. Rapamycin and AZD8055 significantly decreased the expression of P70S6K1, 4E-BP1 and PCNA compared with the SAH and SAH+DMSO (pb0.05, respectively; ANOVA). There was no significant difference between the two inhibitors in mTOR, P70S6K1, 4E-BP1 and PCNA expression.

    Exp Neurol 2012 233, 799-806. AZD8055 purchased from Selleck.

  • After starved in serum-free medium for 24h , A549 cells incubated with the indicated concentrations of AZD8055 for 3h , followed by 20-minute stimolation of 100ng/ml EGF

     
     

     

    Dr. Zhang of Tianjin Medical University. AZD8055 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.
Features First drug to inhibit both types of mTOR protein.
Targets
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
DNA-PK [1]
(MDA-MB-468 cells)
PI3Kδ [1]
(MDA-MB-468 cells)
PI3Kα [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM 1370 nM 3200 nM 3590 nM
In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. [1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. [2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHBTFhKSzVyPUCuNFI{OzFizszN MX;TRW5ITVJ?
NCI-H720 M1zy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TYb2lEPTB;MD6wNlk{QCEQvF2= NWjJXGl3W0GQR1XS
KARPAS-45 NYnReIR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LkemlEPTB;MD6wN|M4OSEQvF2= M1jCWXNCVkeHUh?=
EW-3 NG\OcWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3RfXVKSzVyPUCuNFQxPTZizszN NF30e3VUSU6JRWK=
SBC-1 M1v4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3UNFdWUUN3ME2wMlA1PThzIN88US=> MmW3V2FPT0WU
NCI-H209 NGDIUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\OTWM2OD1yLkC1OFU{KM7:TR?= NGnkSYJUSU6JRWK=
EoL-1-cell M1ryUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ra[WlEPTB;MD6wOlU3QSEQvF2= NXXBZVZ2W0GQR1XS
H9 M1n2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;IWlBXUUN3ME2wMlA3Pjl{IN88US=> M1jkSXNCVkeHUh?=
AN3-CA NXPxW4duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjVTWM2OD1yLkC3PVUyKM7:TR?= NW\hXlFvW0GQR1XS
HH MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzDTWM2OD1yLkC4NFA6KM7:TR?= M3P2UnNCVkeHUh?=
KU812 NV75NGhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfBbG1KSzVyPUCuNFgxPDNizszN NEnMfnhUSU6JRWK=
DU-4475 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHNTWM2OD1yLkC4NFQ4KM7:TR?= NWjYV5VqW0GQR1XS
CTV-1 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn6bY1KSzVyPUCuNFg3PDFizszN M1TjNnNCVkeHUh?=
BV-173 MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{POPWlEPTB;MD6wPVA3OSEQvF2= MVrTRW5ITVJ?
ES5 M2flWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf4eIZZUUN3ME2wMlA6OzVizszN NX\TRYh2W0GQR1XS
G-402 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fLe2lEPTB;MD6wPVk5KM7:TR?= MWfTRW5ITVJ?
MV-4-11 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjNbIZjUUN3ME2wMlExOzR5IN88US=> NH3GZXdUSU6JRWK=
NB69 NHu2RVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMUO1JO69VQ>? NUTlOWZrW0GQR1XS
EGI-1 NHPmPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm1[YRtUUN3ME2wMlE{PTNzIN88US=> MmLHV2FPT0WU
EW-18 NX;xZ5pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu3TWM2OD1yLkG0NFc{KM7:TR?= M{LL[HNCVkeHUh?=
ME-180 NHflSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XpT2lEPTB;MD6xOFY5OSEQvF2= M4S3SnNCVkeHUh?=
D-283MED MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjkXpdwUUN3ME2wMlE1PzJ|IN88US=> NInOUFdUSU6JRWK=
NB14 NXjvelhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMU[0OFch|ryP M{Lk[3NCVkeHUh?=
Ramos-2G6-4C10 NXX6Z4tRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\oWFdDUUN3ME2wMlE3QTh|IN88US=> MkLwV2FPT0WU
NBsusSR M{[4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r5emlEPTB;MD6xO|AyQSEQvF2= MlnEV2FPT0WU
LAMA-84 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\jcmlEPTB;MD6xPFA{OiEQvF2= NWPuPJNEW0GQR1XS
NCI-H1581 M4rxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\MTWM2OD1yLkG4PVY3KM7:TR?= Ml\BV2FPT0WU
A204 NWO5VoVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWWzZ5NJUUN3ME2wMlE5QTdizszN NHfhSoVUSU6JRWK=
A549 MkTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTVTnFKSzVyPUCuNVk2PSEQvF2= MULTRW5ITVJ?
CAL-51 NI\H[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMUm2OVEh|ryP Mn;VV2FPT0WU
NKM-1 NHXRZ5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;HTWM2OD1yLkKwNFI6KM7:TR?= NYDR[IF{W0GQR1XS
LoVo M2PBN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjwWoxbUUN3ME2wMlIxOjB{IN88US=> MVnTRW5ITVJ?
HAL-01 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWmwUXdCUUN3ME2wMlIxOjl5IN88US=> NXPYcJJtW0GQR1XS
HCC2218 M{fURmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H4Z2lEPTB;MD6yNFY5QCEQvF2= M2\DR3NCVkeHUh?=
BEN Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMkGyPVMh|ryP NYjPRlVVW0GQR1XS
LC-2-ad MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPuTWM2OD1yLkKyNFg1KM7:TR?= MYLTRW5ITVJ?
LXF-289 NF3LbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHTTWM2OD1yLkK1NFQyKM7:TR?= NGXCbFlUSU6JRWK=
HGC-27 MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMk[0NVQh|ryP MXfTRW5ITVJ?
LK-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW3VWNTUUN3ME2wMlI3QDJ2IN88US=> MVXTRW5ITVJ?
CTB-1 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD1yLkK3NlE2KM7:TR?= NH3kUFNUSU6JRWK=
697 NFXye4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMkezOlch|ryP MXnTRW5ITVJ?
ES7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMkezPFMh|ryP M{DRRXNCVkeHUh?=
MG-63 NInH[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMke0NFch|ryP NVLISJBoW0GQR1XS
T47D NGToN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TRd2lEPTB;MD6yO|Q4PSEQvF2= NEfiXVJUSU6JRWK=
RPMI-8226 M2X5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PJe2lEPTB;MD6yPFU5QSEQvF2= MW\TRW5ITVJ?
NCI-H292 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkmxOlQh|ryP NHXBbXVUSU6JRWK=
HT MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMkmzPEDPxE1? M2nFOnNCVkeHUh?=
A3-KAW MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMkm3OEDPxE1? MojnV2FPT0WU
LB2241-RCC NYPVcmJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnWN4pEUUN3ME2wMlMxOTl6IN88US=> MlG3V2FPT0WU
BB65-RCC MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwM{C4NFUh|ryP NXzkSZlFW0GQR1XS
G-401 M37kOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwM{C5PFYh|ryP NFraRm5USU6JRWK=
TYK-nu Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwM{G4OlQh|ryP MWLTRW5ITVJ?
NCI-SNU-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrPUIk1UUN3ME2wMlMzOzNzIN88US=> NWGwSJRbW0GQR1XS
CHL-1 NUnvVYo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DQemlEPTB;MD6zNlcxOyEQvF2= NIPTN5dUSU6JRWK=
P30-OHK NFnsXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{K3NFUh|ryP M3jGNHNCVkeHUh?=
PA-1 NEXzd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DzcGlEPTB;MD6zN|YyQSEQvF2= NFX4WVVUSU6JRWK=
LB1047-RCC NH3CdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVThZppkUUN3ME2wMlM1ODR5IN88US=> Ml3hV2FPT0WU
EM-2 MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17zO2lEPTB;MD6zOFE5QCEQvF2= NYnEcVRyW0GQR1XS
VA-ES-BJ NVz4bXc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXUbZpwUUN3ME2wMlM1OjZ6IN88US=> M4H5dHNCVkeHUh?=
NCI-H520 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e2fmlEPTB;MD6zOFg{PCEQvF2= MYDTRW5ITVJ?
