AZD8055

Catalog No.S1555

AZD8055 Chemical Structure

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

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In DMSO USD 156 In stock
USD 120 In stock
USD 370 In stock

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Cited by 38 Publications

8 Customer Reviews

  • PC3-LN4 cells were treated with GSK690693 (5 uM) alone, or in combination with PP242 (2 uM) or AZD8055 (1 uM) for 24 h, and immunoblotting performed.

    Cancer Res 2013 73(11), 3402-11. AZD8055 purchased from Selleck.

    HUVEC were treated with either RAD001 or AZD8055 before PA treatment. p53, GPX1, p53 acetylation, and subcellular PTEN were analyzed with corresponding antibodies. The blot is a representative of the results of three experiments. Values (mean盨D) are expressed as fold over untreated control. *p<0.05 versus their corresponding control groups in the one-way ANOVA.

    Antioxid Redox Signal 2014 20(9), 1382-95. AZD8055 purchased from Selleck.

  • (A) HCT116 or MDA-MB-468 cells were treated with 500 nM AZD8055 for the indicated times. Cell lysates were immunoblotted with the indicated antibodies. (B) HCT116 or MDA-MB-468 cells were treated with 50 nM rapamycin. 500 nM AZD8055, 1 uM MK2206 or dimethyl sulfoxide (DMSO) as control for 12 h. Cell lysates were immunoblotted with the indicated antibodies.

    Oncotarget 2014 5(15), 6015-27. AZD8055 purchased from Selleck.

    CSCs+24/44/ESA at 5,000 cells per well with stem cell culture media in triplicate in an ultra-low adhesion plate were treated with 5 umol/L BMS-777607, 1 umol/L AZD8055 alone, or in their different combinations. Cells were cultured for 72 hours. Cell viability was determined by the MTS assay. Percentages of polyploid cells were determined by counting 300 cells from two different regions. Results shown here were from one of two experiments with similar results.

    Mol Cancer Ther 2014 13(1), 37-48. AZD8055 purchased from Selleck.

  • mTOR kinase inhibitor AZD8055 activates PI3K accompanied with induction of expression of EGFR, HER2, HER3 and IRS1. Serum-deprived CHO-EGFP-AKT cells were incubated with 50 nM AZD8055 for 24 hr. The EGFP signal was detected using confocal microscopy. The white arrows indicate EGFP-AKT located on cellular membrane.

    Int J Cancer 2014 135(10), 2462-74. AZD8055 purchased from Selleck.

    mTOR, P70S6K1, 4E-BP1 and PCNA activation in the basilar artery of SAH. Top, Western blotting bands of antibodies, bottom, density of the protein band from each group. A, mTOR activation in the basilar artery demonstrated an elevated expression of mTOR on day 7 following SAH in SAH and SAH+DMSO animals. The mTOR inhibitors, Rapamycin and AZD8055 reduced the enhanced expression of mTOR (pb0.05, ANOVA). B. P70S6K1 activation. C. 4E-BP1 activation. D. PCNA activation. Rapamycin and AZD8055 significantly decreased the expression of P70S6K1, 4E-BP1 and PCNA compared with the SAH and SAH+DMSO (pb0.05, respectively; ANOVA). There was no significant difference between the two inhibitors in mTOR, P70S6K1, 4E-BP1 and PCNA expression.

    Exp Neurol 2012 233, 799-806. AZD8055 purchased from Selleck.

  • Induction of TCTP expression through 5-FU or oxaliplatin is inhibited by mTOR kinase inhibitors. HCT116 cells were treated for 48 h with 5-FU or oxaliplatin at the indicated concentrations. Where indicated, AZD 8055 (100 nM) or PP242 (1 μM) were added. TCTP levels were assessed by western blotting; signals were quantified and normalised against α-tubulin as a loading control. As a readout of mTOR activity, phosphorylation of the ribosomal protein S6 at Ser 240/244 was assessed using a phospho-specific antibody. a. Representative western blots demonstrating the alteration of the levels of TCTP protein and of phospho-ribosomal protein S6, respectively, in relation to the drug concentration.

    Cell Commun Signal, 2017.. AZD8055 purchased from Selleck.

