ATM Selective Inhibitors | Activators

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1570 KU-60019

KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.

 Selective ATM, IC50: 6.3 nM
S1092 KU-55933 (ATM Kinase Inhibitor)

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

 Selective ATM, IC50: 12.9 nM
S2758 Wortmannin

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.

Selective ATM, IC50: 150 nM
S2245 CP-466722

CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

 Selective ATM, IC50: 410 nM
S4157 Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.

Selective
S2817 Torin 2

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.

 Pan ATM, EC50: 28 nM
S7136 CGK 733

CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.

 Pan ATM, IC50: 200 nM
S8050 ETP-46464

ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.

 Pan ATM, IC50: 545 nM
S7102 VE-822

VE-822 is an ATR inhibitor with IC50 of 19 nM.

 Pan ATM, IC50: 34 μM