Research Area
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Chelerythrine Chloride Chemical Structure
Enzastaurin (LY317615)
Enzastaurin (LY317615) is a potent PKC beta inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.
Zoledronic Acid (Zoledronate)
A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM.
CX-4945
CX-4945 is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
Quercetin (Sophoretin)
Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml.
Fingolimod (FTY720)
Fingolimod (FTY720) Gilenia is Src-bcr-Abl Inhibitor & S1P receptor agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate.
Enzastaurin (LY317615)
Enzastaurin (LY317615) is a potent PKC beta inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.
Zoledronic Acid (Zoledronate)
A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM.
Staurosporine
Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
Theophylline(Theo-Dur)
Theophylline (Theo-Dur) is a methylxanthine agent and has bronchodilator properties and is used in the treatment of asthma and COAD.
CX-4945
CX-4945 is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
Biological Activity
Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus). It is a potent, selective, and cell-permeable PKC inhibitor (IC50 = 660 nM). It has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. [1,2]
References on Chelerythrine Chloride
- [1] BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS November 15, 1990 ;172:993-999
Product Information
| Molecular Weight (WM): | 384.83 |
|---|---|
| Formula: | C21H18NO4.HCl |
| CAS No.: | 3895-92-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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