Disulfiram

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

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In DMSO USD 130 In stock
USD 97 In stock
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Disulfiram  Chemical Structure

Disulfiram Chemical Structure
Molecular Weight: 296.54

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

Related Compound Libraries

Disulfiram is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. [1]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02129257 Recruiting Metastatic Colorectal Cancer Hellenic Cooperative Oncology Group|Sanofi 2014-05 Phase 2
NCT02134002 Not yet recruiting Cocaine Dependence Assistance Publique - Hôpitaux de Paris; National Research Agency, France 2014-06 Phase 4
NCT02101021 Not yet recruiting Metastatic Pancreatic Ductal Adenocarcinoma Gilead Sciences 2014-06 Phase 2
NCT02129699 Not yet recruiting Lung Cancer Non-small Cell Stage IV European Thoracic Oncology Platform|European Organisation for Research and Treatment of Cancer - EORTC|Amgen 2014-08 Phase 3
NCT01622764 Withdrawn Glioblastoma University Medical Centre Groningen 2014-09 Phase 2

Chemical Information

Download Disulfiram SDF
Molecular Weight (MW) 296.54
Formula

C10H20N2S4

CAS No. 97-77-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 59 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 59 mg/mL (198 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Customer Reviews (1)


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Rating
Source J Proteomics, 2013, 79:114-22. Disulfiram purchased from Selleck
Method Motility Assay
Cell Lines human sperm
Concentrations 10-80 uM
Incubation Time 0, 15, 30, 60 or 120 min
Results Disulfiram inhibited sperm motility.

Product Citations (2)

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