Reverse Transcriptase

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine

Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus.

S1252

Entecavir Hydrate

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil

Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S4685New

Efavirenz

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S1742

Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS.

S1398

Stavudine (d4T)

Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

S1719

Zalcitabine

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4187

Salicylanilide

Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

Catalog No. Information Product Use Citations Product Validations
S1401

Tenofovir

Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

S1400

Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.

S1704

Emtricitabine

Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus.

S1252

Entecavir Hydrate

Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

S1718

Adefovir Dipivoxil

Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

S4685New

Efavirenz

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

S1742

Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

S1702

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

S1706

Lamivudine

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS.

S1398

Stavudine (d4T)

Stavudine (d4T) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

S1651

Telbivudine

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

S3080

Etravirine (TMC125)

Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

S2579

Zidovudine

Zidovudine (ZDV) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV.

S1719

Zalcitabine

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

S3165

Abacavir sulfate

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

S2914

Dapivirine (TMC120)

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.

S3076

Foscarnet Sodium

Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs.

S7303

Rilpivirine

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), and used to treat HIV-1 infection.

S4187

Salicylanilide

Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

S7856

Tenofovir Alafenamide (GS-7340)

Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

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