    After starved in serum-free medium for 24h , A549 cells incubated with the indicated concentrations of AZD8055 for 3h , followed by 20-minute stimolation of 100ng/ml EGF

     
     

     

    Dr. Zhang of Tianjin Medical University. AZD8055 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.
Features First drug to inhibit both types of mTOR protein.
Targets
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
DNA-PK [1]
(MDA-MB-468 cells)
PI3Kδ [1]
(MDA-MB-468 cells)
PI3Kα [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM 1370 nM 3200 nM 3590 nM
In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. [1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. [2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 M4fF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKzN|Eh|ryP M33HNXNCVkeHUh?=
NCI-H720 NGnRWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjLOJdEUUN3ME2wMlAzQTN6IN88US=> NWPoWWVxW0GQR1XS
KARPAS-45 NUDSUZJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEOzO|Eh|ryP NXLLOmt[W0GQR1XS
EW-3 NGLYPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7MUmM4UUN3ME2wMlA1ODV4IN88US=> NVfvcYFtW0GQR1XS
SBC-1 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TBXGlEPTB;MD6wOFU5OSEQvF2= MXvTRW5ITVJ?
NCI-H209 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTQTWM2OD1yLkC1OFU{KM7:TR?= NHn4dWVUSU6JRWK=
EoL-1-cell NVHTXYZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrzbFcyUUN3ME2wMlA3PTZ7IN88US=> MlL5V2FPT0WU
H9 M3Pkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLWTWM2OD1yLkC2OlkzKM7:TR?= MkTGV2FPT0WU
AN3-CA NH7LVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T2fmlEPTB;MD6wO|k2OSEQvF2= NU\LcYxrW0GQR1XS
HH NVTpSVFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHrTWM2OD1yLkC4NFA6KM7:TR?= MmfBV2FPT0WU
KU812 MnTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL2TWtKSzVyPUCuNFgxPDNizszN NVH1fHdOW0GQR1XS
DU-4475 M2m2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEiwOFch|ryP NVrweWg3W0GQR1XS
CTV-1 M4nId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjyWGFKSzVyPUCuNFg3PDFizszN NYHuc5FXW0GQR1XS
BV-173 M1zpWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1yLkC5NFYyKM7:TR?= Mo\YV2FPT0WU
ES5 NWnpW|VnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLqeIc2UUN3ME2wMlA6OzVizszN NVrJfpZVW0GQR1XS
G-402 M37ZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXhZ3pKSzVyPUCuNFk6QCEQvF2= MV7TRW5ITVJ?
MV-4-11 NV3nemljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn0enpKSzVyPUCuNVA{PDdizszN M4jmWHNCVkeHUh?=
NB69 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnhTWM2OD1yLkGzOUDPxE1? NV;kZmUzW0GQR1XS
EGI-1 NFPqRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnu0TWM2OD1yLkGzOVMyKM7:TR?= MYDTRW5ITVJ?
EW-18 NEe3N|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInsd5FKSzVyPUCuNVQxPzNizszN NXvNXG9iW0GQR1XS
ME-180 NXHlRmt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFG2XZVKSzVyPUCuNVQ3QDFizszN NHPNXmlUSU6JRWK=
D-283MED NWnvXGRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LqcWlEPTB;MD6xOFczOyEQvF2= MWnTRW5ITVJ?
NB14 NGTuSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j4VWlEPTB;MD6xOlQ1PyEQvF2= NF3SeVhUSU6JRWK=
Ramos-2G6-4C10 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;6VGJKSzVyPUCuNVY6QDNizszN NF6zN5ZUSU6JRWK=
NBsusSR NYS3eXczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMUewNVkh|ryP NGPvOWhUSU6JRWK=
LAMA-84 NYLD[JJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMUiwN|Ih|ryP NXfvNFRCW0GQR1XS
NCI-H1581 NYi2NmFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DLN2lEPTB;MD6xPFk3PiEQvF2= MXnTRW5ITVJ?
A204 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjlPJhKSzVyPUCuNVg6PyEQvF2= Mn;OV2FPT0WU
A549 NH;wWlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\3TWM2OD1yLkG5OVUh|ryP MlLlV2FPT0WU
CAL-51 M3\ROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3XTVRKSzVyPUCuNVk3PTFizszN NIGyRXlUSU6JRWK=
NKM-1 NGriS2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\DT2lKSzVyPUCuNlAxOjlizszN NVXBd|J5W0GQR1XS
LoVo M4rNNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMkCyNFIh|ryP NULFXY9DW0GQR1XS
HAL-01 M3jUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonPTWM2OD1yLkKwNlk4KM7:TR?= NFzvWGxUSU6JRWK=
HCC2218 NVSwNJdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHn[41KSzVyPUCuNlA3QDhizszN M1vSU3NCVkeHUh?=
BEN MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWwTWM2OD1yLkKxNlk{KM7:TR?= MoCyV2FPT0WU
LC-2-ad NXnQbI5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrzTo1KSzVyPUCuNlIxQDRizszN NX;xN4t5W0GQR1XS
LXF-289 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnsRnNWUUN3ME2wMlI2ODRzIN88US=> NVzw[YVEW0GQR1XS
HGC-27 NUTOfIE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq3doJKSzVyPUCuNlY1OTRizszN MY\TRW5ITVJ?
LK-2 M3nIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33tTWlEPTB;MD6yOlgzPCEQvF2= M1eyTnNCVkeHUh?=
CTB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Gzc2lEPTB;MD6yO|IyPSEQvF2= MXXTRW5ITVJ?
697 NGixToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\kcpJKSzVyPUCuNlc{PjdizszN MUjTRW5ITVJ?
ES7 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmzcnBKUUN3ME2wMlI4Ozh|IN88US=> M17JXXNCVkeHUh?=
MG-63 NXz2d|VuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\0XFVIUUN3ME2wMlI4PDB5IN88US=> M4HWcXNCVkeHUh?=
T47D Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n6eGlEPTB;MD6yO|Q4PSEQvF2= NFjEfpRUSU6JRWK=
RPMI-8226 M{HHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDp[lh7UUN3ME2wMlI5PTh7IN88US=> NXrHW4h6W0GQR1XS
NCI-H292 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMkmxOlQh|ryP MVPTRW5ITVJ?
HT MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPLTWM2OD1yLkK5N|gh|ryP M1vqUHNCVkeHUh?=
A3-KAW MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkm3OEDPxE1? MV3TRW5ITVJ?
LB2241-RCC NVTxc|d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm0TWM2OD1yLkOwNVk5KM7:TR?= M170TnNCVkeHUh?=
BB65-RCC NX2xTWFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwM{C4NFUh|ryP M{LCZXNCVkeHUh?=
G-401 M1X5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfhTWM2OD1yLkOwPVg3KM7:TR?= MkT3V2FPT0WU
TYK-nu MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3OxV2lEPTB;MD6zNVg3PCEQvF2= MWDTRW5ITVJ?
NCI-SNU-1 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwM{KzN|Eh|ryP MnzqV2FPT0WU
CHL-1 M3zobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rzfGlEPTB;MD6zNlcxOyEQvF2= NUPpOZY4W0GQR1XS
P30-OHK MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViwcW9PUUN3ME2wMlMzPzB3IN88US=> MYHTRW5ITVJ?
PA-1 NIjlV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfldllNUUN3ME2wMlM{PjF7IN88US=> MUnTRW5ITVJ?
LB1047-RCC M2OzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HrN2lEPTB;MD6zOFA1PyEQvF2= MYrTRW5ITVJ?
EM-2 NYHiOHhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q1VmlEPTB;MD6zOFE5QCEQvF2= NIr4e3VUSU6JRWK=
VA-ES-BJ NXnqRlhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLmeGNKSzVyPUCuN|QzPjhizszN NUfQcllVW0GQR1XS
NCI-H520 M1jlU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOzTWM2OD1yLkO0PFM1KM7:TR?= NYPUXm9XW0GQR1XS
ECC10 NE\QRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13tVGlEPTB;MD6zOVA{PSEQvF2= NUnod5oyW0GQR1XS
LNCaP-Clone-FGC MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwM{WzNVQh|ryP M4OxOnNCVkeHUh?=
ES8 NXjrPIU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HlOWlEPTB;MD6zOlU2OyEQvF2= M3vHbXNCVkeHUh?=
HuO-3N1 NGr5TnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXJdFlKSzVyPUCuN|g{PzlizszN NXLBepNIW0GQR1XS
L-363 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{mwNlYh|ryP MULTRW5ITVJ?
SK-LU-1 M37Hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojOTWM2OD1yLkO5NlA5KM7:TR?= MkO0V2FPT0WU
MCF7 NGrF[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\6TWM2OD1yLkSwOVMh|ryP MXXTRW5ITVJ?
HuO9 M2rFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXNTWM2OD1yLkSwOlY4KM7:TR?= NGrFVWdUSU6JRWK=
