Progesterone Receptor

Endocrinology & Hormones

COX IL Receptor CXCR gp120/CD4 NOD AhR NADPH-oxidase ROS Nrf2 NOS TLR LTR Immunology & Inflammation related MALT STING Galectin NLR TpoR AKR1C SIK cGAS Interleukins IRAK TBK1 Glutathione MIF MmpL3 MyD88 TRIF Arginase FLAP IFN PGES SPHK Complement System GGT GPX FAP IKZF Family AIM2 IFNAR LAG-3 MHC Mucin RANKL/RANK TROP2 Squalene Epoxidase

All (18)
Progesterone Receptor Inhibitors (2)
Progesterone Receptor Antagonist (1)
Progesterone Receptor Agonists (9)
Progesterone Receptor Modulator (1)
New Progesterone Receptor Products

Cat.No.	Product Name	Information	Product Use Citations
S4040	Norethindrone	Norethindrone (Norethisterone) is a synthetic progestin, which mimic the actions of the endogenous ovarian hormone progesterone.	Nat Cancer, 2020, 1(2):235-248
S2606	Mifepristone (RU486)	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.	Pharmacol Res, 2025, 215:107696 Cell Death Dis, 2025, 16(1):237 J Virol, 2025, 99(2):e0147224
S2567	MPA (Medroxyprogesterone acetate)	Medroxyprogesterone acetate (MPA) is a synthetic progestin that acts as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.	Cancer Sci, 2025, 10.1111/cas.70081 Cell Prolif, 2024, e13780. J Transl Med, 2024, 22(1):478
S1304	Megestrol Acetate	Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.	iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1705	Progesterone	Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. This compound is a potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; an agonist of the membrane progesterone receptors(mPRs); an antagonist of the σ1 receptor.	Bone Res, 2025, 13(1):37 Nat Commun, 2024, 15(1):8708 Dev Cell, 2024, S1534-5807(24)00326-5
S1377	Drospirenone	Drospirenone (ZK 3059) is a synthetic progestin that is an analog to spironolactone.	Acta Pharm Sin B, 2023, 13(2):662-677 Nat Cancer, 2020, 1(2):235-248 J Thromb Haemost, 2015, 13(10):1918-24
S3081	Ulipristal Acetate (CDB 2914)	Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.	Nature, 2025, 10.1038/s41586-025-09684-7 J Clin Endocrinol Metab, 2019, 104(12):6256-6264 Cell Prolif, 2017, 50(5)
S1251	Dienogest	Dienogest (STS 557) is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
S3167	Altrenogest	Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone.
E0527	Norgestimate	Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity.
E0937	Segesterone acetate	Segesterone acetate (Nestoron, ST-1435) is a synthetic progestin that binds to the progesterone receptor with EC50 of 50.3 nM.
S4638	Desogestrel	Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
S4883	Lynestrenol	Lynestrenol (Ethinylestrenol) is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity.
S3635	Medroxyprogesterone	Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.
S4097	Dydrogesterone	Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
S4507	17-Hydroxyprogesterone	17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
E2664	Cridanimod	Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
E0742	Melengestrol Acetate	Melengestrol Acetate, progestational steroid suppress the AT3 tumour.
S1304	Megestrol Acetate	Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.	iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
E0742	Melengestrol Acetate	Melengestrol Acetate, progestational steroid suppress the AT3 tumour.
S2606	Mifepristone (RU486)	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.	Pharmacol Res, 2025, 215:107696 Cell Death Dis, 2025, 16(1):237 J Virol, 2025, 99(2):e0147224
S2567	MPA (Medroxyprogesterone acetate)	Medroxyprogesterone acetate (MPA) is a synthetic progestin that acts as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding.	Cancer Sci, 2025, 10.1111/cas.70081 Cell Prolif, 2024, e13780. J Transl Med, 2024, 22(1):478
S1705	Progesterone	Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. This compound is a potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; an agonist of the membrane progesterone receptors(mPRs); an antagonist of the σ1 receptor.	Bone Res, 2025, 13(1):37 Nat Commun, 2024, 15(1):8708 Dev Cell, 2024, S1534-5807(24)00326-5
S3167	Altrenogest	Altrenogest (A35957, RU2267,R2267) is a progestogen structurally related to veterinary steroid trenbolone.
S4638	Desogestrel	Desogestrel (Cerazette, Desogen, Desogestrelum, Org-2969) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
S4883	Lynestrenol	Lynestrenol (Ethinylestrenol) is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity.
S3635	Medroxyprogesterone	Medroxyprogesterone (MP) is a synthetic pregnane steroid and a derivative of progesterone. It is a potent progesterone receptor agonist.
S4097	Dydrogesterone	Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
S4507	17-Hydroxyprogesterone	17-Hydroxyprogesterone (17-OHP) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
E2664	Cridanimod	Cridanimod, a low-Mw interferon-inducer (IFN-inducer), recognizes the intracellular signaling protein stimulator of interferon genes (STING), resulting in the STING-TBK1-IRF3 pathway activation and synthesis of type I IFNs (subtypes IFN-α and IFN-β).
S3081	Ulipristal Acetate (CDB 2914)	Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.	Nature, 2025, 10.1038/s41586-025-09684-7 J Clin Endocrinol Metab, 2019, 104(12):6256-6264 Cell Prolif, 2017, 50(5)