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Dehydrogenase Inhibitors (20)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1501 Mycophenolate Mofetil Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.
  • Front Immunol, 2013, 4:46
S2776 CPI-613 CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. Phase 2.
S1247 Leflunomide Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent.
  • J Proteomics, 2012, 79:114-22
  • Cell Immunol, 2014, 288(1-2):1-7
S7185 AGI-5198 AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
S1158 MK-8245 MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.
S7900 SW033291 SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Kiapp of 1.5 nM and 0.1 nM, respectively.
S7941 NCT-501 NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
S1680 Disulfiram Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.
  • J Proteomics, 2012, 79:114-22
S1404 Trilostane Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.
  • Cell Mol Life Sci, 2014, 71(9):1723-40
  • Biol Reprod, 2012, 87(2):35
  • J Mol Endocrinol, 2014, 53(2):175-90
S4169 Teriflunomide Teriflunomide is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase, used as an immunomodulatory agent.
Cat.No. Product Name Information Product Use Citation Customer Product Validation
S2376 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses.
S8076 PluriSIn #1 (NSC 14613) PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.
S2055 Gimeracil Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.
S2296 Enoxolone Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
S2295 Emodin Emodin is a purgative resin, 6-methyl-1,3,8-trihydroxyanthraquinone, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica).
  • ACS Chem Biol, 2015, 10.1021/cb5009487
  • Food Chem Toxicol, 2013, 55:363-70
S4116 Isovaleramide Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.
S7241 AGI-6780 AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
S2302 Glycyrrhizin (Glycyrrhizic Acid) Glycyrrhizin (Glycyrrhizic Acid) is a widely used anti-inflammatory agent isolated from the licorice root.
S2303 Gossypol Acetate Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
  • Pigment Cell Melanoma Res, 2015, 28(2):161-70
  • Arch Pharm Chem Life Sci, 2015, 348: 1-11
  • Georg August University Gattingen, 2014, Keitel U, et al.
S7262 Vidofludimus Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Phase 2.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1501 Mycophenolate Mofetil <1 mg/mL 86 mg/mL <1 mg/mL
S2776 CPI-613 <1 mg/mL 78 mg/mL 78 mg/mL
S1247 Leflunomide <1 mg/mL 54 mg/mL 54 mg/mL
S7185 AGI-5198 <1 mg/mL 24 mg/mL 14 mg/mL
S1158 MK-8245 <1 mg/mL 93 mg/mL <1 mg/mL
S7900 SW033291 <1 mg/mL 83 mg/mL 32 mg/mL
S7941 NCT-501 <1 mg/mL 32 mg/mL 25 mg/mL
S1680 Disulfiram <1 mg/mL 59 mg/mL 59 mg/mL
S1404 Trilostane <1 mg/mL 65 mg/mL <1 mg/mL
S4169 Teriflunomide <1 mg/mL 32 mg/mL ,1 mg/mL
S2376 Ammonium Glycyrrhizinate 5 mg/mL 168 mg/mL <1 mg/mL
S8076 PluriSIn #1 (NSC 14613) <1 mg/mL 43 mg/mL <1 mg/mL
S2055 Gimeracil <1 mg/mL 29 mg/mL <1 mg/mL
S2296 Enoxolone <1 mg/mL 94 mg/mL <1 mg/mL
S2295 Emodin <1 mg/mL 54 mg/mL 3 mg/mL
S4116 Isovaleramide <1 mg/mL 20 mg/mL 20 mg/mL
S7241 AGI-6780 <1 mg/mL 96 mg/mL 96 mg/mL
S2302 Glycyrrhizin (Glycyrrhizic Acid) 20 mg/mL 117 mg/mL 165 mg/mL
S2303 Gossypol Acetate <1 mg/mL 100 mg/mL 21 mg/mL
S7262 Vidofludimus <1 mg/mL 100 mg/mL 1 mg/mL
Tags: Dehydrogenase inhibition | Dehydrogenase activity | Dehydrogenase assay | Dehydrogenase reaction | Dehydrogenase enzyme activity | pyruvate dehydrogenase inhibition | pyruvate dehydrogenase activity | pyruvate dehydrogenase assay | pyruvate dehydrogenase phosphorylation | pyruvate dehydrogenase cancer | pyruvate dehydrogenase pathway | pyruvate dehydrogenase activation | dihydropyrimidine dehydrogenase activity | stearoyl-CoA desaturase pathway | Dehydrogenase inhibitor review
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