Disulfiram

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

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In DMSO USD 130 In stock
USD 97 In stock
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Disulfiram  Chemical Structure

Disulfiram Chemical Structure
Molecular Weight: 296.54

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

Related Compound Libraries

Disulfiram is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-09-13)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02134002 Not yet recruiting Cocaine Dependence Assistance Publique - Hôpitaux de Paris|National Research Agency, France June 2014 Phase 4
NCT01777919 Not yet recruiting Glioblastoma Multiforme Olympion Medical Center|University of Ioannina|University of Patras|University of Athens March 2014 Phase 2
NCT01907165 Recruiting Glioblastoma Washington University School of Medicine October 2013 --
NCT01944371 Recruiting HIV|Human Immunodeficiency Virus University of California, San Francisco|Monash University|amfAR, The Foundation for AIDS Research|National Institute of Allergy and Infectious Diseases (NIAID) August 2013 Phase 1|Phase 2
NCT01286259 Active, not recruiting HIV-1 Infection University of California, San Francisco|Johns Hopkins University January 2011 --

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Chemical Information

Download Disulfiram SDF
Molecular Weight (MW) 296.54
Formula

C10H20N2S4

CAS No. 97-77-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 59 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 59 mg/mL (198 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Customer Reviews (1)


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Rating
Source J Proteomics, 2013, 79:114-22. Disulfiram purchased from Selleck
Method Motility Assay
Cell Lines human sperm
Concentrations 10-80 uM
Incubation Time 0, 15, 30, 60 or 120 min
Results Disulfiram inhibited sperm motility.

Product Citations (2)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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