Catalog No.S1706 Synonyms: GR109714X

Lamivudine  Chemical Structure

Molecular Weight(MW): 229.26

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 117 In stock
USD 187 In stock
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1 Customer Review

  • The indicated liver cancer cell lines—Hep-3B, Huh-7 and PLC were treated with or without 5 types anti-hepatitis B virus drugs (C) with the concentration of 100 μM, and M1 virus (MOI = 10) for 72 hours. Following 72 hours, cell viabilities were determined by MTT assay (mean ± SD). N.S. Not significant.

    Oncotarget, 2017, 8(15):24694-24705. Lamivudine purchased from Selleck.

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Biological Activity

Description Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase.
Reverse transcriptase [1]
In vitro

Lamivudine’s anti- HBV activity, like its anti-HIV activity, has been shown to depend on the ability of LMV-TP to serve as both substrate and inhibitor of the DNA- and RNA-dependent polymerase activities of the HBV P gene product. Lamivudine owes its activity to the remarkably broad substrate specificity of deoxycytidine kinase and the unusual substrate preference of the HBV polymerases for dNTPs with the unnatural L-conformation, whereas the anti-HBV activity of PCV appears to depend on several factors including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity) by key cellular enzymes, the long intracellular half-life of PCV-TP and the ability of PCV-TP to inhibit the HBV RT priming reaction as well as RT and DNA polymerase activity. [1] Lamivudine and Penciclovir inhibits duck hepatitis B virus (DHBV) replication to a comparable extent when used alone, and in combination, the two nucleoside analogs acts synergistically over a wide range of clinically relevant concentrations. Lamivudine combined with Penciclovir is more effective in reducing the normally recalcitrant viral covalently closed circular (CCC) DNA form of DHBV than either drug alone. [2] Lamivudine inhibits p24 antigen production by HIV-I in PBMC, with ED50s ranging from 0.07 μM to 0.2 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
2.2.15 cells MofMSpVv[3Srb36gZZN{[Xl? MWHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDI[ZBifGm2aYOgRkB3cXK3czCoTGJXMSCrbjCyMlIvOTViY3XscJMtKEWFNUC9NE4xODhizszN Mn;LNVExPTJ5OUW=
PBMC cells Mne5SpVv[3Srb36gZZN{[Xl? M3TXOWVn\mWldHn2[UBkd26lZX70doF1cW:wIITvJIlvcGmkaYSgTGlXNTFiTFHJJIN6fG:yYYTobYNqfHliaX6gVGJOSyClZXzsd{B4[XNiZHX0[ZJucW6nZDDpckB3cXS{bzygSWM2OD1yLkCxNVYh|ryP NHfacVQyPDl5MUi5PC=>
human MT2 cells M1q4c2Z2dmO2aX;uJIF{e2G7 NX74RY1nPSCmYYnz NGnnSINCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEAxNjByNTDNU2khf2muZDD0fZBmKEiLVkGgUmw1NTNiaX7m[YN1\WRiaX6gbJVu[W5iTWSyJINmdGy|IH3lZZN2emWmIHHmeIVzKDViZHH5d{BjgSCUVDDTVGEtKEWFNUC9NE4xPCEQvF2= M2PFUVE5OzF4NUKx
human H9 cells M3XkUWZ2dmO2aX;uJIF{e2G7 NEOwPYtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlvKGi3bXHuJGg6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCkeTDmc5Ju[Xqjbj3iZZNm\CClb372[Y51cW:wYXygZ49td3KrbXX0dolkKHSnY3jubZF2\SxiRVO1NF0xNjB4IN88US=> NHrIfVcyOTR|MECxPS=>
human HuH7 cells MVnDfZRwfG:6aXPpeJkh[XO|YYm= MkPNOEBl[Xm| NHXjelFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGGodHXyJFQh\GG7czDifUBv\XW2cnHsJJJm\CCmeXWgeZB1[WunIHHzd4F6NCCFQ{WwQVAvOSEQvF2= M1rkZVIyOzN|NUO1
MT-4 cell M4jXO2Z2dmO2aX;uJIF{e2G7 NV6yfnFbS2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJN6dnSrY3Gg[o9zdWG2aX;uJIJ6KDVyJTDpckBJUVZvMTDpcoZm[3SnZDDNWE01KGOnbHzzMEBKSzVyPUCuNUDPxE1? Ml3oPFA{PTR{OR?=
HepG2.2.15 cells M2nLZ2Z2dmO2aX;uJIF{e2G7 MnnjSYZn\WO2aY\lJINwdmOnboTyZZRqd25idH:gbY5pcWKrdDDo[ZBifGm2aYOgRkB3cXK3czDjfZRweGG2aHnjbZR6KGmwIFjldGczNjJwMUWgZ4VtdHNid3HzJIRmfGW{bXnu[YQhcW5idnn0do8tKEWFNUC9NE4zKM7:TR?= MonLNVQ6PzF6OUi=
CEM-SS cells Mn63SpVv[3Srb36gZZN{[Xl? NVnIVpZLSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEmYLUGgd5VjfHmyZTCzRkBqdm[nY4Tl[EBqdiCFRV2tV3Mh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB4IHThfZMh[nliWGTUJIF{e2G7LDDFR|UxRTBwMjFOwG0> NETpdoczOjh3OEC5Oy=>
human HeLa P4/R5 cells MXjGeY5kfGmxbjDhd5NigQ>? NGPDU4hCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIHnu[oVkfGWmIHnuJIh2dWGwIFjlUIEhWDRxUkWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdixiSVO1NF0xNjd6IN88US=> MnXZNVk2QTZ6OEW=
HEK293 cells NEjU[o5HfW6ldHnvckBie3OjeR?= NGLSXXU4OiCq M1uzcWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhKXjFic4XieJlx\SCGIHnzc4xifGViODDpcoZm[3SnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{Bz\XCuaXPheIlwdiCjZoTldkA4OiCqcoOsJGVEPTB;Mz6yOUDPxE1? Mlr2NlA{ODh|N{e=
MDCK2 cells MWXGeY5kfGmxbjDhd5NigQ>? MWGxNEDPxE1? MXXJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDNiZYjwdoV{e2WmIHnuJG1FS0t{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiQ13GJIZtfW:{ZYPj[Y5k\SCjdDCxNEB2VSCkeTDDUWZFSSCjc4PhfS=> NGroTXMyPzF5MkOxNS=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 46 mg/mL (200.64 mM)
Water 46 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 229.26


CAS No. 134678-17-4
Storage powder
in solvent
Synonyms GR109714X

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00001644 Completed HIV Infection National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) March 3, 1997 Phase 1
NCT02935075 Not yet recruiting HIV Infections Shanghai Public Health Clinical Center January 2017 Phase 4
NCT02945163 Not yet recruiting HIV Infections Shanghai Public Health Clinical Center January 2017 Phase 4
NCT02659761 Not yet recruiting Human Immunodeficiency Virus University College Dublin|Mater Misericordiae University Hospital|ViiV Healthcare November 2016 Phase 4
NCT02832778 Recruiting HIV St Stephens Aids Trust|Mylan Inc.|United States Agency for International Development (USAID) September 2016 Phase 1
NCT02831673 Recruiting Infection, Human Immunodeficiency Virus ViiV Healthcare|PPD|GlaxoSmithKline July 2016 Phase 3

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Reverse Transcriptase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID