JNK

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JNK Inhibitors | Activators (5)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1460 SP600125 SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
  • Cancer Cell, 2016, 10.1016/j.ccell.2016.01.006
  • Cell Stem Cell, 2013, 12(6):774-86
  • Mol Syst Biol, 2015, 11(3):797
S4901 JNK-IN-8 JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.
  • Cancer Cell, 2016, 10.1016/j.ccell.2016.01.006
  • J Exp Med, 2015, 10.1084/jem.20141957
  • J Clin Endocrinol Metab, 2015, 10.1210/jc.2015-1734
S7508 JNK Inhibitor IX JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.
S7637 DTP3 DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.
S7409 Anisomycin Anisomycin is an antibiotic, which inhibits protein synthesis, and also act as a JNK activator.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1460 SP600125 <1 mg/mL 44 mg/mL <1 mg/mL
S4901 JNK-IN-8 <1 mg/mL 100 mg/mL <1 mg/mL
S7508 JNK Inhibitor IX <1 mg/mL 20 mg/mL <1 mg/mL
S7637 DTP3 100 mg/mL 100 mg/mL 100 mg/mL
S7409 Anisomycin <1 mg/mL 41 mg/mL 17 mg/mL
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