Research Area
Product Type
United States ( Change Country )
SP600125 Chemical Structure
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Biological Activity
SP600125 is a JNK inhibitor (IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). This agent exhibits greater than 300-fold selectivity for JNK against related MAP kinases ERK1 and p38–2, and the serine threonine kinase PKA. [1]
SP600125 is a reversible ATP-competitive inhibitor. In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2, IL-2, IFN-γ, TNF-α, and prevented the activation and differentiation of primary human CD4 cell cultures. [1]
References on SP600125
- [1] PNAS November 20, 2001;98:13681–13686
Chemical Information
| Molecular Weight (WM): | 220.23 |
|---|---|
| Formula: | C14H8N2O |
| CAS No.: | 129-56-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥44mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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Selleck's high quality products have been used in several published research findings, including the following:
Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein
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