BI-78D3

Catalog No.S8201

BI-78D3 Chemical Structure

Molecular Weight(MW): 379.37

BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.

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Biological Activity

Description BI-78D3 is a competitive JNK inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.
Targets
JNK [1]
(Cell-free assay)
280 nM
In vitro

BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation[2].

In vivo In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes[1].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: Osteosarcoma cells (SaOS-2, MG-63, U2OS and LM7), primary (non-malignant) human osteoblasts(Hum63, Hum65 and Hum71)
  • Concentrations: 10 nM
  • Incubation Time: 24 h
  • Method:

    Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (263.59 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 379.37
Formula

C13H9N5O5S2

CAS No. 883065-90-5
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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JNK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID