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KU-55933 Chemical Structure
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Biological Activity
KU-55933 is a potent ATM inhibitor with an IC50 and a Ki of 13 and 2.2 nM, respectively. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3-kinase–like kinases. Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Derivatives of this molecule may serve as novel radio- and chemosensitizors in clinical settings. [1][2]
References on KU-55933
- [1] Cancer Res 2004;64:9152-9159
- [2] NATURE CELL BIOLOGY MAY 2005;7:493-500
Chemical Information
| Molecular Weight (WM): | 395.49 |
|---|---|
| Formula: | C21H17NO3S2 |
| CAS No.: | 587871-26-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥50mg/mL |
| Water <1mg/mL | |
| Ethanol ≥13mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Selleck's high quality products have been used in several published research findings, including the following:
Peroxiredoxin II Restrains DNA Damage-induced Death in Cancer Cells by Positively Regulating JNK-dependent DNA Repair.
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effect of ATM inhibitor in etoposide-induced cell death. The cells were pretreated with KU55933 (2 M) for 1 h before etoposide treatment.
effect of ATM inhibitor in etoposide-induced cell death. The cells were pretreated with KU55933 (2 M) for 1 h before etoposide treatment.
Data from [Journal of Biological Chemistry 2011.March;286:8394-8404] KU-55933 purchased from Selleck
- It was great to talk to you.Our experience of KU55933 from your company is great.It worked as what we expected.In several cancer cell lines, it blocked etoposide-induced ATM phosphorylation at S1981. Also, it significantly reduced etoposide-induced H2AX phosphorylation at S139.
Renkuo LinUniversity of Medicine and Dentistry of New Jersey
- I am writing to provide my feedback on your product KU-55933 (cat#S1092). We have used this inhibitor in our virus infection studies and have obtained some interesting results. We are extremely satified with the quality of your product and the support provided by your customer service. Should this research results in any publication, we will refer your company for the usage of this product.
Meng, XiangbingThe University of Iowa
- As feedback I can tell you that we are happy with the compound.
Coby Meijer PhDUniversity Medical Center Groningen Medische Oncologie, Lab. MOL “de Vitrine”Groningen
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effect of ATM inhibitor in etoposide-induced cell death. The cells were pretreated with KU55933 (2 M) for 1 h before etoposide treatment.
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Data from [Journal of Biological Chemistry 2011.March;286:8394-8404]
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