ECC10 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rMTmlEPTB;MD6zOVA{PSEQvF2= NHXhR5NUSU6JRWK=
LNCaP-Clone-FGC NVv1RZlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLoTWM2OD1yLkO1N|E1KM7:TR?= NFXCRlRUSU6JRWK=
ES8 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fwUWlEPTB;MD6zOlU2OyEQvF2= MmnEV2FPT0WU
HuO-3N1 MnfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fjWmlEPTB;MD6zPFM4QSEQvF2= MmD5V2FPT0WU
L-363 NEjvUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrU2xKSzVyPUCuN|kxOjZizszN MlzzV2FPT0WU
SK-LU-1 M174OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\a[Y5KSzVyPUCuN|kzODhizszN NHXYbYpUSU6JRWK=
MCF7 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPzVoVKSzVyPUCuOFA2OyEQvF2= MoHLV2FPT0WU
HuO9 NEHxU3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETu[mZKSzVyPUCuOFA3PjdizszN NFrHelJUSU6JRWK=
BHT-101 M2ixWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzOUlNYUUN3ME2wMlQxPzh5IN88US=> MlvXV2FPT0WU
MZ2-MEL Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrmTWM2OD1yLkSwPFgzKM7:TR?= MlLUV2FPT0WU
NOS-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XnSGlEPTB;MD60NVA4PCEQvF2= NHWzcYtUSU6JRWK=
NEC8 NUSycot2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUizUZd3UUN3ME2wMlQyPjl3IN88US=> M2m2THNCVkeHUh?=
COR-L88 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwNEKyOlch|ryP NHnUfVVUSU6JRWK=
MFM-223 M{\O[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnaTYVLUUN3ME2wMlQzPjF5IN88US=> M4KybHNCVkeHUh?=
HSC-3 NGX6S3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q2TGlEPTB;MD60NlkxQCEQvF2= NHXi[GZUSU6JRWK=
OVCAR-5 M1vROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfLSVBKSzVyPUCuOFI6OzNizszN MoP3V2FPT0WU
MFE-280 M1PrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzZTWM2OD1yLkSzNFMzKM7:TR?= M2\ZXHNCVkeHUh?=
KP-N-YS NGW5TIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfvbVNKSzVyPUCuOFMxPyEQvF2= NF;RSmtUSU6JRWK=
EPLC-272H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHxd2NKSzVyPUCuOFMxPzdizszN Mo\RV2FPT0WU
KE-37 M37wUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwNEOyOFch|ryP M2n5dXNCVkeHUh?=
HuH-7 NUXMZolKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\reGlEPTB;MD60N|M4OiEQvF2= MkjiV2FPT0WU
CHP-212 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwNEO2PVch|ryP M4PDVXNCVkeHUh?=
SK-MES-1 MkGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTHTWM2OD1yLkSzPFQ5KM7:TR?= NFXKVFBUSU6JRWK=
SJSA-1 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwNES1OVQh|ryP NIfKS|NUSU6JRWK=
QIMR-WIL MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG0TWM2OD1yLkS1NVUh|ryP M{XxcHNCVkeHUh?=
ES4 NFLWSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jmZWlEPTB;MD60OVM{PiEQvF2= M3K3U3NCVkeHUh?=
TI-73 NXroUmxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwNEW2PFYh|ryP MVjTRW5ITVJ?
COLO-684 NX\GZ4M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDSWtLUUN3ME2wMlQ2PzJ4IN88US=> NF7IOolUSU6JRWK=
GCIY NXzMfI97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr4TWM2OD1yLkS1O|U1KM7:TR?= Mn3DV2FPT0WU
JVM-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnJ[phtUUN3ME2wMlQ3Ojl{IN88US=> Mo\sV2FPT0WU
MPP-89 M2fBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnHepdvUUN3ME2wMlQ3QTR5IN88US=> M3nUNnNCVkeHUh?=
M14 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC4TWM2OD1yLkS3NVch|ryP NInUeHZUSU6JRWK=
SW962 M4P0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLTRVVvUUN3ME2wMlQ4OTlizszN NW\WUFRtW0GQR1XS
VM-CUB-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwNEeyPFYh|ryP NHT2VIVUSU6JRWK=
A101D NWLOW3pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrieFZUUUN3ME2wMlQ5QTZ6IN88US=> MnT3V2FPT0WU
DB M{LrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HQeWlEPTB;MD61NFAzOSEQvF2= NHPMSo5USU6JRWK=
KNS-62 M1vGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwNUC1Olgh|ryP MVrTRW5ITVJ?
