Home Metabolism Dehydrogenase inhibitor Isovaleramide

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Isovaleramide Dehydrogenase inhibitor

Cat.No.S4116

Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases.
Isovaleramide Dehydrogenase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 101.15

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Quality Control

Purity: >97%
97

Solubility

In vitro
Batch:

DMSO : 20 mg/mL (197.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 20 mg/mL

Ethanol : 20 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 101.15 Formula

C5H11NO

 Storage (From the date of receipt)
CAS No. 541-46-8 Download SDF Storage of Stock Solutions

Synonyms 3-Methylbutanamide Smiles CC(C)CC(=O)N

Mechanism of Action

Targets/IC50/Ki
alcohol dehydrogenase
In vitro

Isovaleramide is isolated from the most active fraction of Valeriana pavonii. This compound (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. It is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. This chemical (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3.

In vivo

Isovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). This compound produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. It shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits.

References
  • [4] https://pubmed.ncbi.nlm.nih.gov/6343601/

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