Ivosidenib (AG-120)

Catalog No.S8206

Ivosidenib (AG-120) Chemical Structure

Molecular Weight(MW): 582.96

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.

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Biological Activity

Description Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
Targets
IDH1 [1]
In vitro

TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation[1].

Protocol

Cell Research:

[1]

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  • Cell lines: TF-1 cells
  • Concentrations: 0.5, 1.0, and 5.0 μM
  • Incubation Time: 6 days
  • Method:

    TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (171.53 mM)
Ethanol 100 mg/mL (171.53 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 582.96
Formula

C28H22ClF3N6O3

CAS No. 1448347-49-6
Storage powder
Synonyms

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID