Catalog No.S1606

Clotrimazole alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.

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Clotrimazole Chemical Structure

Clotrimazole Chemical Structure
Molecular Weight: 344.84

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Clotrimazole is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Clotrimazole alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.
In vitro Clotrimazole causes a sustained depletion of intracellular Ca2+ stores, which results in activation of PKR, phosphorylation of eIF2alpha, and thereby in inhibition of protein synthesis at the level of translation initiation. Clotrimazole preferentially decreases the expression of the growth promoting proteins cyclin A, E and D1, resulting in inhibition of cyclin-dependent kinase activity and blockage of cell cycle in G1.[1] Clotrimazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2(hTRPM2). Clotrimazole (3 mM to 30 mM) produces an essentially complete inhibition of theTRPM2-mediated current. Clotrimazole antagonizes ADP-ribose-activated whole-cell and single-channel currents in the rat insulinoma cell-line CRI-G1. [2] Clotrimazole (2 mM) causes a sharp decline in parasitemia, complete inhibition of parasite replication, and destruction of parasites and host cells within a single intraerythrocytic asexual cycle (approximately 48 hours). Clotrimazole effectively and rapidly inhibits parasite growth in five different strains of P. falciparum, in vitro, irrespective of their Chloroquine sensitivity. [3]
In vivo Clotrimazole stimulates a subset of capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, and evoked nocifensive behavior and thermal hypersensitivity with intraplantar injection in mice. Clotrimazole-induced pain behavior is suppressed by the TRPV1-antagonist BCTC [(N-(-4-tertiarybutylphenyl)-4-(3-cholorpyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide)] and absent in TRPV1-deficient mice. Clotrimazole inhibits the cold and menthol receptor TRPM8, and blocks menthol-induced responses in capsaicin- and mustard oil-insensitive trigeminal neurons. [4]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Aktas H, et al. Proc Natl Acad Sci U S A,?998, 95(14), 8280-8285.

[2] Eastman RT, et al. Nat Rev Microbiol,?009, 7(12), 864-874.

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Clinical Trial Information( data from, updated on 2015-11-14)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02582177 Not yet recruiting Tinea Ache Laboratorios Farmaceuticos S.A. July 2016 Phase 3
NCT02180828 Completed Candidiasis, Vulvovaginal Peking University Shenzhen Hospital|Bayer July 2014 Phase 4
NCT02248506 Completed Candidiasis, Vulvovaginal Instituto Palacios|GYNEA Laboratorios S. L. June 2013 Phase 4
NCT01993823 Completed Otomycosis Salvat May 2013 Phase 3
NCT01105013 Not yet recruiting Fungal Infections|Tinea Pedis|Tinea Cruris|Tinea Corporis Laboratório Teuto Brasileiro S/A April 2012 Phase 3

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Chemical Information

Download Clotrimazole SDF
Molecular Weight (MW) 344.84


CAS No. 23593-75-1
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms BAY b 5097, FB 5097
Solubility (25°C) * In vitro DMSO 11 mg/mL (31.89 mM)
Ethanol 69 mg/mL (200.09 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-​[(2-​chlorophenyl)​diphenylmethyl]​-1H-​imidazole

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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