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HER2 Human Epidermal Growth Factor Receptor 2

HER2 Inhibitors (15)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1028 Lapatinib Ditosylate (Tykerb) Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
S1167 CP-724714 CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.
S2216 Mubritinib (TAK 165) Mubritinib (TAK 165) is a potent inhibitor of ErbB2 with IC50 of 6 nM.
S2150 Neratinib (HKI-272) Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.
S2192 AZD8931 AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, respectively.
S1011 Afatinib (BIBW2992) BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.
S2111 Lapatinib Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
S1019 CI-1033 (Canertinib) CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.
S1194 CUDC-101 CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.
S2752 Arry-380 ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.
Cat.No. Product Name Information Product Citations Customer Reviews
S1056 BMS-599626 (AC480) BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.
S1486 AEE788 (NVP-AEE788) AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively.
S2784 TAK-285 TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively.
S2816 Tyrphostin AG 879 (AG 879) AG879 inhibits both ErbB2 and Flk-1 with IC50 of 1 μM.
S2733 AV-412 AV-412 is a second-generation, orally bioavailable dual EGFR/HER2 tyrosine kinase inhibitor.
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All HER2 Inhibitors
Tags: HER2 inhibition | HER2 cancer | HER2 positive cancer | HER2 receptor | HER2 breast cancer treatment | HER2 negative breast cancer | HER2 overexpression | HER2 protein | HER2 amplification | HER2 immunohistochemistry | Neu receptor | Neu protein | HER2-overexpressing breast cancer | HER2 pathway | ErbB2 receptor | HER2 mutation | HER2-positive advanced breast cancer | ErbB2 protein | Neu mutation | HER2 activation | HER2 kinase inhibitor | HER2 phosphorylation | HER2 inhibitor review