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Motesanib Diphosphate (AMG-706) Chemical Structure
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Biological Activity
Motesanib (AMG-706) is an orally bioavailable diphosphate salt of a multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity[1]. This reagent selectively targets and inhibits VEGFR1/2/3(IC50: 2 nM /3 nM /6 nM), PDGFR (84nM), kit (8nM), and Ret (59nM)receptors, thereby inhibiting angiogenesis and cellular proliferation. Oral administration of AMG 706 potently inhibited VEGF-induced angiogenesis in the rat corneal model and induced regression of established A431 xenografts [1] .This compound also performed antitumor activity in breast cancer xenografts and was currently being studied in clinical trials for the treatment of thyroid cancer and other advanced solid tumors[2,3,4]
References on Motesanib Diphosphate (AMG-706)
- [1] Cancer Res 2006;66:8715-8721
- [2] Clin Cancer Res 2009;15:110-118
- [3] N Engl J Med 2008;359:31-42
- [4] J Clin Oncol 2007;25:2369-2376.
Chemical Information
| Molecular Weight (WM): | 569.44 |
|---|---|
| Formula: | C22H23N5O.2H3PO4 |
| CAS No.: | 857876-30-3 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥114mg/mL |
| Water ≥114mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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