JNK

Sigaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1460 SP600125 <1 mg/mL 44 mg/mL <1 mg/mL
S4901 JNK-IN-8 <1 mg/mL 100 mg/mL <1 mg/mL
S7544 Vacquinol-1 <1 mg/mL 70 mg/mL <1 mg/mL
S7409 Anisomycin <1 mg/mL 41 mg/mL 17 mg/mL
S7508 JNK Inhibitor IX <1 mg/mL 20 mg/mL <1 mg/mL
S8490 Tanzisertib(CC-930) 4 mg/mL 89 mg/mL 89 mg/mL
S8201 BI-78D3 <1 mg/mL 100 mg/mL <1 mg/mL
S7637 DTP3 100 mg/mL 100 mg/mL 100 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1460

SP600125

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.

S4901

JNK-IN-8

JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.

S7544

Vacquinol-1

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

S7508

JNK Inhibitor IX

JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.

S8490New

Tanzisertib(CC-930)

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

S8201New

BI-78D3

BI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.

S7409

Anisomycin

Anisomycin is an antibiotic, which inhibits protein synthesis, and also act as a JNK activator.

S7637

DTP3

DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.

Catalog No. Information Product Use Citations Product Validations
S1460

SP600125

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.

S4901

JNK-IN-8

JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.

S7544

Vacquinol-1

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

S7508

JNK Inhibitor IX

JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.

S8490New

Tanzisertib(CC-930)

CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.

S8201New

BI-78D3

BI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.

Catalog No. Information Product Use Citations Product Validations
S7409

Anisomycin

Anisomycin is an antibiotic, which inhibits protein synthesis, and also act as a JNK activator.

2017, 8(1):e2529

2016, 6:37388

S7637

DTP3

DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.