BHT-101 M2fXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTYTWM2OD1yLkSwO|g4KM7:TR?= MoHQV2FPT0WU
MZ2-MEL MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTnTWM2OD1yLkSwPFgzKM7:TR?= M37NVHNCVkeHUh?=
NOS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTIeJBKSzVyPUCuOFExPzRizszN MmfWV2FPT0WU
NEC8 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoNYZ3UUN3ME2wMlQyPjl3IN88US=> NVX1eppJW0GQR1XS
COR-L88 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNEKyOlch|ryP MmL6V2FPT0WU
MFM-223 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnOZ45KSzVyPUCuOFI3OTdizszN M1;VRXNCVkeHUh?=
HSC-3 NGe4bpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTadohqUUN3ME2wMlQzQTB6IN88US=> NUP6[WFVW0GQR1XS
OVCAR-5 M3jaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHCTWM2OD1yLkSyPVM{KM7:TR?= NGjWXlBUSU6JRWK=
MFE-280 M4HYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M330UmlEPTB;MD60N|A{OiEQvF2= NV;UXXZjW0GQR1XS
KP-N-YS NW\lWWZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rlWWlEPTB;MD60N|A4KM7:TR?= MlPJV2FPT0WU
EPLC-272H NX;mOZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrTW4VKSzVyPUCuOFMxPzdizszN M3T6O3NCVkeHUh?=
KE-37 M3;Ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNEOyOFch|ryP MoLFV2FPT0WU
HuH-7 M{nhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFGzdWJKSzVyPUCuOFM{PzJizszN MUPTRW5ITVJ?
CHP-212 MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNEO2PVch|ryP NXP6WY96W0GQR1XS
SK-MES-1 M4LBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrFTFVKSzVyPUCuOFM5PDhizszN NGToTGVUSU6JRWK=
SJSA-1 NFHFd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHqUIM5UUN3ME2wMlQ1PTV2IN88US=> MX7TRW5ITVJ?
QIMR-WIL NGXLe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPRTWM2OD1yLkS1NVUh|ryP M{f4SHNCVkeHUh?=
ES4 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLWR4N{UUN3ME2wMlQ2OzN4IN88US=> MXXTRW5ITVJ?
TI-73 M2O5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrvSlNPUUN3ME2wMlQ2Pjh4IN88US=> NY\VUodjW0GQR1XS
COLO-684 NEfBflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEW3NlYh|ryP MojLV2FPT0WU
GCIY MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nmbmlEPTB;MD60OVc2PCEQvF2= MXjTRW5ITVJ?
JVM-3 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT1[3o6UUN3ME2wMlQ3Ojl{IN88US=> MmfzV2FPT0WU
MPP-89 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNE[5OFch|ryP NIG4V2JUSU6JRWK=
M14 NFyyV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYqwdJZPUUN3ME2wMlQ4OTdizszN NX;Q[WVFW0GQR1XS
SW962 M3rTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni5TWM2OD1yLkS3NVkh|ryP NGDrWodUSU6JRWK=
VM-CUB-1 NH7ybo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLTTWM2OD1yLkS3Nlg3KM7:TR?= NGS1[ZVUSU6JRWK=
A101D MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\xW2lEPTB;MD60PFk3QCEQvF2= M4DSSHNCVkeHUh?=
DB NH;mSopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwNUCwNlEh|ryP NEfFfnRUSU6JRWK=
KNS-62 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwNUC1Olgh|ryP MnnkV2FPT0WU
NCI-H460 M4XzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TJNWlEPTB;MD61NFU6PyEQvF2= M{TSR3NCVkeHUh?=
MDA-MB-361 NGnGRVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDtTWM2OD1yLkWwPFch|ryP MUTTRW5ITVJ?
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OVCAR-8 NHfXcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJwMECyPVUh|ryP M{SybnNCVkeHUh?=
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OVCAR-3 NGPMcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXoTWM2OD1|LkCyNVE2KM7:TR?= MoTMV2FPT0WU
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UACC-257 NHSxWlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzBXVNSUUN3ME2zMlQ3PDNzIN88US=> MoSwV2FPT0WU
LB996-RCC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTNwNE[1NFIh|ryP NXPhRVFEW0GQR1XS
BT-549 M36ydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3lbpZMUUN3ME2zMlUxOjB7IN88US=> NVy3WXNVW0GQR1XS
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SW626 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVuyNpVkUUN3ME2zMlcyOTJ6IN88US=> M4HWbHNCVkeHUh?=
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UACC-62 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTRwNE[1OFUh|ryP NWn6TWlHW0GQR1XS
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ONS-76 NWf3c5hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5cWlEPTB;NT61OVgxOSEQvF2= NIO2WGtUSU6JRWK=
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COLO-741 M4nCV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTqTWM2OD13LkexPVk2KM7:TR?= NVW0NXFtW0GQR1XS
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HCC1187 M{POPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3mTWM2OD13LkixNFA5KM7:TR?= M3PjbHNCVkeHUh?=
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NCI-H630 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S2e2lEPTB;Nj6xNVQ1OSEQvF2= MYfTRW5ITVJ?
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D-502MG MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTZwMUezN|Yh|ryP MWnTRW5ITVJ?
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SK-MEL-24 M3zYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyzTWM2OD14LkK2OFkh|ryP NVTvR|l{W0GQR1XS
NCI-SNU-5 M3;qcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorCTWM2OD14LkK3NVE5KM7:TR?= NVrJcnNwW0GQR1XS
D-392MG MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDkO2ZbUUN3ME22MlM{Ozl7IN88US=> NH;PfJlUSU6JRWK=
A498 NEPQZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTZwNECzNFIh|ryP NFTENlZUSU6JRWK=
OCI-AML2 M{L1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O1TmlEPTB;Nj60OVQ1PSEQvF2= NX7MSWN6W0GQR1XS
HCC2157 NUHU[2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nTfGlEPTB;Nj60OVYyPiEQvF2= M2HzcXNCVkeHUh?=
C3A NGnERmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vQN2lEPTB;Nj61NlAxPCEQvF2= NFXBbmtUSU6JRWK=
NCI-H1650 NUfONpRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Vb2NQUUN3ME22MlcxPTJ{IN88US=> NFX0O5VUSU6JRWK=
DU-145 NXe0N4Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTZwN{ewN{DPxE1? MVXTRW5ITVJ?
COLO-829 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK0TWM2OD14Lke3PFc{KM7:TR?= MnfFV2FPT0WU
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HCC1954 MmjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmwTWM2OD15LkS4NVM1KM7:TR?= NFfZTnBUSU6JRWK=
KURAMOCHI NH3Mb2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnESJBKSzVyPUeuOFg2OzNizszN MkPXV2FPT0WU
Mo-T MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3ITWM2OD15LkWxOFk5KM7:TR?= MWnTRW5ITVJ?
OE19 M4qyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnWTWM2OD15Lk[1OVA{KM7:TR?= M{\ZcXNCVkeHUh?=
COR-L105 NITtVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTdwN{G0NlEh|ryP M3zY[nNCVkeHUh?=
NCI-H2342 NVv3PI1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTdwN{G1NlEh|ryP NYrSfJhwW0GQR1XS
U-87-MG NGXBSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPaWYdZUUN3ME24MlA{OzN2IN88US=> M3nHXHNCVkeHUh?=
MKN28 MmPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XBdmlEPTB;OD6xNVUyPSEQvF2= MUDTRW5ITVJ?
HT-1197 NYKxPWF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D3XGlEPTB;OD6yOVkxPyEQvF2= MU\TRW5ITVJ?
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NCI-H226 NVTXSWZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRThwNESzN|Eh|ryP Mmm3V2FPT0WU
NCI-H2029 MkfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLsNYtKSzVyPUmuNFY4PTlizszN NIfDWllUSU6JRWK=
TE-11 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTlwNEW1PFgh|ryP NIPFNGFUSU6JRWK=
ZR-75-30 M{Lufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjSTWM2OD17LkmyOlM1KM7:TR?= M1;MRnNCVkeHUh?=
SW837 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7ZeFZKSzVyPUGwMlIzQTNizszN NHnUeJNUSU6JRWK=
NCI-H1651 NU\NToRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH0TWM2OD1zMD6yN|I3KM7:TR?= NIPUUZNUSU6JRWK=
NCI-H727 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Lv[GlEPTB;MUCuOFQ6PSEQvF2= MXTTRW5ITVJ?
NCI-H358 M3HsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjIW5VKSzVyPUGwMlg{PjVizszN NVP1N5pbW0GQR1XS
NCI-H2087 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzDfFN[UUN3ME2xNU4xPDN2IN88US=> MmThV2FPT0WU
FTC-133 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFzLkSwOVEh|ryP MWLTRW5ITVJ?
LAN-6 M{CyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO1[VVTUUN3ME2xNk4yOjRizszN NWLycmZ4W0GQR1XS
NCI-H1838 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnYV|F1UUN3ME2xNk42OTVzIN88US=> M1zIUXNCVkeHUh?=
Calu-6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7YfIVTUUN3ME2xOE4yODJzIN88US=> MmL2V2FPT0WU
HCC70 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr1SGlKSzVyPUG0MlQ2OSEQvF2= NYDGc40xW0GQR1XS
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CAL-27 NHvyfpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn3TWM2OD1zNT6zPFQ{KM7:TR?= M4PRZXNCVkeHUh?=
NCI-H82 NV\Bb3FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7NbpJtUUN3ME2xOU42OzJizszN NWLp[VVLW0GQR1XS
no-10 M1vCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\iTWM2OD1zNT65N|gh|ryP NXvCVXVSW0GQR1XS
U251 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF4LkO2O|Uh|ryP NYPheZpVW0GQR1XS
TE-9 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF5LkWxOlYh|ryP NUL0e481W0GQR1XS
TE-10 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF7LkC2NFch|ryP MUnTRW5ITVJ?
COLO-824 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\ncmNKSzVyPUKwMlkzPzZizszN NUX1cpJsW0GQR1XS
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L-428 NIq0N4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWKyUmd1UUN3ME2yNU41ODF4IN88US=> MkPNV2FPT0WU
JAR NVzhV2p{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1K4WWlEPTB;MkGuOVAzKM7:TR?= MlTjV2FPT0WU
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ABC-1 NF;pUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlznTWM2OD1{Nj63PVU4KM7:TR?= MUjTRW5ITVJ?
MHH-NB-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLwOow{UUN3ME2zN{4{PDZ2IN88US=> NXLJR3dNW0GQR1XS
SW1463 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTtTWM2OD1|Mz65PFMh|ryP NV:xV5VEW0GQR1XS
SW1417 NYDSNHk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvCbHhKSzVyPUO3MlA6PTJizszN NHLlOpRUSU6JRWK=
NB12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moi2TWM2OD1|OT60OlU2KM7:TR?= MXvTRW5ITVJ?
NY MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTRzLkOyNFEh|ryP NIfYfWJUSU6JRWK=
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TFK-1 MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LIXFczKGh? M3PRfWROW09? M1nqSGlEPTB;NEegcm0> NUHQcmVHOjVzNUKyOFQ>
EGI-1 NFzwVGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\TbHp7PzJiaB?= M1\zN2ROW09? MV;JR|UxRTV|IH7N MmfmNlUyPTJ{NES=
OCI/AML3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\qNE4zKM7:TR?= NH;u[Yk1QCCq M1y0ZoVvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDz[Yx2dWW2aX7pZi=> Mn;ENlQ4Ozl|OUO=
U937 NY\JWnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HDeFAvOiEQvF2= MU[0PEBp MVjlcohidmOnczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGmwZIXj[YQh[nlic3XseY1mfGmwaXK= M4LhZVI1PzN7M{mz
MOLM13 M{Tyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHqxZlMxNjJizszN NG\tT|c1QCCq M{DQb4VvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDz[Yx2dWW2aX7pZi=> M2O3flI1PzN7M{mz
MCF7 NHvYRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTyO4wzOCCwTR?= MYS3NkBp MWHGRnM> M2XYUZJm\HWlZYOgeIhmKFCHTGCxMY1m\GmjdHXkJIlv[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5 NIDVVpIzPDZ6OEC0Oi=>
TamR NXLncphVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17UdmlEPTB;MUlihKlvVQ>? M2\0U|I1PDV5ME[5
MCF7-X  MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\aTWM2OD1{NDDuUS=> MYeyOFQ2PzB4OR?=
T47D-tamR  MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnlOVlKSzVyPUG5JI5O M1jmeVI1PDV5ME[5
293T  M2DsXmZ2dmO2aX;uJGF{e2G7 MVOyNEBvVQ>? MkPyN{Bp NY\VfmY{\Gm|coXweJMhSWu2LX3l[IlifGWmIGTJSk1KSSC|dHHibYxqfHluIITyZY5{dG:lYYTpc44tKGGwZDDhZ5Rqfmm2eR?= NGT5NWgzPDN4M{S0PS=>
SW620 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLQN2oxNjByMT2xNO69VQ>? NGHZZ3UzPCCq NHjLb4dqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHHzJJRp\SClb37j[Y51emG2aX;uJJJqe2W| NH;qUpAzPDN4M{S0PS=>
Huh7  M{Xkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[5R3E2NTFyMDDuUS=> NVrnTmV6OC1{NDDo NUKwZlNlTE2VTx?= NESxUI5qdmO{ZXHz[ZMh[2WubDDk[YF1cCCrbjDhJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MYKyOFI6PzNyMB?=
Hep3B  MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPpW3Q2NTFyMDDuUS=> MoTrNE0zPCCq MYXEUXNQ NGjFemZqdmO{ZXHz[ZMh[2WubDDk[YF1cCCrbjDhJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ? MYGyOFI6PzNyMB?=
Huh7  Mo\QSpVv[3Srb36gRZN{[Xl? NY\rPVFSOTByIH7N NH3GV3UyOiCq MXzEUXNQ Ml;KbY5lfWOnczDheZRweGijZ4pCpC=> MU[yOFI6PzNyMB?=
U87-MG  NVrGSI46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmryO|IhcA>? MX3HTVUx6oDLPfMAjVc6KG6PwrC= NWPkV4hKOjR{NEm2OFA>
 L3.6pl Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCxJO69VQ>? M{ixSlczKGh? MmO5bY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHPvcYJqdmWmIIfpeIghSk2VLUe3O|YxPw>? MV:yOFI{OzN7OR?=
TE671 NGXqfWtCeG:ydH;zbZMhSXO|YYm= MkHXNUDPxE1? MXq0PEBp NHLFfIxqdmO{ZXHz[ZMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBCSlRvN{O3 Ml\VNlQyOzN{MUi=
RD Mn\HRZBweHSxc3nzJGF{e2G7 M2PCXVEh|ryP MWG0PEBp NITY[YNqdmO{ZXHz[ZMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBCSlRvN{O3 MYeyOFE{OzJzOB?=
RMS13 M2\UU2Fxd3C2b4Ppd{BCe3OjeR?= Mn:wNUDPxE1? NF;p[4Q1QCCq NWroSWJLcW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=> NH3nR4kzPDF|M{KxPC=>
RH30 MVrBdI9xfG:|aYOgRZN{[Xl? M1HZOFEh|ryP NVPBW4FKPDhiaB?= NX;wcnRFcW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=> MoHhNlQyOzN{MUi=
Hep-2 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DhW|AvODFvMTFOwG0> MnfDNVIuQTZiaB?= MXnpcoNz\WG|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI> NX7sR49uOjRzMEO3OFk>
SCC-9 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXiwMlAyNTFizszN MojVNVIuQTZiaB?= NXrpeGkzcW6lcnXhd4V{KGOnbHyg[IVifGhiaX6gZUBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{ MUmyOFExOzd2OR?=
Hep-2 NYexV29QTnWwY4Tpc44hSXO|YYm= NHL4d2sxNjFxMD61JO69VQ>? NYfrfnIzOjRiaB?= M1jYZ4Jtd2OtczDtWG9TSzFiYX7kJI1VV1KFMjDhZ5RqfmG2aX;u NVzTSYxQOjRzMEO3OFk>
SCC-9 M2LPfWZ2dmO2aX;uJGF{e2G7 NH3FU5MxNjFxMD61JO69VQ>? M1nFXVI1KGh? MlyxZoxw[2u|IH3UU3JEOSCjbnSgcXRQWkN{IHHjeIl3[XSrb36= NYW3VXlIOjRzMEO3OFk>
PANC-1 MXjBdI9xfG:|aYOgRZN{[Xl? NGHFU4E2ODBibl2= M2PldFQ5KGh? M4nQbpNmdnOrdHn6[ZMheGGwY4LlZZRq[yClYX7j[ZIh[2WubIOgeI8hemGmaX;0bIVz[XC7 MnSzNlM5QDZ{OUS=
RMG2 MoPoRZBweHSxc3nzJGF{e2G7 NXLDXXZUOS1zMECwJI5O MUO3NkBp MYPGRnM> MXXpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgZ49v[2WwdILheIlwdiCmZYDlcoRmdnSueR?= NVLDVIxZOjN4MUW2N|E>
HAC2 NXHI[VZuSXCxcITvd4l{KEG|c3H5 NHLEWYwyNTFyMECgcm0> NFfZNno4OiCq M4WzXmZDWw>? MXjpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgZ49v[2WwdILheIlwdiCmZYDlcoRmdnSueR?= MWWyN|YyPTZ|MR?=
HT-29 MXvBdI9xfG:|aYOgRZN{[Xl? MY[xJO69VQ>? M{\JTVczKGh? MoLvZZR1\W63YYTld{A2NU[XLXnu[JVk\WRiY3XscEBl\WG2aB?= MXeyNVk1QTF{MR?=
DLD1 NVm2Z416SXCxcITvd4l{KEG|c3H5 NHHxV4wyKM7:TR?= MlfKO|IhcA>? NGDJblNifHSnboXheIV{KDVvRmWtbY5lfWOnZDDj[YxtKGSnYYTo MoLINlE6PDlzMkG=
HT-29 NX;N[o5PTnWwY4Tpc44hSXO|YYm= MUixJO69VQ>? NXTWS49YPzJiaB?= MXzpcoR2[2W|IHH1eI9xcGGpeTD0c{Bkd26oZYKgZ5l1d3C{b4TlZ5Rqd25? MXeyNVk1QTF{MR?=
DLD1 MkfTSpVv[3Srb36gRZN{[Xl? MkHlNUDPxE1? M331WVczKGh? MW\pcoR2[2W|IHH1eI9xcGGpeTD0c{Bkd26oZYKgZ5l1d3C{b4TlZ5Rqd25? NVjzXoxXOjF7NEmxNlE>
Rh41 M1e1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3COHh2UUN3ME2zNE44KG6P NFvqXo8zOTN|N{[3PS=>
Rh18 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljGTWM2OD12MT60JI5O NHr5PGEzOTN|N{[3PS=>
Rh30 NF7EPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF2IH7N M3XoRVIyOzN5Nke5
BT-12 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1noZmlEPTB;MkSuO{BvVQ>? Mn7zNlE{Ozd4N{m=
CHLA-266 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\hTWM2OD1zLkGgcm0> M1S0RVIyOzN5Nke5
TC-71 NWGyc2RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrZTWM2OD12Nj61JI5O NUn2cZFpOjF|M{e2O|k>
CHLA-9 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHsTWM2OD1zNT6zJI5O NXjWcGFZOjF|M{e2O|k>
CHLA-10 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\XdllsUUN3ME2zMlkhdk1? M1ruNlIyOzN5Nke5
CHLA-258 NIPRT4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jDVGlEPTB;MUCuOEBvVQ>? NELhS2ozOTN|N{[3PS=>
GBM2 M1rUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DI[WlEPTB;NECuO{BvVQ>? M4nUZlIyOzN5Nke5
NB-1643 M{P4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH6dJVKSzVyPUOzMlghdk1? MVyyNVM{PzZ5OR?=
NB-EBc1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ5LkGgcm0> NXvYNmtoOjF|M{e2O|k>
CHLA-90 NGDQ[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LHZWlEPTB;M{SuOUBvVQ>? M4nlb|IyOzN5Nke5
CHLA-136 NFT1RmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF4Mj62JI5O Mm[wNlE{Ozd4N{m=
NALM-6 M4jVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvtVWI6UUN3ME2zNk46KG6P MUiyNVM{PzZ5OR?=
COG-LL-317 NEO5c4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3SU5ZKSzVyPUGuN{BvVQ>? NIK0R4MzOTN|N{[3PS=>
RS4;11 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTN3IH7N MoXuNlE{Ozd4N{m=
MOLT-4 NF2x[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRThwNjDuUS=> MUiyNVM{PzZ5OR?=
CCRF-CEM MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTRwMTDuUS=> M{Lpe|IyOzN5Nke5
Kasumi-1 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwNDDuUS=> NH;XVnYzOTN|N{[3PS=>
Karpas-299 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfUO3JDUUN3ME2yNU44KG6P MXiyNVM{PzZ5OR?=
Ramos-RA1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WxWmlEPTB;OD6yJI5O MoDZNlE{Ozd4N{m=
H838 M17ORmZ2dmO2aX;uJGF{e2G7 M2LSbFEh|ryP M4LzflQ5KGh? M4X0U4lv\HWlZYOgZ4VtdCCjdYTvdIhi\3l? Mnz0NlA{PjRzMUO=
H838 NXq5NnNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnCdXJuOC1|IN88US=> MlTFO|IhcA>? NYXiR3RXcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7 MofCNlAxOjh6NUS=
A549  MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIS2PJkxNTNizszN NXnNN2x2PzJiaB?= MVTpcoR2[2W|IHfyc5d1cCCrbnjpZol1cW:wIHHu[EBifXSxcHjh[5k> Moj3NlAxOjh6NUS=

... Click to View More Cell Line Experimental Data

In vivo AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. [1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. [4]

Protocol

Kinase Assay:[1]
+ Expand

Cell-based determinations of mTOR inhibition:

A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:[1]
+ Expand
  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 1 nM - 1 μM
  • Incubation Time: 72 to 96 hours
  • Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk).
  • Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v)
  • Dosages: 2.5-20 mg/kg
  • Administration: Oral gavage once or twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL warmed (107.4 mM)
Ethanol 3 mg/mL (6.44 mM)
Water <1 mg/mL
In vivo 4% DMSO+30% PEG 300+ddH2O 5mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C25H31N5O4

CAS No. 1009298-09-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01316809 Completed Glioblastoma Multiforme|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma|Malignant Glioma|Brainstem Glioma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 4, 2011 Phase 1
NCT00999882 Completed Cancer|Advanced Hepatocellular Carcinoma AstraZeneca October 2009 Phase 1
NCT00973076 Completed Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca August 2009 Phase 1
NCT00731263 Completed Solid Tumors AstraZeneca July 2008 Phase 1
NCT01194193 Withdrawn Cancer|Advanced Solid Tumours|Lymphomas AstraZeneca null Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID