Clotrimazole

Catalog No.S1606

Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole.

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In DMSO USD 130 In stock
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Clotrimazole Chemical Structure

Clotrimazole Chemical Structure
Molecular Weight: 344.84

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Clotrimazole is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Clotrimazole(Canesten) is a synthetic, antifungal and broad-spectrum derivate of imidazole. Clotrimazole inhibits biosynthesis of sterols, particularly inhibiting ergosterol, which is an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in the  leakage and the loss of essential intracellular compounds, and eventually causes the lysis of cell.  [1, 2]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-12-20)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02180828 Recruiting Candidiasis, Vulvovaginal Peking University Shenzhen Hospital|Bayer July 2014 Phase 4
NCT02180828 Recruiting Candidiasis, Vulvovaginal Peking University Shenzhen Hospital|Bayer July 2014 Phase 4
NCT02248506 Recruiting Candidiasis, Vulvovaginal Instituto Palacios|GYNEA Laboratorios S. L. June 2013 Phase 4
NCT02248506 Recruiting Candidiasis, Vulvovaginal Instituto Palacios|GYNEA Laboratorios S. L. June 2013 Phase 4
NCT01993823 Recruiting Otomycosis Salvat May 2013 Phase 3

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Chemical Information

Download Clotrimazole SDF
Molecular Weight (MW) 344.84
Formula

C22H17ClN2

CAS No. 23593-75-1
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms
Solubility (25°C) * In vitro DMSO 11 mg/mL (31.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol 69 mg/mL (200.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-​[(2-​chlorophenyl)​diphenylmethyl]​-1H-​imidazole

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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