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Mineralocorticoid Receptor

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Cat.No. Product Name Information Product Use Citations Product Validations
S1707 Eplerenone Eplerenone is a mineralocorticoid receptor antagonist, and blocks the action of aldosterone, used to control high blood pressure.
J Immunother Cancer, 2024, 12(11)e009805
Acta Pharm Sin B, 2023, 13(2):662-677
Oncol Rep, 2021, 46(3)202
E1239 Apararenone Apararenone (MT-3995) is a selective, long-acting nonsteroidal mineralocorticoid receptors (MR) antagonist.
S5273 Canrenone Canrenone (Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone), a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nonselective aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.
S9702 Finerenone (BAY 94-8862) Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
E0704 Esaxerenone (CS-3150) Esaxerenone (CS-3150), a selective nonsteroidal mineralocorticoid receptor (MR) antagonist, binds to mineralocorticoid receptor and inhibits (3)H-aldosterone binding to mineralocorticoid receptor with an IC50 value of 9.4 nM. This compound also has the property of increasing the likelihood of albuminuria returning to normal levels and reducing progression of albuminuria to higher levels.