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S1009
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BEZ235 (NVP-BEZ235) |
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
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S1092
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KU-55933 |
KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively. |
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S2758
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Wortmannin |
Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, and also potentlt inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM (less sensitive to ATR with IC50 of 1.8 μM). |
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S1570
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KU-60019 |
KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM. |
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S8007
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VE-821 |
VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively. |
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S2245
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CP-466722 |
CP-466722 is an potent and reversible ATM inhibitor. |
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S2817
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Torin 2 |
Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively. |
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