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E7080 (Lenvatinib) Chemical Structure
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Biological Activity
E7080 (Lenvatinib) is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among those small-molecule inhibitors of VEGF-R kinases, such as sunitinib, sorafenib, and CEP-7055. It has been evaluated in vitro (pre-clinical) for anti-cancer effects. E7080 (Lenvatinib) suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of angiogenesis and lymphangiogenesis. [2,3]
It has had promising results from a phase I clinical trial in 2006 and is being tested in several Phase I and II trials as of October 2009, for example against hepatocellular carcinoma and non-small cell lung carcinoma. [1]
References on E7080 (Lenvatinib)
- [1] Clin Cancer Res 2009;15:7229-7237
- [2] Clin Cancer Res 2008;14:5459-5465
- [3] Int. J. Cancer 2008;122:664–671
Chemical Information
| Molecular Weight (WM): | 426.85 |
|---|---|
| Formula: | C21H19ClN4O4 |
| CAS No.: | 417716-92-8 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥16mg/mL |
| Water <1mg/mL | |
| Ethanol ≥1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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