NCI-H460 M3e0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfsTWM2OD1yLkWwOVk4KM7:TR?= MoS5V2FPT0WU
MDA-MB-361 Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3JTWM2OD1yLkWwPFch|ryP NUHoZ5MxW0GQR1XS
DOK NEKxOJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70b4tKSzVyPUCuOVE{OzNizszN MYjTRW5ITVJ?
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MOLT-16 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7RV3k{UUN3ME2wMlk{QDR3IN88US=> M3;WPXNCVkeHUh?=
ACN M4ri[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTZfnk4UUN3ME2wMlk1Ojd5IN88US=> NVzXfpNUW0GQR1XS
SNU-449 NH32dolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwOUW5NlQh|ryP NYXpW|VPW0GQR1XS
A427 M2nuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfzTWM2OD1yLkm2NVk5KM7:TR?= NV;vc45MW0GQR1XS
DEL NXLsTpp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi4eItKSzVyPUCuPVY4PzNizszN NX;HOnFFW0GQR1XS
NCI-H1792 NUnJSXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvWTWM2OD1yLkm3NVAyKM7:TR?= NEf2UlVUSU6JRWK=
A2058 MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwOUezOkDPxE1? M2rUdHNCVkeHUh?=
SW13 MoD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnPU5dKSzVyPUCuPVg{QTJizszN M2DXdnNCVkeHUh?=
T98G MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\NcYdkUUN3ME2xMlAyOzZ2IN88US=> NEXzXXhUSU6JRWK=
LU-134-A NHmyWWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFwMEK2O|Uh|ryP Mn;0V2FPT0WU
GI-ME-N NIH4bHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLlToNKSzVyPUGuNFI5OjdizszN NFe2SWhUSU6JRWK=
D-423MG NEXmVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX0W4I{UUN3ME2xMlAzQTZ|IN88US=> M2XyPHNCVkeHUh?=
PANC-03-27 M1rI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TBeGlEPTB;MT6wN|E1OSEQvF2= NIPkOnVUSU6JRWK=
P12-ICHIKAWA MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwMEO0NFYh|ryP MWPTRW5ITVJ?
SCH MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTFwMEO0OUDPxE1? Mkf6V2FPT0WU
D-566MG NIf2NpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\xT3lKSzVyPUGuNFY4OjZizszN NFnNV3VUSU6JRWK=
OS-RC-2 M2nsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W3T2lEPTB;MT6wO|k1KM7:TR?= NHfZenpUSU6JRWK=
KOSC-2 M2XCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LUfWlEPTB;MT6wPFAzOSEQvF2= MoK2V2FPT0WU
SH-4 NFHjT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LwZmlEPTB;MT6wPFQ{OSEQvF2= M4\vU3NCVkeHUh?=
786-0 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjDTWVCUUN3ME2xMlA5QTN2IN88US=> MoLSV2FPT0WU
Mewo M1nNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jXUmlEPTB;MT6wPVI1QCEQvF2= Mlf5V2FPT0WU
AGS MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTFwMEm0OVkh|ryP MnizV2FPT0WU
Daoy NGDSPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHlTWM2OD1zLkC5OlI5KM7:TR?= M{\Xb3NCVkeHUh?=
SW48 NUDNRmNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPxTWM2OD1zLkGwPVEyKM7:TR?= NFO2U4tUSU6JRWK=
KYSE-180 NUfDe2V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvyZmJIUUN3ME2xMlEyODJzIN88US=> MmPVV2FPT0WU
NH-12 M{DPd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj2TWM2OD1zLkGxNlM4KM7:TR?= NWK4XWdVW0GQR1XS
BE-13 Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWOwdFhFUUN3ME2xMlEyPzV7IN88US=> NUTFTG16W0GQR1XS
ES3 NUT5[3NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFwMUOxO|Eh|ryP M33pdXNCVkeHUh?=
NCI-H1092 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\t[mlEPTB;MT6xN|Qh|ryP NG\MUoVUSU6JRWK=
NCI-H1755 M1fCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH74cpZKSzVyPUGuNVM6PDFizszN NEiwZpBUSU6JRWK=
EKVX MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTmN4w1UUN3ME2xMlE1ODBzIN88US=> NV;FRmRLW0GQR1XS
NB13 NGraXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW2WZdKSzVyPUGuNVQ1PSEQvF2= MYjTRW5ITVJ?
NCI-H2405 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zGfmlEPTB;MT6xOFU4PCEQvF2= NILUUHVUSU6JRWK=
LS-411N M13uc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfLdY5KSzVyPUGuNVUxOTdizszN NF3ocHhUSU6JRWK=
MDA-MB-453 NGnuVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwMUW2NlQh|ryP MUPTRW5ITVJ?
SCC-15 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTFwMU[5OVYh|ryP NIjudGdUSU6JRWK=
C2BBe1 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL0dG5iUUN3ME2xMlE4ODV4IN88US=> MV;TRW5ITVJ?
HT-144 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLvUFFKSzVyPUGuNVcxPyEQvF2= M4LyfnNCVkeHUh?=
HEC-1 NILWNYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFwMUe2Nlch|ryP NULjRm1qW0GQR1XS
HCE-T NGnxenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFwMUe5PFMh|ryP M4L6T3NCVkeHUh?=
IST-MEL1 NWOxUo5JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXiOmVKSzVyPUGuNVkxQDJizszN M{f0bnNCVkeHUh?=
Detroit562 NXLkUHJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfqTFJSUUN3ME2xMlE6PDN7IN88US=> MXrTRW5ITVJ?
A4-Fuk NHfaeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwMkC0OFEh|ryP M2XVPXNCVkeHUh?=
HDLM-2 NX7rOIV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17uNWlEPTB;MT6yNVMzPiEQvF2= Mn\mV2FPT0WU
MKN7 NWPSb|dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTFwMkG3NFIh|ryP NHfG[XBUSU6JRWK=
MDA-MB-415 NUi4Z|BCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHoR29pUUN3ME2xMlIyPzB{IN88US=> NV;FbpdGW0GQR1XS
BT-20 NWPOe4FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDjO25KSzVyPUGuNlI1PDRizszN NUPiRZJ7W0GQR1XS
NCI-H2030 NWrFd|lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSzTWM2OD1zLkK0NVA3KM7:TR?= MXzTRW5ITVJ?
LS-123 M1rUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFwMkS3OVMh|ryP M2\tTXNCVkeHUh?=
SK-MEL-3 NFKxeW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XVbmlEPTB;MT6yOFc4PiEQvF2= M2PVZnNCVkeHUh?=
KS-1 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jp[mlEPTB;MT6yOVE4OSEQvF2= MnrsV2FPT0WU
LU-65 NHjYNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDGeYU2UUN3ME2xMlI2PjB4IN88US=> NXnBXmtwW0GQR1XS
NCI-H596 NITRcJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTITWM2OD1zLkK1PVI6KM7:TR?= NEj2N5lUSU6JRWK=
KYSE-410 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPOVHd7UUN3ME2xMlI4ODF2IN88US=> M1TwTXNCVkeHUh?=
NCI-H2228 NYnuOZpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i0O2lEPTB;MT6yO|E3PyEQvF2= M1m4UHNCVkeHUh?=
LN-405 M3vPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonKTWM2OD1zLkK4NFIyKM7:TR?= M1u2eXNCVkeHUh?=
8505C NHnzWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm1TWM2OD1zLkK4PFI{KM7:TR?= MWXTRW5ITVJ?
BFTC-909 NIPUNIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwMkm0N|Qh|ryP Ml;KV2FPT0WU
OC-314 NXP5V5JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqzbHRQUUN3ME2xMlI6QTJ7IN88US=> NV\2N|ltW0GQR1XS
NMC-G1 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELVbFdKSzVyPUGuN|EyOzVizszN NWDpOnlqW0GQR1XS
SKG-IIIa MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LMdmlEPTB;MT6zNVQzQCEQvF2= MUDTRW5ITVJ?
GAK MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\aTWM2OD1zLkOxPFU5KM7:TR?= M2\vZXNCVkeHUh?=
D-263MG M3zOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\HVG5KSzVyPUGuN|I3PDFizszN NFnn[YVUSU6JRWK=
NCI-H446 NV;obnd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFwM{K5NFIh|ryP NX\ZVJZvW0GQR1XS
TGBC1TKB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3pTWM2OD1zLkOyPVk5KM7:TR?= MoPIV2FPT0WU
GCT NV25RVdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvWb5BKSzVyPUGuN|Q{PDVizszN MoXLV2FPT0WU
COR-L23 M174NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTFwM{S4OFUh|ryP MkHZV2FPT0WU
TK10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHzTWM2OD1zLkO1O|k4KM7:TR?= M3zTUXNCVkeHUh?=
ES6 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36xXWlEPTB;MT6zOlM4PiEQvF2= NFjSNlVUSU6JRWK=
SW1088 NUPMUXg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPwT4FiUUN3ME2xMlM3PjF{IN88US=> NGKw[GpUSU6JRWK=
AM-38 NYiwVopwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\WTWM2OD1zLkO3NVk6KM7:TR?= Mn7lV2FPT0WU
CHP-134 NVOxPGVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTFwM{e4OFQh|ryP M2rnZ3NCVkeHUh?=
SW872 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPoXnZbUUN3ME2xMlM5PTV3IN88US=> NXjDWo1ZW0GQR1XS
LB831-BLC NH\FOnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml73TWM2OD1zLkO5NFY4KM7:TR?= MmS4V2FPT0WU
TE-12 Mn7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;uTWM2OD1zLkSwOlAyKM7:TR?= MmLiV2FPT0WU
LCLC-97TM1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j1V2lEPTB;MT60NVA1PiEQvF2= M3zhfnNCVkeHUh?=
HCT-116 M2nBVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwNEK4OVQh|ryP MWHTRW5ITVJ?
ALL-PO NYTr[5d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjiUXJKSzVyPUGuOFM4PzRizszN NX[yd|k{W0GQR1XS
EW-16 Moi1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwNEO4OFIh|ryP MV\TRW5ITVJ?
NCI-H661 NF3oWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3wcYtKSzVyPUGuOFQ4PzVizszN Mo\EV2FPT0WU
TE-8 M1nSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW5c|BsUUN3ME2xMlQ2PTZizszN NHH6Sm1USU6JRWK=
TCCSUP M2T4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKzTWM2OD1zLkS2PVYh|ryP M4HMcnNCVkeHUh?=
SW1990 NGTDXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwNEe1N|Mh|ryP NYC5OHZjW0GQR1XS
UM-UC-3 M4PvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7CRVJ[UUN3ME2xMlQ4Pjd3IN88US=> M4PXbHNCVkeHUh?=
HuP-T4 NFjWNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXtTWM2OD1zLkS4OlA4KM7:TR?= MUDTRW5ITVJ?
NCI-H1299 NXH4O2dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGwWJFVUUN3ME2xMlUxODh4IN88US=> M335RnNCVkeHUh?=
RO82-W-1 M2PzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;1TWM2OD1zLkWyNFgyKM7:TR?= M4nsNnNCVkeHUh?=
Becker NUSzU3V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTVXldWUUN3ME2xMlUzOTh5IN88US=> MlPTV2FPT0WU
SNU-387 Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFwNUKyOFEh|ryP NHvNdplUSU6JRWK=
CAL-85-1 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nyXWlEPTB;MT61NlU6QSEQvF2= MVLTRW5ITVJ?
647-V MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDITWM2OD1zLkWzPFgh|ryP MkO4V2FPT0WU
SBC-5 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHLTWM2OD1zLkW0OVk{KM7:TR?= Ml7CV2FPT0WU
NCI-H23 NH3BSnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXlToo3UUN3ME2xMlU2PzF2IN88US=> NGPXU5dUSU6JRWK=
CGTH-W-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHWxclhKSzVyPUGuOVU5OTlizszN M{HkUXNCVkeHUh?=
SK-N-FI NIXjNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjiVFFKSzVyPUGuOVU6ODhizszN MUPTRW5ITVJ?
KM-H2 M4rNb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[1WG1KSzVyPUGuOVY1PzRizszN NYnLZppHW0GQR1XS
KY821 NWrWZWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXHWGM3UUN3ME2xMlU3PjF5IN88US=> NFrsO4VUSU6JRWK=
RH-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S3SmlEPTB;MT61Olc3OiEQvF2= MWDTRW5ITVJ?
KYSE-270 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFwNUe0NlMh|ryP NEP6e4ZUSU6JRWK=
SF539 NGjRS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwNUe5Olkh|ryP MX;TRW5ITVJ?
JEG-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXHTWM2OD1zLkW4NFk1KM7:TR?= M{XKVnNCVkeHUh?=
SCC-25 NXjFZYVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\tOotXUUN3ME2xMlU5PDN{IN88US=> NVjkO4N7W0GQR1XS
SW1573 NGrZe|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwNkCxOVgh|ryP NGLpVG1USU6JRWK=
EW-1 M1n4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzlTWM2OD1zLk[xN|UyKM7:TR?= MW\TRW5ITVJ?
YKG-1 NYXweYJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fROWlEPTB;MT62NVQ{QCEQvF2= NIPvR|dUSU6JRWK=
EW-11 NHvWOmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPYe5BHUUN3ME2xMlYyPzRzIN88US=> Mn;uV2FPT0WU
DJM-1 NHnXPWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn73TWM2OD1zLk[xPFI2KM7:TR?= MkHJV2FPT0WU
Calu-3 NIO3b|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Sz[GlEPTB;MT62OVIyOyEQvF2= MXnTRW5ITVJ?
HT-3 NETqdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHiSXBKSzVyPUGuOlU3PiEQvF2= MnzuV2FPT0WU
NCI-H69 NES4eZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXGNFBKSzVyPUGuOlc{PDNizszN NFHlXWJUSU6JRWK=
NCI-H2126 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:xfVZbUUN3ME2xMlY4Pzl5IN88US=> NVL0VppWW0GQR1XS
RPMI-2650 M{noR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnoU3BKSzVyPUGuOlg{OTdizszN NHXLeIlUSU6JRWK=
TE-6 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm2TWM2OD1zLkewPFc1KM7:TR?= NFzJOXdUSU6JRWK=
MDA-MB-231 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXQSmdKSzVyPUGuO|E6QTNizszN NVHqeWxRW0GQR1XS
A2780 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwN{KyNFch|ryP M2GwW3NCVkeHUh?=
GOTO MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzB[YNKSzVyPUGuO|M2PiEQvF2= NW\EbpRTW0GQR1XS
KYSE-70 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCzTWM2OD1zLke0OFQzKM7:TR?= MULTRW5ITVJ?
GMS-10 M1y3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwN{S2OlIh|ryP M4TmSnNCVkeHUh?=
CaR-1 NHHjS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG5UXZKSzVyPUGuO|Q5OTJizszN MX3TRW5ITVJ?
SW900 M1XSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NISyVXRKSzVyPUGuO|Q6QTNizszN NXHmcI1PW0GQR1XS
BB49-HNC NEDSN4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H4b2lEPTB;MT63OVE3QCEQvF2= MW\TRW5ITVJ?
SNB75 NXHFb49PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHWTWM2OD1zLke1OFkzKM7:TR?= NVizcG5uW0GQR1XS
SK-PN-DW NILURmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO2TWM2OD1zLke1OlgzKM7:TR?= Mne0V2FPT0WU
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U-118-MG M1POZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfCeGVpUUN3ME2xMlg1PjJ{IN88US=> NHW0T5BUSU6JRWK=
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AU565 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ve3BjUUN3ME2yMlA2QTB3IN88US=> MVHTRW5ITVJ?
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NCI-H1155 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPhTWM2OD1{LkKyOlkh|ryP MnLoV2FPT0WU
SK-MEL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC4OWFxUUN3ME2yMlI5OThzIN88US=> Mn3sV2FPT0WU
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CAL-72 NYrkellQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXoZnVbUUN3ME20MlM2PDd5IN88US=> M2TIcHNCVkeHUh?=
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UACC-62 NEPnTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjhR2FyUUN3ME20MlQ3PTR3IN88US=> MWrTRW5ITVJ?
MS-1 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33BW2lEPTB;ND60PVEyPSEQvF2= Mmr3V2FPT0WU
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YAPC MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[0XmlEPTB;ND63NVMyOyEQvF2= MX\TRW5ITVJ?
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OAW-28 NFu4O25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[5[2w{UUN3ME20MlkzPDN3IN88US=> MofyV2FPT0WU
MEG-01 NGPnRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTVwMEizNlgh|ryP NYHDTWt3W0GQR1XS
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CAPAN-1 MkfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PzZ2lEPTB;NT6zPVQ{OiEQvF2= MkPIV2FPT0WU
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DLD1 M2LvbGZ2dmO2aX;uJGF{e2G7 MYOxJO69VQ>? NWPKd|JoPzJiaB?= MkPNbY5lfWOnczDheZRweGijZ4mgeI8h[2:wZnXyJIN6fG:ycn;0[YN1cW:w NYjYT|FjOjF7NEmxNlE>
Rh41 M4DjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Lo[GlEPTB;M{CuO{BvVQ>? M{fjfFIyOzN5Nke5
Rh18 NHjCWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HNUWlEPTB;NEGuOEBvVQ>? MVuyNVM{PzZ5OR?=
Rh30 NXXJNYc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTF2IH7N MortNlE{Ozd4N{m=
BT-12 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q3c2lEPTB;MkSuO{BvVQ>? Mo\INlE{Ozd4N{m=
CHLA-266 M1PNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnlS5pvUUN3ME2xMlEhdk1? NWDtclA6OjF|M{e2O|k>
TC-71 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\CTWM2OD12Nj61JI5O MVuyNVM{PzZ5OR?=
CHLA-9 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG3UYplUUN3ME2xOU4{KG6P MlfKNlE{Ozd4N{m=
CHLA-10 NH\2ZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTNwOTDuUS=> MYmyNVM{PzZ5OR?=
CHLA-258 M1;h[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFyLkSgcm0> MkX5NlE{Ozd4N{m=
GBM2 M2Hje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPrTWM2OD12MD63JI5O MnL5NlE{Ozd4N{m=
NB-1643 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3OOotzUUN3ME2zN{45KG6P NYTtWHNFOjF|M{e2O|k>
NB-EBc1 NUDUdHZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfvV2dvUUN3ME2yO{4yKG6P MWeyNVM{PzZ5OR?=
CHLA-90 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnJd2NKSzVyPUO0MlUhdk1? MlrKNlE{Ozd4N{m=
CHLA-136 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXvWFVKSzVyPUG2Nk43KG6P MmPtNlE{Ozd4N{m=
NALM-6 NFrETnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHwSIlKSzVyPUOyMlkhdk1? NUj2NWlbOjF|M{e2O|k>
COG-LL-317 NV\FeIlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LJNmlEPTB;MT6zJI5O MYKyNVM{PzZ5OR?=
RS4;11 NFXRO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTN3IH7N MUCyNVM{PzZ5OR?=
MOLT-4 M2W0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nBfmlEPTB;OD62JI5O NWT1SpRJOjF|M{e2O|k>
CCRF-CEM MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyxTWM2OD12LkGgcm0> NXjIR2Y1OjF|M{e2O|k>
Kasumi-1 MoPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHDV2NKSzVyPUGuOEBvVQ>? NYXBfYhWOjF|M{e2O|k>
Karpas-299 NHXUOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJzLkegcm0> MXeyNVM{PzZ5OR?=
Ramos-RA1 NWn2NYplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u4[GlEPTB;OD6yJI5O NWXPXYtSOjF|M{e2O|k>
H838 NF7ObplHfW6ldHnvckBCe3OjeR?= MUixJO69VQ>? MVG0PEBp MofpbY5lfWOnczDj[YxtKGG3dH;wbIFogQ>? M2fxZlIxOzZ2MUGz
H838 NHPO[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HPOVAuOyEQvF2= M2X2ZVczKGh? NX6xeFBpcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7 MYmyNFAzQDh3NB?=
A549  M2\oVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j4XVAuOyEQvF2= MnHnO|IhcA>? NFHVb2ZqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l? MU[yNFAzQDh3NB?=

... Click to View More Cell Line Experimental Data

In vivo AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. [1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. [4]

Protocol

Kinase Assay:[1]
+ Expand

Cell-based determinations of mTOR inhibition:

A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:[1]
+ Expand
  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 1 nM - 1 μM
  • Incubation Time: 72 to 96 hours
  • Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk).
  • Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v)
  • Dosages: 2.5-20 mg/kg
  • Administration: Oral gavage once or twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (107.4 mM) warming
Ethanol 3 mg/mL (6.44 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C25H31N5O4

CAS No. 1009298-09-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01316809 Completed Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 4, 2011 Phase 1
NCT00999882 Completed Cancer|Advanced Hepatocellular Carcinoma AstraZeneca October 2009 Phase 1
NCT00973076 Completed Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca August 2009 Phase 1
NCT00731263 Completed Solid Tumors AstraZeneca July 2008 Phase 1
NCT01194193 Withdrawn Cancer|Advanced Solid Tumours|Lymphomas AstraZeneca null Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID