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Ki8751 Chemical Structure
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Biological Activity
Ki8751 is a potent, selective VEGFR-2 tyrosine kinase inhibitor with IC50 of 0.9, 40, 67, 170 nM for VEGF-2, c-Kit, PDGFRα and FGFR-2, respectively. It exhibited no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. It is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for EGFR and HGFR). It inhibits VEGF-
stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo. [1][2]
References on Ki8751
- [1] J. Med. Chem 2005;48:1359-1366
- [2] J. Cell. Physiol 2011;226: 1608–1619
Chemical Information
| Molecular Weight (WM): | 469.41 |
|---|---|
| Formula: | C24H18F3N3O4 |
| CAS No.: | 228559-41-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥94mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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